| Nascent RHOH acts as a molecular brake on actomyosin-mediated effector functions of inflammatory neutrophils. | Nascent RHOH acts as a molecular brake on actomyosin-mediated effector functions of inflammatory neutrophils.
Peng S, Stojkov D, Gao J, Oberson K, Latzin P, Casaulta C, Yousefi S, Simon HU., Free PMC Article | 10/8/2022 |
| Deletion of murine Rhoh leads to de-repression of Bcl-6 via decreased KAISO levels and accelerates a malignancy phenotype in a murine model of lymphoma. | Deletion of murine Rhoh leads to de-repression of Bcl-6 via decreased KAISO levels and accelerates a malignancy phenotype in a murine model of lymphoma.
Horiguchi H, Xu H, Duvert B, Ciuculescu F, Yao Q, Sinha A, McGuinness M, Harris C, Brendel C, Troeger A, Chiarle R, Williams DA., Free PMC Article | 02/19/2022 |
| RhoH deficiency in mice induced TH17 polarization during effector T-cell differentiation, thereby inducing psoriasis-like chronic dermatitis | Ras homolog gene family H (RhoH) deficiency induces psoriasis-like chronic dermatitis by promoting T(H)17 cell polarization.
Tamehiro N, Nishida K, Sugita Y, Hayakawa K, Oda H, Nitta T, Nakano M, Nishioka A, Yanobu-Takanashi R, Goto M, Okamura T, Adachi R, Kondo K, Morita A, Suzuki H. | 05/16/2020 |
| These results highlight a novel negative regulatory role for RhoH in eosinophil differentiation, most likely in consequence of altered GATA-2 levels. | RhoH is a negative regulator of eosinophilopoiesis.
Stoeckle C, Geering B, Yousefi S, Rožman S, Andina N, Benarafa C, Simon HU., Free PMC Article | 12/23/2017 |
| An excess amount of RhoH is able to initiate pre-TCR signaling in the absence of pre-TCR complexes. | Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint.
Tamehiro N, Oda H, Shirai M, Suzuki H., Free PMC Article | 04/30/2016 |
| The C-terminal insert domain regulates RhoH protein stability via chaperone-mediated autophagy. | A unique carboxyl-terminal insert domain in the hematopoietic-specific, GTPase-deficient Rho GTPase RhoH regulates post-translational processing.
Troeger A, Chae HD, Senturk M, Wood J, Williams DA., Free PMC Article | 03/8/2014 |
| RhoH plays a critical role in prosurvival chronic lymphocytic leukemia cell-cell and cell-microenvironment interactions with this agent. | RhoH is critical for cell-microenvironment interactions in chronic lymphocytic leukemia in mice and humans.
Troeger A, Johnson AJ, Wood J, Blum WG, Andritsos LA, Byrd JC, Williams DA., Free PMC Article | 07/21/2012 |
| Results suggest that RhoH regulates TCR signaling via recruitment of ZAP-70 and Lck to CD3zeta in the immunological synapse. | RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling.
Chae HD, Siefring JE, Hildeman DA, Gu Y, Williams DA., Free PMC Article | 04/30/2011 |
| These findings stress the importance of Rhoh for the function of peripheral T cells. | Rhoh deficiency reduces peripheral T-cell function and attenuates allogenic transplant rejection.
Porubsky S, Wang S, Kiss E, Dehmel S, Bonrouhi M, Dorn T, Luckow B, Brakebusch C, Gröne HJ. | 02/5/2011 |
| RhoH has a function in the progression of B-cell chronic lymphocytic leukemia (CLL) in a murine model and show RhoH expression is altered in human primary lymphocytic (CLL) samples. | Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia.
Sanchez-Aguilera A, Rattmann I, Drew DZ, Müller LU, Summey V, Lucas DM, Byrd JC, Croce CM, Gu Y, Cancelas JA, Johnston P, Moritz T, Williams DA., Free PMC Article | 02/1/2010 |
| RhoH/TTF represents an inducible feedback inhibitor in neutrophils that is involved in the limitation of innate immune responses. | RhoH/TTF negatively regulates leukotriene production in neutrophils.
Daryadel A, Yousefi S, Troi D, Schmid I, Schmidt-Mende J, Mordasini C, Dahinden CA, Ziemiecki A, Simon HU. | 01/21/2010 |
| RhoH plays critical roles in mast cell function by facilitating phosphorylation of Syk kinase in Fc epsilon I receptor-dependent signal transduction. | RhoH plays critical roles in Fc epsilon RI-dependent signal transduction in mast cells.
Oda H, Fujimoto M, Patrick MS, Chida D, Sato Y, Azuma Y, Aoki H, Abe T, Suzuki H, Shirai M. | 01/21/2010 |
| An antagonistic role of RhoH in regulation of cortical F-actin assembly and chemotaxis via suppressing Rac1 membrane targeting and activation in primary hematopoietic progenitor cells, is identified. | Cross-talk between RhoH and Rac1 in regulation of actin cytoskeleton and chemotaxis of hematopoietic progenitor cells.
Chae HD, Lee KE, Williams DA, Gu Y., Free PMC Article | 01/21/2010 |
| RhoH is a critical regulator of thymocyte development and TCR signaling by mediating recruitment and activation of Zap70. | RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development.
Gu Y, Chae HD, Siefring JE, Jasti AC, Hildeman DA, Williams DA. | 01/21/2010 |
| RhoH serves as a negative regulator of both growth and actin-based function of hematopoietic progenitor cells possibly via suppression of Rac-mediated signaling. | RhoH, a hematopoietic-specific Rho GTPase, regulates proliferation, survival, migration, and engraftment of hematopoietic progenitor cells.
Gu Y, Jasti AC, Jansen M, Siefring JE. | 01/21/2010 |
| RhoH is important for pre-T-cell receptor and T-cell receptor signaling | RhoH is important for positive thymocyte selection and T-cell receptor signaling.
Dorn T, Kuhn U, Bungartz G, Stiller S, Bauer M, Ellwart J, Peters T, Scharffetter-Kochanek K, Semmrich M, Laschinger M, Holzmann B, Klinkert WE, Straten PT, Køllgaard T, Sixt M, Brakebusch C. | 01/21/2010 |