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    Actn1 actinin, alpha 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81634, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    that a mechanism by which Hippo pathway and F-actin synergize to modulate YAP activation and localization in the context of intervertebral disc degeneration and help to control nucleus pulposus cells proliferation

    AMOT130 linking F-actin to YAP is involved in intervertebral disc degeneration.
    Zhang C, Wang F, Xie Z, Chen L, Sinkemani A, Yu H, Wu X., Free PMC Article

    12/22/2018
    After 6 hours of antiorthostatic suspension alpha-actinin 1 and alpha-actinin 4 levels decreased in the membranous fraction of proteins of cardiomyocytes and soleus muscle fibers.

    Possible role of non-muscle alpha-actinins in muscle cell mechanosensitivity.
    Ogneva IV, Biryukov NS, Leinsoo TA, Larina IM., Free PMC Article

    11/22/2014
    Desmin and alpha-actinin-2 content in rat soleus muscle in the dynamics of gravitational unloading and subsequent reloading.

    Desmin and α-actinin-2 content in rat soleus muscle in the dynamics of gravitational unloading and subsequent reloading.
    Mirzoev TM, Shenkman BS, Ushakov IB, Ogneva IV.

    11/17/2012
    The alpha-actinin-1 form a complex with CLP36 and RIL.

    CLP36 and RIL recruit α-actinin-1 to stress fibers and differentially regulate stress fiber dynamics in F2408 fibroblasts.
    Miyazaki K, Ohno K, Tamura N, Sasaki T, Sato K.

    09/15/2012
    Data describe alterations of myocardial intercellular and cell-matrix contacts in hypertrophic tissue, and show intracellular translocation of beta-catenin, alpha-actinin and chondroitin sulfate proteoglycan 6 in both an animal model and in LVH patients.

    Expression and tissue localization of beta-catenin, alpha-actinin and chondroitin sulfate proteoglycan 6 is modulated during rat and human left ventricular hypertrophy.
    Ridinger H, Rutenberg C, Lutz D, Buness A, Petersen I, Amann K, Maercker C.

    01/21/2010
    Alpha-Actinin mediates the formation of the template and organization of adhesions associated with actin filaments, suggesting that actin crosslinking has a major role in this process.

    Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner.
    Choi CK, Vicente-Manzanares M, Zareno J, Whitmore LA, Mogilner A, Horwitz AR., Free PMC Article

    01/21/2010
    two sm-titin Zq domains interact with each other and with the two R2-R3 sites in the alpha-actinin central rod

    Smooth muscle titin Zq domain interaction with the smooth muscle alpha-actinin central rod.
    Chi RJ, Simon AR, Bienkiewicz EA, Felix A, Keller TC 3rd., Free PMC Article

    01/21/2010
    Cardiac dysfunction induced by peroxynitrite involves degradation of alpha-actinin that may be mediated by the proteolytic action of MMP-2.

    Matrix metalloproteinase-2 degrades the cytoskeletal protein alpha-actinin in peroxynitrite mediated myocardial injury.
    Sung MM, Schulz CG, Wang W, Sawicki G, Bautista-López NL, Schulz R.

    01/21/2010
    PINCH1, Ilk and actinin from a complex to costameres in neonatal rat ventricular myocytes. This complex is stimulated by fibronectins and phenylephrine, and by both by drug synergism, to regulate cardiac myocyte hypertrophy.

    Role of the integrin-linked kinase/PINCH1/alpha-parvin complex in cardiac myocyte hypertrophy.
    Chen H, Huang XN, Yan W, Chen K, Guo L, Tummalapali L, Dedhar S, St-Arnaud R, Wu C, Sepulveda JL.

    01/21/2010
    an alpha-actinin-dependent association between the actin cytoskeleton and A2AR trafficking

    The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin.
    Burgueño J, Blake DJ, Benson MA, Tinsley CL, Esapa CT, Canela EI, Penela P, Mallol J, Mayor F Jr, Lluis C, Franco R, Ciruela F.

    01/21/2010
    Brain-specific splicing of alpha-actinin 1 (ACTN1) mRNA.

    Brain-specific splicing of alpha-actinin 1 (ACTN1) mRNA.
    Kremerskothen J, Teber I, Wendholt D, Liedtke T, Böckers TM, Barnekow A.

    01/21/2010
    the focal adhesion component alpha-actinin interacts with syndecan-4 in a beta-integrin-independent manner

    Syndecan-4 associates with alpha-actinin.
    Greene DK, Tumova S, Couchman JR, Woods A.

    01/21/2010
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