| TYROBP as a molecular target in cholangiocarcinoma, renal cancer and abdominal aortic aneurysm. | TYROBP as a molecular target in cholangiocarcinoma, renal cancer and abdominal aortic aneurysm.
Jia W, Chen L, Hou S, Kang C, Deng H., Free PMC Article | 01/30/2024 |
| MMP9 and TYROBP affect the survival of circulating tumor cells in clear cell renal cell carcinoma by adapting to tumor immune microenvironment. | MMP9 and TYROBP affect the survival of circulating tumor cells in clear cell renal cell carcinoma by adapting to tumor immune microenvironment.
Guo L, An T, Zhou H, Wan Z, Huang Z, Chong T., Free PMC Article | 05/3/2023 |
| Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia. | Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia.
Zhou Y, Tada M, Cai Z, Andhey PS, Swain A, Miller KR, Gilfillan S, Artyomov MN, Takao M, Kakita A, Colonna M., Free PMC Article | 03/8/2023 |
| TYRO protein tyrosine kinase-binding protein predicts favorable overall survival in osteosarcoma and correlates with antitumor immunity. | TYRO protein tyrosine kinase-binding protein predicts favorable overall survival in osteosarcoma and correlates with antitumor immunity.
Xu HR, Chen JJ, Shen JM, Ding WH, Chen J., Free PMC Article | 10/8/2022 |
| The role of SPI1-TYROBP-FCER1G network in oncogenesis and prognosis of osteosarcoma, and its association with immune infiltration. | The role of SPI1-TYROBP-FCER1G network in oncogenesis and prognosis of osteosarcoma, and its association with immune infiltration.
Li J, Shi H, Yuan Z, Wu Z, Li H, Liu Y, Lu M, Lu M., Free PMC Article | 05/14/2022 |
| TYROBP, TLR4 and ITGAM regulated macrophages polarization and immune checkpoints expression in osteosarcoma. | TYROBP, TLR4 and ITGAM regulated macrophages polarization and immune checkpoints expression in osteosarcoma.
Liang T, Chen J, Xu G, Zhang Z, Xue J, Zeng H, Jiang J, Chen T, Qin Z, Li H, Ye Z, Nie Y, Liu C, Zhan X., Free PMC Article | 12/25/2021 |
| TYROBP is a potential prognostic biomarker of clear cell renal cell carcinoma. | TYROBP is a potential prognostic biomarker of clear cell renal cell carcinoma.
Wu P, Xiang T, Wang J, Lv R, Wu G., Free PMC Article | 12/4/2021 |
| Non-pathological roles of microglial TREM2/DAP12: TREM2/DAP12 regulates the physiological functions of microglia from development to aging. | Non-pathological roles of microglial TREM2/DAP12: TREM2/DAP12 regulates the physiological functions of microglia from development to aging.
Konishi H, Kiyama H. | 10/23/2021 |
| Elevated TYROBP expression predicts poor prognosis and high tumor immune infiltration in patients with low-grade glioma. | Elevated TYROBP expression predicts poor prognosis and high tumor immune infiltration in patients with low-grade glioma.
Lu J, Peng Y, Huang R, Feng Z, Fan Y, Wang H, Zeng Z, Ji Y, Wang Y, Wang Z., Free PMC Article | 10/23/2021 |
| Identification of TYROBP and FCER1G as Key Genes with Prognostic Value in Clear Cell Renal Cell Carcinoma by Bioinformatics Analysis. | Identification of TYROBP and FCER1G as Key Genes with Prognostic Value in Clear Cell Renal Cell Carcinoma by Bioinformatics Analysis.
Wang L, Lin Y, Yuan Y, Liu F, Sun K. | 10/2/2021 |
| Constitutively Activated DAP12 Induces Functional Anti-Tumor Activation and Maturation of Human Monocyte-Derived DC. | Constitutively Activated DAP12 Induces Functional Anti-Tumor Activation and Maturation of Human Monocyte-Derived DC.
Dalton R, Calescibetta A, Zhou JM, Maurin M, Ward G, Trinh TL, Tu N, Gilvary D, Chen X, Cheng P, Kostenko E, Wei S, Wright KL, Eksioglu EA., Free PMC Article | 09/11/2021 |
| Three-gene prognostic biomarkers for seminoma identified by weighted gene co-expression network analysis. | Three-gene prognostic biomarkers for seminoma identified by weighted gene co-expression network analysis.
Chen H, Chen G, Pan Y, Jin X., Free PMC Article | 12/12/2020 |
| REVIEW: Siglecs that Associate with DAP12 | Siglecs that Associate with DAP12.
Angata T. | 03/28/2020 |
| Results suggest that TYROBP/DAP12 could represent a novel therapeutic target to slow, arrest, or prevent the development of sporadic LOAD. These data establish that the network pathology observed in postmortem human LOAD brain can be faithfully recapitulated in the brain of a genetically manipulated mouse. | Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden.
Haure-Mirande JV, Wang M, Audrain M, Fanutza T, Kim SH, Heja S, Readhead B, Dudley JT, Blitzer RD, Schadt EE, Zhang B, Gandy S, Ehrlich ME., Free PMC Article | 12/7/2019 |
| High DAP12 expression is associated with Intestinal Inflammation and Immune Dysfunction in Inflammatory Bowel Diseases. | Genetic and Pharmacological Dissection of the Role of Spleen Tyrosine Kinase (Syk) in Intestinal Inflammation and Immune Dysfunction in Inflammatory Bowel Diseases.
Biagioli M, Mencarelli A, Carino A, Cipriani S, Marchianò S, Fiorucci C, Donini A, Graziosi L, Baldelli F, Distrutti E, Costantino G, Fiorucci S. | 02/23/2019 |
| Heterozygous carriership of the TYROBP deletion is not a major risk factor of cognitive impairment. | Heterozygous TYROBP deletion (PLOSL(FIN)) is not a strong risk factor for cognitive impairment.
Kaivola K, Jansson L, Saarentaus E, Kiviharju A, Rantalainen V, Eriksson JG, Strandberg TE, Polvikoski T, Myllykangas L, Tienari PJ. | 09/29/2018 |
| Mutations in TYROBP are not a common cause of dementia in this Turkish cohort. | Mutations in TYROBP are not a common cause of dementia in a Turkish cohort.
Darwent L, Carmona S, Lohmann E, Guven G, Kun-Rodrigues C, Bilgic B, Hanagasi H, Gurvit H, Erginel-Unaltuna N, Pak M, Hardy J, Singleton A, Brás J, Guerreiro R., Free PMC Article | 02/17/2018 |
| Rare TYROBP variants might contribute to early-onset Alzheimer's disease risk by reduction of TREM2 expression, a well-established risk factor for AD. | TYROBP genetic variants in early-onset Alzheimer's disease.
Pottier C, Ravenscroft TA, Brown PH, Finch NA, Baker M, Parsons M, Asmann YW, Ren Y, Christopher E, Levitch D, van Blitterswijk M, Cruchaga C, Campion D, Nicolas G, Richard AC, Guerreiro R, Bras JT, Zuchner S, Gonzalez MA, Bu G, Younkin S, Knopman DS, Josephs KA, Parisi JE, Petersen RC, Ertekin-Taner N, Graff-Radford NR, Boeve BF, Dickson DW, Rademakers R., Free PMC Article | 10/14/2017 |
| TYROBP influences a batch of genes that are related to Alzheimer's disease; ZNF329 and RB1 significantly regulate those 'mesenchymal' gene expression signature genes for brain tumors. By merely leveraging gene expression data, Context Based Dependency Network (CBDN) can efficiently infer the existence of gene-gene interactions as well as their regulatory directions. | Reconstructing directed gene regulatory network by only gene expression data.
Zhang L, Feng XK, Ng YK, Li SC., Free PMC Article | 09/16/2017 |
| TYROBP/CSTA gene interaction might play pivotal roles in the occurrence and development of Postmenopausal Osteoporosis | Identification of crucial genes related to postmenopausal osteoporosis using gene expression profiling.
Ma M, Chen X, Lu L, Yuan F, Zeng W, Luo S, Yin F, Cai J. | 01/14/2017 |
| The different expression of DAP12 compared to TREM2 represents the first description of such variable expressivity in Nasu-Hakola disease (NHD) microglia. | Variable expression of microglial DAP12 and TREM2 genes in Nasu-Hakola disease.
Sasaki A, Kakita A, Yoshida K, Konno T, Ikeuchi T, Hayashi S, Matsuo H, Shioda K. | 06/28/2016 |
| the microglial membrane adaptor protein DAP12 was required for both nerve injury- and intrathecal CSF1-induced upregulation of pain-related microglial genes and the ensuing pain, but not for microglial proliferation | Injured sensory neuron-derived CSF1 induces microglial proliferation and DAP12-dependent pain.
Guan Z, Kuhn JA, Wang X, Colquitt B, Solorzano C, Vaman S, Guan AK, Evans-Reinsch Z, Braz J, Devor M, Abboud-Werner SL, Lanier LL, Lomvardas S, Basbaum AI., Free PMC Article | 05/28/2016 |
| Impaired signaling by the TREM2-DAP12 pathway leads to altered immune responses in phagocytosis, cytokine production, and microglial proliferation and survival, thus contributing to disease pathogenesis. Review. | TREM2 in CNS homeostasis and neurodegenerative disease.
Painter MM, Atagi Y, Liu CC, Rademakers R, Xu H, Fryer JD, Bu G., Free PMC Article | 03/26/2016 |
| T cells modified to express a KIR-CAR and DAP12 exhibit superior antitumor activity compared with standard first- and second-generation CD3zeta-based CARs in a xenograft model of mesothelioma highly resistant to immunotherapy. | Generation of Potent T-cell Immunotherapy for Cancer Using DAP12-Based, Multichain, Chimeric Immunoreceptors.
Wang E, Wang LC, Tsai CY, Bhoj V, Gershenson Z, Moon E, Newick K, Sun J, Lo A, Baradet T, Feldman MD, Barrett D, Puré E, Albelda S, Milone MC., Free PMC Article | 03/26/2016 |
| This study reveled that TYROBP having a central role in the bipolar disease and schizophrenia manifestation. | Innate immune response is differentially dysregulated between bipolar disease and schizophrenia.
de Baumont A, Maschietto M, Lima L, Carraro DM, Olivieri EH, Fiorini A, Barreta LA, Palha JA, Belmonte-de-Abreu P, Moreira Filho CA, Brentani H. | 01/2/2016 |