| The effects of corticotropin-releasing factor on motor learning. | The effects of corticotropin-releasing factor on motor learning.
Takeuchi E, Hatanaka T, Iijima T, Kimura M, Katoh A., Free PMC Article | 08/12/2024 |
| Two Adverse Early Life Events Induce Differential Changes in Brain CRH and Serotonin Systems in Rats along with Hyperphagia and Depression. | Two Adverse Early Life Events Induce Differential Changes in Brain CRH and Serotonin Systems in Rats along with Hyperphagia and Depression.
Alcántara-Alonso V, García-Luna C, Soberanes-Chávez P, Estrada-Camarena E, de Gortari P. | 03/4/2024 |
| Corticotropin-releasing hormone neurons in the central nucleus of amygdala are required for chronic stress-induced hypertension. | Corticotropin-releasing hormone neurons in the central nucleus of amygdala are required for chronic stress-induced hypertension.
Sheng ZF, Zhang H, Phaup JG, Zheng P, Kang X, Liu Z, Chang HM, Yeh ETH, Johnson AK, Pan HL, Li DP., Free PMC Article | 07/23/2023 |
| Corticotropin Releasing Factor Mediates KCa3.1 Inhibition, Hyperexcitability, and Seizures in Acquired Epilepsy. | Corticotropin Releasing Factor Mediates K(Ca)3.1 Inhibition, Hyperexcitability, and Seizures in Acquired Epilepsy.
Tiwari MN, Mohan S, Biala Y, Shor O, Benninger F, Yaari Y., Free PMC Article | 08/6/2022 |
| Early life stress induces a transient increase in hippocampal corticotropin-releasing hormone in rat neonates that precedes the effects on hypothalamic neuropeptides. | Early life stress induces a transient increase in hippocampal corticotropin-releasing hormone in rat neonates that precedes the effects on hypothalamic neuropeptides.
Roque A, Valles Méndez KM, Ruiz R, Pineda E, Lajud N. | 06/11/2022 |
| Stress and corticotropin releasing factor (CRF) promote necrotizing enterocolitis in a formula-fed neonatal rat model. | Stress and corticotropin releasing factor (CRF) promote necrotizing enterocolitis in a formula-fed neonatal rat model.
Bell RL, Withers GS, Kuypers FA, Stehr W, Bhargava A., Free PMC Article | 10/23/2021 |
| Cytokines in the colon, central nervous system and serum of irritable bowel syndrome rats. | Cytokines in the colon, central nervous system and serum of irritable bowel syndrome rats.
Chao G, Wang Z, Chen X, Zhang S., Free PMC Article | 10/16/2021 |
| Overexpression of corticotropin-releasing factor in the nucleus accumbens enhances the reinforcing effects of nicotine in intact female versus male and ovariectomized female rats. | Overexpression of corticotropin-releasing factor in the nucleus accumbens enhances the reinforcing effects of nicotine in intact female versus male and ovariectomized female rats.
Uribe KP, Correa VL, Pinales BE, Flores RJ, Cruz B, Shan Z, Bruijnzeel AW, Khan AM, O'Dell LE., Free PMC Article | 01/2/2021 |
| CRF2 plays an important role in gastric hyperalgesia produced by stress; CRF2 signaling may be a useful therapeutic target for functional dyspepsia | The role of peripheral corticotropin-releasing factor signaling in a rat model of stress-induced gastric hyperalgesia.
Kozakai Y, Hori K, Aye-Mon A, Okuda H, Harada SI, Hayashi K, Ozaki N. | 06/27/2020 |
| central amygdala neurons that release the stress neuropeptide corticotropin-releasing factor drive anxiety-like behaviors in rats via a pathway to dorsal bed nucleus of the stria terminalis | A Corticotropin Releasing Factor Network in the Extended Amygdala for Anxiety.
Pomrenze MB, Tovar-Diaz J, Blasio A, Maiya R, Giovanetti SM, Lei K, Morikawa H, Hopf FW, Messing RO., Free PMC Article | 12/14/2019 |
| mediates stress-induced visceral allodynia and increased colonic permeability | Altered colonic sensory and barrier functions by CRF: roles of TLR4 and IL-1.
Nozu T, Miyagishi S, Nozu R, Takakusaki K, Okumura T. | 09/14/2019 |
| corticotropin-releasing factor (CRF) and alpha1 adrenergic receptor (alpha1AR) signaling enhance the plasticity of NMDA-receptor-mediated glutamatergic transmission in ventral tegmental area. | Cooperative CRF and α1 Adrenergic Signaling in the VTA Promotes NMDA Plasticity and Drives Social Stress Enhancement of Cocaine Conditioning.
Tovar-Díaz J, Pomrenze MB, Kan R, Pahlavan B, Morikawa H., Free PMC Article | 06/22/2019 |
| Gastric corticotropin-releasing factor influences mast cell infiltration in a rat model of functional dyspepsia | Gastric corticotropin-releasing factor influences mast cell infiltration in a rat model of functional dyspepsia.
Hagiwara SI, Kaushal E, Paruthiyil S, Pasricha PJ, Hasdemir B, Bhargava A., Free PMC Article | 02/23/2019 |
| These findings robustly demonstrate aberrant interactions of stress and reward networks after early-life adversity and suggest mechanistic roles for Crh-expressing amygdala neurons in emotional deficits portending major neuropsychiatric disorders. | Anhedonia Following Early-Life Adversity Involves Aberrant Interaction of Reward and Anxiety Circuits and Is Reversed by Partial Silencing of Amygdala Corticotropin-Releasing Hormone Gene.
Bolton JL, Molet J, Regev L, Chen Y, Rismanchi N, Haddad E, Yang DZ, Obenaus A, Baram TZ., Free PMC Article | 07/21/2018 |
| CRF (25-200 nM) concentration-dependently diminished evoked compound excitatory postsynaptic potentials, but increased miniature excitatory postsynaptic current frequencies similarly in central amygdala neurons of both naive and ethanol-dependent rats, indicating reduced evoked glutamatergic responses and enhanced vesicular glutamate release, respectively. CRF primarily acts at presynaptic CRF1. | CRF modulates glutamate transmission in the central amygdala of naïve and ethanol-dependent rats.
Varodayan FP, Correia D, Kirson D, Khom S, Oleata CS, Luu G, Schweitzer P, Roberto M., Free PMC Article | 06/16/2018 |
| the results from the present study suggest that the activation of the CRF system in anxiety-related regions (such as the cingulate cortex, the hippocampus, the amygdala) | Effects of acute restraint and unpredictable chronic mild stress on brain corticotrophin releasing factor mRNA in the elevated T-maze.
de Andrade JS, Céspedes IC, Abrão RO, da Silva JM, Ceneviva R, Ribeiro DA, Bittencourt JC, Viana MB. | 06/9/2018 |
| CRH suppressed CXCL5 production in glia via CRHR1 in the hippocampus of male rats. | Corticotropin-Releasing Hormone Suppresses Synapse Formation in the Hippocampus of Male Rats via Inhibition of CXCL5 Secretion by Glia.
Zhang Y, Zheng Y, Xu Y, Sheng H, Ni X. | 05/19/2018 |
| site-specific methylation and MeCP2 are required for maintenance of basal levels of CRH gene expression. | CpG methylation and the methyl CpG binding protein 2 (MeCP2) are required for restraining corticotropin releasing hormone (CRH) gene expression.
Bhave SA, Uht RM. | 04/28/2018 |
| These results indicate that the central CRF signal, rather than the peripheral CRF signal would be related to anxiety and other behavioral changes, and CRF1 receptor antagonism in the central nervous system may be critical for identifying drug candidates for anxiety and mood disorders | Characterization of CRF(1) receptor antagonists with differential peripheral vs central actions in CRF challenge in rats.
Tanaka M, Tomimatsu Y, Sakimura K, Ootani Y, Sako Y, Kojima T, Aso K, Yano T, Hirai K. | 04/28/2018 |
| Results of the present study indicate that corticotropin-releasing factor neurons are the output neurons of the oval nucleus of the bed nucleus of the stria terminalis and they send projections not only to the centres of neuroendocrine and autonomic regulation, but also regions modulating reward and motivation, vigilance and motor function, as well as affective behaviour. | Targeting Corticotropin-Releasing Factor Projections from the Oval Nucleus of the Bed Nucleus of the Stria Terminalis Using Cell-Type Specific Neuronal Tracing Studies in Mouse and Rat Brain.
Dabrowska J, Martinon D, Moaddab M, Rainnie DG., Free PMC Article | 01/6/2018 |
| age-related alterations in acute central anorexigenic and hypermetabolic effects of CRF show different non-parallel patterns in males and females. Our findings underline the importance of gender differences. They also call the attention to the differential age-related changes in the CRF1 and CRF2 receptor systems | Acute central effects of corticotropin-releasing factor (CRF) on energy balance: Effects of age and gender.
Tenk J, Rostás I, Füredi N, Mikó A, Soós S, Solymár M, Gaszner B, Székely M, Pétervári E, Balaskó M. | 12/2/2017 |
| Chronic restraint stress (5 weeks, 3h/day) attenuated CRF expression in the paraventricular nucleus of the hypothalamus and dentate gyrus of high-anxiety rats, which was probably due to dysregulation of hormonal feedback mechanisms and enhancement of local neurodegenerative processes; induced symptoms of anhedonia (decreased consumption of 1% sucrose solution) in high-anxiety rats. | Behavioral effects and CRF expression in brain structures of high- and low-anxiety rats after chronic restraint stress.
Wisłowska-Stanek A, Lehner M, Skórzewska A, Krząścik P, Płaźnik A. | 12/2/2017 |
| Results from this study demonstrate the convergence of three important systems, norepinephrine, corticotropin-releasing factor, and delta opioid receptors, in the amygdala and provide insight into their functional role in modulating stress and anxiety responses. | Localization of the delta opioid receptor and corticotropin-releasing factor in the amygdalar complex: role in anxiety.
Reyes BAS, Kravets JL, Connelly KL, Unterwald EM, Van Bockstaele EJ., Free PMC Article | 10/21/2017 |
| Chronic noise significantly accelerated the progressive overproduction of corticosterone and upregulated CRF and CRFR1 mRNA and protein, both of which persisted 7-14days after noise exposure. | Effects of chronic noise on mRNA and protein expression of CRF family molecules and its relationship with p-tau in the rat prefrontal cortex.
Gai Z, Li K, Sun H, She X, Cui B, Wang R. | 04/22/2017 |
| The CRF plays important roles in responses to stress in extrahypothalamic circuits such as the mesocorticolimbic dopamine system. | Epigenetic regulation of nociceptin/orphanin FQ and corticotropin-releasing factor system genes in frustration stress-induced binge-like palatable food consumption.
Pucci M, Micioni Di Bonaventura MV, Giusepponi ME, Romano A, Filaferro M, Maccarrone M, Ciccocioppo R, Cifani C, D'Addario C. | 03/18/2017 |