| STEAP4 modulates cell proliferation and oxidative stress in benign prostatic hyperplasia. | STEAP4 modulates cell proliferation and oxidative stress in benign prostatic hyperplasia.
Liu J, Zhou W, Yang L, Li Y, Qiu J, Fu X, Ren P, Guo F, Zhou Y, Liu J, Chen P, DiSanto ME, Zhang X. | 12/5/2023 |
| STEAP4 promoter methylation correlates with tumorigenesis of hepatocellular carcinoma. | STEAP4 promoter methylation correlates with tumorigenesis of hepatocellular carcinoma.
Tang Y, Wang Y, Xu X, Sun H, Tang W. | 05/7/2022 |
| sSTEAP4 regulates cellular homeostasis and improves high-fat-diet-caused oxidative stress in hepatocytes. | sSTEAP4 regulates cellular homeostasis and improves high-fat-diet-caused oxidative stress in hepatocytes.
Zhu L, Li B, Chen D, Chen N, Xu L, Li Q, Chen X. | 03/26/2022 |
| Predictive potential of STEAP family for survival, immune microenvironment and therapy response in glioma. | Predictive potential of STEAP family for survival, immune microenvironment and therapy response in glioma.
Zhao Z, Wang Z, Song Z, Wu Y, Jin Q, Zhao Z. | 03/19/2022 |
| Stamp2 Protects From Maladaptive Structural Remodeling and Systolic Dysfunction in Post-Ischemic Hearts by Attenuating Neutrophil Activation. | Stamp2 Protects From Maladaptive Structural Remodeling and Systolic Dysfunction in Post-Ischemic Hearts by Attenuating Neutrophil Activation.
Mollenhauer M, Bokredenghel S, Geißen S, Klinke A, Morstadt T, Torun M, Strauch S, Schumacher W, Maass M, Konradi J, Peters VBM, Berghausen E, Vantler M, Rosenkranz S, Mehrkens D, Braumann S, Nettersheim F, Hof A, Simsekyilmaz S, Winkels H, Rudolph V, Baldus S, Adam M, Freyhaus HT., Free PMC Article | 12/25/2021 |
| The six-transmembrane protein Stamp2 ameliorates pulmonary vascular remodeling and pulmonary hypertension in mice. | The six-transmembrane protein Stamp2 ameliorates pulmonary vascular remodeling and pulmonary hypertension in mice.
Batool M, Berghausen EM, Zierden M, Vantler M, Schermuly RT, Baldus S, Rosenkranz S, Ten Freyhaus H., Free PMC Article | 10/23/2021 |
| The Tumor Suppressive Roles and Prognostic Values of STEAP Family Members in Breast Cancer. | The Tumor Suppressive Roles and Prognostic Values of STEAP Family Members in Breast Cancer.
Wu HT, Chen WJ, Xu Y, Shen JX, Chen WT, Liu J., Free PMC Article | 04/24/2021 |
| Hepatic STAMP2 mediates recombinant FGF21-induced improvement of hepatic iron overload in nonalcoholic fatty liver disease. | Hepatic STAMP2 mediates recombinant FGF21-induced improvement of hepatic iron overload in nonalcoholic fatty liver disease.
Kim HY, Kwon WY, Park JB, Lee MH, Oh YJ, Suh S, Baek YH, Jeong JS, Yoo YH. | 03/20/2021 |
| Enhancing STAMP2 expression with cilostazol represents a potential therapeutic avenue for treatment of NAFLD. | Cilostazol Improves HFD-Induced Hepatic Steatosis by Upregulating Hepatic STAMP2 Expression through AMPK.
Oh YJ, Kim HY, Lee MH, Suh SH, Choi Y, Nam TG, Kwon WY, Lee SY, Yoo YH. | 05/4/2019 |
| this study identified specific up-regulation of spliced variant STEAP4 in rheumatoid arthritis monocytes. This variant of STEAP4 might play a crucial role in the production of TNF-alpha and IL-6 through NF-kappaB and STAT-3 pathways, resulting in the generation of rheumatoid arthritis | Clinical and functional significance of STEAP4-splice variant in CD14(+) monocytes in patients with rheumatoid arthritis.
Ebe H, Matsumoto I, Kawaguchi H, Kurata I, Tanaka Y, Inoue A, Kondo Y, Tsuboi H, Sumida T., Free PMC Article | 02/9/2019 |
| cryo-electron microscopy structures of human STEAP4 in absence and presence of Fe(3+)-NTA, are reported. | Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction.
Oosterheert W, van Bezouwen LS, Rodenburg RNP, Granneman J, Förster F, Mattevi A, Gros P., Free PMC Article | 01/12/2019 |
| These findings suggest that increased STEAP4 mRNA expression is associated with inflammatory stimuli, whereas lower STEAP4 expression is associated with obesity in human islets. | STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation.
Gordon HM, Majithia N, MacDonald PE, Fox JEM, Sharma PR, Byrne FL, Hoehn KL, Evans-Molina C, Langman L, Brayman KL, Nunemaker CS., Free PMC Article | 03/31/2018 |
| STEAP4 plays role in metal homeostasis is critical to the maintenance of cellular homeostasis , and in preventing the onset of metabolic disease. [review] | STEAP4: its emerging role in metabolism and homeostasis of cellular iron and copper.
Scarl RT, Lawrence CM, Gordon HM, Nunemaker CS., Free PMC Article | 10/21/2017 |
| a down regulation of STEAP4 and up-regulation of HIF-1alpha are observed in morbidly obese patients | STEAP4 and HIF-1α gene expressions in visceral and subcutaneous adipose tissue of the morbidly obese patients.
Ozmen F, Ozmen MM, Gelecek S, Bilgic İ, Moran M, Sahin TT. | 09/9/2017 |
| The expression of TNFAIP9 significantly decreased in the adipose tissue of obese children, and its levels are closely related to blood lipid level, insulin resistance, and obesity. | Expression and clinical significance of the obesity-related gene TNFAIP9 in obese children.
Gui LY, Hu YL, Hou ZL, Wang P. | 04/8/2017 |
| the expression of STEAP4 was significantly downregulated in the adipose tissue of obese children. | Expression and clinical significance of obesity-associated gene STEAP4 in obese children.
Xu HM, Cui YZ, Wang WG, Cheng HX, Sun YJ, Zhao HY, Yan YQ. | 03/4/2017 |
| Some SNPs of the STEAP4 gene altered the risk of developing a metabolic syndrome in the Han Chinese population. | Genetic Variants in Six-Transmembrane Epithelial Antigen of Prostate 4 Increase Risk of Developing Metabolic Syndrome in a Han Chinese Population.
Qi Y, Yu Y, Wu Y, Wang S, Yu Q, Shi J, Xu Z, Zhang Q, Fu Y, Fu Y, Kou C., Free PMC Article | 09/24/2016 |
| These data suggest that STAMP2 is required for prostate cancer progression and thus may serve as a novel therapeutic target. | STAMP2 increases oxidative stress and is critical for prostate cancer.
Jin Y, Wang L, Qu S, Sheng X, Kristian A, Mælandsmo GM, Pällmann N, Yuca E, Tekedereli I, Gorgulu K, Alpay N, Sood A, Lopez-Berestein G, Fazli L, Rennie P, Risberg B, Wæhre H, Danielsen HE, Ozpolat B, Saatcioglu F., Free PMC Article | 11/7/2015 |
| may interact with mitochondria [review] | STAMPing into Mitochondria.
Yoo SK, Cheong J, Kim HY., Free PMC Article | 11/22/2014 |
| Our results show increased mRNA expression of STEAP4 and NGAL in human visceral adipose tissue in obese patients. | Six-transmembrane epithelial antigen of prostate 4 and neutrophil gelatinase-associated lipocalin expression in visceral adipose tissue is related to iron status and inflammation in human obesity.
Catalán V, Gómez-Ambrosi J, Rodríguez A, Ramírez B, Rotellar F, Valentí V, Silva C, Gil MJ, Salvador J, Frühbeck G. | 04/26/2014 |
| Our findings revealed that STAMP2 gene polymorphisms are likely to significantly contribute to the risk of MetS in male Han Chinese population. | Association of the six transmembrane protein of prostate 2 gene polymorphisms with metabolic syndrome in Han Chinese population.
Zhang W, Tang M, Zhong M, Wang Z, Shang Y, Gong H, Zhang Y, Zhang W. | 04/5/2014 |
| three polymorphisms (rs8122, rs1981529 and rs34741656) of STAMP2 gene may be not related with type 2 diabetes mellitus in Xinjiang Uygur population | Genetic polymorphism of six transmembrane protein of prostate 2 associated with diabetes mellitus in Xinjiang Uygur population.
Han RM, Li NF, Yan ZT, Guo YY, Zhang JH, Wang HM, Hong J, Zhou L. | 03/8/2014 |
| STEAP4 was highly induced in human adipose cells differentiated in the presence of 1,25D. | Induction of STEAP4 correlates with 1,25-dihydroxyvitamin D3 stimulation of adipogenesis in mesenchymal progenitor cells derived from human adipose tissue.
Narvaez CJ, Simmons KM, Brunton J, Salinero A, Chittur SV, Welsh JE. | 11/16/2013 |
| STAMP2 antagonizes HBx-mediated hepatocyte dysfunction, thereby protecting hepatocytes from hepatitis B virus gene expression. | Hepatic STAMP2 decreases hepatitis B virus X protein-associated metabolic deregulation.
Kim HY, Cho HK, Yoo SK, Cheong JH., Free PMC Article | 05/18/2013 |
| STEAP4 genetic variations are likely to be associated with obesity-related insulin resistance in Uygur Chinese general population. | Association of STEAP4 genetic polymorphisms with insulin resistance in Uygur Chinese general population.
Guo YY, Zhou L, Yao XG, Yan ZT, Wang HM, Luo WL, Shen Y, Li NF. | 02/9/2013 |