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    SPY Tetratricopeptide repeat (TPR)-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820327, updated on 18-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    SPINDLY mediates O-fucosylation of hundreds of proteins and sugar-dependent growth in Arabidopsis.

    SPINDLY mediates O-fucosylation of hundreds of proteins and sugar-dependent growth in Arabidopsis.
    Bi Y, Shrestha R, Zhang Z, Hsu CC, Reyes AV, Karunadasa S, Baker PR, Maynard JC, Liu Y, Hakimi A, Lopez-Ferrer D, Hassan T, Chalkley RJ, Xu SL, Wang ZY., Free PMC Article

    04/24/2023
    Structure and dynamics of the Arabidopsis O-fucosyltransferase SPINDLY.

    Structure and dynamics of the Arabidopsis O-fucosyltransferase SPINDLY.
    Kumar S, Wang Y, Zhou Y, Dillard L, Li FW, Sciandra CA, Sui N, Zentella R, Zahn E, Shabanowitz J, Hunt DF, Borgnia MJ, Bartesaghi A, Sun TP, Zhou P., Free PMC Article

    03/29/2023
    SPINDLY O-fucosylates nuclear and cytoplasmic proteins involved in diverse cellular processes in plants.

    SPINDLY O-fucosylates nuclear and cytoplasmic proteins involved in diverse cellular processes in plants.
    Zentella R, Wang Y, Zahn E, Hu J, Jiang L, Shabanowitz J, Hunt DF, Sun TP., Free PMC Article

    03/21/2023
    Structural insights into mechanism and specificity of the plant protein O-fucosyltransferase SPINDLY.

    Structural insights into mechanism and specificity of the plant protein O-fucosyltransferase SPINDLY.
    Zhu L, Wei X, Cong J, Zou J, Wan L, Xu S., Free PMC Article

    12/10/2022
    The Arabidopsis O-fucosyltransferase SPINDLY regulates root hair patterning independently of gibberellin signaling.

    The Arabidopsis O-fucosyltransferase SPINDLY regulates root hair patterning independently of gibberellin signaling.
    Mutanwad KV, Zangl I, Lucyshyn D., Free PMC Article

    04/13/2021
    Nuclear Localized O-Fucosyltransferase SPY Facilitates PRR5 Proteolysis to Fine-Tune the Pace of Arabidopsis Circadian Clock.

    Nuclear Localized O-Fucosyltransferase SPY Facilitates PRR5 Proteolysis to Fine-Tune the Pace of Arabidopsis Circadian Clock.
    Wang Y, He Y, Su C, Zentella R, Sun TP, Wang L., Free PMC Article

    11/28/2020
    posttranslational modification of TCP14/15 by SPY inhibits their proteolysis.

    The Putative O-Linked N-Acetylglucosamine Transferase SPINDLY Inhibits Class I TCP Proteolysis to Promote Sensitivity to Cytokinin.
    Steiner E, Livne S, Kobinson-Katz T, Tal L, Pri-Tal O, Mosquna A, Tarkowská D, Mueller B, Tarkowski P, Weiss D., Free PMC Article

    09/23/2017
    The study revealed that SPY-dependent protein O-fucosylation plays a key role in regulating plant development.

    The Arabidopsis O-fucosyltransferase SPINDLY activates nuclear growth repressor DELLA.
    Zentella R, Sui N, Barnhill B, Hsieh WP, Hu J, Shabanowitz J, Boyce M, Olszewski NE, Zhou P, Hunt DF, Sun TP., Free PMC Article

    04/29/2017
    SPINDLY regulates cortex proliferation by maintaining cellular redox homeostasis

    SPINDLY, ERECTA, and its ligand STOMAGEN have a role in redox-mediated cortex proliferation in the Arabidopsis root.
    Cui H, Kong D, Wei P, Hao Y, Torii KU, Lee JS, Li J., Free PMC Article

    08/1/2015
    SPY plays a negative role in plant abiotic stress tolerance, probably by integrating environmental stress signals via gibberellic acid and Cytokinins cross talk.

    SPINDLY, a negative regulator of gibberellic acid signaling, is involved in the plant abiotic stress response.
    Qin F, Kodaira KS, Maruyama K, Mizoi J, Tran LS, Fujita Y, Morimoto K, Shinozaki K, Yamaguchi-Shinozaki K., Free PMC Article

    06/7/2014
    Data suggest that responses of leaves and flowers to CK are mediated by SPY-dependent TCP14 and TCP15 activities.

    The Arabidopsis O-linked N-acetylglucosamine transferase SPINDLY interacts with class I TCPs to facilitate cytokinin responses in leaves and flowers.
    Steiner E, Efroni I, Gopalraj M, Saathoff K, Tseng TS, Kieffer M, Eshed Y, Olszewski N, Weiss D., Free PMC Article

    06/16/2012
    SPY acts in the cytosol to suppress gibberellin responses and to promote cytokinin signaling.

    Cytosolic activity of SPINDLY implies the existence of a DELLA-independent gibberellin-response pathway.
    Maymon I, Greenboim-Wainberg Y, Sagiv S, Kieber JJ, Moshelion M, Olszewski N, Weiss D.

    01/21/2010
    spy-4 partially suppressed the reduced abundance of CONSTANS and FLOWERING LOCUS T RNA and the late flowering of gigantea mutant plants

    SPINDLY and GIGANTEA interact and act in Arabidopsis thaliana pathways involved in light responses, flowering, and rhythms in cotyledon movements.
    Tseng TS, Salomé PA, McClung CR, Olszewski NE., Free PMC Article

    01/21/2010
    Our results demonstrate that SPY acts as both a repressor of GA responses and a positive regulator of cytokinin signaling. Hence, SPY may play a central role in the regulation of GA/cytokinin cross talk during plant development.

    Cross talk between gibberellin and cytokinin: the Arabidopsis GA response inhibitor SPINDLY plays a positive role in cytokinin signaling.
    Greenboim-Wainberg Y, Maymon I, Borochov R, Alvarez J, Olszewski N, Ori N, Eshed Y, Weiss D., Free PMC Article

    01/21/2010
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