| Mutations of Rad6 E2 ubiquitin-conjugating enzymes at alanine-126 in helix-3 affect ubiquitination activity and decrease enzyme stability. | Mutations of Rad6 E2 ubiquitin-conjugating enzymes at alanine-126 in helix-3 affect ubiquitination activity and decrease enzyme stability.
Shukla PK, Sinha D, Leng AM, Bissell JE, Thatipamula S, Ganguly R, Radmall KS, Skalicky JJ, Shrieve DC, Chandrasekharan MB., Free PMC Article | 12/3/2022 |
| UBE2B promotes ovarian cancer growth via promoting RAD18 mediated ZMYM2 monoubiquitination and stabilization. | UBE2B promotes ovarian cancer growth via promoting RAD18 mediated ZMYM2 monoubiquitination and stabilization.
Zeng X, Zheng W, Sheng Y, Ma H., Free PMC Article | 05/7/2022 |
| RAD6B Loss Disrupts Expression of Melanoma Phenotype in Part by Inhibiting WNT/beta-Catenin Signaling. | RAD6B Loss Disrupts Expression of Melanoma Phenotype in Part by Inhibiting WNT/β-Catenin Signaling.
Sarma A, Gajan A, Kim S, Gurdziel K, Mao G, Nangia-Makker P, Shekhar MPV., Free PMC Article | 02/20/2021 |
| High Expression of UBE2B as a Poor Prognosis Factor in Patients With Rectal Cancer Following Chemoradiotherapy. | High Expression of UBE2B as a Poor Prognosis Factor in Patients With Rectal Cancer Following Chemoradiotherapy.
Huang WL, Luo CW, Chou CL, Yang CC, Chen TJ, Li CF, Pan MR. | 11/21/2020 |
| These RAD6B activities are unaffected by BRCA1 status. | RAD6B is a major mediator of triple negative breast cancer cisplatin resistance: Regulation of translesion synthesis/Fanconi anemia crosstalk and BRCA1 independence.
Haynes B, Gajan A, Nangia-Makker P, Shekhar MP., Free PMC Article | 07/11/2020 |
| Authors confirmed that RAD6BDeltaexon4 and RAD6Bintron5ins variants are expressed as 14 and 15 kDa proteins, respectively, with functional in vivo ubiquitin conjugating activity. | Alternative Splicing of RAD6B and Not RAD6A is Selectively Increased in Melanoma: Identification and Functional Characterization.
Gajan A, Martin CE, Kim S, Joshi M, Michelhaugh SK, Sloma I, Mittal S, Firestine S, Shekhar MPV., Free PMC Article | 07/11/2020 |
| RAD6 is upregulated in response to chemotherapy and significantly correlated with expression of ovarian cancer (OC) stem cell signaling genes ALDH1A1 and SOX2 and poor prognosis of OC patients. | RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance.
Somasagara RR, Spencer SM, Tripathi K, Clark DW, Mani C, Madeira da Silva L, Scalici J, Kothayer H, Westwell AD, Rocconi RP, Palle K., Free PMC Article | 12/9/2017 |
| These data deepen insights into the vital role of RAD6/translesion synthesis in platinum drug tolerance and reveal clinical benefits of targeting RAD6 with SMI#9 for managing chemoresistant cancers. | Pharmacological targeting of RAD6 enzyme-mediated translesion synthesis overcomes resistance to platinum-based drugs.
Sanders MA, Haynes B, Nangia-Makker P, Polin LA, Shekhar MP., Free PMC Article | 07/8/2017 |
| These results point to an important role of the affinity between RNF4 and its cognate RAD6B or UBCH5B in governing the multiplicity of substrate ubiquitination. | Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination.
DiBello A, Datta AB, Zhang X, Wolberger C., Free PMC Article | 07/1/2017 |
| RAD6 promotes proteasome activity and nuclear translocation by enhancing the degradation of PSMF1 and the lamin B receptor. | Interactome Analysis Reveals a Novel Role for RAD6 in the Regulation of Proteasome Activity and Localization in Response to DNA Damage.
An H, Yang L, Wang C, Gan Z, Gu H, Zhang T, Huang X, Liu Y, Li Y, Chang SJ, Lai J, Li YB, Chen S, Sun FL., Free PMC Article | 07/1/2017 |
| In conclusion, we reveal that miR-455-5p expression is regulated by the TGF-beta-dependent pathway, which subsequently leads to UBE2B down-regulation and contributes to oral cancer tumourigenesis. | Up-regulation of miR-455-5p by the TGF-β-SMAD signalling axis promotes the proliferation of oral squamous cancer cells by targeting UBE2B.
Cheng CM, Shiah SG, Huang CC, Hsiao JR, Chang JY. | 05/6/2017 |
| Data show that the ubiquitin-conjugating enzyme E2 RAD6A/B-MDM2 ubiquitin ligase machinery regulates anti-silencing function 1A protein (ASF1A) degradation. | A conserved RAD6-MDM2 ubiquitin ligase machinery targets histone chaperone ASF1A in tumorigenesis.
Wang C, Chang JF, Yan H, Wang DL, Liu Y, Jing Y, Zhang M, Men YL, Lu D, Yang XM, Chen S, Sun FL., Free PMC Article | 08/6/2016 |
| These findings show the importance of Rad6 in ovarian cancer and emphasize the need for further studies of Rad6 as a potential target for the treatment of ovarian cancer. | Rad6 upregulation promotes stem cell-like characteristics and platinum resistance in ovarian cancer.
Somasagara RR, Tripathi K, Spencer SM, Clark DW, Barnett R, Bachaboina L, Scalici J, Rocconi RP, Piazza GA, Palle K., Free PMC Article | 05/28/2016 |
| A novel variant (Chr5.133706925 A > G) residing in the UBE2B gene promoter region confers a high risk for idiopathic azoospermia in a Chinese population. | A functional variant in the UBE2B gene promoter is associated with idiopathic azoospermia.
Mou L, Zhang Q, Diao R, Cai Z, Gui Y., Free PMC Article | 03/26/2016 |
| RAD6 physically interacts with heterochromatin protein 1alpha and ubiquitinates HP1alpha at residue K154, thereby promoting heterochromatin protein 1alpha degradation through the autophagy pathway | RAD6 promotes homologous recombination repair by activating the autophagy-mediated degradation of heterochromatin protein HP1.
Chen S, Wang C, Sun L, Wang DL, Chen L, Huang Z, Yang Q, Gao J, Yang XB, Chang JF, Chen P, Lan L, Mao Z, Sun FL., Free PMC Article | 03/21/2015 |
| UBE2B mRNA alterations are associated with severe oligozoospermia in infertile men. | UBE2B mRNA alterations are associated with severe oligozoospermia in infertile men.
Yatsenko AN, Georgiadis AP, Murthy LJ, Lamb DJ, Matzuk MM., Free PMC Article | 12/14/2013 |
| RNF168, in complex with RAD6A or RAD6B, is activated in the DNA-damage-induced protein ubiquitination cascade. | RNF168 forms a functional complex with RAD6 during the DNA damage response.
Liu C, Wang D, Wu J, Keller J, Ma T, Yu X., Free PMC Article | 11/2/2013 |
| UBE2B polymorphisms g.-293T>G, g.20016A>G and g.9157A>G are not associated with male infertility, and the GA haplotype is likely a protective factor for male fertility in Northeast Chinese men. | Genetic association of UBE2B variants with susceptibility to male infertility in a Northeast Chinese population.
Hu Y, Wen W, Yu JG, Qu SQ, Wang SS, Liu J, Li BS, Luo Y. | 10/19/2013 |
| beta-catenin and Rad6B interacting regions, were identified. | Lysine 394 is a novel Rad6B-induced ubiquitination site on beta-catenin.
Gerard B, Sanders MA, Visscher DW, Tait L, Shekhar MP., Free PMC Article | 11/24/2012 |
| Hydroquinone could upregulate the expression of Rad6B in L-02 hepatic cells. | [Effect of hydroquinone on the expression of ubiquitin-conjugating enzyme Rad6B in human L-02 hepatic cells].
Hu G, Zhuang Z, Yang J, Huang H. | 08/25/2012 |
| The Rad6-Rad18 enzyme plays an essential role in promoting replication through DNA lesions by translesion synthesis in mammalian cells. | Requirement of Rad18 protein for replication through DNA lesions in mouse and human cells.
Yoon JH, Prakash S, Prakash L., Free PMC Article | 07/28/2012 |
| RAD6 can form a ternary complex with MDM2 and p53 that contributes to the degradation of p53. | RAD6 regulates the dosage of p53 by a combination of transcriptional and posttranscriptional mechanisms.
Chen S, Wang DL, Liu Y, Zhao L, Sun FL., Free PMC Article | 02/25/2012 |
| Data show that the homodimeric Rad18 RING domain can recruit two Rad6b E2 enzymes, whereas the full-length Rad18 homodimer binds only to a single Rad6b molecule. | Symmetry and asymmetry of the RING-RING dimer of Rad18.
Huang A, Hibbert RG, de Jong RN, Das D, Sixma TK, Boelens R. | 10/15/2011 |
| Ubc2/Rad6 ser(120) regulates ubiquitin-dependent N-end rule targeting by E3{alpha}/Ubr1 | Ser(120) of Ubc2/Rad6 regulates ubiquitin-dependent N-end rule targeting by E3{alpha}/Ubr1.
Kumar B, Lecompte KG, Klein JM, Haas AL., Free PMC Article | 02/26/2011 |
| Rad6B is a fundamental component of postreplication DNA repair and can be used as an independent marker for determining response to neoadjuvant chemotherapy. | Utility of DNA postreplication repair protein Rad6B in neoadjuvant chemotherapy response.
Shekhar MP, Biernat LA, Pernick N, Tait L, Abrams J, Visscher DW. | 01/15/2011 |