| TBX18 knockdown sensitizes esophageal squamous cell carcinoma to radiotherapy by blocking the CHN1/RhoA axis. | TBX18 knockdown sensitizes esophageal squamous cell carcinoma to radiotherapy by blocking the CHN1/RhoA axis.
Zhou J, Wu J, Wu G, Huang J, Zhang Y, Che J, Zhu K, Geng J, Fan Q. | 08/25/2023 |
| Permissive ureter specification by TBX18-mediated repression of metanephric gene expression. | Permissive ureter specification by TBX18-mediated repression of metanephric gene expression.
Weiss AC, Blank E, Bohnenpoll T, Kleppa MJ, Rivera-Reyes R, Taketo MM, Trowe MO, Kispert A. | 03/27/2023 |
| Tbx18-positive cells-derived myofibroblasts contribute to renal interstitial fibrosis via transforming growth factor-beta signaling. | Tbx18-positive cells-derived myofibroblasts contribute to renal interstitial fibrosis via transforming growth factor-β signaling.
Yuan X, Zhang L, Du J. | 10/16/2021 |
| Characterization of the adiponectin promoter + Cre recombinase insertion in the Tg(Adipoq-cre)1Evdr mouse by targeted locus amplification and droplet digital PCR. | Characterization of the adiponectin promoter + Cre recombinase insertion in the Tg(Adipoq-cre)1Evdr mouse by targeted locus amplification and droplet digital PCR.
Wong AM, Patel TP, Altman EK, Tugarinov N, Trivellin G, Yanovski JA., Free PMC Article | 10/9/2021 |
| Data indicate an extended landscape of promoter-contacting regions throughout a 1.5-2 million base pair domain surrounding the T-box protein 18 (Tbx18) gene. | An extended regulatory landscape drives Tbx18 activity in a variety of prostate-associated cell lineages.
Negi S, Bolt CC, Zhang H, Stubbs L., Free PMC Article | 04/20/2019 |
| Tbx18, Ripply2, and Hes7 repress the activation of the Hes7 essential region by the aforementioned transcription factors. | Presomitic mesoderm-specific expression of the transcriptional repressor Hes7 is controlled by E-box, T-box, and Notch signaling pathways.
Hayashi S, Nakahata Y, Kohno K, Matsui T, Bessho Y., Free PMC Article | 02/23/2019 |
| Study identified and characterized new TBX18 binding partners that may influence the transcriptional activity of TBX18 in vivo. Proteomic screen strongly supports an exclusive nuclear function of TBX18 as a repressor of chromatin accessibility. | Proteomic analysis identifies transcriptional cofactors and homeobox transcription factors as TBX18 binding proteins.
Rivera-Reyes R, Kleppa MJ, Kispert A., Free PMC Article | 01/19/2019 |
| TBX18 gene transduction may facilitate the differentiation of brown adipose-derived stem cell and white adipose-derived stem cellinto pacemakerlike myocardial cells, and brown adipose-derived stem cell may have a higher capacity than white adipose-derived stem cell for this differentiation. | Comparison of mouse brown and white adipose‑derived stem cell differentiation into pacemaker‑like cells induced by TBX18 transduction.
Sun AJ, Qiao L, Huang C, Zhang X, Li YQ, Yang XQ., Free PMC Article | 09/29/2018 |
| The expression of Tbx3 and shox2, the other two important transcription factors in the development of pacemaker cells, was decreased by silencing Tbx18, which suggests that Tbx18 mediates the differentiation of BATSCs into a pacemaker phenotype via these two downstream transcription factors. | Tbx18-dependent differentiation of brown adipose tissue-derived stem cells toward cardiac pacemaker cells.
Chen L, Deng ZJ, Zhou JS, Ji RJ, Zhang X, Zhang CS, Li YQ, Yang XQ. | 07/14/2018 |
| hypoxia intervention was sufficient to induce the differentiation of Tbx18-positive epicardial cells to coronary vascular smooth muscle cells. | Hypoxia induced the differentiation of Tbx18-positive epicardial cells to CoSMCs.
Jing X, Gao Y, Xiao S, Qin Q, Wei X, Yan Y, Wu L, Deng S, Du J, Liu Y, She Q., Free PMC Article | 04/28/2018 |
| Tbx18 does not function redundantly with Tbx2 or Tbx20 in epicardial development. | Lack of Genetic Interaction between Tbx18 and Tbx2/Tbx20 in Mouse Epicardial Development.
Greulich F, Rudat C, Farin HF, Christoffels VM, Kispert A., Free PMC Article | 07/22/2017 |
| We conclude that exclusion of Tbx18 expression from the developing atria and (right) ventricle is important to achieve normal cardiac left-right patterning and myocardial differentiation, and that Tbx18 is not sufficient to induce full SAN differentiation of chamber cardiomyocytes in fetal mice. | Misexpression of Tbx18 in cardiac chambers of fetal mice interferes with chamber-specific developmental programs but does not induce a pacemaker-like gene signature.
Greulich F, Trowe MO, Leffler A, Stoetzer C, Farin HF, Kispert A. | 06/3/2017 |
| Tbx18 is essential to the differentiation and maintenance of the prostate periurethral mesenchyme; it indirectly regulates epithelial differentiation through control of stromal-epithelial signaling. | Tbx18 Regulates the Differentiation of Periductal Smooth Muscle Stroma and the Maintenance of Epithelial Integrity in the Prostate.
Bolt CC, Negi S, Guimarães-Camboa N, Zhang H, Troy JM, Lu X, Kispert A, Evans SM, Stubbs L., Free PMC Article | 03/25/2017 |
| The temporal suppression of Tbx18 gene expression by the hypermethylation of its promoter seems to trigger the differentiation of mesenchymal cells into hypertrophic chondrocytes in the early stages of endochondral ossification. | Epigenetic regulation of Tbx18 gene expression during endochondral bone formation.
Haraguchi R, Kitazawa R, Kitazawa S. | 10/31/2015 |
| A distant downstream enhancer directs essential expression of Tbx18 in urogenital tissues. | A distant downstream enhancer directs essential expression of Tbx18 in urogenital tissues.
Bolt CC, Elso CM, Lu X, Pan F, Kispert A, Stubbs L., Free PMC Article | 09/20/2014 |
| Tbx18 has a role in normal development of vasculature network and glomerular mesangium in the mammalian kidney | Tbx18 is essential for normal development of vasculature network and glomerular mesangium in the mammalian kidney.
Xu J, Nie X, Cai X, Cai CL, Xu PX., Free PMC Article | 06/28/2014 |
| Tbx18, a T-box family member highly expressed in the proepicardium, controls critical early steps in coronary development. | Tbx18 regulates development of the epicardium and coronary vessels.
Wu SP, Dong XR, Regan JN, Su C, Majesky MW., Free PMC Article | 12/28/2013 |
| Tbx18 is required to prepattern mouse ureteric mesenchyme | Tbx18 expression demarcates multipotent precursor populations in the developing urogenital system but is exclusively required within the ureteric mesenchymal lineage to suppress a renal stromal fate.
Bohnenpoll T, Bettenhausen E, Weiss AC, Foik AB, Trowe MO, Blank P, Airik R, Kispert A. | 08/31/2013 |
| Tbx18 and Wt1 directly bound to the Slug promoter region and regulated Slug expression | The transcription factors Tbx18 and Wt1 control the epicardial epithelial-mesenchymal transition through bi-directional regulation of Slug in murine primary epicardial cells.
Takeichi M, Nimura K, Mori M, Nakagami H, Kaneda Y., Free PMC Article | 08/31/2013 |
| Tbx18 is dispensable for epicardial development but that a transcriptional activator form of Tbx18 is sufficient to induce premature smooth muscle differentiation of epicardial cells. | Tbx18 function in epicardial development.
Greulich F, Farin HF, Schuster-Gossler K, Kispert A. | 04/27/2013 |
| Tbx18 is dispensable for normal dermal papilla function. | Tbx18 targets dermal condensates for labeling, isolation, and gene ablation during embryonic hair follicle formation.
Grisanti L, Clavel C, Cai X, Rezza A, Tsai SY, Sennett R, Mumau M, Cai CL, Rendl M., Free PMC Article | 03/16/2013 |
| Data show that Tbx18- and Wt1-deficient mice additionally exhibit partial pericardial absence. | Partial absence of pleuropericardial membranes in Tbx18- and Wt1-deficient mice.
Norden J, Grieskamp T, Christoffels VM, Moorman AF, Kispert A., Free PMC Article | 03/9/2013 |
| phenotypes result from competition between the ectopically expressed Tbx6 and the endogenously expressed Tbx18 and Tbx15 at the binding sites of target genes | Tbx18 and Tbx15 null-like phenotypes in mouse embryos expressing Tbx6 in somitic and lateral plate mesoderm.
Wehn AK, Chapman DL. | 11/6/2010 |
| SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation. | SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation.
Nie X, Sun J, Gordon RE, Cai CL, Xu PX., Free PMC Article | 03/22/2010 |
| Tbx18 controls the formation of the SAN head from mesenchymal precursors on which Tbx3 subsequently imposes the pacemaker gene program. | Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3.
Wiese C, Grieskamp T, Airik R, Mommersteeg MT, Gardiwal A, de Gier-de Vries C, Schuster-Gossler K, Moorman AF, Kispert A, Christoffels VM. | 01/21/2010 |