| Endothelial RSPO3 mediates pulmonary endothelial regeneration by LGR4-dependent activation of beta-catenin and ILK signaling pathways after inflammatory vascular injury. | Endothelial RSPO3 mediates pulmonary endothelial regeneration by LGR4-dependent activation of β-catenin and ILK signaling pathways after inflammatory vascular injury.
Zhang H, Liu D, Xu QF, Wei J, Zhao Y, Xu DF, Wang Y, Liu YJ, Zhu XY, Jiang L. | 07/3/2024 |
| Rspo1 and Rspo3 are required for sensory lineage neural crest formation in mouse embryos. | Rspo1 and Rspo3 are required for sensory lineage neural crest formation in mouse embryos.
Shinozuka T, Aoki M, Hatakeyama Y, Sasai N, Okamoto H, Takada S. | 04/4/2024 |
| Increased R-spondin 3 contributes to aerobic exercise-induced protection against renal vascular endothelial hyperpermeability and acute kidney injury. | Increased R-spondin 3 contributes to aerobic exercise-induced protection against renal vascular endothelial hyperpermeability and acute kidney injury.
Xu QF, Zhang H, Zhao Y, Liu D, Wei J, Jiang L, Liu YJ, Zhu XY. | 11/28/2023 |
| R-spondin-3 promotes proliferation and invasion of breast cancer cells independently of Wnt signaling. | R-spondin-3 promotes proliferation and invasion of breast cancer cells independently of Wnt signaling.
Ter Steege EJ, Doornbos LW, Haughton PD, van Diest PJ, Hilkens J, Derksen PWB, Bakker ERM. | 07/24/2023 |
| R-spondin 3/LGR4 (Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 4) Axis Is a Novel Inflammatory and Neurite Outgrowth Signaling System in the Ischemic Brain in Mice. | R-spondin 3/LGR4 (Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 4) Axis Is a Novel Inflammatory and Neurite Outgrowth Signaling System in the Ischemic Brain in Mice.
Shimamura M, Hayashi H, Ju N, Yoshida S, Baba S, Sasaki T, Mochizuki H, Morishita R, Nakagami H. | 05/25/2023 |
| R-spondin/YAP axis promotes gastric oxyntic gland regeneration and Helicobacter pylori-associated metaplasia in mice. | R-spondin/YAP axis promotes gastric oxyntic gland regeneration and Helicobacter pylori-associated metaplasia in mice.
Fischer AS, Müllerke S, Arnold A, Heuberger J, Berger H, Lin M, Mollenkopf HJ, Wizenty J, Horst D, Tacke F, Sigal M., Free PMC Article | 01/28/2023 |
| R-spondin 3 deletion induces Erk phosphorylation to enhance Wnt signaling and promote bone formation in the appendicular skeleton. | R-spondin 3 deletion induces Erk phosphorylation to enhance Wnt signaling and promote bone formation in the appendicular skeleton.
Nagano K, Yamana K, Saito H, Kiviranta R, Pedroni AC, Raval D, Niehrs C, Gori F, Baron R., Free PMC Article | 01/28/2023 |
| R-spondin-3 is an oncogenic driver of poorly differentiated invasive breast cancer. | R-spondin-3 is an oncogenic driver of poorly differentiated invasive breast cancer.
Ter Steege EJ, Boer M, Timmer NC, Ammerlaan CM, Song JY, Derksen PW, Hilkens J, Bakker ER., Free PMC Article | 10/8/2022 |
| R-spondin3 is a myokine that differentiates myoblasts to type I fibres. | R-spondin3 is a myokine that differentiates myoblasts to type I fibres.
Mita Y, Zhu H, Furuichi Y, Hamaguchi H, Manabe Y, Fujii NL., Free PMC Article | 08/6/2022 |
| Synergistic roles of Wnt modulators R-spondin2 and R-spondin3 in craniofacial morphogenesis and dental development. | Synergistic roles of Wnt modulators R-spondin2 and R-spondin3 in craniofacial morphogenesis and dental development.
Alhazmi N, Carroll SH, Kawasaki K, Woronowicz KC, Hallett SA, Macias Trevino C, Li EB, Baron R, Gori F, Yelick PC, Harris MP, Liao EC., Free PMC Article | 12/11/2021 |
| Rspo3 regulates the abnormal differentiation of small intestinal epithelial cells in diabetic state. | Rspo3 regulates the abnormal differentiation of small intestinal epithelial cells in diabetic state.
Shan TD, Yue H, Sun XG, Jiang YP, Chen L., Free PMC Article | 09/4/2021 |
| RSPO3 was found to be highly elevated in the active lesions of fibrotic tissues in mouse models of fibrosis. | Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs.
Zhang M, Haughey M, Wang NY, Blease K, Kapoun AM, Couto S, Belka I, Hoey T, Groza M, Hartke J, Bennett B, Cain J, Gurney A, Benish B, Castiglioni P, Drew C, Lachowicz J, Carayannopoulos L, Nathan SD, Distler J, Brenner DA, Hariharan K, Cho H, Xie W., Free PMC Article | 07/11/2020 |
| Results show that R-spondin3 protein (Rspo3) is essential for epithelial repair via induction of of Wnt signaling in differentiated cells. | R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon.
Harnack C, Berger H, Antanaviciute A, Vidal R, Sauer S, Simmons A, Meyer TF, Sigal M., Free PMC Article | 01/18/2020 |
| Study found that R-Spo3 was the major R-Spo family member produced in the intestine and it was predominantly produced by CD45-CD90+CD31+ lymphatic endothelial cells (LECs) in the lamina propria of the intestinal mucosa. LECs were significantly reduced in number, and their R-Spo3 production was impaired in intestinal graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. | Intestinal Lymphatic Endothelial Cells Produce R-Spondin3.
Ogasawara R, Hashimoto D, Kimura S, Hayase E, Ara T, Takahashi S, Ohigashi H, Yoshioka K, Tateno T, Yokoyama E, Ebata K, Kondo T, Sugita J, Onozawa M, Iwanaga T, Teshima T., Free PMC Article | 11/2/2019 |
| RSPO3 knockdown in basal-like mouse mammary tumor cells reduced canonical Wnt signaling, epithelial-to-mesenchymal transition-like features, migration capacity, and tumor formation in vivo Conversely, RSPO3 overexpression, which was associated with some LGR and RUNX factors, highly correlated with the basal-like subtype among patients with breast cancer | R-spondin3 Is Associated with Basal-Progenitor Behavior in Normal and Tumor Mammary Cells.
Tocci JM, Felcher CM, García Solá ME, Goddio MV, Zimberlin MN, Rubinstein N, Srebrow A, Coso OA, Abba MC, Meiss RP, Kordon EC. | 09/28/2019 |
| Rspo2 and Rspo3 fusion events are sufficient to initiate hyperplasia and tumour development. | R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine.
Han T, Schatoff EM, Murphy C, Zafra MP, Wilkinson JE, Elemento O, Dow LE., Free PMC Article | 01/5/2019 |
| These results shed new light on the role of Rspo3 in heart development and demonstrate that LGR4 is the principal R-spondin 3 receptor in the heart. | Myocardial-specific R-spondin3 drives proliferation of the coronary stems primarily through the Leucine Rich Repeat G Protein coupled receptor LGR4.
Da Silva F, Massa F, Motamedi FJ, Vidal V, Rocha AS, Gregoire EP, Cai CL, Wagner KD, Schedl A., Free PMC Article | 08/11/2018 |
| Results identify a mechanism through which localized expression of RSPO3 induces proliferation of the coronary arteries at their stems and permits their formation. | Coronary Artery Formation Is Driven by Localized Expression of R-spondin3.
Da Silva F, Rocha AS, Motamedi FJ, Massa F, Basboga C, Morrison H, Wagner KD, Schedl A. | 05/19/2018 |
| Rspo3-LGR4 axis protects hepatocytes from hypoxia/reoxygenation injury via activating beta-catenin. | R-spondin3-LGR4 signaling protects hepatocytes against DMOG-induced hypoxia/reoxygenation injury through activating β-catenin.
Liu S, Yin Y, Yu R, Li Y, Zhang W., Free PMC Article | 04/14/2018 |
| H. pylori infection increases stromal R-spondin 3 expression and expands the Axin2(+) cell pool to cause hyperproliferation and gland hyperplasia; the ability of stromal niche cells to control and adapt epithelial stem cell dynamics constitutes a sophisticated mechanism that orchestrates epithelial regeneration and maintenance of tissue integrity | Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.
Sigal M, Logan CY, Kapalczynska M, Mollenkopf HJ, Berger H, Wiedenmann B, Nusse R, Amieva MR, Meyer TF. | 01/27/2018 |
| We provide in vivo evidence that RSPO3 stimulates the crypt stem cell and niche compartments and drives rapid intestinal tumorigenesis. | RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis.
Hilkens J, Timmer NC, Boer M, Ikink GJ, Schewe M, Sacchetti A, Koppens MAJ, Song JY, Bakker ERM., Free PMC Article | 08/5/2017 |
| Rspo3 function remains essential in adult life to ensure replenishment of lost cells and maintain the properties of the zona glomerulosa | The adrenal capsule is a signaling center controlling cell renewal and zonation through Rspo3.
Vidal V, Sacco S, Rocha AS, da Silva F, Panzolini C, Dumontet T, Doan TM, Shan J, Rak-Raszewska A, Bird T, Vainio S, Martinez A, Schedl A., Free PMC Article | 05/13/2017 |
| Conditional deletion of Rspo3 in mice disrupts activation of central fate, demonstrating its crucial role in determining and maintaining beta-catenin-dependent zonation. | The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation.
Rocha AS, Vidal V, Mertz M, Kendall TJ, Charlet A, Okamoto H, Schedl A. | 12/17/2016 |
| data identify endothelial RSPO3-driven non-canonical WNT/Ca(2+)/NFAT signaling as a critical maintenance pathway of the remodeling vasculature | Endothelial RSPO3 Controls Vascular Stability and Pruning through Non-canonical WNT/Ca(2+)/NFAT Signaling.
Scholz B, Korn C, Wojtarowicz J, Mogler C, Augustin I, Boutros M, Niehrs C, Augustin HG. | 05/28/2016 |
| Nkx2-5 has a role in regulating cardiac growth through modulation of Wnt signaling by R-spondin3 | Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3.
Cambier L, Plate M, Sucov HM, Pashmforoush M., Free PMC Article | 09/20/2014 |