| HSPA12B overexpression interacts with AKAP12 and downregulate TXNIP in diabetic rats following acute myocardial infarction. | Regulation of A-Kinase-Anchoring Protein 12 by Heat Shock Protein A12B to Prevent Ventricular Dysfunction Following Acute Myocardial Infarction in Diabetic Rats.
Selvaraju V, Suresh SC, Thirunavukkarasu M, Mannu J, Foye JLC, Mathur PP, Palesty JA, Sanchez JA, McFadden DW, Maulik N. | 01/20/2018 |
| SSeCKS play an important role in sciatic nerve fibers and neurons in spinal cord and dorsal root ganglion during inflammation. | Expression of SRC suppressed C kinase substrate in rat neural tissues during inflammation.
Yan M, Zhao J, Zhu S, Shao X, Zhang L, Gao H, Yao D. | 11/29/2014 |
| Dynamic temporal changes in SSeCKS and Src expression may modulate angiogenesis and cerebral edema formation after focal cerebral ischemia. | Temporal profile of Src, SSeCKS, and angiogenic factors after focal cerebral ischemia: correlations with angiogenesis and cerebral edema.
Zan L, Wu H, Jiang J, Zhao S, Song Y, Teng G, Li H, Jia Y, Zhou M, Zhang X, Qi J, Wang J., Free PMC Article | 05/12/2012 |
| Data show that SSeCKS can regulate LPS-induced TNF-alpha secretion through beta-1,4-GalT-I in rat primary astrocytes. | The relationship between Src-suppressed C kinase substrate and β-1,4 galactosyltransferase-I in the process of lipopolysaccharide-induced TNF-α secretion in rat primary astrocytes.
Shao B, Li C, Yang H, Shen A, Wu X, Yuan Q, Wu X, Kang L, Liu Z, Zhang G, Lu X, Cheng C. | 04/21/2012 |
| study delineates that SSeCKS may be important for host defenses in spinal inflammation and suggests a valuable molecular mechanism by which astrocytes modify neuronal viability during pathological states | Involvement of SRC-suppressed C kinase substrate in neuronal death caused by the lipopolysaccharide-induced reactive astrogliosis.
Wang P, Sun L, Shen A, Yang J, Li X, Liu H, Tao T, Cheng C, Lu X. | 04/23/2011 |
| Data show that SSeCKS is involved in the endothelial hyperpermeability induced by IL-1beta and TNF-alpha in inflammatory process. | Role of src-suppressed C kinase substrate in rat pulmonary microvascular endothelial hyperpermeability stimulated by inflammatory cytokines.
You QH, Sun GY, Wang N, Chen S, Luo QL. | 01/29/2011 |
| Results suggest that SRC-suppressed C kinase substrate (SSeCKS) might be critical for the activation of astrocytes in neuropathic pain. | A critical role of SRC-suppressed C kinase substrate in rat astrocytes after chronic constriction injury.
Xia Y, Liu H, Shen A, Liu Y, Sun L, Tao T, Ke Q, Cheng C. | 01/15/2011 |
| Platelet-activating factor can upregulate the expression of SSeCKS mRNA in a dose- and time-dependent manner in rat pulmonary microvascular endothelial cells. | [Induction effect of platelet-activating factor on Src-suppressed C kinase substrate gene expression in rat pulmonary microvascular endothelial cells].
Chen S, Sun GY, You QH, Wang N. | 12/11/2010 |
| Data indicate that SSeCKS may play a critical role in Abeta-induced PC12 cells apoptosis through its phosphorylation. | SSeCKS promote beta-amyloid-induced PC12 cells neurotoxicity by up-regulating tau phosphorylation in Alzheimer's disease.
Cui Z, Tao T, Cheng C, Yang J, Shen Q, Ji Y, Li X, Liu H, Shen A, Lu X. | 09/27/2010 |
| SSeCKS promoted p38 and JNK activation in Schwann cells treated by TNF-alpha. | SSeCKS promotes tumor necrosis factor-alpha autocrine via activating p38 and JNK pathways in Schwann cells.
Zhou Z, Tao T, Ji Y, Yang H, Wang Y, Cheng C, Shen A, Lu X. | 09/20/2010 |
| SSeCKS upregulated in astrocytes in experimental autoimmune encephalomyelitis (EAE); understanding the mechanism of SSeCKS in the pathogenesis of EAE may contribute to the development of new therapeutic strategies against EAE and multiple sclerosis | Involvement of Src-suppressed C kinase substrate in experimental autoimmune encephalomyelitis: a link between release of astrocyte proinflammatory factor and oligodendrocyte apoptosis.
Li X, Yan M, Hu L, Sun L, Zhang F, Ji H, Jiang J, Wang P, Liu H, Gao Y, Tao T, He X, Cheng C, Shen A. | 09/20/2010 |
| signaling component essential for IL-17F-induced endothelial hyperpermeability | Interleukin-17F-induced pulmonary microvascular endothelial monolayer hyperpermeability via the protein kinase C pathway.
You QH, Sun GY, Wang N, Shen JL, Wang Y. | 07/5/2010 |
| In long-term SSeCKS-reduced Schwann cells, cell morphology changed and myelin gene expression induced by cAMP was accelerated. Myelination was also enhanced in SSeCKS-suppressed Schwann cells co-culture with dorsal root ganglion (DRG). | SSeCKS is a suppressor in Schwann cell differentiation and myelination.
Ji Y, Tao T, Cheng C, Yang H, Wang Y, Yang J, Liu H, He X, Wang H, Shen A. | 03/29/2010 |
| LPS could induce up-regulation of SSeCKS, and methylprednisolone sodium succinate inhibited the increase of SSeCKS mRNA induced by LPS. | [Studies on the expression of Src-suppressed C kinase substrate mRNA in pulmonary microvascular endothelial cells induced by lipopolysaccharide].
Li H, Sun GY, Fei LM, Shen JL. | 01/21/2010 |
| These results indicate that Cited2 and Akap12 are silenced in radiation-induced osteosarcomas, and therefore are novel candidate tumor-suppressor genes of this tumor. | Silencing of Cited2 and Akap12 genes in radiation-induced rat osteosarcomas.
Daino K, Roch-Lefevre S, Ugolin N, Altmeyer-Morel S, Guilly MN, Chevillard S. | 01/21/2010 |
| SSeCKS modulate Schwann cells adhesion, spreading and migration by reorganization of the actin cytoskeleton. | Essential role of SRC suppressed C kinase substrates in Schwann cells adhesion, spreading and migration.
Yan M, Cheng C, Jiang J, Liu Y, Gao Y, Guo Z, Liu H, Shen A. | 01/21/2010 |
| participates in the adaptive response to peripheral nerve injury and may be associated with regeneration | Spatiotemporal expression of SSeCKS in injured rat sciatic nerve.
Chen L, Qin J, Cheng C, Niu S, Liu Y, Shi S, Liu H, Shen A. | 01/21/2010 |
| SSeCKS is located downstream of PKC; SSeCKS and PKC are both necessary for LPS-induced stress fiber formation. | Lipopolysaccharide induces expression of SSeCKS in rat lung microvascular endothelial cell.
Cheng C, Liu H, Ge H, Qian J, Qin J, Sun L, Chen M, Yan M, Shen A. | 01/21/2010 |
| that SSeCKS is involved in the lipopolysaccharide-induced TNF-alpha expression in astrocytes mediated by protein kinase C | Src suppressed C kinase substrate regulates the lipopolysaccharide-induced TNF-alpha biosynthesis in rat astrocytes.
Sun LL, Cheng C, Liu HO, Shen CC, Xiao F, Qin J, Yang JL, Shen AG. | 01/21/2010 |
| SSeCKS could be detected in the whole brain of developing rat embryos and reached its peak at 1 week after birth, while during mature period, its level was decreasing | Developmental regulation of SSeCKS expression in rat brain.
Chen L, Qin J, Cheng C, Liu H, Niu S, Qian J, Sun L, Xiao F, Shi S, Shen A. | 01/21/2010 |
| SSeCKS functions in PDGF-BB-, LPA-, EPA-, and NaB-mediated cell signaling | Ligand-specific control of src-suppressed C kinase substrate gene expression.
Coats SR, Pabón-Peña LM, Covington JW, Vaughan DE. | 01/21/2010 |
| Transfected rat SSeCKS can suppress Src-induced oncogenesis in 3T3 cells by modulating gene expression downstream of Src kinase activity. | SSeCKS/Gravin/AKAP12 attenuates expression of proliferative and angiogenic genes during suppression of v-Src-induced oncogenesis.
Liu Y, Gao L, Gelman IH., Free PMC Article | 01/21/2010 |
| SSeCKS modulate endothelial cells adhesion and spreading by reorganization of the actin cytoskeleton. | Essential role of Src suppressed C kinase substrates in endothelial cell adhesion and spreading.
Cheng C, Liu H, Ge H, Qian J, Qin J, Sun L, Shen A. | 01/21/2010 |
| alternately targeted anchoring protein isoforms provide a mechanism for genetic control of signaling specificity by AKAP12 | Multiple promoters direct expression of three AKAP12 isoforms with distinct subcellular and tissue distribution profiles.
Streb JW, Kitchen CM, Gelman IH, Miano JM. | 01/21/2010 |
| TNF-alpha induced rapid phosphorylation of protein kinase C substrates in C6 glioma cells, and upregulated SSeCKS expression in a time and concentration dependent manner. | Changes of Src-suppressed C kinase substrate expression in cytokine induced reactive C6 glioma cells.
Sun LL, Cheng C, Liu HO, Xiao F, Qin J, Shao XY, Shen AG., Free PMC Article | 01/21/2010 |