| Role of endothelial Raptor in abnormal arteriogenesis after lower limb ischaemia in type 2 diabetes. | Role of endothelial Raptor in abnormal arteriogenesis after lower limb ischaemia in type 2 diabetes.
Liu T, Zhang J, Chang F, Sun M, He J, Ai D. | 09/9/2024 |
| Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide. | Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide.
Le TDV, Liu D, Besing GK, Raghavan R, Ellis BJ, Ceddia RP, Collins S, Ayala JE., Free PMC Article | 01/31/2024 |
| Knockdown of regulatory associated protein of TOR (raptor) in hypothalamus-stimulated folliculogenesis and induced ovarian cysts. | Knockdown of regulatory associated protein of TOR (raptor) in hypothalamus-stimulated folliculogenesis and induced ovarian cysts.
Tartarin P, Keller M, Guibert E, Trives E, Bourdon G, Chamero P, Negre D, Cornilleau F, Guillory V, JeanPierre E, Costa C, Migrenne S, Dupont J, Froment P. | 02/27/2023 |
| Raptor downregulation rescues neuronal phenotypes in mouse models of Tuberous Sclerosis Complex. | Raptor downregulation rescues neuronal phenotypes in mouse models of Tuberous Sclerosis Complex.
Karalis V, Caval-Holme F, Bateup HS., Free PMC Article | 08/20/2022 |
| Raptor is critical for increasing the mitochondrial proteome and skeletal muscle force during hypertrophy. | Raptor is critical for increasing the mitochondrial proteome and skeletal muscle force during hypertrophy.
Baraldo M, Nogara L, Dumitras GA, Tchampda Dondjang AH, Geremia A, Scalabrin M, Türk C, Telkamp F, Zentilin L, Giacca M, Krüger M, Blaauw B. | 12/25/2021 |
| Hepatic peroxisomal beta-oxidation suppresses lipophagy via RPTOR acetylation and MTOR activation. | Hepatic peroxisomal β-oxidation suppresses lipophagy via RPTOR acetylation and MTOR activation.
He A, Dean JM, Lu D, Chen Y, Lodhi IJ., Free PMC Article | 07/31/2021 |
| AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation. | AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation.
Van Nostrand JL, Hellberg K, Luo EC, Van Nostrand EL, Dayn A, Yu J, Shokhirev MN, Dayn Y, Yeo GW, Shaw RJ., Free PMC Article | 04/24/2021 |
| mTORC1 Deficiency Modifies Volume Homeostatic Responses to Dietary Sodium in a Sex-Specific Manner. | mTORC1 Deficiency Modifies Volume Homeostatic Responses to Dietary Sodium in a Sex-Specific Manner.
Brooks DL, Garza AE, Caliskan Guzelce E, Gholami SK, Treesaranuwattana T, Maris S, Ranjit S, Tay CS, Lee JM, Romero JR, Adler GK, Pojoga LH, Williams GH., Free PMC Article | 01/9/2021 |
| Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-kappaB Activity. | Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity.
Kouloulia S, Hallin EI, Simbriger K, Amorim IS, Lach G, Amvrosiadis T, Chalkiadaki K, Kampaite A, Truong VT, Hooshmandi M, Jafarnejad SM, Skehel P, Kursula P, Khoutorsky A, Gkogkas CG., Free PMC Article | 09/26/2020 |
| Raptor determines beta-cell identity and plasticity independent of hyperglycemia in mice. | Raptor determines β-cell identity and plasticity independent of hyperglycemia in mice.
Yin Q, Ni Q, Wang Y, Zhang H, Li W, Nie A, Wang S, Gu Y, Wang Q, Ning G., Free PMC Article | 08/22/2020 |
| These results reveal the cell autonomous requirement for RPTOR in the formation or maintenance of the foundational self-renewing spermatogonial stem cell pool in the mouse testis and underscore complex roles for mTORC1 and its constituent proteins in male germ cell development. | The mTORC1 component RPTOR is required for maintenance of the foundational spermatogonial stem cell pool in mice†.
Serra N, Velte EK, Niedenberger BA, Kirsanov O, Geyer CB., Free PMC Article | 04/4/2020 |
| Ablation of Raptor in neonatal beta-cells led to autonomous loss of cell identity, decelerated cell cycle progression, compromised proliferation, and caused neonatal diabetes as a result of inadequate establishment of functional beta-cell mass at postnatal day 14. | Dual Effect of Raptor on Neonatal β-Cell Proliferation and Identity Maintenance.
Wang Y, Sun J, Ni Q, Nie A, Gu Y, Wang S, Zhang W, Ning G, Wang W, Wang Q. | 03/21/2020 |
| Targeted deletion of Rptor in osterix-expressing pre-osteoblasts (Rptorob(-/-)) reduces the number of B-cells in the bone marrow, peripheral blood and spleen at 4 and 12 weeks of age. Rptorob(-/-) mice exhibit a reduction in pre-B and immature B-cells in the BM, due to a block in B-cell development from the pro-B to pre-B cell stage. Circulating levels of IL-7 and CXCL12 are reduced in Rptorob(-/-) mice. | mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis.
Martin SK, Fitter S, El Khawanky N, Grose RH, Walkley CR, Purton LE, Ruegg MA, Hall MN, Gronthos S, Zannettino ACW., Free PMC Article | 12/21/2019 |
| Depletion of Raptor promoted beige adipogenesis through prostaglandin signaling. Raptor-deficient mice were resistant to diet-induced obesity and COX-2 downregulation. | Adipose mTORC1 Suppresses Prostaglandin Signaling and Beige Adipogenesis via the CRTC2-COX-2 Pathway.
Zhang X, Luo Y, Wang C, Ding X, Yang X, Wu D, Silva F, Yang Z, Zhou Q, Wang L, Wang X, Zhou J, Boyd N, Spafford M, Burge M, Yang XO, Liu M., Free PMC Article | 12/14/2019 |
| This study demonstrated that mTORC1 functions in osteocytes to negatively regulate trabecular bone mass by promoting bone resorption, and suggested that osteocyte-specific inhibition of mTORC1 may be potentially used as a novel approach to the treatment of osteoporosis. | Osteocyte-intrinsic mTORC1 signaling restrains trabecular bone accrual in mice.
Liu Q, Liu C, Yang Y, Yang H, Chen J. | 12/14/2019 |
| Loss of intestinal specific-Raptor is protective of the development of diet-induced obesity by reducing food intake without altering the metabolic profile. | Intestinal epithelial cell-specific Raptor is essential for high fat diet-induced weight gain in mice.
Onufer EJ, Tay S, Barron LK, Courtney CM, Warner BW, Guo J., Free PMC Article | 05/25/2019 |
| Persistent mTORC1 deficiency in macrophages contributes to the progression of Nonalcoholic Steatohepatitis. | Macrophage Raptor Deficiency-Induced Lysosome Dysfunction Exacerbates Nonalcoholic Steatohepatitis.
Liu W, Ye C, Cheng Q, Zhang X, Yao L, Li Q, Huang J, Liu Y, Zou Z, Wang H, Yan J, Zhu Y, Wang C, Ai D., Free PMC Article | 05/4/2019 |
| Study reveals that enterocyte specific Raptor is required for initiating a type 2 immune response which appears to function through the regulation of mTORC1 activity. | Epithelial cell specific Raptor is required for initiation of type 2 mucosal immunity in small intestine.
Aladegbami B, Barron L, Bao J, Colasanti J, Erwin CR, Warner BW, Guo J., Free PMC Article | 02/23/2019 |
| Raptor-deficient beta cells display reduced glucose responsiveness and exhibit a glucose metabolic profile resembling fetal beta cells. | Raptor regulates functional maturation of murine beta cells.
Ni Q, Gu Y, Xie Y, Yin Q, Zhang H, Nie A, Li W, Wang Y, Ning G, Wang W, Wang Q., Free PMC Article | 01/5/2019 |
| It has been shown, via conditional deletion of Raptor (mTORC1) or Rictor (mTORC2), that mTORC1 and mTORC2 promote NK cell maturation in a cooperative and non-redundant manner, mainly by controlling the expression of Tbx21 and Eomes. | Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function.
Wang F, Meng M, Mo B, Yang Y, Ji Y, Huang P, Lai W, Pan X, You T, Luo H, Guan X, Deng Y, Yuan S, Chu J, Namaka M, Hughes T, Ye L, Yu J, Li X, Deng Y., Free PMC Article | 12/22/2018 |
| Study shows that USP9X deubiquitylating enzyme maintains RAPTOR protein levels, mTORC1 signalling and proliferation in neural progenitors. USP9X is the first deubiquitylating enzyme shown to stabilize RAPTOR. | USP9X deubiquitylating enzyme maintains RAPTOR protein levels, mTORC1 signalling and proliferation in neural progenitors.
Bridges CR, Tan MC, Premarathne S, Nanayakkara D, Bellette B, Zencak D, Domingo D, Gecz J, Murtaza M, Jolly LA, Wood SA., Free PMC Article | 09/1/2018 |
| Our study provides, for the first time, a global analysis of phosphorylation events in spermatogonial progenitor cells (SPCs) in response to GDNF, and we have identified activation of mTORC1 signaling through ERK kinase-mediated phosphorylation of multiple sites of raptor protein as an important pathway for SPC proliferation. | The Glial Cell-Derived Neurotrophic Factor (GDNF)-responsive Phosphoprotein Landscape Identifies Raptor Phosphorylation Required for Spermatogonial Progenitor Cell Proliferation.
Wang M, Guo Y, Wang M, Zhou T, Xue Y, Du G, Wei X, Wang J, Qi L, Zhang H, Li L, Ye L, Guo X, Wu X., Free PMC Article | 03/24/2018 |
| Thus, the various regulatory elements that impinge upstream of mTORC1 activation pathways are differentially required for HSC homeostasis in vivo. | Distinct roles of Rheb and Raptor in activating mTOR complex 1 for the self-renewal of hematopoietic stem cells.
Peng H, Kasada A, Ueno M, Hoshii T, Tadokoro Y, Nomura N, Ito C, Takase Y, Vu HT, Kobayashi M, Xiao B, Worley PF, Hirao A. | 12/30/2017 |
| Deletion of Raptor reduced the size of limb bud cells, resulting in overall diminution of the limb bud without affecting skeletal patterning. We then examined the potential role of mTORC1 in chondrogenic differentiation in vitro. | mTORC1 Signaling Promotes Limb Bud Cell Growth and Chondrogenesis.
Jiang M, Fu X, Yang H, Long F, Chen J., Free PMC Article | 11/4/2017 |
| Results provide genetic evidence indicating that mTOR and Raptor are required for sensory axon regeneration enhanced by peripheral lesions in mice, whereas Rictor plays a minor role. The peripheral lesion activates rapamycin-resistant mTOR signaling to modulate Stat3 activity and further promotes axon regeneration. | Rapamycin-Resistant mTOR Activity Is Required for Sensory Axon Regeneration Induced by a Conditioning Lesion.
Chen W, Lu N, Ding Y, Wang Y, Chan LT, Wang X, Gao X, Jiang S, Liu K., Free PMC Article | 10/28/2017 |