| Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation. | Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation.
Xu YR, Shi ML, Zhang Y, Kong N, Wang C, Xiao YF, Du SS, Zhu QY, Lei CQ., Free PMC Article | 07/2/2022 |
| miR-582-5p inhibits migration and chemo-resistant capabilities of colorectal cancer cells by targeting TNKS2. | miR-582-5p inhibits migration and chemo-resistant capabilities of colorectal cancer cells by targeting TNKS2.
Xiao W, Zhou H, Chen B, Shen B, Zhou J. | 05/28/2022 |
| Down-regulation of hsa_circ_0045474 induces macrophage autophagy in tuberculosis via miR-582-5p/TNKS2 axis. | Down-regulation of hsa_circ_0045474 induces macrophage autophagy in tuberculosis via miR-582-5p/TNKS2 axis.
Wu M, Liu Z, Zhang S., Free PMC Article | 05/14/2022 |
| Mapping methylation quantitative trait loci in cardiac tissues nominates risk loci and biological pathways in congenital heart disease. | Mapping methylation quantitative trait loci in cardiac tissues nominates risk loci and biological pathways in congenital heart disease.
Li M, Lyu C, Huang M, Do C, Tycko B, Lupo PJ, MacLeod SL, Randolph CE, Liu N, Witte JS, Hobbs CA., Free PMC Article | 12/25/2021 |
| PARP5B is required for nonhomologous end joining during tumorigenesis in vivo. | PARP5B is required for nonhomologous end joining during tumorigenesis in vivo.
Wu J, Crowe DL. | 12/25/2021 |
| MicroRNA-206 inhibits influenza A virus replication by targeting tankyrase 2. | MicroRNA-206 inhibits influenza A virus replication by targeting tankyrase 2.
Bamunuarachchi G, Yang X, Huang C, Liang Y, Guo Y, Liu L., Free PMC Article | 10/16/2021 |
| Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1. | Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.
Ryan K, Bolaňos B, Smith M, Palde PB, Cuenca PD, VanArsdale TL, Niessen S, Zhang L, Behenna D, Ornelas MA, Tran KT, Kaiser S, Lum L, Stewart A, Gajiwala KS., Free PMC Article | 08/28/2021 |
| MicroRNA-490-3p inhibits migration and chemoresistance of colorectal cancer cells via targeting TNKS2. | MicroRNA-490-3p inhibits migration and chemoresistance of colorectal cancer cells via targeting TNKS2.
Li J, Mo R, Zheng L., Free PMC Article | 06/26/2021 |
| Arpin Regulates Migration Persistence by Interacting with Both Tankyrases and the Arp2/3 Complex. | Arpin Regulates Migration Persistence by Interacting with Both Tankyrases and the Arp2/3 Complex.
Simanov G, Dang I, Fokin AI, Oguievetskaia K, Campanacci V, Cherfils J, Gautreau AM., Free PMC Article | 05/15/2021 |
| Association of Relative Leucocyte Telomere Length and Gene Single Nucleotide Polymorphisms (TERT, TRF1, TNKS2) in Laryngeal Squamous Cell Carcinoma. | Association of Relative Leucocyte Telomere Length and Gene Single Nucleotide Polymorphisms (TERT, TRF1, TNKS2) in Laryngeal Squamous Cell Carcinoma.
Vaiciulis P, Liutkeviciene R, Liutkevicius V, Vilkeviciute A, Gedvilaite G, Uloza V., Free PMC Article | 02/13/2021 |
| Regulation of poly ADP-ribosylation of VEGF by an interplay between PARP-16 and TNKS-2. | Regulation of poly ADP-ribosylation of VEGF by an interplay between PARP-16 and TNKS-2.
Kunhiraman H, Ramachandran V, Edatt L, Sameer Kumar VB. | 02/6/2021 |
| RP11-81H3.2 Acts as an Oncogene via microRNA-490-3p Inhibition and Consequential Tankyrase 2 Up-Regulation in Hepatocellular Carcinoma. | RP11-81H3.2 Acts as an Oncogene via microRNA-490-3p Inhibition and Consequential Tankyrase 2 Up-Regulation in Hepatocellular Carcinoma.
Chen W, Li K, Zhu K, Yan R, Cai QC, Li WH, Dang CX. | 01/2/2021 |
| A FRET-based high-throughput screening platform for the discovery of chemical probes targeting the scaffolding functions of human tankyrases. | A FRET-based high-throughput screening platform for the discovery of chemical probes targeting the scaffolding functions of human tankyrases.
Sowa ST, Vela-Rodríguez C, Galera-Prat A, Cázares-Olivera M, Prunskaite-Hyyryläinen R, Ignatev A, Lehtiö L., Free PMC Article | 12/12/2020 |
| The dimer is weak and may only form in the context of the sterile alpha motif (SAM )domain-mediated oligomers of TNKS2, consistent with the dependence of the TNKS2 activity on the SAM domain. | Regulation of tankyrase activity by a catalytic domain dimer interface.
Fan C, Yarravarapu N, Chen H, Kulak O, Dasari P, Herbert J, Yamaguchi K, Lum L, Zhang X., Free PMC Article | 03/16/2019 |
| CTIF was identified as a novel PARylation target of the TNKS2 in the centrosomal region of cells, which plays a role in the distribution of the centrosomal satellites. | Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets.
Krastev DB, Pettitt SJ, Campbell J, Song F, Tanos BE, Stoynov SS, Ashworth A, Lord CJ., Free PMC Article | 12/22/2018 |
| Either tankyrase 1 or 2 is sufficient to maintain telomere length, but both are required to resolve telomere cohesion and maintain mitotic spindle integrity. Tankyrases are required for Notch2 to exit the plasma membrane and enter the nucleus to activate transcription. | Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation.
Bhardwaj A, Yang Y, Ueberheide B, Smith S., Free PMC Article | 11/10/2018 |
| Finally, through functional validation, we uncovered a role for TNKS/2 in peroxisome homeostasis and determined that this function is independent of TNKS enzyme activities. | Proteomic Analysis of the Human Tankyrase Protein Interaction Network Reveals Its Role in Pexophagy.
Li X, Han H, Zhou MT, Yang B, Ta AP, Li N, Chen J, Wang W. | 04/7/2018 |
| Polymerization is required for Tankyrase to drive beta-catenin-dependent transcription. The polymeric state supports PARP activity and allows Tankyrase to effectively access destruction complexes through enabling avidity-dependent AXIN binding. | Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling.
Mariotti L, Templeton CM, Ranes M, Paracuellos P, Cronin N, Beuron F, Morris E, Guettler S., Free PMC Article | 09/2/2017 |
| These structural insights will be invaluable for the functional and biophysical characterization of TNKS1/2, including the role of TNKS oligomerization in protein poly(ADP-ribosyl)ation (PARylation) and PARylation-dependent ubiquitylation. | Structural insights into SAM domain-mediated tankyrase oligomerization.
DaRosa PA, Ovchinnikov S, Xu W, Klevit RE., Free PMC Article | 07/15/2017 |
| High TNKS2 expression is associated with breast cancer. | Identification of novel biomarkers associated with poor patient outcomes in invasive breast carcinoma.
Canevari RA, Marchi FA, Domingues MA, de Andrade VP, Caldeira JR, Verjovski-Almeida S, Rogatto SR, Reis EM. | 02/18/2017 |
| The tumor suppressive activity of miR-490-3p is largely mediated through downregulation of TNKS2 and inactivation of beta-catenin signaling. Thus, miR-490-3p may represent a potential therapeutic target for triple-negative breast cancer. | miR-490-3p inhibits the growth and invasiveness in triple-negative breast cancer by repressing the expression of TNKS2.
Jia Z, Liu Y, Gao Q, Han Y, Zhang G, Xu S, Cheng K, Zou W. | 01/28/2017 |
| Data show that E7449 represents a dual Poly(ADP-ribose) Polymerase 1/2 and tankyrase 1/2 inhibitor which has the advantage of targeting Wnt/beta-catenin signaling addicted tumors. | E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling.
McGonigle S, Chen Z, Wu J, Chang P, Kolber-Simonds D, Ackermann K, Twine NC, Shie JL, Miu JT, Huang KC, Moniz GA, Nomoto K., Free PMC Article | 10/1/2016 |
| rs1340420 SNP was associated with lower NSCLC risk, whereas rs1770474 SNP was associated with higher squamous-cell carcinoma risk | Tankyrase 2 (TNKS2) polymorphism associated with risk in developing non-small cell lung cancer in a Chinese population.
Wang Y, Jiang W, Liu X, Zhang Y. | 09/10/2016 |
| Tankyrase inhibition is a potential therapeutic approach for treating a subgroup HCC with aberrant WNT/beta-catenin signaling pathway. | Tankyrase inhibitors attenuate WNT/β-catenin signaling and inhibit growth of hepatocellular carcinoma cells.
Ma L, Wang X, Jia T, Wei W, Chua MS, So S., Free PMC Article | 07/30/2016 |
| TNKS2 is recruited to DNA lesions by MDC1 and promotes homologous recombination in response to DNA double strand breaks. | Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs.
Nagy Z, Kalousi A, Furst A, Koch M, Fischer B, Soutoglou E., Free PMC Article | 07/16/2016 |