| Stratification and therapeutic potential of ELL in cytogenetic normal acute myeloid leukemia. | Stratification and therapeutic potential of ELL in cytogenetic normal acute myeloid leukemia.
Zha J, Zhong M, Pan G, Chen Q, Jiang Y, Lai Q, Tan J, Zhou H, Wu H, Xu B. | 02/4/2023 |
| ATM-mediated ELL phosphorylation enhances its self-association through increased EAF1 interaction and inhibits global transcription during genotoxic stress. | ATM-mediated ELL phosphorylation enhances its self-association through increased EAF1 interaction and inhibits global transcription during genotoxic stress.
Pal S, Yadav D, Biswas D., Free PMC Article | 11/12/2022 |
| ELL Facilitates RNA Polymerase II-Mediated Transcription of Human Epidermal Proliferation Genes. | ELL Facilitates RNA Polymerase II-Mediated Transcription of Human Epidermal Proliferation Genes.
Li J, Bansal V, Tiwari M, Chen Y, Sen GL., Free PMC Article | 11/22/2021 |
| E1A-associated p300 protein -mediated site-specific acetylation increases, whereas histone deacetylase 3-mediated deacetylation decreases, transcriptional elongation factor ELL stability through polyubiquitylation by the E3 ubiquitin ligase Siah1. Knockdown of human cell cycle and apoptosis regulator 2 reduces ELL levels and expression of a significant number of genes, including those involved in glucose metabolism. | DBC1, p300, HDAC3, and Siah1 coordinately regulate ELL stability and function for expression of its target genes.
Basu S, Barad M, Yadav D, Nandy A, Mukherjee B, Sarkar J, Chakrabarti P, Mukhopadhyay S, Biswas D., Free PMC Article | 08/15/2020 |
| The results indicate that p53 interferes with the interaction between ELL/EAF and ICE1 and represses transcription of small nuclear RNA genes by Pol II. | p53 represses the transcription of snRNA genes by preventing the formation of little elongation complex.
Anwar D, Takahashi H, Watanabe M, Suzuki M, Fukuda S, Hatakeyama S. | 11/4/2017 |
| This work reveals a previously unrecognized function for ELL as an E3 ubiquitin ligase for c-Myc and a potential tumour suppressor. | ELL targets c-Myc for proteasomal degradation and suppresses tumour growth.
Chen Y, Zhou C, Ji W, Mei Z, Hu B, Zhang W, Zhang D, Wang J, Liu X, Ouyang G, Zhou J, Xiao W., Free PMC Article | 09/3/2016 |
| The Tax oncogene enhances ELL incorporation into p300 and P-TEFb containing protein complexes to activate transcription. | The Tax oncogene enhances ELL incorporation into p300 and P-TEFb containing protein complexes to activate transcription.
Fufa TD, Byun JS, Wakano C, Fernandez AG, Pise-Masison CA, Gardner K. | 11/28/2015 |
| eleven-nineteen lysine-rich leukemia protein enhanced E2F1 deacetylation via recruitment of histone deacetylase 1 | ELL inhibits E2F1 transcriptional activity by enhancing E2F1 deacetylation via recruitment of histone deacetylase 1.
Zhang W, Ji W, Liu X, Ouyang G, Xiao W., Free PMC Article | 03/22/2014 |
| ELL is an essential player for RNA Pol II restart during cellular DNA damage response. | ELL, a novel TFIIH partner, is involved in transcription restart after DNA repair.
Mourgues S, Gautier V, Lagarou A, Bordier C, Mourcet A, Slingerland J, Kaddoum L, Coin F, Vermeulen W, Gonzales de Peredo A, Monsarrat B, Mari PO, Giglia-Mari G., Free PMC Article | 01/11/2014 |
| Studies indicate that the super elongation complex (SEC) consisting of ELL, P-TEFb (CDK9) and MLL required for rapid transcriptional induction in the presence or absence of paused RNA polymerase II (Pol II). | The super elongation complex (SEC) family in transcriptional control.
Luo Z, Lin C, Shilatifard A. | 11/3/2012 |
| ELL has an early and essential role during rapid high-amplitude gene expression that is required for both Pol II pause site entry and release | ELL facilitates RNA polymerase II pause site entry and release.
Byun JS, Fufa TD, Wakano C, Fernandez A, Haggerty CM, Sung MH, Gardner K., Free PMC Article | 07/28/2012 |
| Our findings suggest that ELL and HIF-1alpha are binding partners and can modulate the functions of each other in hypoxia. | ELL is an HIF-1alpha partner that regulates and responds to hypoxia response in PC3 cells.
Liu L, Ai J, Xiao W, Liu J, Wang Y, Xin D, He Z, Guo Y, Wang Z., Free PMC Article | 05/10/2010 |
| ELL (Eleven-Nineteen Lysine-rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation | Elongation factor ELL (Eleven-Nineteen Lysine-rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation.
Zhou J, Feng X, Ban B, Liu J, Wang Z, Xiao W., Free PMC Article | 01/21/2010 |
| In the Acute Myeloid Leukemia patients, detected MLL rearrangements consisting of MLL/AF6, MLL/AF9, MLL/AF17 , MLL/ELL and MLL partial tandem duplication. MLL rearrangement include chromosome translocation and partial tandem duplication. | [Application of reverse transcription-multiplex nested PCR to detect MLL rearrangement in AML-M4/M5].
Pan JL, Xue YQ, Jiang HY, He J, Wang W, Wu YF. | 01/21/2010 |