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    HA2 H[+]-ATPase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829142, updated on 18-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Transceptor NRT1.1 and receptor-kinase QSK1 complex controls PM H[+]-ATPase activity under low nitrate.

    Transceptor NRT1.1 and receptor-kinase QSK1 complex controls PM H(+)-ATPase activity under low nitrate.
    Zhu Z, Krall L, Li Z, Xi L, Luo H, Li S, He M, Yang X, Zan H, Gilbert M, Gombos S, Wang T, Neuhäuser B, Jacquot A, Lejay L, Zhang J, Liu J, Schulze WX, Wu XN.

    04/16/2024
    Arabidopsis leaf hydraulic conductance is regulated by xylem sap pH, controlled, in turn, by a P-type H(+) -ATPase of vascular bundle sheath cells.

    Arabidopsis leaf hydraulic conductance is regulated by xylem sap pH, controlled, in turn, by a P-type H(+) -ATPase of vascular bundle sheath cells.
    Grunwald Y, Wigoda N, Sade N, Yaaran A, Torne T, Gosa SC, Moran N, Moshelion M.

    08/28/2021
    A conserved, buried cysteine near the P-site is accessible to cysteine modifications and increases ROS stability in the P-type plasma membrane H+-ATPase.

    A conserved, buried cysteine near the P-site is accessible to cysteine modifications and increases ROS stability in the P-type plasma membrane H+-ATPase.
    Welle M, Pedersen JT, Ravnsborg T, Hayashi M, Maaß S, Becher D, Jensen ON, Stöhr C, Palmgren M.

    06/19/2021
    Danger-Associated Peptide Regulates Root Growth by Promoting Protons Extrusion in an AHA2-Dependent Manner in Arabidopsis.

    Danger-Associated Peptide Regulates Root Growth by Promoting Protons Extrusion in an AHA2-Dependent Manner in Arabidopsis.
    Shen N, Jing Y, Tu G, Fu A, Lan W., Free PMC Article

    03/13/2021
    Intermolecular and Intramolecular Interactions of the Arabidopsis Plasma Membrane Proton Pump Revealed Using a Mass Spectrometry Cleavable Cross-Linker.

    Intermolecular and Intramolecular Interactions of the Arabidopsis Plasma Membrane Proton Pump Revealed Using a Mass Spectrometry Cleavable Cross-Linker.
    Nguyen TT, Blackburn MR, Sussman MR.

    02/27/2021
    Study find that AHA2 drives root cell expansion during growth but that, unexpectedly, restriction of root hair elongation is dependent on AHA2 and AHA7, with each having different roles in this process.

    Roles of plasma membrane proton ATPases AHA2 and AHA7 in normal growth of roots and root hairs in Arabidopsis thaliana.
    Hoffmann RD, Olsen LI, Ezike CV, Pedersen JT, Manstretta R, López-Marqués RL, Palmgren M., Free PMC Article

    08/10/2019
    A "head-to-tail" organization of ATPase monomers in which the C-terminal domain of one ATPase molecule interacts with the actuator domain of another ATPase molecule.

    In vivo cross-linking supports a head-to-tail mechanism for regulation of the plant plasma membrane P-type H(+)-ATPase.
    Nguyen TT, Sabat G, Sussman MR., Free PMC Article

    06/1/2019
    The accumulation of AHA2 in intracellular compartments is consistent with reduced H(+) secretion near the transition zone and the suppression of root growth.

    Environmental and Genetic Factors Regulating Localization of the Plant Plasma Membrane H(+)-ATPase.
    Haruta M, Tan LX, Bushey DB, Swanson SJ, Sussman MR., Free PMC Article

    08/18/2018
    Under low-phosphorus stress conditions, AHA2 acts mainly to modulate primary root elongation by mediating H+ efflux in the root elongation zone, whereas AHA7 plays an important role in root hair formation by mediating H+ efflux in the root hair zone.

    Arabidopsis plasma membrane H+-ATPase genes AHA2 and AHA7 have distinct and overlapping roles in the modulation of root tip H+ efflux in response to low-phosphorus stress.
    Yuan W, Zhang D, Song T, Xu F, Lin S, Xu W, Li Q, Zhu Y, Liang J, Zhang J., Free PMC Article

    07/21/2018
    the PM proton pump AHA2 (Arabidopsis plasma membrane H(+) -ATPase isoform 2) is important for root growth and development during different nitrogen regimes.

    The plasma membrane H(+) -ATPase AHA2 contributes to the root architecture in response to different nitrogen supply.
    Młodzińska E, Kłobus G, Christensen MD, Fuglsang AT.

    03/5/2016
    The major plasma membrane proton pumps in Arabidopsis, AHA1 and AHA2, interact directly in vitro and in planta with PSY1R, a receptor kinase of the plasma membrane that serves as a receptor for the peptide growth hormone PSY1.

    Receptor kinase-mediated control of primary active proton pumping at the plasma membrane.
    Fuglsang AT, Kristensen A, Cuin TA, Schulze WX, Persson J, Thuesen KH, Ytting CK, Oehlenschlæger CB, Mahmood K, Sondergaard TE, Shabala S, Palmgren MG.

    10/24/2015
    AHA2 is activated by lysophospholipids directly via a mechanism involving N-and C- terminal domains.

    Specific Activation of the Plant P-type Plasma Membrane H+-ATPase by Lysophospholipids Depends on the Autoinhibitory N- and C-terminal Domains.
    Wielandt AG, Pedersen JT, Falhof J, Kemmer GC, Lund A, Ekberg K, Fuglsang AT, Pomorski TG, Buch-Pedersen MJ, Palmgren M., Free PMC Article

    10/3/2015
    analysis of Arabidopsis thaliana plasma membrane H(+)-ATPase isoform 2 reconstituted into soluble nanoscale lipid bilayers, also termed nanodiscs

    Active plasma membrane P-type H+-ATPase reconstituted into nanodiscs is a monomer.
    Justesen BH, Hansen RW, Martens HJ, Theorin L, Palmgren MG, Martinez KL, Pomorski TG, Fuglsang AT., Free PMC Article

    12/21/2013
    Asn-106 is important for closure of the proton entrance pathway prior to proton translocation across the membrane in AHA2

    A conserved asparagine in a P-type proton pump is required for efficient gating of protons.
    Ekberg K, Wielandt AG, Buch-Pedersen MJ, Palmgren MG., Free PMC Article

    06/1/2013
    ABA has no effect on blue light-induced phosphorylation of the H+-ATPase in ABA-insensitive mutants

    Immunohistochemical detection of blue light-induced phosphorylation of the plasma membrane H+-ATPase in stomatal guard cells.
    Hayashi M, Inoue S, Takahashi K, Kinoshita T.

    12/24/2011
    AHA2 and Na+,K+-ATPase crystals were both highly fragile and sensitive to manipulation, resulting in only low-resolution heavy-atom derivative data sets being available for phasing (6-9 A degrees maximum resolution).

    Structure determination using poorly diffracting membrane-protein crystals: the H+-ATPase and Na+,K+-ATPase case history.
    Pedersen BP, Morth JP, Nissen P.

    03/22/2010
    the rhizosphere acidification in response to Fe deficiency is chiefly mediated by AHA2...

    Dissecting iron deficiency-induced proton extrusion in Arabidopsis roots.
    Santi S, Schmidt W.

    01/21/2010
    Results indicate that protein RIN4 functions with the PM H(+)-ATPase to regulate stomatal apertures, inhibiting the entry of bacterial pathogens into the plant leaf during infection.

    RIN4 functions with plasma membrane H+-ATPases to regulate stomatal apertures during pathogen attack.
    Liu J, Elmore JM, Fuglsang AT, Palmgren MG, Staskawicz BJ, Coaker G., Free PMC Article

    01/21/2010
    first structure of a P-type proton pump (AHA2) determined by X-ray crystallography

    Crystal structure of the plasma membrane proton pump.
    Pedersen BP, Buch-Pedersen MJ, Morth JP, Palmgren MG, Nissen P.

    01/21/2010
    These results suggest that PKS5 is part of a calcium-signaling pathway mediating PM H+ -ATPase regulation.

    Arabidopsis protein kinase PKS5 inhibits the plasma membrane H+ -ATPase by preventing interaction with 14-3-3 protein.
    Fuglsang AT, Guo Y, Cuin TA, Qiu Q, Song C, Kristiansen KA, Bych K, Schulz A, Shabala S, Schumaker KS, Palmgren MG, Zhu JK., Free PMC Article

    01/21/2010
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