| SMS2 siRNA inhibits pancreatic tumor growth by tumor microenvironment modulation. | SMS2 siRNA inhibits pancreatic tumor growth by tumor microenvironment modulation.
Jiang X, Yuan Z, Ding T, Yu K, Dong J. | 10/17/2024 |
| Disruption of sphingomyelin synthase 2 gene alleviates cognitive impairment in a mouse model of Alzheimer's disease. | Disruption of sphingomyelin synthase 2 gene alleviates cognitive impairment in a mouse model of Alzheimer's disease.
Uchiumi O, Zou J, Yamaki S, Hori Y, Ono M, Yamamoto R, Kato N. | 05/29/2024 |
| Modulation of function and structure of stratum corneum in sphingomyelin synthase 2-deficient mice. | Modulation of function and structure of stratum corneum in sphingomyelin synthase 2-deficient mice.
Honma N, Hatta I, Okazaki T, Tokudome Y. | 12/3/2022 |
| SMS2 deficiency impairs PKCdelta-regulated B cell tolerance in the germinal center. | SMS2 deficiency impairs PKCδ-regulated B cell tolerance in the germinal center.
Ou P, Stanek A, Huan Z, Roman CAJ, Huan C. | 02/19/2022 |
| Sphingomyelin synthases 1 and 2 exhibit phosphatidylcholine phospholipase C activity. | Sphingomyelin synthases 1 and 2 exhibit phosphatidylcholine phospholipase C activity.
Chiang YP, Li Z, Chen Y, Cao Y, Jiang XC., Free PMC Article | 01/29/2022 |
| Sphingomyelin synthase related protein is a mammalian phosphatidylethanolamine phospholipase C. | Sphingomyelin synthase related protein is a mammalian phosphatidylethanolamine phospholipase C.
Chiang YP, Li Z, Chen Y, Cao Y, Jiang XC., Free PMC Article | 12/4/2021 |
| Effect of liver total sphingomyelin synthase deficiency on plasma lipid metabolism. | Effect of liver total sphingomyelin synthase deficiency on plasma lipid metabolism.
Li Z, Chiang YP, He M, Zhang K, Zheng J, Wu W, Cai J, Chen Y, Chen G, Chen Y, Dong J, Worgall TS, Jiang XC., Free PMC Article | 07/3/2021 |
| Sphingomyelin synthase 2 loss suppresses steatosis but exacerbates fibrosis in the liver of mice fed with choline-deficient, L-amino acid-defined, high-fat diet. | Sphingomyelin synthase 2 loss suppresses steatosis but exacerbates fibrosis in the liver of mice fed with choline-deficient, L-amino acid-defined, high-fat diet.
Sugimoto M, Hamada T, Wakabayasi M, Yoshioka T, Kato H, Konishi H, Nagai R, Suzuki M, Numata Y, Igarashi Y, Yukioka H. | 03/20/2021 |
| Sphingomyelin Synthase 2 Inhibition Ameliorates Cerebral Ischemic Reperfusion Injury Through Reducing the Recruitment of Toll-Like Receptor 4 to Lipid Rafts. | Sphingomyelin Synthase 2 Inhibition Ameliorates Cerebral Ischemic Reperfusion Injury Through Reducing the Recruitment of Toll-Like Receptor 4 to Lipid Rafts.
Xue J, Yu Y, Zhang X, Zhang C, Zhao Y, Liu B, Zhang L, Wang L, Chen R, Gao X, Jiao P, Song G, Jiang XC, Qin S., Free PMC Article | 12/19/2020 |
| Sgms2-knockout and wild-type control mice were exposed to cigarette smoke for 6 months.Chronic cigarette smoke reduces SGMS activity and gene expression in mouse lungs. Sgms2-deficient mice have enhanced airway and tissue resistance after chronic cigarette smoke exposure, but similar degrees of emphysema to wild-type. Sgms2(-/-) mice had greater AKT phosphorylation, peribronchial collagen deposition and protease activity. | Airway Resistance Caused by Sphingomyelin Synthase 2 Insufficiency in Response to Cigarette Smoke.
Gupta G, Baumlin N, Poon J, Ahmed B, Chiang YP, Railwah C, Kim MD, Rivas M, Goldenberg H, Elgamal Z, Salathe M, Panwala AA, Dabo A, Huan C, Foronjy R, Jiang XC, Wadgaonkar R, Geraghty P., Free PMC Article | 08/1/2020 |
| Investigated role of sphingomyelin synthase 1 (SMS1) and sphingomyelin synthase 2 (SMS2) in osteoblast differentiation in order to better understand the role SMS1 and SMS2 play in skeletal development. | Deficiency of sphingomyelin synthase 1 but not sphingomyelin synthase 2 reduces bone formation due to impaired osteoblast differentiation.
Matsumoto G, Hashizume C, Watanabe K, Taniguchi M, Okazaki T., Free PMC Article | 07/11/2020 |
| These results suggest that SMS2 regulates osteoclast differentiation by inducing RANKL expression via RXRalpha. | Knockdown of sphingomyelin synthase 2 inhibits osteoclastogenesis by decreasing RANKL expression in mouse primary osteoblasts.
Yoshikawa Y, Yoshizawa T, Domae E, Hirai Y, Kamada A, Okazaki T, Ikeo T. | 02/15/2020 |
| SMS2 generates sphingomyelin in the epidermis and contributes to epidermal permeability barrier function | Epidermal permeability barrier function and sphingolipid content in the skin of sphingomyelin synthase 2 deficient mice.
Nomoto K, Itaya Y, Watanabe K, Yamashita T, Okazaki T, Tokudome Y. | 07/13/2019 |
| 2-Hydroxy-oleic acid inhibited rather than activated recombinant SMS1 (rSMS1) and rSMS2 in a dose-dependent fashion. | 2-Hydroxy-oleic acid does not activate sphingomyelin synthase activity.
Lou B, Liu Q, Hou J, Kabir I, Liu P, Ding T, Dong J, Mo M, Ye D, Chen Y, Bui HH, Roth K, Cao Y, Jiang XC., Free PMC Article | 06/29/2019 |
| This study showed that MWM learning was deteriorated and associated with depression-like tendency in SMS2 KO mice. | Stressful learning paradigm precludes manifestation of cognitive ability in sphingomyelin synthase-2 knockout mice.
Wang M, Uchiumi O, Ogiso H, Shui Y, Zou J, Hashizume C, Taniguchi M, Okazaki T, Kato N. | 12/23/2017 |
| These results demonstrate that SMS2 deficiency inhibits DSS-induced colitis and subsequent colitis-associated colon cancer via inhibition of colon epithelial cell-mediated inflammation; therefore, inhibition of SMS2 may be a potential therapeutic target for human colitis and colorectal cancer. | Sphingomyelin synthase 2 deficiency inhibits the induction of murine colitis-associated colon cancer.
Ohnishi T, Hashizume C, Taniguchi M, Furumoto H, Han J, Gao R, Kinami S, Kosaka T, Okazaki T. | 10/14/2017 |
| It was suggested that very long chain SM but not long chain SM were decreased in SMS2-deficient mice liver and plasma. And the exogenously added very long chain SM (d18:1/24:0) could activate macrophages directly, suggesting a novel role of plasma very long chain SM in modulating macrophage activation and resulting inflammation. | Possible roles of long-chain sphingomyelines and sphingomyelin synthase 2 in mouse macrophage inflammatory response.
Sakamoto H, Yoshida T, Sanaki T, Shigaki S, Morita H, Oyama M, Mitsui M, Tanaka Y, Nakano T, Mitsutake S, Igarashi Y, Takemoto H. | 05/27/2017 |
| These findings suggested that the degree of lung injury was reduced during the acute inflammatory reaction when NFkappaB was inhibited, and that the expression of sphingomyelin synthase 2 may affect the induction of the NFkappaB pathway by lipopolysaccharide through CD14. | Sphingomyelin synthase 2 affects CD14‑associated induction of NF‑κB by lipopolysaccharides in acute lung injury in mice.
Hu S, Ding Y, Gong J, Yan N. | 04/15/2017 |
| Study provides a mouse model for fetal alcohol spectrum disorder. Due to the accumulation of ceramide in vivo, SMS2 knockout mice allows to investigate how ceramide regulates alcohol-induced neural apoptosis. | Prenatal alcohol exposure inducing the apoptosis of mossy cells in hippocampus of SMS2-/- mice.
Wang L, Wu L, Wang X, Deng J, Ma Z, Fan W, He W, Deng J. | 10/8/2016 |
| study provided evidence that genetic inhibition of SMS2 elevated glucose clearance through activation of glucose uptake into insulin-targeted tissues such as skeletal muscle by a mechanism independent of hepatic SMS2 | Characterization of the role of sphingomyelin synthase 2 in glucose metabolism in whole-body and peripheral tissues in mice.
Sugimoto M, Shimizu Y, Zhao S, Ukon N, Nishijima K, Wakabayashi M, Yoshioka T, Higashino K, Numata Y, Okuda T, Tamaki N, Hanamatsu H, Igarashi Y, Kuge Y. | 09/10/2016 |
| Thus, imaging mass spectrometry can provide visual assessment of the contribution of SMS2 on acyl-chain- and region-specific sphingomyelin metabolism in the kidneys | Imaging Mass Spectrometry Reveals Acyl-Chain- and Region-Specific Sphingolipid Metabolism in the Kidneys of Sphingomyelin Synthase 2-Deficient Mice.
Sugimoto M, Wakabayashi M, Shimizu Y, Yoshioka T, Higashino K, Numata Y, Okuda T, Zhao S, Sakai S, Igarashi Y, Kuge Y., Free PMC Article | 08/6/2016 |
| characterization of enzymes catalyzing ceramide phosphoethanolamine biosynthesis in mice | Functional characterization of enzymes catalyzing ceramide phosphoethanolamine biosynthesis in mice.
Bickert A, Ginkel C, Kol M, vom Dorp K, Jastrow H, Degen J, Jacobs RL, Vance DE, Winterhager E, Jiang XC, Dörmann P, Somerharju P, Holthuis JC, Willecke K., Free PMC Article | 12/19/2015 |
| study reveals that all mouse SMS family members (SMSr, SMS1, and SMS2) have CPE synthase activity | All members in the sphingomyelin synthase gene family have ceramide phosphoethanolamine synthase activity.
Ding T, Kabir I, Li Y, Lou C, Yazdanyar A, Xu J, Dong J, Zhou H, Park T, Boutjdir M, Li Z, Jiang XC., Free PMC Article | 11/21/2015 |
| Increasing ceramide levels in the liver can be achieved by SMS2 inhibition to prevent liver steatosis via PPARgamma suppression. | Sphingomyelin synthase 2 activity and liver steatosis: an effect of ceramide-mediated peroxisome proliferator-activated receptor γ2 suppression.
Li Y, Dong J, Ding T, Kuo MS, Cao G, Jiang XC, Li Z., Free PMC Article | 08/31/2013 |
| Data show that LCAT activity was significantly higher in long chain base biosynthesis protein 2 (Sptlc2)+/- and sphingomyelin synthase 2 (Sms2)-/- mice, but markedly lower in ApoE-/- and Ldlr-/- mice. | Regulation of plasma cholesterol esterification by sphingomyelin: effect of physiological variations of plasma sphingomyelin on lecithin-cholesterol acyltransferase activity.
Subbaiah PV, Jiang XC, Belikova NA, Aizezi B, Huang ZH, Reardon CA., Free PMC Article | 02/2/2013 |