| Clostridium butyricum upregulates GPR109A/AMPK/PGC-1alpha and ameliorates acute pancreatitis-associated intestinal barrier injury in mice. | Clostridium butyricum upregulates GPR109A/AMPK/PGC-1α and ameliorates acute pancreatitis-associated intestinal barrier injury in mice.
Deng G, Wen B, Jia L, Liu J, Yan Q. | 05/24/2024 |
| Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a. | Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a.
Sun Y, Nie Q, Zhang S, He H, Zuo S, Chen C, Yang J, Chen H, Hu J, Li S, Cheng J, Zhang B, Zheng Z, Pan S, Huang P, Lian L, Nie S., Free PMC Article | 11/29/2023 |
| GPR109A expressed on medullary thymic epithelial cells affects thymic Treg development. | GPR109A expressed on medullary thymic epithelial cells affects thymic Treg development.
Ni D, Tan J, Robert R, Taitz J, Ge A, Potier-Villette C, Reyes JGA, Spiteri A, Wishart C, Mackay C, Piccio L, King NJC, Macia L. | 11/6/2023 |
| Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation. | Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.
Zhao C, Wang H, Liu Y, Cheng L, Wang B, Tian X, Fu H, Wu C, Li Z, Shen C, Yu J, Yang S, Hu H, Fu P, Ma L, Wang C, Yan W, Shao Z. | 09/13/2023 |
| Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models. | Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models.
He D, Fu S, Ye B, Wang H, He Y, Li Z, Li J, Gao X, Liu D., Free PMC Article | 04/6/2023 |
| GPR109a Regulates Phenotypic and Functional Alterations in Macrophages and the Progression of Type 1 Diabetes. | GPR109a Regulates Phenotypic and Functional Alterations in Macrophages and the Progression of Type 1 Diabetes.
Zhang Z, Li J, Zhang M, Li B, Pan X, Dong X, Pan LL, Sun J. | 12/10/2022 |
| Expression and activation of the ketone body receptor HCAR2/GPR109A promotes preservation of retinal endothelial cell barrier function. | Expression and activation of the ketone body receptor HCAR2/GPR109A promotes preservation of retinal endothelial cell barrier function.
Abdelrahman AA, Powell FL, Jadeja RN, Jones MA, Thounaojam MC, Bartoli M, Al-Shabrawey M, Martin PM. | 07/16/2022 |
| GPR109A gene deletion ameliorates gonadectomy-induced bone loss in mice. | GPR109A gene deletion ameliorates gonadectomy-induced bone loss in mice.
Chen JR, Lazarenko OP, Blackburn ML. | 06/18/2022 |
| The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer's disease. | The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer's disease.
Moutinho M, Puntambekar SS, Tsai AP, Coronel I, Lin PB, Casali BT, Martinez P, Oblak AL, Lasagna-Reeves CA, Lamb BT, Landreth GE., Free PMC Article | 05/7/2022 |
| Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior. | Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior.
Cook TM, Gavini CK, Jesse J, Aubert G, Gornick E, Bonomo R, Gautron L, Layden BT, Mansuy-Aubert V., Free PMC Article | 03/26/2022 |
| Activation of microglial GPR109A alleviates thermal hyperalgesia in female lupus mice by suppressing IL-18 and glutamatergic synaptic activity. | Activation of microglial GPR109A alleviates thermal hyperalgesia in female lupus mice by suppressing IL-18 and glutamatergic synaptic activity.
Viatchenko-Karpinski V, Kong L, Weng HR., Free PMC Article | 03/19/2022 |
| Ketone Body 3-Hydroxybutyrate Ameliorates Atherosclerosis via Receptor Gpr109a-Mediated Calcium Influx. | Ketone Body 3-Hydroxybutyrate Ameliorates Atherosclerosis via Receptor Gpr109a-Mediated Calcium Influx.
Zhang SJ, Li ZH, Zhang YD, Chen J, Li Y, Wu FQ, Wang W, Cui ZJ, Chen GQ., Free PMC Article | 11/22/2021 |
| Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway. | Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway.
Wu Y, He F, Zhang C, Zhang Q, Su X, Zhu X, Liu A, Shi W, Lin W, Jin Z, Yang H, Lin J., Free PMC Article | 11/22/2021 |
| Hydroxycarboxylic Acid Receptor 2, a Pleiotropically Linked Receptor for the Multiple Sclerosis Drug, Monomethyl Fumarate. Possible Implications for the Inflammatory Response. | Hydroxycarboxylic Acid Receptor 2, a Pleiotropically Linked Receptor for the Multiple Sclerosis Drug, Monomethyl Fumarate. Possible Implications for the Inflammatory Response.
Parodi B, Sanna A, Cedola A, Uccelli A, Kerlero de Rosbo N., Free PMC Article | 10/2/2021 |
| The Role of GPR109a Signaling in Niacin Induced Effects on Fed and Fasted Hepatic Metabolism. | The Role of GPR109a Signaling in Niacin Induced Effects on Fed and Fasted Hepatic Metabolism.
Geisler CE, Miller KE, Ghimire S, Renquist BJ., Free PMC Article | 05/15/2021 |
| Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease. | Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease.
Kaye DM, Shihata WA, Jama HA, Tsyganov K, Ziemann M, Kiriazis H, Horlock D, Vijay A, Giam B, Vinh A, Johnson C, Fiedler A, Donner D, Snelson M, Coughlan MT, Phillips S, Du XJ, El-Osta A, Drummond G, Lambert GW, Spector TD, Valdes AM, Mackay CR, Marques FZ. | 04/3/2021 |
| Niacin Ameliorates Hepatic Steatosis by Inhibiting De Novo Lipogenesis Via a GPR109A-Mediated PKC-ERK1/2-AMPK Signaling Pathway in C57BL/6 Mice Fed a High-Fat Diet. | Niacin Ameliorates Hepatic Steatosis by Inhibiting De Novo Lipogenesis Via a GPR109A-Mediated PKC-ERK1/2-AMPK Signaling Pathway in C57BL/6 Mice Fed a High-Fat Diet.
Ye L, Cao Z, Lai X, Shi Y, Zhou N. | 08/22/2020 |
| The results of this study indicate that GPR109a does not play a critical role in intestinal homeostasis in a model of type 1 diabetes or in the development of diabetic nephropathy. | Exploring the role of the metabolite-sensing receptor GPR109a in diabetic nephropathy.
Snelson M, Tan SM, Higgins GC, Lindblom RSJ, Coughlan MT. | 07/18/2020 |
| These results indicate that during aging, GPR109A modulates de novo lipid accumulation in liver and adipose tissue, and its dysregulation can lead to age-associated obesity and hepatic steatosis. | Loss of GPR109A/HCAR2 induces aging-associated hepatic steatosis.
Jadeja RN, Jones MA, Fromal O, Powell FL, Khurana S, Singh N, Martin PM., Free PMC Article | 04/4/2020 |
| The Gpr109a receptor-mediated pathway contributed significantly to niacin mediated salutary effect. Further studies showed improvement in markers of cellular energetics and attenuation of inflammatory response with niacin treatment. In conclusion, Gpr109a-dependent signalling is important in restoring cellular energetics and immunometabolism following hemorrhagic shock. | Deficiency of metabolite sensing receptor HCA2 impairs the salutary effect of niacin in hemorrhagic shock.
Subramani K, Chu X, Warren M, Lee M, Lu S, Singh N, Raju R., Free PMC Article | 11/2/2019 |
| data suggest that the systemic treatment of diabetic C57BL6J mice with beta-hydroxybutyrate activates retinal HCA2 and inhibits local damage. | The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome.
Trotta MC, Maisto R, Guida F, Boccella S, Luongo L, Balta C, D'Amico G, Herman H, Hermenean A, Bucolo C, D'Amico M., Free PMC Article | 10/26/2019 |
| These findings indicate that GPR109A regulates the gut microbiota, contributing to intestinal epithelial barrier integrity and decreased mortality in cecum ligation and puncture-induced sepsis. | G Protein-Coupled Receptor 109A and Host Microbiota Modulate Intestinal Epithelial Integrity During Sepsis.
Chen G, Huang B, Fu S, Li B, Ran X, He D, Jiang L, Li Y, Liu B, Xie L, Liu J, Wang W., Free PMC Article | 10/5/2019 |
| results pave the way for investigating the mechanisms by which HCAR2 regulates neuropathic pain plasticity | Ketones and pain: unexplored role of hydroxyl carboxylic acid receptor type 2 in the pathophysiology of neuropathic pain.
Boccella S, Guida F, De Logu F, De Gregorio D, Mazzitelli M, Belardo C, Iannotta M, Serra N, Nassini R, de Novellis V, Geppetti P, Maione S, Luongo L. | 09/21/2019 |
| These findings demonstrate that HCA2 is a molecular target of DMF treatment in EBA and suggest that HCA2 activation limits skin pathology by inhibiting the infiltration of neutrophils and monocytes into the skin. | The Immunometabolomic Interface Receptor Hydroxycarboxylic Acid Receptor 2 Mediates the Therapeutic Effects of Dimethyl Fumarate in Autoantibody-Induced Skin Inflammation.
Wannick M, Assmann JC, Vielhauer JF, Offermanns S, Zillikens D, Sadik CD, Schwaninger M., Free PMC Article | 09/21/2019 |
| HCA2 plays a critical role in host protection against pro-inflammatory insults. | Activated niacin receptor HCA2 inhibits chemoattractant-mediated macrophage migration via Gβγ/PKC/ERK1/2 pathway and heterologous receptor desensitization.
Shi Y, Lai X, Ye L, Chen K, Cao Z, Gong W, Jin L, Wang C, Liu M, Liao Y, Wang JM, Zhou N., Free PMC Article | 11/10/2018 |