| Pseudomonas effector AvrB is a glycosyltransferase that rhamnosylates plant guardee protein RIN4. | Pseudomonas effector AvrB is a glycosyltransferase that rhamnosylates plant guardee protein RIN4.
Peng W, Garcia N, Servage KA, Kohler JJ, Ready JM, Tomchick DR, Fernandez J, Orth K., Free PMC Article | 02/21/2024 |
| The RIN4-like/NOI proteins NOI10 and NOI11 modulate the response to biotic stresses mediated by RIN4 in Arabidopsis. | The RIN4-like/NOI proteins NOI10 and NOI11 modulate the response to biotic stresses mediated by RIN4 in Arabidopsis.
Contreras E, Martinez M., Free PMC Article | 02/16/2024 |
| Direct acetylation of a conserved threonine of RIN4 by the bacterial effector HopZ5 or AvrBsT activates RPM1-dependent immunity in Arabidopsis. | Direct acetylation of a conserved threonine of RIN4 by the bacterial effector HopZ5 or AvrBsT activates RPM1-dependent immunity in Arabidopsis.
Choi S, Prokchorchik M, Lee H, Gupta R, Lee Y, Chung EH, Cho B, Kim MS, Kim ST, Sohn KH. | 01/29/2022 |
| The receptor-like cytoplasmic kinase CDG1 negatively regulates Arabidopsis pattern-triggered immunity and is involved in AvrRpm1-induced RIN4 phosphorylation. | The receptor-like cytoplasmic kinase CDG1 negatively regulates Arabidopsis pattern-triggered immunity and is involved in AvrRpm1-induced RIN4 phosphorylation.
Yang Q, Guo J, Zeng H, Xu L, Xue J, Xiao S, Li JF. | 08/21/2021 |
| The resistance associated protein RIN4 promotes the extracellular transport of AtEXO70E2. | The resistance associated protein RIN4 promotes the extracellular transport of AtEXO70E2.
Wu X, Huang J, Cao Y, Gao Z. | 07/3/2021 |
| Differential N-end Rule Degradation of RIN4/NOI Fragments Generated by the AvrRpt2 Effector Protease. | Differential N-end Rule Degradation of RIN4/NOI Fragments Generated by the AvrRpt2 Effector Protease.
Goslin K, Eschen-Lippold L, Naumann C, Linster E, Sorel M, Klecker M, de Marchi R, Kind A, Wirtz M, Lee J, Dissmeyer N, Graciet E., Free PMC Article | 08/29/2020 |
| Bacterial effector AvrB-induced RPM1 interacting protein 4 (RIN4) phosphorylation depends on receptor-like cytoplasmic kinase (RLCK) in Arabidopsis. | The Bacterial Effector AvrB-Induced RIN4 Hyperphosphorylation Is Mediated by a Receptor-Like Cytoplasmic Kinase Complex in Arabidopsis.
Xu N, Luo X, Li W, Wang Z, Liu J. | 06/9/2018 |
| Transiently expressed RIN4, but not the plasma membrane (PM) protein aquaporin PIP2, recruits EXO70B1 to the plasma membrane (PM). Unlike EXO70B1, RIN4 does not recruit the core exocyst subunit SEC6 to the PM under these conditions. | RIN4 recruits the exocyst subunit EXO70B1 to the plasma membrane.
Sabol P, Kulich I, Žárský V., Free PMC Article | 02/24/2018 |
| RIN4 is intrinsically disordered and it's AvrRpt2 cleavage sites coincide with Molecular Recognition Features (MoRFs) that typically direct protein-protein interaction within other disordered proteins. | The intrinsically disordered structural platform of the plant defence hub protein RPM1-interacting protein 4 provides insights into its mode of action in the host-pathogen interface and evolution of the nitrate-induced domain protein family.
Sun X, Greenwood DR, Templeton MD, Libich DS, McGhie TK, Xue B, Yoon M, Cui W, Kirk CA, Jones WT, Uversky VN, Rikkerink EH. | 03/7/2017 |
| RIN4 T21D/S160D/T166D phosphomimetic mutants exhibited enhanced disease susceptibility upon surface inoculation with P. syringae, wider stomatal apertures, and enhanced plasma membrane H(+)-ATPase activity. | Phosphorylation of the Plant Immune Regulator RPM1-INTERACTING PROTEIN4 Enhances Plant Plasma Membrane H⁺-ATPase Activity and Inhibits Flagellin-Triggered Immune Responses in Arabidopsis.
Lee D, Bourdais G, Yu G, Robatzek S, Coaker G., Free PMC Article | 05/28/2016 |
| AvrB and AvrPphB target a conserved defense signaling pathway in Arabidopsis and soybean that includes RIPK and RIN4. | Pseudomonas syringae Effector AvrPphB Suppresses AvrB-Induced Activation of RPM1 but Not AvrRpm1-Induced Activation.
Russell AR, Ashfield T, Innes RW. | 10/17/2015 |
| Authors demonstrate that recognition of the flagellin peptide microbe-associated molecular pattern flg22 triggers accumulation of RIN4 phosphorylated at serine 141 (pS141) that mediates derepression of several immune outputs. | A plant phosphoswitch platform repeatedly targeted by type III effector proteins regulates the output of both tiers of plant immune receptors.
Chung EH, El-Kasmi F, He Y, Loehr A, Dangl JL. | 06/20/2015 |
| Consistent with this, RIN4 Pro149 undergoes cis/trans isomerization in the presence of ROC1. | Proline isomerization of the immune receptor-interacting protein RIN4 by a cyclophilin inhibits effector-triggered immunity in Arabidopsis.
Li M, Ma X, Chiang YH, Yadeta KA, Ding P, Dong L, Zhao Y, Li X, Yu Y, Zhang L, Shen QH, Xia B, Coaker G, Liu D, Zhou JM., Free PMC Article | 06/20/2015 |
| RIN4 is a multifunctional suppressor of PTI and that a virulence function of AvrRpt2 may include cleaving RIN4 into active defense-suppressing fragments. | Separable fragments and membrane tethering of Arabidopsis RIN4 regulate its suppression of PAMP-triggered immunity.
Afzal AJ, da Cunha L, Mackey D., Free PMC Article | 07/14/2012 |
| RIPK (At2g05940) phosphorylates the host target RIN4, leading to the activation of RPM1 during Pseudomonas syringae infection. | A receptor-like cytoplasmic kinase phosphorylates the host target RIN4, leading to the activation of a plant innate immune receptor.
Liu J, Elmore JM, Lin ZJ, Coaker G., Free PMC Article | 06/4/2011 |
| Threonine phosphorylation of Arabidopsis RIN4 by Pseudomonas AvrRpm1 and AvrB activates Arabidopsis immune receptor RPM1. | Specific threonine phosphorylation of a host target by two unrelated type III effectors activates a host innate immune receptor in plants.
Chung EH, da Cunha L, Wu AJ, Gao Z, Cherkis K, Afzal AJ, Mackey D, Dangl JL., Free PMC Article | 06/4/2011 |
| Pseudomonas syringae virulence activity was not observed in plants genetically lacking RIN4. | The type III effector HopF2Pto targets Arabidopsis RIN4 protein to promote Pseudomonas syringae virulence.
Wilton M, Subramaniam R, Elmore J, Felsensteiner C, Coaker G, Desveaux D., Free PMC Article | 03/8/2010 |
| Multiple bacterial effectors besides AvrRpt2 elicit proteolysis of RIN4 in planta. | Proteolysis of a negative regulator of innate immunity is dependent on resistance genes in tomato and Nicotiana benthamiana and induced by multiple bacterial effectors.
Luo Y, Caldwell KS, Wroblewski T, Wright ME, Michelmore RW., Free PMC Article | 01/21/2010 |
| Results indicate that protein RIN4 functions with the PM H(+)-ATPase to regulate stomatal apertures, inhibiting the entry of bacterial pathogens into the plant leaf during infection. | RIN4 functions with plasma membrane H+-ATPases to regulate stomatal apertures during pathogen attack.
Liu J, Elmore JM, Fuglsang AT, Palmgren MG, Staskawicz BJ, Coaker G., Free PMC Article | 01/21/2010 |
| These results indicate that the virulence activity of AvrRpt2 in Arabidopsis thaliana is likely to rely on the modification of host susceptibility factors other than, or in addition to, RIN4. | The Pseudomonas syringae type III effector AvrRpt2 promotes virulence independently of RIN4, a predicted virulence target in Arabidopsis thaliana.
Lim MT, Kunkel BN. | 01/21/2010 |
| In addition to characterizing the RPS2-RIN4 association in N. benthamiana, we have moved forward to show that the biological relevance of these amino acid changes is applicable in Arabidopsis as well. | Molecular basis for the RIN4 negative regulation of RPS2 disease resistance.
Day B, Dahlbeck D, Huang J, Chisholm ST, Li D, Staskawicz BJ., Free PMC Article | 01/21/2010 |
| demonstrate that the RIN4-NDR1 interaction occurs on the cytoplasmically localized N-terminal portion of NDR1 and that this interaction is required for the activation of resistance signaling following infection by P. syringae | NDR1 interaction with RIN4 mediates the differential activation of multiple disease resistance pathways in Arabidopsis.
Day B, Dahlbeck D, Staskawicz BJ., Free PMC Article | 01/21/2010 |
| RIN4 was attached to the plasma membrane at its carboxyl terminus; RIN4 was cleaved by AvrRpt2 at two PxFGxW motifs. | Membrane release and destabilization of Arabidopsis RIN4 following cleavage by Pseudomonas syringae AvrRpt2.
Takemoto D, Jones DA. | 01/21/2010 |
| AvrB is activated inside the host cell by nucleotide binding and subsequent phosphorylation and interacts with RIN4. Aactivated AvrB, bound to RIN4, is indirectly recognized by RPM1 to initiate plant immune system function. | Type III effector activation via nucleotide binding, phosphorylation, and host target interaction.
Desveaux D, Singer AU, Wu AJ, McNulty BC, Musselwhite L, Nimchuk Z, Sondek J, Dangl JL., Free PMC Article | 01/21/2010 |