U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 [ Homo sapiens (human) ]

    Gene ID: 8128, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Identification of a buried beta-strand as a novel disease-related motif in the human polysialyltransferases.

    Identification of a buried β-strand as a novel disease-related motif in the human polysialyltransferases.
    Hatanaka R, Hane M, Hayakawa K, Morishita S, Ohno S, Yamaguchi Y, Wu D, Kitajima K, Sato C., Free PMC Article

    02/9/2024
    A cancer-unique glycan: de-N-acetyl polysialic acid (dPSA) linked to cell surface nucleolin depends on re-expression of the fetal polysialyltransferase ST8SIA2 gene.

    A cancer-unique glycan: de-N-acetyl polysialic acid (dPSA) linked to cell surface nucleolin depends on re-expression of the fetal polysialyltransferase ST8SIA2 gene.
    Moe GR, Steirer LM, Lee JA, Shivakumar A, Bolanos AD., Free PMC Article

    01/22/2022
    High ST8SIA2 expression is associated with lung cancer Invasion.

    Characterization of Distinct Populations of Carcinoma-Associated Fibroblasts from Non-Small Cell Lung Carcinoma Reveals a Role for ST8SIA2 in Cancer Cell Invasion.
    Hao J, Zeltz C, Pintilie M, Li Q, Sakashita S, Wang T, Cabanero M, Martins-Filho SN, Wang DY, Pasko E, Venkat K, Joseph J, Raghavan V, Zhu CQ, Wang YH, Moghal N, Tsao MS, Navab R., Free PMC Article

    11/30/2019
    8 SNPs of ST8SIA2 and 2 SNPs of NCAM1 are associated with seasonality in mood changes and circadian preference

    Effects of genetic variants of ST8SIA2 and NCAM1 genes on seasonal mood changes and circadian preference in the general population.
    Yang SY, Baek JH, Cho Y, Cho EY, Choi Y, Kim Y, Park T, Hong KS.

    03/9/2019
    The ST8SIA2 risk haplotype copy number did not show any differential effects on white matter in schizophrenia.

    Differential effect of disease-associated ST8SIA2 haplotype on cerebral white matter diffusion properties in schizophrenia and healthy controls.
    Fullerton JM, Klauser P, Lenroot RK, Shaw AD, Overs B, Heath A, Cairns MJ, Atkins J, Scott R, Australian Schizophrenia Research Bank, Schofield PR, Weickert CS, Pantelis C, Fornito A, Whitford TJ, Weickert TW, Zalesky A., Free PMC Article

    12/1/2018
    Different properties of polysialic acids synthesized by the polysialyltransferases ST8SIA2 and ST8SIA4 have been described.

    Different properties of polysialic acids synthesized by the polysialyltransferases ST8SIA2 and ST8SIA4.
    Mori A, Hane M, Niimi Y, Kitajima K, Sato C.

    04/28/2018
    impairment of the regulated expression of ST8SIA2 and the resulting downstream effects on gene products by these two intronic single nucleotide polymorphism contribute to the development of these psychiatric disorders.

    Effects of intronic single nucleotide polymorphisms (iSNPs) of a polysialyltransferase, ST8SIA2 gene found in psychiatric disorders on its gene products.
    Hane M, Kitajima K, Sato C.

    05/27/2017
    ST8SiaII role in the invasiveness and metastasis of small cell lung cancer cells

    Effects of the regulation of polysialyltransferase ST8SiaII on the invasiveness and metastasis of small cell lung cancer cells.
    Gong L, Zhou X, Yang J, Jiang Y, Yang H.

    03/18/2017
    the relationships between psychiatric disorders and polySia and/or ST8SIA2

    Relationship between ST8SIA2, polysialic acid and its binding molecules, and psychiatric disorders.
    Sato C, Hane M, Kitajima K.

    09/10/2016
    Data indicate a possible role of STX polysialyltransferase (ST8SIA2) in the common susceptibility of schizophrenia and bipolar I disorder (BD-I).

    Association between ST8SIA2 and the Risk of Schizophrenia and Bipolar I Disorder across Diagnostic Boundaries.
    Yang SY, Huh IS, Baek JH, Cho EY, Choi MJ, Ryu S, Kim JS, Park T, Ha K, Hong KS., Free PMC Article

    06/4/2016
    Our study showed interesting sex-specific associations between ST8SIAII and schizophrenia.

    Sex-specific association of the ST8SIAII gene with schizophrenia in a Spanish population.
    Gilabert-Juan J, Nacher J, Sanjuán J, Moltó MD.

    08/8/2015
    the role of ST8SIA2 sequence variation affecting polysialic acid-NCAM formation in 48 Caucasian cases with bipolar disorder

    Characterisation of genetic variation in ST8SIA2 and its interaction region in NCAM1 in patients with bipolar disorder.
    Shaw AD, Tiwari Y, Kaplan W, Heath A, Mitchell PB, Schofield PR, Fullerton JM., Free PMC Article

    12/20/2014
    translational modification of the neural cell adhesion molecule NCAM and the polysialyltransferase ST8SiaII in mammalian semen involves polysialic acid

    Polysialic acid is present in mammalian semen as a post-translational modification of the neural cell adhesion molecule NCAM and the polysialyltransferase ST8SiaII.
    Simon P, Bäumner S, Busch O, Röhrich R, Kaese M, Richterich P, Wehrend A, Müller K, Gerardy-Schahn R, Mühlenhoff M, Geyer H, Geyer R, Middendorff R, Galuska SP., Free PMC Article

    09/14/2013
    Expression of ST8SIA2 in omental fat at baseline was significantly associated with weight loss after Roux-en-Y gastric bypass.

    Weight loss after gastric bypass is associated with a variant at 15q26.1.
    Hatoum IJ, Greenawalt DM, Cotsapas C, Daly MJ, Reitman ML, Kaplan LM., Free PMC Article

    07/6/2013
    that variation the ST8SIA2 gene is associated with increased risk to mental illness

    Identification of sialyltransferase 8B as a generalized susceptibility gene for psychotic and mood disorders on chromosome 15q25-26.
    McAuley EZ, Scimone A, Tiwari Y, Agahi G, Mowry BJ, Holliday EG, Donald JA, Weickert CS, Mitchell PB, Schofield PR, Fullerton JM., Free PMC Article

    10/27/2012
    NCAM and polySia are expressed and developmentally regulated in chick corneas. Both membrane-associated and soluble NCAM isoforms are expressed in chick corneas.

    Expression and localization of neural cell adhesion molecule and polysialic acid during chick corneal development.
    Mao X, Schwend T, Conrad GW., Free PMC Article

    05/12/2012
    STX(G421A) shows a dramatic decrease in polySia synthetic activity on NCAM, whereas STX(C621G) does not; polySia shows a dopamine (DA) binding activity

    Structural and functional impairments of polysialic acid by a mutated polysialyltransferase found in schizophrenia.
    Isomura R, Kitajima K, Sato C., Free PMC Article

    09/3/2011
    ST8SIA2 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.

    The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
    Warnatz HJ, Schmidt D, Manke T, Piccini I, Sultan M, Borodina T, Balzereit D, Wruck W, Soldatov A, Vingron M, Lehrach H, Yaspo ML., Free PMC Article

    09/14/2011
    This study provided that ST8SIA2 are associated with Bipolar I in the Han Chinese population.

    Genome-wide association study of bipolar I disorder in the Han Chinese population.
    Lee MT, Chen CH, Lee CS, Chen CC, Chong MY, Ouyang WC, Chiu NY, Chuo LJ, Chen CY, Tan HK, Lane HY, Chang TJ, Lin CH, Jou SH, Hou YM, Feng J, Lai TJ, Tung CL, Chen TJ, Chang CJ, Lung FW, Chen CK, Shiah IS, Liu CY, Teng PR, Chen KH, Shen LJ, Cheng CS, Chang TP, Li CF, Chou CH, Chen CY, Wang KH, Fann CS, Wu JY, Chen YT, Cheng AT.

    08/20/2011
    Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)

    A genome-wide scan for common alleles affecting risk for autism.
    Anney R, Klei L, Pinto D, Regan R, Conroy J, Magalhaes TR, Correia C, Abrahams BS, Sykes N, Pagnamenta AT, Almeida J, Bacchelli E, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bölte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Carson AR, Casallo G, Casey J, Chu SH, Cochrane L, Corsello C, Crawford EL, Crossett A, Dawson G, de Jonge M, Delorme R, Drmic I, Duketis E, Duque F, Estes A, Farrar P, Fernandez BA, Folstein SE, Fombonne E, Freitag CM, Gilbert J, Gillberg C, Glessner JT, Goldberg J, Green J, Guter SJ, Hakonarson H, Heron EA, Hill M, Holt R, Howe JL, Hughes G, Hus V, Igliozzi R, Kim C, Klauck SM, Kolevzon A, Korvatska O, Kustanovich V, Lajonchere CM, Lamb JA, Laskawiec M, Leboyer M, Le Couteur A, Leventhal BL, Lionel AC, Liu XQ, Lord C, Lotspeich L, Lund SC, Maestrini E, Mahoney W, Mantoulan C, Marshall CR, McConachie H, McDougle CJ, McGrath J, McMahon WM, Melhem NM, Merikangas A, Migita O, Minshew NJ, Mirza GK, Munson J, Nelson SF, Noakes C, Noor A, Nygren G, Oliveira G, Papanikolaou K, Parr JR, Parrini B, Paton T, Pickles A, Piven J, Posey DJ, Poustka A, Poustka F, Prasad A, Ragoussis J, Renshaw K, Rickaby J, Roberts W, Roeder K, Roge B, Rutter ML, Bierut LJ, Rice JP, Salt J, Sansom K, Sato D, Segurado R, Senman L, Shah N, Sheffield VC, Soorya L, Sousa I, Stoppioni V, Strawbridge C, Tancredi R, Tansey K, Thiruvahindrapduram B, Thompson AP, Thomson S, Tryfon A, Tsiantis J, Van Engeland H, Vincent JB, Volkmar F, Wallace S, Wang K, Wang Z, Wassink TH, Wing K, Wittemeyer K, Wood S, Yaspan BL, Zurawiecki D, Zwaigenbaum L, Betancur C, Buxbaum JD, Cantor RM, Cook EH, Coon H, Cuccaro ML, Gallagher L, Geschwind DH, Gill M, Haines JL, Miller J, Monaco AP, Nurnberger JI Jr, Paterson AD, Pericak-Vance MA, Schellenberg GD, Scherer SW, Sutcliffe JS, Szatmari P, Vicente AM, Vieland VJ, Wijsman EM, Devlin B, Ennis S, Hallmayer J., Free PMC Article

    09/15/2010
    Amino acid substitutions in conserved sequences are critical for the protein-specific polysialylation of NCAM.

    Identification of sequences in the polysialyltransferases ST8Sia II and ST8Sia IV that are required for the protein-specific polysialylation of the neural cell adhesion molecule, NCAM.
    Foley DA, Swartzentruber KG, Colley KJ., Free PMC Article

    01/21/2010
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (2) articles

    Positive association between SIAT8B and schizophrenia in the Chinese Han population.
    Tao R, Li C, Zheng Y, Qin W, Zhang J, Li X, Xu Y, Shi YY, Feng G, He L.

    Association between polymorphisms in the promoter region of the sialyltransferase 8B (SIAT8B) gene and schizophrenia.
    Arai M, Yamada K, Toyota T, Obata N, Haga S, Yoshida Y, Nakamura K, Minabe Y, Ujike H, Sora I, Ikeda K, Mori N, Yoshikawa T, Itokawa M, Arai M, Yamada K, Toyota T, Obata N, Haga S, Yoshida Y, Nakamura K, Minabe Y, Ujike H, Sora I, Ikeda K, Mori N, Yoshikawa T, Itokawa M.

    03/13/2008
    SIAT8B gene is involved in schizophrenia in the Japanese.

    Association between polymorphisms in the promoter region of the sialyltransferase 8B (SIAT8B) gene and schizophrenia.
    Arai M, Yamada K, Toyota T, Obata N, Haga S, Yoshida Y, Nakamura K, Minabe Y, Ujike H, Sora I, Ikeda K, Mori N, Yoshikawa T, Itokawa M, Arai M, Yamada K, Toyota T, Obata N, Haga S, Yoshida Y, Nakamura K, Minabe Y, Ujike H, Sora I, Ikeda K, Mori N, Yoshikawa T, Itokawa M.

    01/21/2010
    SIAT8B has a role in neural development and sialic acid synthesis on NCAM

    ST8Sia II and ST8Sia IV polysialyltransferases exhibit marked differences in utilizing various acceptors containing oligosialic acid and short polysialic acid. The basis for cooperative polysialylation by two enzymes.
    Angata K, Suzuki M, Fukuda M.

    01/21/2010
    The upregulation of ST8SIA4 and the donwregulation of ST8SIA2 by valproic acid in HUVEC and tumor cell lines are reported.

    Valproic acid modulates NCAM polysialylation and polysialyltransferase mRNA expression in human tumor cells.
    Beecken WD, Engl T, Ogbomo H, Relja B, Cinatl J, Bereiter-Hahn J, Oppermann E, Jonas D, Blaheta RA.

    01/21/2010
    firstprevious page of 1 nextlast