| IRTA1 positivity helps identify a MALT-lymphoma-like subset of primary cutaneous marginal zone lymphomas, largely but not exclusively defined by IgM expression. | IRTA1 positivity helps identify a MALT-lymphoma-like subset of primary cutaneous marginal zone lymphomas, largely but not exclusively defined by IgM expression.
Carlsen ED, Bhavsar S, Cook JR, Swerdlow SH. | 03/19/2022 |
| The Multiple Roles of B Cells in the Pathogenesis of Sjogren's Syndrome. | The Multiple Roles of B Cells in the Pathogenesis of Sjögren's Syndrome.
Du W, Han M, Zhu X, Xiao F, Huang E, Che N, Tang X, Zou H, Jiang Q, Lu L., Free PMC Article | 10/30/2021 |
| Fc receptor-like 4 and 5 define human atypical memory B cells. | Fc receptor-like 4 and 5 define human atypical memory B cells.
Li H, Dement-Brown J, Liao PJ, Mazo I, Mills F, Kraus Z, Fitzsimmons S, Tolnay M. | 10/2/2021 |
| Gene expression profiling of epithelium-associated FcRL4(+) B cells in primary Sjogren's syndrome reveals a pathogenic signature. | Gene expression profiling of epithelium-associated FcRL4(+) B cells in primary Sjögren's syndrome reveals a pathogenic signature.
Verstappen GM, Ice JA, Bootsma H, Pringle S, Haacke EA, de Lange K, van der Vries GB, Hickey P, Vissink A, Spijkervet FKL, Lessard CJ, Kroese FGM., Free PMC Article | 08/7/2021 |
| IRTA1 and MNDA are useful markers in the differential diagnosis of marginal zone lymphomas (MZLs). | IRTA1 and MNDA Expression in Marginal Zone Lymphoma: Utility in Differential Diagnosis and Implications for Classification.
Wang Z, Cook JR. | 01/4/2020 |
| Abs with reactivity to commensal microbiota were enriched in FCRL4(+) cells. | Antibodies Encoded by FCRL4-Bearing Memory B Cells Preferentially Recognize Commensal Microbial Antigens.
Liu Y, McDaniel JR, Khan S, Campisi P, Propst EJ, Holler T, Grunebaum E, Georgiou G, Ippolito GC, Ehrhardt GRA., Free PMC Article | 04/13/2019 |
| We conclude that these activated B cells are a component of the local autoimmune response, and through their RANKL expression, can contribute to joint destruction. Furthermore, their expression of FcRL4 and their enrichment in the IgA isotype points towards a potential role for these cells in the link between mucosal and joint inflammation. | B cells expressing the IgA receptor FcRL4 participate in the autoimmune response in patients with rheumatoid arthritis.
Amara K, Clay E, Yeo L, Ramsköld D, Spengler J, Sippl N, Cameron JA, Israelsson L, Titcombe PJ, Grönwall C, Sahbudin I, Filer A, Raza K, Malmström V, Scheel-Toellner D., Free PMC Article | 03/31/2018 |
| intraepithelial FcRL4(+) B-cells are present in the salivary glands of pSS patients. These cells are likely involved in the epithelial changes seen in pSS. Their enrichment in parotid glands may explain why MALT lymphomas in pSS patients preferentially develop at this specific location. | FcRL4(+) B-cells in salivary glands of primary Sjögren's syndrome patients.
Haacke EA, Bootsma H, Spijkervet FKL, Visser A, Vissink A, Kluin PM, Kroese FGM. | 03/31/2018 |
| Commercially available IRTA1 antibody can immunohistochemically distinguish MALT lymphoma from other low-grade B-cell lymphomas. | Immunohistochemical analysis of the novel marginal zone B-cell marker IRTA1 in malignant lymphoma.
Ikeda JI, Kohara M, Tsuruta Y, Nojima S, Tahara S, Ohshima K, Kurashige M, Wada N, Morii E. | 09/2/2017 |
| decreased FCRL4 expression and association of FCRL2 expression with inflammatory markers and disease activity suggested the contribution of these molecules to rheumatoid arthritis inflammatory processes. | Investigation of the human FCRL1, 2, and 4 gene expressions in patients with rheumatoid arthritis.
Khanzadeh A, Habibagahi Z, Hosseini A, Amirghofran Z. | 08/12/2017 |
| Significantly increased FCRL4 mRNA only in Graves disease patients but not in Hashimoto patients compared to normal controls. | Expression Profile of Human Fc Receptor-Like 1, 2, and 4 Molecules in Peripheral Blood Mononuclear Cells of Patients with Hashimoto's Thyroiditis and Graves' Disease.
Rostamzadeh D, Dabbaghmanesh MH, Shabani M, Hosseini A, Amirghofran Z. | 06/4/2016 |
| The observed significant gene-environment interaction suggests that drinking and cooking oil use with FCRL4 gene polymorphism has a significant interaction. | Case-only designs for exploring the interaction between FCRL4 gene and suspected environmental factors in patients with ankylosing spondylitis.
Ding N, Hu Y, Zeng Z, Liu S, Liu L, Yang T, Wu S, Fan D, Xu S, Xu J, Wang J, Pan F. | 12/19/2015 |
| we provide evidence for involvement of HCK and FGR in FCRL4-mediated immunoregulation and for the functional importance of posttranslational modifications of the FCRL4 molecule. | Involvement of the HCK and FGR src-family kinases in FCRL4-mediated immune regulation.
Liu Y, Bezverbnaya K, Zhao T, Parsons MJ, Shi M, Treanor B, Ehrhardt GR., Free PMC Article | 08/22/2015 |
| IRTA1 and T-bet are positive markers for the diagnosis of nodal marginal zone lymphoma | Nodal reactive and neoplastic proliferation of monocytoid and marginal zone B cells: an immunoarchitectural and molecular study highlighting the relevance of IRTA1 and T-bet as positive markers.
Bob R, Falini B, Marafioti T, Paterson JC, Pileri S, Stein H. | 09/27/2014 |
| Data indicate that signaling by HIV-1 gp120 through integrin alpha4beta7 resulted in increased expression of the immunosuppressive cytokine TGF-beta1 and FcRL4. | The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression.
Jelicic K, Cimbro R, Nawaz F, Huang da W, Zheng X, Yang J, Lempicki RA, Pascuccio M, Van Ryk D, Schwing C, Hiatt J, Okwara N, Wei D, Roby G, David A, Hwang IY, Kehrl JH, Arthos J, Cicala C, Fauci AS., Free PMC Article | 01/25/2014 |
| The cytological features, growth pattern and IRTA1 positivity in nodal marginal zone lymphomas suggest they may derive from IRTA1(+) perifollicular B cells or monocytoid B cells detectable in reactive lymph nodes. | IRTA1 is selectively expressed in nodal and extranodal marginal zone lymphomas.
Falini B, Agostinelli C, Bigerna B, Pucciarini A, Pacini R, Tabarrini A, Falcinelli F, Piccioli M, Paulli M, Gambacorta M, Ponzoni M, Tiacci E, Ascani S, Martelli MP, Dalla Favera R, Stein H, Pileri SA. | 04/20/2013 |
| The FCRL4 polymorphisms may play an important role in the susceptibility and severity of ankylosing spondylitis in the Chinese Han population. | Association of FCRL4 polymorphisms on disease susceptibility and severity of ankylosing spondylitis in Chinese Han population.
Zeng Z, Duan Z, Zhang T, Wang S, Li G, Mei Y, Gao J, Ge R, Ye D, Zou Y, Xu S, Xu J, Zhang L, Pan F. | 03/30/2013 |
| In cellular binding assays, as a bona fide receptor FcRL4 binds efficiently to immunoglobulin (Ig)A. | Cutting edge: human FcRL4 and FcRL5 are receptors for IgA and IgG.
Wilson TJ, Fuchs A, Colonna M., Free PMC Article | 08/11/2012 |
| Data suggest that expression of FcRL4 in B-cells results in inhibition of BCR signaling at point of Syk phosphorylation by mechanism that involves phosphorylation of FcRL4 and its association with SHP-1/SHP-2. | FcRL4 acts as an adaptive to innate molecular switch dampening BCR signaling and enhancing TLR signaling.
Sohn HW, Krueger PD, Davis RS, Pierce SK., Free PMC Article | 02/18/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. | 04/7/2010 |
| FCRL4 is located on atypical memory B cells population significantly expanded in Plasmodium falciparum-exposed Malian adults and children | Atypical memory B cells are greatly expanded in individuals living in a malaria-endemic area.
Weiss GE, Crompton PD, Li S, Walsh LA, Moir S, Traore B, Kayentao K, Ongoiba A, Doumbo OK, Pierce SK., Free PMC Article | 01/21/2010 |
| Down-regulation of FCRL4 is associated with acute lymphoblastic leukemia. | Low representation of Fc receptor-like 1-5 molecules in leukemic cells from Iranian patients with acute lymphoblastic leukemia.
Kazemi T, Asgarian-Omran H, Memarian A, Shabani M, Sharifian RA, Vossough P, Ansaripour B, Rabbani H, Shokri F., Free PMC Article | 01/21/2010 |
| Fc receptor-like 1-5 molecules are similarly expressed in progressive and indolent clinical subtypes of B-cell chronic lymphocytic leukemia. | Fc receptor-like 1-5 molecules are similarly expressed in progressive and indolent clinical subtypes of B-cell chronic lymphocytic leukemia.
Kazemi T, Asgarian-Omran H, Hojjat-Farsangi M, Shabani M, Memarian A, Sharifian RA, Razavi SM, Jeddi-Tehrani M, Rabbani H, Shokri F. | 01/21/2010 |
| role of IRTA1 in the immune function of B cells within epithelia | Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT).
Falini B, Tiacci E, Pucciarini A, Bigerna B, Kurth J, Hatzivassiliou G, Droetto S, Galletti BV, Gambacorta M, Orazi A, Pasqualucci L, Miller I, Kuppers R, Dalla-Favera R, Cattoretti G. | 01/21/2010 |