| FGF20 modulates gut microbiota to mitigate dextran sodium sulfate-induced ulcerative colitis in mouse models. | FGF20 modulates gut microbiota to mitigate dextran sodium sulfate-induced ulcerative colitis in mouse models.
Jin Z, Liu Z, Pan J, Wang S, Cui M, He C, Lin M, Liu X, Yu X, Gong F. | 10/17/2024 |
| Skeletal dysmorphology and mineralization defects in Fgf20 KO mice. | Skeletal dysmorphology and mineralization defects in Fgf20 KO mice.
Dlugosova S, Spoutil F, Madureira Trufen CE, Melike Ogan B, Prochazkova M, Fedosieieva O, Nickl P, Aranaz Novaliches G, Sedlacek R, Prochazka J., Free PMC Article | 09/23/2024 |
| Fibroblast growth factor 20 attenuates pathological cardiac hypertrophy by activating the SIRT1 signaling pathway. | Fibroblast growth factor 20 attenuates pathological cardiac hypertrophy by activating the SIRT1 signaling pathway.
Chen Y, An N, Zhou X, Mei L, Sui Y, Chen G, Chen H, He S, Jin C, Hu Z, Li W, Wang Y, Lin Z, Chen P, Jin L, Guan X, Wang X., Free PMC Article | 04/23/2022 |
| FGF20-FGFR1 signaling through MAPK and PI3K controls sensory progenitor differentiation in the organ of Corti. | FGF20-FGFR1 signaling through MAPK and PI3K controls sensory progenitor differentiation in the organ of Corti.
Su Y, Yang LM, Ornitz DM., Free PMC Article | 01/22/2022 |
| Analysis of FGF20-regulated genes in organ of Corti progenitors by translating ribosome affinity purification. | Analysis of FGF20-regulated genes in organ of Corti progenitors by translating ribosome affinity purification.
Yang LM, Stout L, Rauchman M, Ornitz DM., Free PMC Article | 11/6/2021 |
| Nephron Progenitor Maintenance Is Controlled through Fibroblast Growth Factors and Sprouty1 Interaction. | Nephron Progenitor Maintenance Is Controlled through Fibroblast Growth Factors and Sprouty1 Interaction.
Huh SH, Ha L, Jang HS., Free PMC Article | 03/13/2021 |
| Fgf20 is only involved in differentiation. The Fgf20-KO cochlear phenotype is less severe than the Fgfr1-CKO phenotype. Sox2 and Fgf20 interact during cochlea development. Fgf20-KO organ of Corti exhibits premature differentiation. | Sox2 and FGF20 interact to regulate organ of Corti hair cell and supporting cell development in a spatially-graded manner.
Yang LM, Cheah KSE, Huh SH, Ornitz DM., Free PMC Article | 12/21/2019 |
| dermal condensation occurs via directed cell movement and Fgf20 orchestrates the early cellular and molecular events. | Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation.
Biggs LC, Mäkelä OJ, Myllymäki SM, Das Roy R, Närhi K, Pispa J, Mustonen T, Mikkola ML., Free PMC Article | 03/2/2019 |
| loss of Fgf20 delays formation of Eda-induced supernumerary mammary buds and normalizes the embryonic and postnatal hyperbranching phenotype of Eda overexpressing mice. | Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty.
Elo T, Lindfors PH, Lan Q, Voutilainen M, Trela E, Ohlsson C, Huh SH, Ornitz DM, Poutanen M, Howard BA, Mikkola ML., Free PMC Article | 01/19/2019 |
| Data show that Fibroblast Growth Factors (FGF) 9 and 20 regulate the number of cochlear progenitors. | Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling.
Huh SH, Warchol ME, Ornitz DM., Free PMC Article | 01/30/2016 |
| fibroblast growth factor 20 (Fgf20) is expressed in hair placodes and is induced by and functions downstream from epithelial ectodysplasin (Eda)/Edar and Wnt/beta-Catenin signaling to initiate formation of the underlying dermal condensation | Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles.
Huh SH, Närhi K, Lindfors PH, Häärä O, Yang L, Ornitz DM, Mikkola ML., Free PMC Article | 04/13/2013 |
| We hypothesized that Fgf20 plays a role in specification, amplification, or maintenance of Sox2 expression in prosensory progenitors of the developing mammalian cochlea. | Notch prosensory effects in the Mammalian cochlea are partially mediated by Fgf20.
Munnamalai V, Hayashi T, Bermingham-McDonogh O., Free PMC Article | 12/8/2012 |
| Fgf20 is a major downstream effector of ectodysplasin and affects ectodysplasin-regulated characteristics of tooth morphogenesis, including the number, size and shape of teeth. | Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signaling.
Häärä O, Harjunmaa E, Lindfors PH, Huh SH, Fliniaux I, Åberg T, Jernvall J, Ornitz DM, Mikkola ML, Thesleff I., Free PMC Article | 10/20/2012 |
| The data suggested that, at a minimum, Fgf9/20 and Bmp7 organize the nephron progenitor niche. FGF signaling likely regulates multiple important steps in the niche, including survival, proliferation, and competence. | FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man.
Barak H, Huh SH, Chen S, Jeanpierre C, Martinovic J, Parisot M, Bole-Feysot C, Nitschké P, Salomon R, Antignac C, Ornitz DM, Kopan R., Free PMC Article | 09/1/2012 |
| Data indicate that the viability and hearing loss in Fgf20 knockout mice suggest that FGF20 may also be a deafness-associated gene in humans. | Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal.
Huh SH, Jones J, Warchol ME, Ornitz DM., Free PMC Article | 05/12/2012 |
| Fgf20 is expressed at the right time and place to mediate sensory cell specification and is the likely activator/ligand of fibroblast growth factor (FGF) receptor 1 during cochlear development. | Fgf20 is required for sensory epithelial specification in the developing cochlea.
Hayashi T, Ray CA, Bermingham-McDonogh O., Free PMC Article | 01/21/2010 |
| expression of FGF20 in calvarial and limb development | Expression patterns of fibroblast growth factors-18 and -20 in mouse embryos is suggestive of novel roles in calvarial and limb development.
Hajihosseini MK, Heath JK. | 01/21/2010 |