| The effects of different training modalities on monocarboxylate transporters MCT1 and MCT4, hypoxia inducible factor-1alpha (HIF-1alpha), and PGC-1alpha gene expression in rat skeletal muscles. | The effects of different training modalities on monocarboxylate transporters MCT1 and MCT4, hypoxia inducible factor-1α (HIF-1α), and PGC-1α gene expression in rat skeletal muscles.
Ahmadi A, Sheikholeslami-Vatani D, Ghaeeni S, Baazm M. | 05/22/2021 |
| Inhibition of Hypothalamic MCT4 and MCT1-MCT4 Expressions Affects Food Intake and Alters Orexigenic and Anorexigenic Neuropeptide Expressions. | Inhibition of Hypothalamic MCT4 and MCT1-MCT4 Expressions Affects Food Intake and Alters Orexigenic and Anorexigenic Neuropeptide Expressions.
Elizondo-Vega R, Oyarce K, Salgado M, Barahona MJ, Recabal A, Ordenes P, López S, Pincheira R, Luz-Crawford P, García-Robles MA., Free PMC Article | 11/28/2020 |
| The MCT4 membrane expression varied with estrous cycle stage with expression significantly lower than males. MCT4 membrane expression in OVX females was also lower than males, suggesting that androgens play a role in membrane expression of MCT4. | Sex Hormones Regulate Rat Hepatic Monocarboxylate Transporter Expression and Membrane Trafficking.
Cao J, Ng M, Felmlee MA. | 07/21/2018 |
| Decreased expression of MCT1/4 in distal airway epithelium may disrupt lung branching morphogenesis and thus contribute to the development of pulmonary hypoplasia in the nitrofen-induced congenital diaphragmatic hernia model. | Decreased expression of monocarboxylate transporter 1 and 4 in the branching airway epithelium of nitrofen-induced congenital diaphragmatic hernia.
Takahashi T, Friedmacher F, Zimmer J, Puri P. | 04/29/2017 |
| MPC inhibition is the most sensitive anti-tumour target for LND, with additional inhibitory effects on MCT-mediated L-lactic acid efflux and glutamine/glutamate oxidation. | The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters.
Nancolas B, Guo L, Zhou R, Nath K, Nelson DS, Leeper DB, Blair IA, Glickson JD, Halestrap AP., Free PMC Article | 08/13/2016 |
| resistance to oxygen- and glucose-deprivation injury in astrocyte-neuron co-cultures occurs via an MCT-dependent mechanism. | Monocarboxylate transporter-dependent mechanism confers resistance to oxygen- and glucose-deprivation injury in astrocyte-neuron co-cultures.
Gao C, Zhou L, Zhu W, Wang H, Wang R, He Y, Li Z. | 09/26/2015 |
| Decreased astroglial monocarboxylate transporter 4 expression in temporal lobe epilepsy | Decreased astroglial monocarboxylate transporter 4 expression in temporal lobe epilepsy.
Liu B, Niu L, Shen MZ, Gao L, Wang C, Li J, Song LJ, Tao Y, Meng Q, Yang QL, Gao GD, Zhang H. | 09/12/2015 |
| hypoxia/ischemia induced an upregulation of monocarboxylate transporter 4 expression | Intermittent hypoxia preconditioning-induced epileptic tolerance by upregulation of monocarboxylate transporter 4 expression in rat hippocampal astrocytes.
Gao C, Wang C, Liu B, Wu H, Yang Q, Jin J, Li H, Dong S, Gao G, Zhang H. | 08/1/2015 |
| MCT4 increased 5-10 h postexercise in the hypothalamus only. | Acute exercise increases brain region-specific expression of MCT1, MCT2, MCT4, GLUT1, and COX IV proteins.
Takimoto M, Hamada T. | 01/31/2015 |
| Results suggest that acute exercise-induced increases in MCT1 and MCT4 mRNA expression may be possibly mediated by AMPK activation, at least in part in fast-twitch muscle. | Possible involvement of AMPK in acute exercise-induced expression of monocarboxylate transporters MCT1 and MCT4 mRNA in fast-twitch skeletal muscle.
Takimoto M, Takeyama M, Hamada T. | 01/11/2014 |
| These data indicate that MCT1 is the high affinity lactate transporter and MCT4 is the high affinity butyrate transporter in the intestinal epithelial cell line IEC-18. | Monocarboxylate 4 mediated butyrate transport in a rat intestinal epithelial cell line.
Kekuda R, Manoharan P, Baseler W, Sundaram U. | 06/8/2013 |
| Transfer of nicotinate from blood to retina across the inner blood-retinal barrier occurs primarily via H(+)-coupled monocarboxylate transporters. | Retinal transfer of nicotinate by H+ -monocarboxylate transporter at the inner blood-retinal barrier.
Tachikawa M, Murakami K, Martin PM, Hosoya K, Ganapathy V., Free PMC Article | 03/17/2012 |
| Administration of Phellinus linteus increased endurance exercise performance through inhibition of serotonin production in the brain and increased the expression of MCT1 and MCT4 in muscles. | Effects of Phellinus linteus administration on serotonin synthesis in the brain and expression of monocarboxylate transporters in the muscle during exhaustive exercise in rats.
Seo JH, Sung YH, Kim KJ, Shin MS, Lee EK, Kim CJ. | 08/20/2011 |
| tanycytes participate in glucose sensing based on a metabolic interaction with neurons of the arcuate nucleus, which are stimulated by lactate released from MCT1 and MCT4-expressing tanycytes. | MCT expression and lactate influx/efflux in tanycytes involved in glia-neuron metabolic interaction.
Cortés-Campos C, Elizondo R, Llanos P, Uranga RM, Nualart F, García MA., Free PMC Article | 08/6/2011 |
| Disrupting the expression of the astrocytic lactate transporters monocarboxylate transporter 4 (MCT4) or MCT1 causes amnesia, which, like long-term potentiation impairment, is rescued by L-lactate but not equicaloric glucose. | Astrocyte-neuron lactate transport is required for long-term memory formation.
Suzuki A, Stern SA, Bozdagi O, Huntley GW, Walker RH, Magistretti PJ, Alberini CM., Free PMC Article | 04/23/2011 |
| MCT4 transport activity is enhanced both by injected and by coexpressed carbonic anhydrase II, similar to MCT1, with the highest augmentation at low extracellular pH and low lactate concentrations. | Nonenzymatic augmentation of lactate transport via monocarboxylate transporter isoform 4 by carbonic anhydrase II.
Becker HM, Klier M, Deitmer JW. | 06/28/2010 |
| MCT4 protein expression was not reduced in skeletal muscle | PGC-1alpha increases skeletal muscle lactate uptake by increasing the expression of MCT1 but not MCT2 or MCT4.
Benton CR, Yoshida Y, Lally J, Han XX, Hatta H, Bonen A. | 01/21/2010 |