MANF serves as a novel hepatocyte factor to promote liver regeneration after 2/3 partial hepatectomy via doubly targeting Wnt/β-catenin signaling.
Liang Y, Mei Q, He E, Ballar P, Wei C, Wang Y, Dong Y, Zhou J, Tao X, Qu W, Zhao M, Chhetri G, Wei L, Shao J, Shen Y, Liu J, Feng L, Shen Y., Free PMC Article

Mesencephalic Astrocyte-derived Neurotrophic Factor Supports Hepatitis B Virus-induced Immunotolerance.
Xie H, Deng H, Yang X, Gao X, Yang S, Chen W, Wang Y, Yang N, Yong L, Hou X., Free PMC Article

MANF Promotes Unexplained Recurrent Miscarriages by Interacting with NPM1 and Downregulating Trophoblast Cell Migration and Invasion.
Fang Y, Zhang J, Zhu D, Mei Q, Liao T, Cheng H, He Y, Cao Y, Wei Z., Free PMC Article

Mesencephalic astrocyte-derived neurotrophic factor (MANF) alleviates cerebral ischemia/reperfusion injury in mice by regulating microglia polarization via A20/NF-κB pathway.
Zhao X, Wang Z, Wang J, Xu F, Zhang Y, Han D, Fang W.

Deletion of mesencephalic astrocyte-derived neurotrophic factor delays and damages the development of white pulp in spleen.
Zhou C, Han D, Fang H, Huang D, Cai H, Shen Y, Shen Y, Liu J.

S100a16 Deficiency Prevents Alcohol-induced Fatty Liver Injury via Inducing MANF Expression in Mice.
Wang D, Zhang R, Qin X, Wang J, Hu Y, Lu S, Kan J, Ge Y, Jin K, Zhang WS, Liu Y., Free PMC Article

MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice.
Kim Y, Li C, Gu C, Fang Y, Tycksen E, Puri A, Pietka TA, Sivapackiam J, Kidd K, Park SJ, Johnson BG, Kmoch S, Duffield JS, Bleyer AJ, Jackrel ME, Urano F, Sharma V, Lindahl M, Chen YM., Free PMC Article

Upregulation of mesencephalic astrocyte-derived neurotrophic factor (MANF) expression offers protection against alcohol neurotoxicity.
Wen W, Wang Y, Li H, Hu D, Zhang Z, Lin H, Luo J., Free PMC Article

MANF inhibits Sjögren's syndrome salivary gland epithelial cell apoptosis and antigen expression of Ro52/SSA through endoplasmic reticulum stress/autophagy pathway.
Cheng D, Zhou T, Liu H, Li L, Xuan Y, Huang L, Liu Y, Zhang X, Wei W, Wu H.

Aging disrupts MANF-mediated immune modulation during skeletal muscle regeneration.
Sousa NS, Brás MF, Antunes IB, Lindholm P, Neves J, Sousa-Victor P.

The Unconventional Growth Factors Cerebral Dopamine Neurotrophic Factor and Mesencephalic Astrocyte-Derived Neurotrophic Factor Promote Post-ischemic Neurological Recovery, Perilesional Brain Remodeling, and Lesion-Remote Axonal Plasticity.
Caglayan AB, Beker MC, Sertel Evren E, Caglayan B, Kilic Ü, Ates N, Caglayan A, Dasdelen MF, Doeppner TR, Saarma M, Hermann DM, Kilic E.

Mesencephalic astrocyte-derived neurotrophic factor restores blood-brain barrier integrity of aged mice after ischaemic stroke/reperfusion through anti-inflammation via TLR4/MyD88/NF-κB pathway.
Han D, Li F, Zhang H, Ji C, Shu Q, Wang C, Ni H, Zhu Y, Wang S.

Deficiency of mesencephalic astrocyte-derived neurotrophic factor affects neurogenesis in mouse brain.
Wang Y, Wen W, Li H, Xu H, Xu M, Ma M, Luo J., Free PMC Article

Mesencephalic astrocyte-derived neurotrophic factor reprograms macrophages to ameliorate acetaminophen-induced acute liver injury via p38 MAPK pathway.
Hou X, Liu Q, Gao Y, Yong L, Xie H, Li W, Zhou Y, Liu J, Feng L, Xu L, Shen Y, Wang H., Free PMC Article

Mono-macrophage-Derived MANF Alleviates Bacterial Myocarditis by Inhibiting NF-kappaB Activation and Myocardial Inflammation.
Wang C, Bao Q, Hou C, Sun M, Song X, Cao S, Wang X, Shen Q, Zhao Y, Wang D.

MANF is neuroprotective against ethanol-induced neurodegeneration through ameliorating ER stress.
Wang Y, Wen W, Li H, Clementino M, Xu H, Xu M, Ma M, Frank J, Luo J., Free PMC Article

Mono-macrophage-Derived MANF Protects Against Lipopolysaccharide-Induced Acute Kidney Injury via Inhibiting Inflammation and Renal M1 Macrophages.
Hou C, Mei Q, Song X, Bao Q, Li X, Wang D, Shen Y.

Feeding-induced hepatokine, Manf, ameliorates diet-induced obesity by promoting adipose browning via p38 MAPK pathway.
Wu T, Liu Q, Li Y, Li H, Chen L, Yang X, Tang Q, Pu S, Kuang J, Li R, Huang Y, Zhang J, Zhang Z, Zhou J, Huang C, Zhang G, Zhao Y, Zou M, Jiang W, Mo L, He J., Free PMC Article

The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor.
Eesmaa A, Yu LY, Göös H, Nõges K, Kovaleva V, Hellman M, Zimmermann R, Jung M, Permi P, Varjosalo M, Lindholm P, Saarma M., Free PMC Article

MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System.
Pakarinen E, Danilova T, Võikar V, Chmielarz P, Piepponen P, Airavaara M, Saarma M, Lindahl M., Free PMC Article

Mesencephalic astrocyte-derived neurotrophic factor alleviates alcohol induced hepatic steatosis via activating Stat3-mediated autophagy.
Zhang G, Liu Q, Li Y, Huang C, Zhou J, Zhao Y, Wu T, Tang Q, Li R, Zhang Z, Zhang J, Huang Y, Huang H, Xia Y, Yan J, Jing X, He J.

Hepatocyte-derived MANF alleviates hepatic ischaemia-reperfusion injury via regulating endoplasmic reticulum stress-induced apoptosis in mice.
Yang Y, Wang P, Zhang C, Huang F, Pang G, Wei C, Lv C, Chhetri G, Jiang T, Liu J, Shen Y, Shen Y.

Deficiency of the ER-stress-regulator MANF triggers progressive outer hair cell death and hearing loss.
Herranen A, Ikäheimo K, Lankinen T, Pakarinen E, Fritzsch B, Saarma M, Lindahl M, Pirvola U., Free PMC Article

MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage.
Sousa-Victor P, Neves J, Cedron-Craft W, Ventura PB, Liao CY, Riley RR, Soifer I, van Bruggen N, Kolumam GA, Villeda SA, Lamba DA, Jasper H., Free PMC Article

Mesencephalic astrocyte-derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart.
Arrieta A, Blackwood EA, Stauffer WT, Santo Domingo M, Bilal AS, Thuerauf DJ, Pentoney AN, Aivati C, Sarakki AV, Doroudgar S, Glembotski CC., Free PMC Article