| Mitochondrial fission factor (Mff) is required for organization of the mitochondrial sheath in spermatids. | Mitochondrial fission factor (Mff) is required for organization of the mitochondrial sheath in spermatids.
Varuzhanyan G, Chen H, Rojansky R, Ladinsky MS, McCaffery JM, Chan DC., Free PMC Article | 07/3/2021 |
| MAVS is energized by Mff which senses mitochondrial metabolism via AMPK for acute antiviral immunity. | MAVS is energized by Mff which senses mitochondrial metabolism via AMPK for acute antiviral immunity.
Hanada Y, Ishihara N, Wang L, Otera H, Ishihara T, Koshiba T, Mihara K, Ogawa Y, Nomura M., Free PMC Article | 12/5/2020 |
| the Drp1 'receptor' Mitochondrial fission factor (MFF) is required for determining the size of mitochondria entering the axon. | MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size.
Lewis TL Jr, Kwon SK, Lee A, Shaw R, Polleux F., Free PMC Article | 01/5/2019 |
| The cardiac ischemia/reperfusion injury - induced DUSP1 deficiency promoted the activation of JNK which upregulated the expression of the mitochondrial fission factor (Mff). | DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways.
Jin Q, Li R, Hu N, Xin T, Zhu P, Hu S, Ma S, Zhu H, Ren J, Zhou H., Free PMC Article | 07/21/2018 |
| mitochondrial fission factor | Mff-Dependent Mitochondrial Fission Contributes to the Pathogenesis of Cardiac Microvasculature Ischemia/Reperfusion Injury via Induction of mROS-Mediated Cardiolipin Oxidation and HK2/VDAC1 Disassociation-Involved mPTP Opening.
Zhou H, Hu S, Jin Q, Shi C, Zhang Y, Zhu P, Ma Q, Tian F, Chen Y., Free PMC Article | 03/10/2018 |
| MiD51 can suppress Mff-dependent enhancement of Drp1 GTPase activity. | Cooperative and independent roles of the Drp1 adaptors Mff, MiD49 and MiD51 in mitochondrial fission.
Osellame LD, Singh AP, Stroud DA, Palmer CS, Stojanovski D, Ramachandran R, Ryan MT., Free PMC Article | 08/12/2017 |
| Mff cannot bind to assembly-deficient mutants of Drp1, suggesting that Mff selectively interacts with higher-order complexes of Drp1. | The mitochondrial fission receptor Mff selectively recruits oligomerized Drp1.
Liu R, Chan DC., Free PMC Article | 10/22/2016 |
| These findings provide a mechanism wherein the multimeric states of both Mff and Drp1 regulate their collaborative interaction. | Dynamin-related Protein 1 Oligomerization in Solution Impairs Functional Interactions with Membrane-anchored Mitochondrial Fission Factor.
Clinton RW, Francy CA, Ramachandran R, Qi X, Mears JA., Free PMC Article | 05/21/2016 |
| membrane-anchored Mff differentially regulates various Drp1 isoforms. | Distinct Splice Variants of Dynamin-related Protein 1 Differentially Utilize Mitochondrial Fission Factor as an Effector of Cooperative GTPase Activity.
Macdonald PJ, Francy CA, Stepanyants N, Lehman L, Baglio A, Mears JA, Qi X, Ramachandran R., Free PMC Article | 05/21/2016 |
| Ablating Mfn1 eliminates the cardiac-related lethality of Mff knockout mice. | Titration of mitochondrial fusion rescues Mff-deficient cardiomyopathy.
Chen H, Ren S, Clish C, Jain M, Mootha V, McCaffery JM, Chan DC., Free PMC Article | 03/12/2016 |
| Mitochondrial fission factor has been identified as a new AMPK substrate. | Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: identification of mitochondrial fission factor as a new AMPK substrate.
Ducommun S, Deak M, Sumpton D, Ford RJ, Núñez Galindo A, Kussmann M, Viollet B, Steinberg GR, Foretz M, Dayon L, Morrice NA, Sakamoto K. | 12/19/2015 |
| This study reveals a novel model of mitochondrial fission regulation, which is composed of miR-761 and mitochondrial fission factor | miR-761 regulates the mitochondrial network by targeting mitochondrial fission factor.
Long B, Wang K, Li N, Murtaza I, Xiao JY, Fan YY, Liu CY, Li WH, Cheng Z, Li P., Free PMC Article | 08/15/2015 |
| MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and suggest that they provide specificity to the division of mitochondria. | Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission.
Palmer CS, Elgass KD, Parton RG, Osellame LD, Stojanovski D, Ryan MT., Free PMC Article | 11/30/2013 |
| immunofluorescence analysis of Drp1 suggests that Fis1 and Mff are important for the number and size of Drp1 puncta on mitochondria. | Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission.
Losón OC, Song Z, Chen H, Chan DC., Free PMC Article | 09/14/2013 |