| From phenotype to mechanism: Prenatal spectrum of NKAP mutation-related disorder and its pathogenesis inducing congenital heart disease. | From phenotype to mechanism: Prenatal spectrum of NKAP mutation-related disorder and its pathogenesis inducing congenital heart disease.
Xu X, Gao C, Ye F, Peng A, Xu J, Jin K, Zhang J, Ye Y, Yang Y, Zhang X, Shen S, Jin F., Free PMC Article | 05/3/2024 |
| RNA binding protein NKAP protects glioblastoma cells from ferroptosis by promoting SLC7A11 mRNA splicing in an m(6)A-dependent manner. | RNA binding protein NKAP protects glioblastoma cells from ferroptosis by promoting SLC7A11 mRNA splicing in an m(6)A-dependent manner.
Sun S, Gao T, Pang B, Su X, Guo C, Zhang R, Pang Q., Free PMC Article | 04/16/2022 |
| MARCKS cooperates with NKAP to activate NF-kB signaling in smoke-related lung cancer. | MARCKS cooperates with NKAP to activate NF-kB signaling in smoke-related lung cancer.
Liu J, Chen SJ, Hsu SW, Zhang J, Li JM, Yang DC, Gu S, Pinkerton KE, Chen CH., Free PMC Article | 07/31/2021 |
| NKAP promotes renal cell carcinoma growth via AKT/mTOR signalling pathway. | NKAP promotes renal cell carcinoma growth via AKT/mTOR signalling pathway.
Ma Q, Hou L, Gao X, Yan K. | 05/22/2021 |
| The critical role of NKAP in transcriptional regulation. | Missense Mutations in NKAP Cause a Disorder of Transcriptional Regulation Characterized by Marfanoid Habitus and Cognitive Impairment.
Fiordaliso SK, Iwata-Otsubo A, Ritter AL, Quesnel-Vallières M, Fujiki K, Nishi E, Hancarova M, Miyake N, Morton JEV, Lee S, Hackmann K, Bando M, Masuda K, Nakato R, Arakawa M, Bhoj E, Li D, Hakonarson H, Takeda R, Harr M, Keena B, Zackai EH, Okamoto N, Mizuno S, Ko JM, Valachova A, Prchalova D, Vlckova M, Pippucci T, Seiler C, Choi M, Matsumoto N, Di Donato N, Barash Y, Sedlacek Z, Shirahige K, Izumi K., Free PMC Article | 04/4/2020 |
| Study determines that NKAP was upregulated in colon cancer. Its knockdown resulted in a significant decrease in the proliferation and invasion of colon cancer cells, as well as induction of apoptosis and autophagy, whereas its overexpression promoted cell proliferation and invasion, and inhibited apoptosis and autophagy. | The oncogenic role of NKAP in the growth and invasion of colon cancer cells.
Shu W, Liu G, Dai Y, Feng A, Chen Z, Han J, Li X. | 02/29/2020 |
| Observations suggest that NKAP promotes glioma growth by TAM chemoattraction through upregulation of Notch1. | NKAP alters tumor immune microenvironment and promotes glioma growth via Notch1 signaling.
Gu G, Gao T, Zhang L, Chen X, Pang Q, Wang Y, Wang D, Li J, Liu Q., Free PMC Article | 02/1/2020 |
| SUMOylated NKAP is essential for chromosome alignment by anchoring CENP-E to kinetochores | SUMOylated NKAP is essential for chromosome alignment by anchoring CENP-E to kinetochores.
Li T, Chen L, Cheng J, Dai J, Huang Y, Zhang J, Liu Z, Li A, Li N, Wang H, Yin X, He K, Yu M, Zhou T, Zhang X, Xia Q., Free PMC Article | 09/29/2018 |
| NKAP is required for T cell maturation and the acquisition of functional competency | NKAP is required for T cell maturation and acquisition of functional competency.
Hsu FC, Pajerowski AG, Nelson-Holte M, Sundsbak R, Shapiro VS., Free PMC Article | 08/27/2011 |
| NKAP functions as a transcriptional repressor, acting on Notch target genes, and is required for alphabeta T cell development. | NKAP is a transcriptional repressor of notch signaling and is required for T cell development.
Pajerowski AG, Nguyen C, Aghajanian H, Shapiro MJ, Shapiro VS., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Association of genetic profiles to Crohn's disease by linear combinations of single nucleotide polymorphisms.
D'Addabbo A, Latiano A, Palmieri O, Creanza MT, Maglietta R, Annese V, Ancona N. | 01/11/2009 |
| NKAP is a novel nuclear regulator of TNF- and IL-1-induced NF-kappaB activation | Identification of a nuclear protein that promotes NF-kappaB activation.
Chen D, Li Z, Yang Q, Zhang J, Zhai Z, Shu HB. | 01/21/2010 |