| The investigation of WNT6 and WNT10A single nucleotide polymorphisms as potential biomarkers for dental pulp calcification in orthodontic patients. | The investigation of WNT6 and WNT10A single nucleotide polymorphisms as potential biomarkers for dental pulp calcification in orthodontic patients.
Ramirez I, Kirschneck C, Silva-Sousa AC, Proff P, S Antunes L, Gabbardo MC, de Oliveira DS, Sousa-Neto MD, Baratto-Filho F, Küchler EC., Free PMC Article | 08/14/2023 |
| WNT6 participates in the occurrence and development of ovarian cancer by upregulating/activating the typical Wnt pathway and Notch1 signaling pathway. | WNT6 participates in the occurrence and development of ovarian cancer by upregulating/activating the typical Wnt pathway and Notch1 signaling pathway.
Bao H, Wu W, Li Y, Zong Z, Chen S. | 10/8/2022 |
| The glycoprotein Wnt6 regulates human dental papilla cells differentiation by canonical Wnt signaling pathway. | The glycoprotein Wnt6 regulates human dental papilla cells differentiation by canonical Wnt signaling pathway.
Fu H, Tan X, Ye L, Wang C. | 07/16/2022 |
| Wnt4, Wnt6 and beta-catenin expression in human placental tissue - is there a link with first trimester miscarriage? Results from a pilot study. | Wnt4, Wnt6 and β-catenin expression in human placental tissue - is there a link with first trimester miscarriage? Results from a pilot study.
Chronopoulou E, Koika V, Tsiveriotis K, Stefanidis K, Kalogeropoulos S, Georgopoulos N, Adonakis G, Kaponis A., Free PMC Article | 04/2/2022 |
| Wnt6 plays a complex role in maintaining human limbal stem/progenitor cells. | Wnt6 plays a complex role in maintaining human limbal stem/progenitor cells.
Bonnet C, Oh D, Mei H, Robertson S, Chang D, Bourges JL, Behar-Cohen F, Zheng JJ, Deng SX., Free PMC Article | 01/22/2022 |
| A novel molecular link between HOXA9 and WNT6 in glioblastoma identifies a subgroup of patients with particular poor prognosis. | A novel molecular link between HOXA9 and WNT6 in glioblastoma identifies a subgroup of patients with particular poor prognosis.
Gonçalves CS, Xavier-Magalhães A, Martins EP, Pinto AA, Pires MM, Pinheiro C, Reis RM, Sousa N, Costa BM., Free PMC Article | 07/3/2021 |
| MiR-566 protects the malignant progression of breast cancer by negatively regulating WNT6. | MiR-566 protects the malignant progression of breast cancer by negatively regulating WNT6.
Zhao MC, Zhang MM, Li T, Tao ZH, Du YQ, Wang LP, Zhang J, Wang BY, Hu XC. | 04/24/2021 |
| Secreted Wnt6 binds to FZD4 to activate the canonical Wnt6 signaling pathway, which is upstream of ROCK1 and 14-3-3sigma, and that this is the cell signaling pathway underlying diabetes-associated centrosome amplification. | Secreted Wnt6 mediates diabetes-associated centrosome amplification via its receptor FZD4.
He QJ, Wang P, Liu QQ, Wu QG, Li YF, Wang J, Lee SC. | 05/9/2020 |
| The authors show that WNT6 is significantly overexpressed in glioblastoma, as compared to lower-grade gliomas and normal brain, at mRNA and protein levels. Functionally, WNT6 increases typical oncogenic activities in glioblastoma cells, including viability, proliferation, glioma stem cell capacity, invasion, migration, and resistance to temozolomide chemotherapy. | WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma.
Gonçalves CS, Vieira de Castro J, Pojo M, Martins EP, Queirós S, Chautard E, Taipa R, Pires MM, Pinto AA, Pardal F, Custódia C, Faria CC, Clara C, Reis RM, Sousa N, Costa BM., Free PMC Article | 09/7/2019 |
| Study results indicated that PLAGL2 was overexpressed in colorectal cancer (CRC) as a protooncogene and that it could active the Wnt/betacatenin pathway as a transcription factor by binding with the promoter region of Wnt6. | Overexpressed PLAGL2 transcriptionally activates Wnt6 and promotes cancer development in colorectal cancer.
Li N, Li D, Du Y, Su C, Yang C, Lin C, Li X, Hu G., Free PMC Article | 02/2/2019 |
| WNT6 may be a diagnostic and prognostic marker in osteosarcoma | WNT6 is an effective marker for osteosarcoma diagnosis and prognosis.
Jiang K, Li S, Li L, Wang X, Gu Y, Jin Z., Free PMC Article | 12/22/2018 |
| our results support the concept that WNT6 may play a role in tumor progression | Increased WNT6 expression in tumor cells predicts unfavorable survival in esophageal squamous cell carcinoma patients.
Zhang L, Yuan G, Fang Y, Qiu M, Lin J, Sun J, Yang D., Free PMC Article | 12/17/2016 |
| WNT6 activates the JNK signaling pathway in HDPCs, leading to migration and differentiation. | WNT6 promotes the migration and differentiation of human dental pulp cells partly through c-Jun N-terminal kinase signaling pathway.
Li R, Wang C, Tong J, Su Y, Lin Y, Zhou X, Ye L. | 09/3/2016 |
| analysis of missense mutation in WNT6 in couples with unexplained recurrent miscarriage | Novel missense mutation in WNT6 in 100 couples with unexplained recurrent miscarriage.
Zhang Y, Li G, Fan Y, Cui Y, Huang S, Ma J, Yan J, Chen ZJ. | 01/2/2016 |
| WNT6 and Cav1 are upregulated by chemotherapeutics and enhance the resistance of GC cells to anthracycline drugs | WNT6 is a novel target gene of caveolin-1 promoting chemoresistance to epirubicin in human gastric cancer cells.
Yuan G, Regel I, Lian F, Friedrich T, Hitkova I, Hofheinz RD, Ströbel P, Langer R, Keller G, Röcken C, Zimmermann W, Schmid RM, Ebert MP, Burgermeister E. | 03/16/2013 |
| The WNT6 rs6747776 homozygous minor allele (CC) was associated with increased risk of colorectal adenoma. | Polymorphisms in WNT6 and WNT10A and colorectal adenoma risk.
Galbraith RL, Poole EM, Duggan D, Muehling J, Hsu L, Makar K, Xiao L, Potter JD, Ulrich CM., Free PMC Article | 09/17/2011 |
| Wnt6 plays an important role in tooth development by promoting human dental papilla cell differentiation, without significant effects on cell proliferation. | Effect of Wnt6 on human dental papilla cells in vitro.
Wang C, Ren L, Peng L, Xu P, Dong G, Ye L. | 05/31/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesMaternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC. Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations.
Beaty TH, Hetmanski JB, Fallin MD, Park JW, Sull JW, McIntosh I, Liang KY, Vanderkolk CA, Redett RJ, Boyadjiev SA, Jabs EW, Chong SS, Cheah FS, Wu-Chou YH, Chen PK, Chiu YF, Yeow V, Ng IS, Cheng J, Huang S, Ye X, Wang H, Ingersoll R, Scott AF. | 03/13/2008 |