| The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8[+] T cells. | The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8(+) T cells.
Liao X, Li W, Zhou H, Rajendran BK, Li A, Ren J, Luan Y, Calderwood DA, Turk B, Tang W, Liu Y, Wu D., Free PMC Article | 02/8/2024 |
| Cullin5 drives experimental asthma exacerbations by modulating alveolar macrophage antiviral immunity. | Cullin5 drives experimental asthma exacerbations by modulating alveolar macrophage antiviral immunity.
Zhang H, Xue K, Li W, Yang X, Gou Y, Su X, Qian F, Sun L., Free PMC Article | 01/11/2024 |
| The ubiquitin ligase Cul5 regulates CD4(+) T cell fate choice and allergic inflammation. | The ubiquitin ligase Cul5 regulates CD4(+) T cell fate choice and allergic inflammation.
Kumar B, Field NS, Kim DD, Dar AA, Chen Y, Suresh A, Pastore CF, Hung LY, Porter N, Sawada K, Shah P, Elbulok O, Moser EK, Herbert DR, Oliver PM., Free PMC Article | 05/28/2022 |
| work identifies the essential role of CUL5- and SOCS3-mediated integrin beta1 turnover in controlling small-cell lung cancer metastasis, which might have therapeutic implications. | Cullin5 deficiency promotes small-cell lung cancer metastasis by stabilizing integrin β1.
Zhao G, Gong L, Su D, Jin Y, Guo C, Yue M, Yao S, Qin Z, Ye Y, Tang Y, Wu Q, Zhang J, Cui B, Ding Q, Huang H, Hu L, Chen Y, Zhang P, Hu G, Chen L, Wong KK, Gao D, Ji H., Free PMC Article | 02/29/2020 |
| r results show that Cul5, but not Rbx2, is required during early embryogenesis and suggests that Cul5 has Rbx2-independent functions in early development. | Comparative Analysis of cul5 and rbx2 Expression in the Developing and Adult Murine Brain and Their Essentiality During Mouse Embryogenesis.
Hino K, Simó S, Cooper JA., Free PMC Article | 05/18/2019 |
| neural precursor cell expressed developmentally downregulated protein 8 (Nedd8) modification of Cul-5 is required for its interaction with TRAF6. | Nedd8 modification of Cullin-5 regulates lipopolysaccharide-induced acute lung injury.
Zhu Z, Sun L, Hao R, Jiang H, Qian F, Ye RD. | 08/5/2017 |
| Our results show that endogenous Cul5 suppresses epithelial cell transformation by several pathways, including inhibition of Src-Cas-induced ruffling through SOCS6 | Cullin 5 destabilizes Cas to inhibit Src-dependent cell transformation.
Teckchandani A, Laszlo GS, Simó S, Shah K, Pilling C, Strait AA, Cooper JA., Free PMC Article | 09/20/2014 |
| The expression of cullin5 on retinal cells and reduction in the percentage of dead retinal cells induced by L-glutamate suggest that cullin5 has neuroprotective properties in retinal cells. | Cullin5 reduces retinal cell death induced by glutamate toxicity.
Kanamoto T, Okumichi H, Rimayanti U, Kiuchi Y. | 03/26/2011 |
| SOCS box acts as an independent binding domain capable of recruiting elonginBC and cullin5 to promote E3 ligase formation. | The SOCS box domain of SOCS3: structure and interaction with the elonginBC-cullin5 ubiquitin ligase.
Babon JJ, Sabo JK, Soetopo A, Yao S, Bailey MF, Zhang JG, Nicola NA, Norton RS., Free PMC Article | 03/9/2011 |
| The role of Cul5 is to degrade disabled homolog 1 (Dab1) and thus control neuron migration speed and neuron insertion at the top of the cortical plate. | Cullin 5 regulates cortical layering by modulating the speed and duration of Dab1-dependent neuronal migration.
Simó S, Jossin Y, Cooper JA., Free PMC Article | 05/10/2010 |
| data imply the existence of two distinct subclasses of SOCS proteins with a high affinity for Cullin5, the E3 ligase scaffold, possibly reflecting complete dependence upon ubiquitination for suppression of cytokine signalling | The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression.
Babon JJ, Sabo JK, Zhang JG, Nicola NA, Norton RS., Free PMC Article | 01/21/2010 |
| These results suggest that, when Src is activated by mutation or physiological mechanisms, its effects are limited by Culllin 5, which downregulates active Src and its phosphorylated substrates. | Restriction of Src activity by Cullin-5.
Laszlo GS, Cooper JA., Free PMC Article | 01/21/2010 |