| Hypoxia-induced factor 1alpha promotes osteotomy-induced regional acceleratory phenomenon via DC-STAMP mediated membrane fusion. | Hypoxia-induced factor 1α promotes osteotomy-induced regional acceleratory phenomenon via DC-STAMP mediated membrane fusion.
Tang Y, Li X, Cai Y, Bie M, Tian Y, Shao Q, Kang F. | 06/15/2023 |
| Connective tissue growth factor (CTGF) regulates the fusion of osteoclast precursors by inhibiting Bcl6 in periodontitis. | Connective tissue growth factor (CTGF) regulates the fusion of osteoclast precursors by inhibiting Bcl6 in periodontitis.
Choi Y, Yoo JH, Lee JH, Lee Y, Bae MK, Kim YD, Kim HJ., Free PMC Article | 12/19/2020 |
| Multinuclear macrophages of BCG-infected mice express CD antigens and DC-STAMP in the process of fusion. | In Vitro Analysis of the Expression of CD11, CD29, CD36, and DC-STAMP Molecules during the Formation of Multinuclear Macrophages in BCG-Infected Mice.
Il'in DA, Shkurupy VA. | 04/4/2020 |
| These results suggested that hyperphosphatemia in the patients with CKD suppresses bone resorption by inhibiting osteoclastogenesis, and this impairs the regulation of bone metabolism. | Inorganic phosphate-induced impairment of osteoclast cell-cell fusion by the inhibition of AP-1-mediated DC-STAMP expression.
Arioka M, Takahashi-Yanaga F, Tatsumoto N, Sasaguri T. | 10/28/2017 |
| Immunoreceptor tyrosine-based inhibitory motif DC-STAMP is a functional motif that regulates osteoclast differentiation through the NFATc1/Ca(2+) axis. | Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) Regulates Osteoclast Differentiation via the Ca(2+) /NFATc1 Axis.
Chiu YH, Schwarz E, Li D, Xu Y, Sheu TR, Li J, de Mesy Bentley KL, Feng C, Wang B, Wang JC, Albertorio-Saez L, Wood R, Kim M, Wang W, Ritchlin CT., Free PMC Article | 08/12/2017 |
| These results suggest that Luman regulates the multinucleation of osteoclasts by promoting cell fusion of mononuclear osteoclasts through DC-STAMP induction and intracellular distribution during osteoclastogenesis. | Luman is involved in osteoclastogenesis through the regulation of DC-STAMP expression, stability and localization.
Kanemoto S, Kobayashi Y, Yamashita T, Miyamoto T, Cui M, Asada R, Cui X, Hino K, Kaneko M, Takai T, Matsuhisa K, Takahashi N, Imaizumi K., Free PMC Article | 09/10/2016 |
| miR-7b inhibits osteoclastogenesis and cell-cell fusion by directly targeting DC-STAMP. | MiR-7b directly targets DC-STAMP causing suppression of NFATc1 and c-Fos signaling during osteoclast fusion and differentiation.
Dou C, Zhang C, Kang F, Yang X, Jiang H, Bai Y, Xiang J, Xu J, Dong S. | 01/17/2015 |
| our data indicate that Pin1 is a determinant of bone mass through the regulation of the osteoclast fusion protein DC-STAMP | Pin1 regulates osteoclast fusion through suppression of the master regulator of cell fusion DC-STAMP.
Islam R, Bae HS, Yoon WJ, Woo KM, Baek JH, Kim HH, Uchida T, Ryoo HM. | 10/25/2014 |
| Mechanical vibration of osteoclast precursor cells reduces DC-STAMP expression in osteoclast precursor cells. | Mechanical vibration inhibits osteoclast formation by reducing DC-STAMP receptor expression in osteoclast precursor cells.
Kulkarni RN, Voglewede PA, Liu D., Free PMC Article | 06/14/2014 |
| DC-STAMP, Siglec-15, Tspan7 and Mst1r expression was downregulated by docosahexaenoic acid, but not eicosapentaenoic acid during osteoclastogenesis in vitro. | Impact of docosahexaenoic acid on gene expression during osteoclastogenesis in vitro--a comprehensive analysis.
Akiyama M, Nakahama K, Morita I., Free PMC Article | 03/1/2014 |
| Results indicate that NFATc1 binding to the DC-STAMP promoter was inhibited by 60.9% with RvE1 treatment. | Resolvin E1 regulates osteoclast fusion via DC-STAMP and NFATc1.
Zhu M, Van Dyke TE, Gyurko R., Free PMC Article | 12/21/2013 |
| Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP. | Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP.
Maruyama K, Uematsu S, Kondo T, Takeuchi O, Martino MM, Kawasaki T, Akira S., Free PMC Article | 11/23/2013 |
| These results suggest that short-term mechanical stress strongly inhibits osteoclastogenesis through the downregulation of DC-STAMP. | Short-term mechanical stress inhibits osteoclastogenesis via suppression of DC-STAMP in RAW264.7 cells.
Kameyama S, Yoshimura Y, Kameyama T, Kikuiri T, Matsuno M, Deyama Y, Suzuki K, Iida J. | 11/16/2013 |
| Fusogenic mechanisms in macrophage-lineage cells are regulated via OC-STAMP and DC-STAMP. | Osteoclast stimulatory transmembrane protein and dendritic cell–specific transmembrane protein cooperatively modulate cell–cell fusion to form osteoclasts and foreign body giant cells.
Miyamoto H, Suzuki T, Miyauchi Y, Iwasaki R, Kobayashi T, Sato Y, Miyamoto K, Hoshi H, Hashimoto K, Yoshida S, Hao W, Mori T, Kanagawa H, Katsuyama E, Fujie A, Morioka H, Matsumoto M, Chiba K, Takeya M, Toyama Y, Miyamoto T. | 09/15/2012 |
| found that DC-STAMP, a key regulator of osteoclast cell fusion, is a direct target gene of Tal1 and show that Tal1 represses DC-STAMP expression by counteracting the activating function of the transcription factors PU.1 and MITF | Tal1 regulates osteoclast differentiation through suppression of the master regulator of cell fusion DC-STAMP.
Courtial N, Smink JJ, Kuvardina ON, Leutz A, Göthert JR, Lausen J. | 04/14/2012 |
| DC-STAMP is an ITIM-bearing molecule. Based on the 4 distinct patterns of DCSTAMP on human PBMC, it has potential to serve as a susceptible biomarker of psoriasis (Ps) as well as severity marker of Psoriatic Arthritis (PsA). | Regulation of human osteoclast development by dendritic cell-specific transmembrane protein (DC-STAMP).
Chiu YH, Mensah KA, Schwarz EM, Ju Y, Takahata M, Feng C, McMahon LA, Hicks DG, Panepento B, Keng PC, Ritchlin CT., Free PMC Article | 02/1/2012 |
| regulates cytokine production and T-cell stimulatory capacity of LPS-matured dendritic cells | DC-STAMP knock-down deregulates cytokine production and T-cell stimulatory capacity of LPS-matured dendritic cells.
Sanecka A, Ansems M, Prosser AC, Danielski K, Warner K, den Brok MH, Jansen BJ, Eleveld-Trancikova D, Adema GJ., Free PMC Article | 01/28/2012 |
| CCN2 expressed during osteoclastogenesis promotes osteoclast formation via induction of and interaction with DC-STAMP | CCN family 2/connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP).
Nishida T, Emura K, Kubota S, Lyons KM, Takigawa M., Free PMC Article | 04/30/2011 |
| DC-STAMP is expressed on osteoclast precursors as a dimer. RANKL induces osteoclastogenesis by stimulating DC-STAMP internalization in some osteoclast progenitors. | RANKL induces heterogeneous DC-STAMP(lo) and DC-STAMP(hi) osteoclast precursors of which the DC-STAMP(lo) precursors are the master fusogens.
Mensah KA, Ritchlin CT, Schwarz EM., Free PMC Article | 03/15/2010 |
| DC-STAMP over-expressing transgenic mice under the control of an actin promoter showed significantly accelerated cell-cell fusion of osteoclasts and bone resorption, with decreased osteoblastic activity and bone mass. | Cell fusion in osteoclasts plays a critical role in controlling bone mass and osteoblastic activity.
Iwasaki R, Ninomiya K, Miyamoto K, Suzuki T, Sato Y, Kawana H, Nakagawa T, Suda T, Miyamoto T. | 01/21/2010 |
| dendritic cell antigen presentation activity is up-regulated in DC-STAMP-deficient mice; autoimmunity is present | The role of DC-STAMP in maintenance of immune tolerance through regulation of dendritic cell function.
Sawatani Y, Miyamoto T, Nagai S, Maruya M, Imai J, Miyamoto K, Fujita N, Ninomiya K, Suzuki T, Iwasaki R, Toyama Y, Shinohara M, Koyasu S, Suda T. | 01/21/2010 |
| the expression of DC-STAMP affects myeloid development of hematopoietic progenitor cells, specifically suppressing granulocytic development | The DC-derived protein DC-STAMP influences differentiation of myeloid cells.
Eleveld-Trancikova D, Janssen RA, Hendriks IA, Looman MW, Moulin V, Jansen BJ, Jansen JH, Figdor CG, Adema GJ. | 01/21/2010 |
| DC-STAMP expression is regulated differently in osteoclasts and macrophage giant cells. | Induction of DC-STAMP by alternative activation and downstream signaling mechanisms.
Yagi M, Ninomiya K, Fujita N, Suzuki T, Iwasaki R, Morita K, Hosogane N, Matsuo K, Toyama Y, Suda T, Miyamoto T. | 01/21/2010 |
| DC-STAMP has an essential role in osteoclastogenesis. | RANKL-induced DC-STAMP is essential for osteoclastogenesis.
Kukita T, Wada N, Kukita A, Kakimoto T, Sandra F, Toh K, Nagata K, Iijima T, Horiuchi M, Matsusaki H, Hieshima K, Yoshie O, Nomiyama H., Free PMC Article | 01/21/2010 |