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    MIR654 microRNA 654 [ Homo sapiens (human) ]

    Gene ID: 724024, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Long noncoding RNA LINC00885 upregulates NCK1 to promote cell viability and migration of triple-negative breast cancer cells through sponging miR-654-3p.

    Long noncoding RNA LINC00885 upregulates NCK1 to promote cell viability and migration of triple-negative breast cancer cells through sponging miR-654-3p.
    He P, Liu Z, Qi J, Shan J, Sheng J., Free PMC Article

    02/2/2024
    Circular RNA EFR3A promotes nasopharyngeal carcinoma progression through modulating the miR-654-3p/EFR3A axis.

    Circular RNA EFR3A promotes nasopharyngeal carcinoma progression through modulating the miR-654-3p/EFR3A axis.
    Jiang P, Xia B.

    01/5/2024
    Circ_0084188 promotes colorectal cancer progression by sponging miR-654-3p and regulating kruppel-like factor 12.

    Circ_0084188 promotes colorectal cancer progression by sponging miR-654-3p and regulating kruppel-like factor 12.
    Wu CC, Hou BC, Yang YH, Li XF, Ma HC, Li BX.

    11/13/2023
    miR-654-5p Suppresses Migration and Proliferation of Vascular Smooth Muscle Cells by Targeting ADAMTS-7.

    miR-654-5p Suppresses Migration and Proliferation of Vascular Smooth Muscle Cells by Targeting ADAMTS-7.
    Li L, Wang S, Wang M, Liu G, Yang Z, Wang L.

    07/26/2023
    MiR-654-3p targets SRC to suppress tumor growth in non-small cell lung cancer.

    MiR-654-3p targets SRC to suppress tumor growth in non-small cell lung cancer.
    Pang M, Jiang Y, Huang Y, Ren B, He L, Jiang L.

    06/22/2023
    CircPLXNB2 regulates acute myeloid leukemia progression through miR-654-3p/CCND1 axis.

    CircPLXNB2 regulates acute myeloid leukemia progression through miR-654-3p/CCND1 axis.
    Wang J, Wu C, Zhou W.

    06/7/2023
    LncRNA NEAT1 inhibits apoptosis and autophagy of ovarian granulosa cells through miR-654/STC2-mediated MAPK signaling pathway.

    LncRNA NEAT1 inhibits apoptosis and autophagy of ovarian granulosa cells through miR-654/STC2-mediated MAPK signaling pathway.
    Liu YX, Ke Y, Qiu P, Gao J, Deng GP.

    03/9/2023
    CircRNA CORO1C Regulates miR-654-3p/USP7 Axis to Mediate Laryngeal Squamous Cell Carcinoma Progression.

    CircRNA CORO1C Regulates miR-654-3p/USP7 Axis to Mediate Laryngeal Squamous Cell Carcinoma Progression.
    Zhang J, Li H, Li J, Ke S.

    09/24/2022
    Comprehensive Analysis of hsa-miR-654-5p's Tumor-Suppressing Functions.

    Comprehensive Analysis of hsa-miR-654-5p's Tumor-Suppressing Functions.
    Liu C, Min L, Kuang J, Zhu C, Qiu X, Wu X, Zhang T, Xie S, Zhu L., Free PMC Article

    07/2/2022
    EMX2OS Delays Wilms'Tumor Progression via Targeting miR-654-3p.

    EMX2OS Delays Wilms'Tumor Progression via Targeting miR-654-3p.
    Chen ZH, Cui MY, Zhang HM.

    04/9/2022
    LncRNA TP73-AS1 promotes oxidized low-density lipoprotein-induced apoptosis of endothelial cells in atherosclerosis by targeting the miR-654-3p/AKT3 axis.

    LncRNA TP73-AS1 promotes oxidized low-density lipoprotein-induced apoptosis of endothelial cells in atherosclerosis by targeting the miR-654-3p/AKT3 axis.
    Ni J, Huang Z, Wang D., Free PMC Article

    12/25/2021
    LINC02532 Contributes to Radiosensitivity in Clear Cell Renal Cell Carcinoma through the miR-654-5p/YY1 Axis.

    LINC02532 Contributes to Radiosensitivity in Clear Cell Renal Cell Carcinoma through the miR-654-5p/YY1 Axis.
    Zhou X, Zeng B, Li Y, Wang H, Zhang X., Free PMC Article

    12/18/2021
    Interference with circRNA DOCK1 inhibits hepatocellular carcinoma cell proliferation, invasion and migration by regulating the miR-654-5p/SMAD2 axis.

    Interference with circRNA DOCK1 inhibits hepatocellular carcinoma cell proliferation, invasion and migration by regulating the miR-654-5p/SMAD2 axis.
    Lu Y, Zhang J, Wu Y., Free PMC Article

    10/30/2021
    miR6545p inhibits autophagy by targeting ATG7 via mTOR signaling in intervertebral disc degeneration.

    miR‑654‑5p inhibits autophagy by targeting ATG7 via mTOR signaling in intervertebral disc degeneration.
    Wang S, Guo Y, Zhang X, Wang C., Free PMC Article

    10/23/2021
    Long intergenic noncoding RNA LINC01232 contributes to esophageal squamous cell carcinoma progression by sequestering microRNA6543p and consequently promoting hepatomaderived growth factor expression.

    Long intergenic non‑coding RNA LINC01232 contributes to esophageal squamous cell carcinoma progression by sequestering microRNA‑654‑3p and consequently promoting hepatoma‑derived growth factor expression.
    Zhao M, Cui H, Zhao B, Li M, Man H., Free PMC Article

    07/10/2021
    Long noncoding RNA MKLN1AS aggravates hepatocellular carcinoma progression by functioning as a molecular sponge for miR6543p, thereby promoting hepatomaderived growth factor expression.

    Long non‑coding RNA MKLN1‑AS aggravates hepatocellular carcinoma progression by functioning as a molecular sponge for miR‑654‑3p, thereby promoting hepatoma‑derived growth factor expression.
    Gao W, Chen X, Chi W, Xue M., Free PMC Article

    07/3/2021
    Circular RNA hsa_circ_0085131 is involved in cisplatin-resistance of non-small-cell lung cancer cells by regulating autophagy.

    Circular RNA hsa_circ_0085131 is involved in cisplatin-resistance of non-small-cell lung cancer cells by regulating autophagy.
    Kong R.

    06/26/2021
    miR6543p suppresses cell viability and promotes apoptosis by targeting RASAL2 in nonsmallcell lung cancer.

    miR‑654‑3p suppresses cell viability and promotes apoptosis by targeting RASAL2 in non‑small‑cell lung cancer.
    Xiong J, Xing S, Dong Z, Niu L, Xu Q, Li Y, Liu P, Yang P., Free PMC Article

    05/8/2021
    Hsa_circ_0079480 promotes tumor progression in acute myeloid leukemia via miR-654-3p/HDGF axis.

    Hsa_circ_0079480 promotes tumor progression in acute myeloid leukemia via miR-654-3p/HDGF axis.
    Hu Q, Gu Y, Chen S, Tian Y, Yang S., Free PMC Article

    05/8/2021
    MiR-654-5p regulated cell progression and tumor growth through targeting SIRT6 in osteosarcoma.

    MiR-654-5p regulated cell progression and tumor growth through targeting SIRT6 in osteosarcoma.
    Xu XZ, Song H, Zhao Y, Zhang L.

    04/3/2021
    miR-654-3p predicts the prognosis of hepatocellular carcinoma and inhibits the proliferation, migration, and invasion of cancer cells.

    miR-654-3p predicts the prognosis of hepatocellular carcinoma and inhibits the proliferation, migration, and invasion of cancer cells.
    Yang J, Zhang Z, Chen S, Dou W, Xie R, Gao J.

    02/6/2021
    MiRNA Regulation of MIF in SLE and Attenuation of Murine Lupus Nephritis With miR-654.

    MiRNA Regulation of MIF in SLE and Attenuation of Murine Lupus Nephritis With miR-654.
    Tu Y, Guo R, Li J, Wang S, Leng L, Deng J, Bucala R, Lu L., Free PMC Article

    11/21/2020
    miR-654-5p Targets HAX-1 to Regulate the Malignancy Behaviors of Colorectal Cancer Cells.

    miR-654-5p Targets HAX-1 to Regulate the Malignancy Behaviors of Colorectal Cancer Cells.
    Huang F, Wu X, Wei M, Guo H, Li H, Shao Z, Wu Y, Pu J., Free PMC Article

    11/21/2020
    Study found that miR-654 was up-regulated in gastric cancer (GC) tissues and cells, and promoted the proliferation of GC cells. miR-654 can inhibit the protein expression of p21 in GC cells, whereas circRHOBTB3 enhanced the protein expression of p21. circRHOBTB3 inhibited the activity of miR-654, and thus, reversed the miR- 654 induced cell proliferation and upregulated the protein expression of p21 indirectly.

    Circular RNA circRHOBTB3 acts as a sponge for miR-654-3p inhibiting gastric cancer growth.
    Deng G, Mou T, He J, Chen D, Lv D, Liu H, Yu J, Wang S, Li G., Free PMC Article

    06/6/2020
    CDCP1 and PLAGL2 oncogenes were found to be the most relevant direct miR-654-5p targets and both genes convey in a molecular signature associated with key cancer pathways relevant to ovarian tumorigenesis, such as MYC, WNT and AKT pathways. This unveiled the tumor suppressor function of miR-654-5p, suggesting that its restoration or co-targeting of CDCP1 and PLAGL2 may be an effective therapeutic approach for cancer.

    MicroRNA-654-5p suppresses ovarian cancer development impacting on MYC, WNT and AKT pathways.
    Majem B, Parrilla A, Jiménez C, Suárez-Cabrera L, Barber M, Marín A, Castellví J, Tamayo G, Moreno-Bueno G, Ponce J, Matias-Guiu X, Alameda F, Romero I, Sánchez JL, Pérez-Benavente A, Moran S, Esteller M, Reventós J, Rigau M, Gil-Moreno A, Segura MF, Santamaría A.

    02/1/2020
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