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    EIN2 NRAMP metal ion transporter family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831889, updated on 18-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    MYB44 regulates PTI by promoting the expression of EIN2 and MPK3/6 in Arabidopsis.

    MYB44 regulates PTI by promoting the expression of EIN2 and MPK3/6 in Arabidopsis.
    Wang Z, Li X, Yao X, Ma J, Lu K, An Y, Sun Z, Wang Q, Zhou M, Qin L, Zhang L, Zou S, Chen L, Song C, Dong H, Zhang M, Chen X., Free PMC Article

    11/16/2023
    Arabidopsis EIN2 represses ABA responses during germination and early seedling growth by inactivating HLS1 protein independently of the canonical ethylene pathway.

    Arabidopsis EIN2 represses ABA responses during germination and early seedling growth by inactivating HLS1 protein independently of the canonical ethylene pathway.
    Guo R, Wen X, Zhang W, Huang L, Peng Y, Jin L, Han H, Zhang L, Li W, Guo H.

    09/15/2023
    Endosperm and Maternal-specific expression of EIN2 in the endosperm affects endosperm cellularization and seed size in Arabidopsis.

    Endosperm and Maternal-specific expression of EIN2 in the endosperm affects endosperm cellularization and seed size in Arabidopsis.
    Ando A, Kirkbride RC, Qiao H, Chen ZJ., Free PMC Article

    02/13/2023
    Arabidopsis WRKY71 regulates ethylene-mediated leaf senescence by directly activating EIN2, ORE1 and ACS2 genes.

    Arabidopsis WRKY71 regulates ethylene-mediated leaf senescence by directly activating EIN2, ORE1 and ACS2 genes.
    Yu Y, Qi Y, Xu J, Dai X, Chen J, Dong CH, Xiang F.

    01/29/2022
    Ethylene signaling in salt-stressed Arabidopsis thaliana ein2-1 and ctr1-1 mutants - A dissection of molecular mechanisms involved in acclimation.

    Ethylene signaling in salt-stressed Arabidopsis thaliana ein2-1 and ctr1-1 mutants - A dissection of molecular mechanisms involved in acclimation.
    Vaseva II, Simova-Stoilova L, Kirova E, Mishev K, Depaepe T, Van Der Straeten D, Vassileva V.

    10/16/2021
    The TOR-EIN2 axis mediates nuclear signalling to modulate plant growth.

    The TOR-EIN2 axis mediates nuclear signalling to modulate plant growth.
    Fu L, Liu Y, Qin G, Wu P, Zi H, Xu Z, Zhao X, Wang Y, Li Y, Yang S, Peng C, Wong CCL, Yoo SD, Zuo Z, Liu R, Cho YH, Xiong Y.

    08/7/2021
    EIN2-directed histone acetylation requires EIN3-mediated positive feedback regulation in response to ethylene.

    EIN2-directed histone acetylation requires EIN3-mediated positive feedback regulation in response to ethylene.
    Wang L, Zhang Z, Zhang F, Shao Z, Zhao B, Huang A, Tran J, Hernandez FV, Qiao H., Free PMC Article

    07/17/2021
    Here the authors identify a chromatin-dependent regulatory mechanism at EIN2 requiring two genes: ETHYLENE-INSENSITIVE6 (EIN6), which is a H3K27me3 demethylase also known as RELATIVE OF EARLY FLOWERING6 (REF6), and EIN6 ENHANCER (EEN), the Arabidopsis homolog of the yeast INO80 chromatin remodeling complex subunit IES6 (INO EIGHTY SUBUNIT).

    Epigenetic silencing of a multifunctional plant stress regulator.
    Zander M, Willige BC, He Y, Nguyen TA, Langford AE, Nehring R, Howell E, McGrath R, Bartlett A, Castanon R, Nery JR, Chen H, Zhang Z, Jupe F, Stepanova A, Schmitz RJ, Lewsey MG, Chory J, Ecker JR., Free PMC Article

    02/22/2020
    Ethylene-Insensitive Arabidopsis Mutants etr1-1 and ein2-1 Have a Decreased Freezing Tolerance

    Ethylene-Insensitive Arabidopsis Mutants etr1-1 and ein2-1 Have a Decreased Freezing Tolerance.
    Popov VN, Deryabin AN, Astakhova NV, Antipina OV, Suvorova TA, Alieva GP, Moshkov IE.

    12/7/2019
    ENAP1 may potentially mediate ethylene-induced histone acetylation via its interactions with EIN2 C terminus.

    EIN2-dependent regulation of acetylation of histone H3K14 and non-canonical histone H3K23 in ethylene signalling.
    Zhang F, Qi B, Wang L, Zhao B, Rode S, Riggan ND, Ecker JR, Qiao H., Free PMC Article

    09/29/2018
    In the presence of ethylene, EIN2 interacts with ENAP1, elevating the levels of H3K14Ac and H3K23Ac, promoting more EIN3 binding to the targets shared with ENAP1 and resulting in a rapid transcriptional regulation.

    EIN2 mediates direct regulation of histone acetylation in the ethylene response.
    Zhang F, Wang L, Qi B, Zhao B, Ko EE, Riggan ND, Chin K, Qiao H., Free PMC Article

    06/9/2018
    These results indicate that root responses to 6-pentyl-2H-pyran-2-one involve components of auxin transport and signaling and the ethylene-response modulator EIN2.

    The volatile 6-pentyl-2H-pyran-2-one from Trichoderma atroviride regulates Arabidopsis thaliana root morphogenesis via auxin signaling and ETHYLENE INSENSITIVE 2 functioning.
    Garnica-Vergara A, Barrera-Ortiz S, Muñoz-Parra E, Raya-González J, Méndez-Bravo A, Macías-Rodríguez L, Ruiz-Herrera LF, López-Bucio J.

    12/24/2016
    Mitogen-activated protein kinase 6 (MPK6) promoted C-terminal end of ORE3/EIN2 (CEND cleavage and nuclear translocation. Nuclear CEND accumulated ETHYLENE INSENSITIVE3 (EIN3), a transcription factor that accelerates MeJA-induced leaf senescence.

    Mitogen-activated protein kinase 6 mediates nuclear translocation of ORE3 to promote ORE9 gene expression in methyl jasmonate-induced leaf senescence.
    Zhang Y, Liu J, Chai J, Xing D.

    09/24/2016
    role in regulating organ growth by restricting cell expansion

    The Arabidopsis EIN2 restricts organ growth by retarding cell expansion.
    Feng G, Liu G, Xiao J., Free PMC Article

    03/19/2016
    Characterization of one of the targets of the translation regulatory machinery, the ethylene signaling component EBF2, indicates that the signaling molecule EIN2 and the nonsense-mediated decay proteins UPFs play a central role in this ethylene-induced translational response.

    Gene-specific translation regulation mediated by the hormone-signaling molecule EIN2.
    Merchante C, Brumos J, Yun J, Hu Q, Spencer KR, Enríquez P, Binder BM, Heber S, Stepanova AN, Alonso JM.

    02/6/2016
    Study reports another mechanism of EIN2-mediated ethylene signaling, whereby EIN2 imposes the translational repression of EBF1 and EBF2 mRNA and find that the EBF1/2 3' UTRs mediate EIN2-directed translational repression and identify multiple poly-uridylates (PolyU) motifs as functional cis elements of 3' UTRs.

    EIN2-directed translational regulation of ethylene signaling in Arabidopsis.
    Li W, Ma M, Feng Y, Li H, Wang Y, Ma Y, Li M, An F, Guo H.

    02/6/2016
    The signaling pathway involving EIN2-EIN3-miR164-NAC2 regulates leaf senescence and provides a mechanistic insight into how ethylene promotes the progression of leaf senescence in Arabidopsis thaliana.

    Ethylene-insensitive3 is a senescence-associated gene that accelerates age-dependent leaf senescence by directly repressing miR164 transcription in Arabidopsis.
    Li Z, Peng J, Wen X, Guo H., Free PMC Article

    05/16/2015
    The data provide insight into an EIN2-mediated senescence signalling pathway that coordinates global gene expression during leaf senescence via a gene regulatory network.

    Gene regulatory cascade of senescence-associated NAC transcription factors activated by ETHYLENE-INSENSITIVE2-mediated leaf senescence signalling in Arabidopsis.
    Kim HJ, Hong SH, Kim YW, Lee IH, Jun JH, Phee BK, Rupak T, Jeong H, Lee Y, Hong BS, Nam HG, Woo HR, Lim PO., Free PMC Article

    04/4/2015
    the ore1 loss-of-function mutants were epistatic to nes1, suggesting the dominant role of ORE1 and the antagonistic role of NES1 during nitric oxide-induced cotyledon senescence in Arabidopsis.

    Nitric oxide induces cotyledon senescence involving co-operation of the NES1/MAD1 and EIN2-associated ORE1 signalling pathways in Arabidopsis.
    Du J, Li M, Kong D, Wang L, Lv Q, Wang J, Bao F, Gong Q, Xia J, He Y., Free PMC Article

    04/4/2015
    EIN2 may be cleaved at alternative positions

    Separation anxiety: an analysis of ethylene-induced cleavage of EIN2.
    Cooper B., Free PMC Article

    07/5/2014
    Interactions between ECIP1 and EIN2 or ethylene receptors regulate ethylene response and stress response.

    EIN2 regulates salt stress response and interacts with a MA3 domain-containing protein ECIP1 in Arabidopsis.
    Lei G, Shen M, Li ZG, Zhang B, Duan KX, Wang N, Cao YR, Zhang WK, Ma B, Ling HQ, Chen SY, Zhang JS.

    08/31/2013
    Data indicate that the expression and phosphorylation of ERF110 were regulated by ethylene via both Ethylene-Insensitive2-dependent and -independent pathways, which constitute a dual-and-opposing mechanism for ethylene in the regulation of bolting.

    Functional phosphoproteomic analysis reveals that a serine-62-phosphorylated isoform of ethylene response factor110 is involved in Arabidopsis bolting.
    Zhu L, Liu D, Li Y, Li N., Free PMC Article

    07/27/2013
    study demonstrated that EIN2 harboring a functional nuclear localization signal is subjected to a cleavage event, followed by transporting its carboxyl end (CEND) into the nucleus, where CEND acts to stabilize EIN3 and activate ethylene responses

    Activation of ethylene signaling is mediated by nuclear translocation of the cleaved EIN2 carboxyl terminus.
    Wen X, Zhang C, Ji Y, Zhao Q, He W, An F, Jiang L, Guo H., Free PMC Article

    05/18/2013
    reducing jasmonic acid levels, either mutationally or chemically, caused ein2 ethylene-insensitive mutants to become ethylene responsive. This effect was not seen with the ethylene-insensitive etr1-1 mutants that affect receptor function.

    Reducing jasmonic acid levels causes ein2 mutants to become ethylene responsive.
    Kim J, Patterson SE, Binder BM.

    03/9/2013
    Phosphorylation of EIN2 by CTR1 prevents EIN2 from signaling in the absence of ethylene, whereas inhibition of CTR1 upon ethylene perception is a signal for cleavage and nuclear localization of the EIN2 C terminus.

    CTR1 phosphorylates the central regulator EIN2 to control ethylene hormone signaling from the ER membrane to the nucleus in Arabidopsis.
    Ju C, Yoon GM, Shemansky JM, Lin DY, Ying ZI, Chang J, Garrett WM, Kessenbrock M, Groth G, Tucker ML, Cooper B, Kieber JJ, Chang C., Free PMC Article

    02/2/2013
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