| MiR-181a-5p may regulate cell proliferation and autophagy in myopia and the associated retinopathy. | MiR-181a-5p may regulate cell proliferation and autophagy in myopia and the associated retinopathy.
Jiang B, Hong N, Zhang L, Xu B, He Q, Qian X, Li F, Dong F. | 08/2/2024 |
| Intermittent hypoxia increased the expression of ESM1 and ICAM-1 in vascular endothelial cells via the downregulation of microRNA-181a1. | Intermittent hypoxia increased the expression of ESM1 and ICAM-1 in vascular endothelial cells via the downregulation of microRNA-181a1.
Takasawa S, Makino M, Yamauchi A, Sakuramoto-Tsuchida S, Hirota R, Fujii R, Asai K, Takeda Y, Uchiyama T, Shobatake R, Ota H., Free PMC Article | 02/5/2024 |
| MicroRNA-181a-5p alleviates acute liver failure in mice by inhibiting HMGB1. | MicroRNA-181a-5p alleviates acute liver failure in mice by inhibiting HMGB1.
Zhang Q, He Y, Xu H, Zeng Y, Wang L, Xue Z, Sun Q, Wang L. | 10/10/2023 |
| miR-181a-5p targets DDX3X to inhibit the progression of osteoarthritis via NF-KappaB signaling pathway. | miR-181a-5p targets DDX3X to inhibit the progression of osteoarthritis via NF-ΚB signaling pathway.
Zhao P, Ma G, Ma L., Free PMC Article | 08/19/2023 |
| MicroRNA-181a-5p Curbs Osteogenic Differentiation and Bone Formation Partially Through Impairing Runx1-Dependent Inhibition of AIF-1 Transcription. | MicroRNA-181a-5p Curbs Osteogenic Differentiation and Bone Formation Partially Through Impairing Runx1-Dependent Inhibition of AIF-1 Transcription.
Liu J, Chang X, Dong D., Free PMC Article | 03/16/2023 |
| MiR-181a-5p promotes osteogenesis by targeting BMP3. | MiR-181a-5p promotes osteogenesis by targeting BMP3.
Long Z, Dou P, Cai W, Mao M, Wu R., Free PMC Article | 02/27/2023 |
| miR-181a Improved Renal Inflammation by Targeting TNF-alpha in a Diabetic Nephropathy Animal Model. | miR-181a Improved Renal Inflammation by Targeting TNF-α in a Diabetic Nephropathy Animal Model.
Liu D, Chen R, Ni H, Liu H. | 12/17/2022 |
| Deficiency of MicroRNA-181a Results in Transcriptome-Wide Cell-Specific Changes in the Kidney and Increases Blood Pressure. | Deficiency of MicroRNA-181a Results in Transcriptome-Wide Cell-Specific Changes in the Kidney and Increases Blood Pressure.
Paterson MR, Jackson KL, Dona MSI, Farrugia GE, Visniauskas B, Watson AMD, Johnson C, Prieto MC, Evans RG, Charchar FJ, Pinto AR, Marques FZ, Head GA., Free PMC Article | 01/22/2022 |
| miR-181a regulates the host immune response against Schistosoma japonicum infection through the TLR4 receptor pathway. | miR-181a regulates the host immune response against Schistosoma japonicum infection through the TLR4 receptor pathway.
Tang Y, Shen Y, Hong Y, Zhang Z, Zhai Q, Fu Z, Li H, Lu K, Lin J., Free PMC Article | 01/1/2022 |
| Inhibition of miR-181a attenuates sepsis-induced inflammation and apoptosis by activating Nrf2 and inhibiting NF-kappaB pathways via targeting SIRT1. | Inhibition of miR-181a attenuates sepsis-induced inflammation and apoptosis by activating Nrf2 and inhibiting NF-κB pathways via targeting SIRT1.
Wu Z, Chen J, Zhao W, Zhuo CH, Chen Q. | 11/6/2021 |
| miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer's disease. | miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer's disease.
Rodriguez-Ortiz CJ, Prieto GA, Martini AC, Forner S, Trujillo-Estrada L, LaFerla FM, Baglietto-Vargas D, Cotman CW, Kitazawa M., Free PMC Article | 05/15/2021 |
| MicroRNA-181a regulates IFN-gamma expression in effector CD8(+) T cell differentiation. | MicroRNA-181a regulates IFN-γ expression in effector CD8(+) T cell differentiation.
Amado T, Amorim A, Enguita FJ, Romero PV, Inácio D, de Miranda MP, Winter SJ, Simas JP, Krueger A, Schmolka N, Silva-Santos B, Gomes AQ., Free PMC Article | 05/1/2021 |
| The Mir181ab1 cluster promotes KRAS-driven oncogenesis and progression in lung and pancreas. | The Mir181ab1 cluster promotes KRAS-driven oncogenesis and progression in lung and pancreas.
Valencia K, Erice O, Kostyrko K, Hausmann S, Guruceaga E, Tathireddy A, Flores NM, Sayles LC, Lee AG, Fragoso R, Sun TQ, Vallejo A, Roman M, Entrialgo-Cadierno R, Migueliz I, Razquin N, Fortes P, Lecanda F, Lu J, Ponz-Sarvise M, Chen CZ, Mazur PK, Sweet-Cordero EA, Vicent S., Free PMC Article | 01/2/2021 |
| Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency. | Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency.
Kim C, Jadhav RR, Gustafson CE, Smithey MJ, Hirsch AJ, Uhrlaub JL, Hildebrand WH, Nikolich-Žugich J, Weyand CM, Goronzy JJ., Free PMC Article | 09/26/2020 |
| MicroRNA-181a protects against pericyte apoptosis via directly targeting FOXO1: implication for ameliorated cognitive deficits in APP/PS1 mice. | MicroRNA-181a protects against pericyte apoptosis via directly targeting FOXO1: implication for ameliorated cognitive deficits in APP/PS1 mice.
Wu Q, Yuan X, Bai J, Han R, Li Z, Zhang H, Xiu R., Free PMC Article | 08/13/2020 |
| miR-181a/b regulate mitochondrial homeostasis | miR-181a/b downregulation exerts a protective action on mitochondrial disease models.
Indrieri A, Carrella S, Romano A, Spaziano A, Marrocco E, Fernandez-Vizarra E, Barbato S, Pizzo M, Ezhova Y, Golia FM, Ciampi L, Tammaro R, Henao-Mejia J, Williams A, Flavell RA, De Leonibus E, Zeviani M, Surace EM, Banfi S, Franco B., Free PMC Article | 05/2/2020 |
| In the absence of miR-181a/b-1, thymic Mucosal-associated invariant T (MAIT) cells failed to acquire functional maturity based on expression of transcription factors PLZF, T-bet and RORgammat. | MicroRNA miR-181a/b-1 controls MAIT cell development.
Winter SJ, Kunze-Schumacher H, Imelmann E, Grewers Z, Osthues T, Krueger A. | 01/18/2020 |
| These results indicate that miR-181a is involved in hippocampal contextual fear memory by activating the mTOR signaling pathway | miR-181a Participates in Contextual Fear Memory Formation Via Activating mTOR Signaling Pathway.
Xu XF, Jing X, Ma HX, Yuan RR, Dong Q, Dong JL, Han XF, Chen ZY, Li XZ, Wang Y. | 11/16/2019 |
| these results demonstrate that miR-181a increases p53 protein expression and transcriptional activity by targeting BIRC6. | Renal inhibition of miR-181a ameliorates 5-fluorouracil-induced mesangial cell apoptosis and nephrotoxicity.
Liu XY, Zhang FR, Shang JY, Liu YY, Lv XF, Yuan JN, Zhang TT, Li K, Lin XC, Liu X, Lei Q, Fu XD, Zhou JG, Liang SJ., Free PMC Article | 11/9/2019 |
| The downregulation of miR-181a expression can be a therapeutic strategy for non-alcoholic fatty liver disease by modulating its target PPARalpha. | Upregulation of miR-181a impairs lipid metabolism by targeting PPARα expression in nonalcoholic fatty liver disease.
Huang R, Duan X, Liu X, Cao H, Wang Y, Fan J, Wang B. | 09/14/2019 |
| miR-181a1 and miR-181b1 are dispensable for TEC differentiation | Despite high levels of expression in thymic epithelial cells, miR-181a1 and miR-181b1 are not required for thymic development.
Stefanski HE, Xing Y, Taylor PA, Maio S, Henao-Meija J, Williams A, Flavell RA, Hollander GA, Blazar BR., Free PMC Article | 01/5/2019 |
| 15d-PGJ2/PPARgamma axis promotes expression of miR-27b-3p, miR-181a-1-3p, and miR-326-5p. miR-27b-3p, miR-181a-1-3p, and miR-326-5p have an inhibitory effect on bone marrow (BM)-derived macrophage activation via 15d-PGJ2/PPARgamma axis. | miR-27b-3p, miR-181a-1-3p, and miR-326-5p are involved in the inhibition of macrophage activation in chronic liver injury.
Li W, Chang N, Tian L, Yang J, Ji X, Xie J, Yang L, Li L. | 06/23/2018 |
| miR-181a/b-1-deficient mice expressing elevated levels of a Valpha14Jalpha18 TCRalpha chain, were examined. | Overexpression of Vα14Jα18 TCR promotes development of iNKT cells in the absence of miR-181a/b-1.
Blume J, Zur Lage S, Witzlau K, Georgiev H, Weiss S, Łyszkiewicz M, Ziȩtara N, Krueger A. | 12/2/2017 |
| We provide evidence that miR-181a-5p may be an important endogenous regulator in the proliferation of thymic epithelial cells (TECs), and the expression levels of miR-181a-5p in TECs may be associated with the age-related thymus involution. | MicroRNA-181a-5p enhances cell proliferation in medullary thymic epithelial cells via regulating TGF-β signaling.
Guo D, Ye Y, Qi J, Zhang L, Xu L, Tan X, Yu X, Liu Q, Liu J, Zhang Y, Ma Y, Li Y. | 03/4/2017 |
| Reduced miR-9 and miR-181a expression down-regulates Bim concentration and promotes survival of osteoclasts from fractured tibias. | Reduced miR-9 and miR-181a expression down-regulates Bim concentration and promote osteoclasts survival.
Wang S, Tang C, Zhang Q, Chen W., Free PMC Article | 02/28/2015 |