| CFP1 governs uterine epigenetic landscapes to intervene in progesterone responses for uterine physiology and suppression of endometriosis. | CFP1 governs uterine epigenetic landscapes to intervene in progesterone responses for uterine physiology and suppression of endometriosis.
Yang SC, Park M, Hong KH, La H, Park C, Wang P, Li G, Chen Q, Choi Y, DeMayo FJ, Lydon JP, Skalnik DG, Lim HJ, Hong SH, Park SH, Kim YS, Kim HR, Song H., Free PMC Article | 06/8/2023 |
| Expression of the histone lysine methyltransferases SETD1B, SETDB1, SETD2, and CFP1 exhibits significant changes in the oocytes and granulosa cells of aged mouse ovaries. | Expression of the histone lysine methyltransferases SETD1B, SETDB1, SETD2, and CFP1 exhibits significant changes in the oocytes and granulosa cells of aged mouse ovaries.
Bilmez Y, Talibova G, Ozturk S. | 07/9/2022 |
| Deficiency of CXXC finger protein 1 leads to small changes in heart rate but moderate epigenetic alterations and significant protein downregulation of hyperpolarization-activated cyclic nucleotide-gated 4 (HCN4) ion channels in mice. | Deficiency of CXXC finger protein 1 leads to small changes in heart rate but moderate epigenetic alterations and significant protein downregulation of hyperpolarization-activated cyclic nucleotide-gated 4 (HCN4) ion channels in mice.
Shi L, Shen J, Jin X, Li Z, Ma J, Huang X, Guo Y, Ma W, Gong D, Yang B, Pan Z. | 02/19/2022 |
| The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation. | The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation.
Kiuchi M, Onodera A, Kokubo K, Ichikawa T, Morimoto Y, Kawakami E, Takayama N, Eto K, Koseki H, Hirahara K, Nakayama T., Free PMC Article | 10/9/2021 |
| Role of CxxC-finger protein 1 in establishing mouse oocyte epigenetic landscapes. | Role of CxxC-finger protein 1 in establishing mouse oocyte epigenetic landscapes.
Sha QQ, Zhu YZ, Xiang Y, Yu JL, Fan XY, Li YC, Wu YW, Shen L, Fan HY., Free PMC Article | 03/27/2021 |
| CXXC finger protein 1-mediated histone H3 lysine-4 trimethylation is essential for proper meiotic crossover formation in mice. | CXXC finger protein 1-mediated histone H3 lysine-4 trimethylation is essential for proper meiotic crossover formation in mice.
Jiang Y, Zhang HY, Lin Z, Zhu YZ, Yu C, Sha QQ, Tong MH, Shen L, Fan HY. | 10/31/2020 |
| A key role for Cfp1 in establishing a complex active promoter chromatin state. | Cfp1 is required for gene expression-dependent H3K4 trimethylation and H3K9 acetylation in embryonic stem cells.
Clouaire T, Webb S, Bird A., Free PMC Article | 10/28/2020 |
| These data define the Cfp1 PHD domain as a reader of histone H3K4me marks and provide evidence that this activity is involved in the regulation of lineage commitment in ES cells. | Efficient differentiation of murine embryonic stem cells requires the binding of CXXC finger protein 1 to DNA or methylated histone H3-Lys4.
Mahadevan J, Skalnik DG. | 10/28/2020 |
| Oocytes lacking CFP1 failed to complete maturation and were unable to gain developmental competence after fertilization, due to defects in cytoplasmic lattice formation, meiotic division, and maternal-zygotic transition. | CFP1 Regulates Histone H3K4 Trimethylation and Developmental Potential in Mouse Oocytes.
Yu C, Fan X, Sha QQ, Wang HH, Li BT, Dai XX, Shen L, Liu J, Wang L, Liu K, Tang F, Fan HY. | 10/28/2020 |
| Dual inhibition of CFP1 removes the SETD1-CFP1 complex from chromatin and ensures appropriate chromosome configuration changes during meiosis and mitosis. | CFP1 coordinates histone H3 lysine-4 trimethylation and meiotic cell cycle progression in mouse oocytes.
Sha QQ, Dai XX, Jiang JC, Yu C, Jiang Y, Liu J, Ou XH, Zhang SY, Fan HY., Free PMC Article | 10/28/2020 |
| we have demonstrated that CFP1 plays a crucial role in GM-CSF-derived macrophages, in which it positively regulates phagocytic and bactericidal activity mainly through promoting Csf2ralpha expression and the subsequent activation of downstream pathways. | Cxxc Finger Protein 1 Positively Regulates GM-CSF-Derived Macrophage Phagocytosis Through Csf2rα-Mediated Signaling.
Hui Z, Zhou L, Xue Z, Zhou L, Luo Y, Lin F, Liu X, Hong S, Li W, Wang D, Lu L, Wang J, Wang L., Free PMC Article | 10/28/2020 |
| CxxC-finger protein 1-dependent H3K4 trimethylation in oocytes was necessary to maintain the expression of key paracrine factors and to facilitate the communication between an oocyte and the surrounding granulosa cells. The distinct gene expression patterns in cumulus cells within preovulatory follicles were disrupted by the Cxxc1 deletion in oocytes. | CFP1-dependent histone H3K4 trimethylation in murine oocytes facilitates ovarian follicle recruitment and ovulation in a cell-nonautonomous manner.
Sha QQ, Jiang Y, Yu C, Xiang Y, Dai XX, Jiang JC, Ou XH, Fan HY., Free PMC Article | 08/1/2020 |
| Cxxc1 deficiency decreased IL-6Ralpha expression and impeded IL-6/STAT3 signaling, whereas the overexpression of IL-6Ralpha could partially reverse the defects in Cxxc1-deficient TH17 cells in vitro and in vivo. | Epigenetic initiation of the T(H)17 differentiation program is promoted by Cxxc finger protein 1.
Lin F, Meng X, Guo Y, Cao W, Liu W, Xia Q, Hui Z, Chen J, Hong S, Zhang X, Wu C, Wang D, Wang J, Lu L, Qian W, Wei L, Wang L., Free PMC Article | 05/23/2020 |
| Results demonstrate that CXXC1 is not an essential link between PRDM9-activated recombination hotspot sites and DSB machinery and that the hotspot recognition pathway in mouse is independent of CXXC1. | CXXC1 is not essential for normal DNA double-strand break formation and meiotic recombination in mouse.
Tian H, Billings T, Petkov PM., Free PMC Article | 02/16/2019 |
| Data indicate that CXXC finger protein 1 (Cfp1) is necessary for hematopoietic stem and multi-potential progenitor cell function and for the developmental potential of differentiating hematopoietic cells. | The epigenetic regulator CXXC finger protein 1 is essential for murine hematopoiesis.
Chun KT, Li B, Dobrota E, Tate C, Lee JH, Khan S, Haneline L, HogenEsch H, Skalnik DG., Free PMC Article | 07/25/2015 |
| NF-kappaB recruitment enhanced the occupancy of the CpG island within the 14-3-3gamma promoter by CFP1.14-3-3gamma induction in CSR is enabled by the CFP1-mediated H3K4me3 enrichment in the promoter, dependent on NF-kappaB and sustained by E2A. | Induction of activation-induced cytidine deaminase-targeting adaptor 14-3-3γ is mediated by NF-κB-dependent recruitment of CFP1 to the 5'-CpG-3'-rich 14-3-3γ promoter and is sustained by E2A.
Mai T, Pone EJ, Li G, Lam TS, Moehlman J, Xu Z, Casali P., Free PMC Article | 03/22/2014 |
| The results demonstrated that Cfp1 is a specificity factor that integrates multiple signals, including promoter CpG content and gene activity, to regulate genome-wide patterns of H3K4me3. | Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells.
Clouaire T, Webb S, Skene P, Illingworth R, Kerr A, Andrews R, Lee JH, Skalnik D, Bird A., Free PMC Article | 10/27/2012 |
| a primary function of non-methylated CpG islands is to genetically influence the local chromatin modification state by interaction with Cfp1 and perhaps other CpG-binding proteins | CpG islands influence chromatin structure via the CpG-binding protein Cfp1.
Thomson JP, Skene PJ, Selfridge J, Clouaire T, Guy J, Webb S, Kerr AR, Deaton A, Andrews R, James KD, Turner DJ, Illingworth R, Bird A., Free PMC Article | 06/14/2010 |
| embryonic stem cells lacking Cfp1 (CXXC1(-/-)) are viable but show increased levels of global histone H3K4 methylation, suggesting that Cfp1 functions to inhibit or restrict the activity of the Setd1A histone H3K4 methyltransferase complex. | CXXC finger protein 1 restricts the Setd1A histone H3K4 methyltransferase complex to euchromatin.
Tate CM, Lee JH, Skalnik DG., Free PMC Article | 02/8/2010 |
| expression of either the amino half of Cfp1 (amino acids 1 to 367 [Cfp1(1-367)]) or the carboxyl half of Cfp1 (Cfp1(361-656)) is sufficient to correct all of the defects observed with embryonic stem cells that lack Cfp1 | CXXC finger protein 1 contains redundant functional domains that support embryonic stem cell cytosine methylation, histone methylation, and differentiation.
Tate CM, Lee JH, Skalnik DG., Free PMC Article | 01/21/2010 |
| findings show that CGBP is essential for normal epigenetic modification of the genome by cytosine methylation and for cellular differentiation, consistent with the requirement for CGBP during early mammalian development | Reduced genomic cytosine methylation and defective cellular differentiation in embryonic stem cells lacking CpG binding protein.
Carlone DL, Lee JH, Young SR, Dobrota E, Butler JS, Ruiz J, Skalnik DG., Free PMC Article | 01/21/2010 |