| Interaction between hTIM-1 and Envelope Protein Is Important for JEV Infection. | Interaction between hTIM-1 and Envelope Protein Is Important for JEV Infection.
Liang Z, Pan J, Xie S, Yang X, Cao R., Free PMC Article | 08/3/2023 |
| Tim protein and DDX11 physically and functionally interact and act in concert to preserve replication fork progression in perturbed conditions. | Tim/Timeless, a member of the replication fork protection complex, operates with the Warsaw breakage syndrome DNA helicase DDX11 in the same fork recovery pathway.
Calì F, Bharti SK, Di Perna R, Brosh RM Jr, Pisani FM., Free PMC Article | 06/28/2016 |
| Data indicate that Rho guanine nucleotide exchange factor 5 (ARHGEF5) is expressed in most human lung adenocarcinoma tissues and cell lines. | Rho Guanine Nucleotide Exchange Factor 5 Increases Lung Cancer Cell Tumorigenesis via MMP-2 and Cyclin D1 Upregulation.
He P, Wu W, Yang K, Tan D, Tang M, Liu H, Wu T, Zhang S, Wang H. | 05/14/2016 |
| Targeting rho guanine nucleotide exchange factor ARHGEF5/TIM with auto-inhibitory peptides in human breast cancer. | Targeting rho guanine nucleotide exchange factor ARHGEF5/TIM with auto-inhibitory peptides in human breast cancer.
Huang O, Wu D, Xie F, Lin L, Wang X, Jiang M, Li Y, Chen W, Shen K, Hu X. | 02/6/2016 |
| The auto-inhibitory state of Rho guanine nucleotide exchange factor ARHGEF5/TIM can be relieved by targeting its SH3 domain with rationally designed peptide aptamers. | The auto-inhibitory state of Rho guanine nucleotide exchange factor ARHGEF5/TIM can be relieved by targeting its SH3 domain with rationally designed peptide aptamers.
He P, Tan DL, Liu HX, Lv FL, Wu W. | 12/5/2015 |
| In conclusion, ARHGEF5/Src can be considered as a prognostic biomarker and a therapeutic target for patients with resected NSCLC. | Co-expression of Rho guanine nucleotide exchange factor 5 and Src associates with poor prognosis of patients with resected non-small cell lung cancer.
He P, Wu W, Wang H, Liao K, Zhang W, Xiong G, Wu F, Meng G, Yang K. | 05/17/2014 |
| A receiver operating characteristic curve constructed with HSP105 and TIM gave a sensitivity of 54.3% and 95% (38/40) specificity in discriminating esophageal squamous cell carcinoma from matched controls. | Identification of tumor antigens that elicit a humoral immune response in the sera of Chinese esophageal squamous cell carcinoma patients by modified serological proteome analysis.
Gao H, Zheng Z, Mao Y, Wang W, Qiao Y, Zhou L, Liu F, He H, Zhao X. | 03/29/2014 |
| This study performed whole exome sequencing demonistrated that the true de novo variants represent mutations in genes (KCNH5, CLCN4, and ARHGEF15) not previously associated with epilepsies in humans. | Exome sequencing reveals new causal mutations in children with epileptic encephalopathies.
Veeramah KR, Johnstone L, Karafet TM, Wolf D, Sprissler R, Salogiannis J, Barth-Maron A, Greenberg ME, Stuhlmann T, Weinert S, Jentsch TJ, Pazzi M, Restifo LL, Talwar D, Erickson RP, Hammer MF., Free PMC Article | 09/7/2013 |
| Tim-Tipin complex might play a role in coupling DNA unwinding and DNA synthesis by directly affecting the catalytic activities of replication fork proteins. | Human Tim-Tipin complex affects the biochemical properties of the replicative DNA helicase and DNA polymerases.
Cho WH, Kang YH, An YY, Tappin I, Hurwitz J, Lee JK., Free PMC Article | 04/13/2013 |
| Overexpression of Arhgef5 promoted actin stress fiber remodeling through activating RhoA, and the activation of RhoA or Cdc42 was required for Src-induced podosome formation. | The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced podosome formation.
Kuroiwa M, Oneyama C, Nada S, Okada M. | 11/5/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| RhoA guanine nucleotide exchange factor Arhgef5 regulates immature dendritic cell migration | Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5.
Wang Z, Kumamoto Y, Wang P, Gan X, Lehmann D, Smrcka AV, Cohn L, Iwasaki A, Li L, Wu D., Free PMC Article | 01/21/2010 |
| The expression level of TIM was decreased in hepatocellular carcinoma. | Disturbance of circadian gene expression in hepatocellular carcinoma.
Lin YM, Chang JH, Yeh KT, Yang MY, Liu TC, Lin SF, Su WW, Chang JG. | 01/21/2010 |
| association in humans of TIM-1 and hypersensitivity and the relationship between TIM1, hygiene, and the environment. | Regulation of tolerance in the respiratory tract: TIM-1, hygiene, and the environment.
Umetsu DT, Dekruyff RH. | 01/21/2010 |