| Hypoxia-induced immortalization of primary cells depends on Tfcp2L1 expression. | Hypoxia-induced immortalization of primary cells depends on Tfcp2L1 expression.
Otero-Albiol D, Santos-Pereira JM, Lucena-Cacace A, Clemente-González C, Muñoz-Galvan S, Yoshida Y, Carnero A., Free PMC Article | 03/4/2024 |
| Temporal and spatial staging of lung alveolar regeneration is determined by the grainyhead transcription factor Tfcp2l1. | Temporal and spatial staging of lung alveolar regeneration is determined by the grainyhead transcription factor Tfcp2l1.
Cardenas-Diaz FL, Liberti DC, Leach JP, Babu A, Barasch J, Shen T, Diaz-Miranda MA, Zhou S, Ying Y, Callaway DA, Morley MP, Morrisey EE., Free PMC Article | 10/28/2023 |
| Requirement for STAT3 and its target, TFCP2L1, in self-renewal of naive pluripotent stem cells in vivo and in vitro. | Requirement for STAT3 and its target, TFCP2L1, in self-renewal of naïve pluripotent stem cells in vivo and in vitro.
Kraunsoe S, Azami T, Pei Y, Martello G, Jones K, Boroviak T, Nichols J., Free PMC Article | 02/23/2023 |
| MK2 promotes Tfcp2l1 degradation via beta-TrCP ubiquitin ligase to regulate mouse embryonic stem cell self-renewal. | MK2 promotes Tfcp2l1 degradation via β-TrCP ubiquitin ligase to regulate mouse embryonic stem cell self-renewal.
Zhang Y, Ding H, Wang X, Wang X, Wan S, Xu A, Gan R, Ye SD. | 02/19/2022 |
| The transcription factor Tfcp2l1 promotes primordial germ cell-like cell specification of pluripotent stem cells. | The transcription factor Tfcp2l1 promotes primordial germ cell-like cell specification of pluripotent stem cells.
Zhang M, Ji J, Wang X, Zhang X, Zhang Y, Li Y, Wang X, Li X, Ban Q, Ye SD., Free PMC Article | 11/27/2021 |
| These findings indicate that TFCP2L1 functions differently in naive and primed pluripotency, insights that may help elucidate the different states of pluripotency. | The transcription factor TFCP2L1 induces expression of distinct target genes and promotes self-renewal of mouse and human embryonic stem cells.
Wang X, Wang X, Zhang S, Sun H, Li S, Ding H, You Y, Zhang X, Ye SD., Free PMC Article | 10/19/2019 |
| Thus, Tfcp2l1 is a critical regulator of intercalated cell-principal cell patterning in kidney collecting ducts, acting cell-autonomously in intercalated cells, and non-cell-autonomously in principal cells. | Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts.
Werth M, Schmidt-Ott KM, Leete T, Qiu A, Hinze C, Viltard M, Paragas N, Shawber CJ, Yu W, Lee P, Chen X, Sarkar A, Mu W, Rittenberg A, Lin CS, Kitajewski J, Al-Awqati Q, Barasch J., Free PMC Article | 03/17/2018 |
| TFCP2L1 depends on its N-terminus and CP2-like domain to maintain the undifferentiated state of mouse embryonic stem cells. | TFCP2L1 represses multiple lineage commitment of mouse embryonic stem cells through MTA1 and LEF1.
Liu K, Zhang Y, Liu D, Ying QL, Ye S. | 03/3/2018 |
| we found that TFCP2L1 is hexamerized in solution via the C-terminal SAM-like domain. We also found that homo-oligomerization of SAM-like domain is dependent on the concentration of the proteins. | Functional Analysis of CP2-Like Domain and SAM-Like Domain in TFCP2L1, Novel Pluripotency Factor of Embryonic Stem Cells.
Kim CM, Jang TH, Park HH. | 02/4/2017 |
| study therefore establishes the pivotal role of Klf2 and Tfcp2l1 in mediating ESC self-renewal promoted by Wnt/beta-catenin signaling. | Klf2 and Tfcp2l1, Two Wnt/β-Catenin Targets, Act Synergistically to Induce and Maintain Naive Pluripotency.
Qiu D, Ye S, Ruiz B, Zhou X, Liu D, Zhang Q, Ying QL., Free PMC Article | 06/11/2016 |
| Tfcp2l1 is at the intersection of LIF- and 2i-mediated self-renewal pathways and plays a critical role in maintaining embryonic stem cell identity. | Embryonic stem cell self-renewal pathways converge on the transcription factor Tfcp2l1.
Ye S, Li P, Tong C, Ying QL., Free PMC Article | 11/23/2013 |
| Tfcp2l1 is the principal bridge between LIF/Stat3 input and the transcription factor core of naive pluripotency. | Identification of the missing pluripotency mediator downstream of leukaemia inhibitory factor.
Martello G, Bertone P, Smith A., Free PMC Article | 11/23/2013 |
| Cp2l1 expression is required for normal duct development in both the salivary gland and kidney. | Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse.
Yamaguchi Y, Yonemura S, Takada S. | 01/21/2010 |