| Roles for Ndel1 in keratin organization and desmosome function. | Roles for Ndel1 in keratin organization and desmosome function.
Kim YB, Hlavaty D, Maycock J, Lechler T., Free PMC Article | 02/12/2022 |
| Role of NDEL1 and VEGF/VEGFR-2 in Mouse Hippocampus After Status Epilepticus. | Role of NDEL1 and VEGF/VEGFR-2 in Mouse Hippocampus After Status Epilepticus.
Zhu L, Dai S, Lu D, Xu P, Chen L, Han Y, Zhong L, Chang L, Wu Q., Free PMC Article | 09/18/2021 |
| results highlight S-Nitrosylation as a key activity-dependent mechanism underlying neonatal brain maturation and suggest that reduction of S-Nitrosylation of NDEL1 acts as a pathological factor mediating neurodevelopmental abnormalities caused by maternal alcohol exposure | Developmental Alcohol Exposure Impairs Activity-Dependent S-Nitrosylation of NDEL1 for Neuronal Maturation.
Saito A, Taniguchi Y, Kim SH, Selvakumar B, Perez G, Ballinger MD, Zhu X, Sabra J, Jallow M, Yan P, Ito K, Rajendran S, Hirotsune S, Wynshaw-Boris A, Snyder SH, Sawa A, Kamiya A., Free PMC Article | 05/5/2018 |
| This study showed that Ndel1 Maintain Postnatal CA1 Hippocampus Integrity in mice. | Ndel1 and Reelin Maintain Postnatal CA1 Hippocampus Integrity.
Jiang Y, Gavrilovici C, Chansard M, Liu RH, Kiroski I, Parsons K, Park SK, Teskey GC, Rho JM, Nguyen MD., Free PMC Article | 07/15/2017 |
| Data indicate that NDEL1 is inducibly expressed in the adult nervous system, and signaling via the CREB/CRE transcriptional pathway is likely involved. Role of NDEL1 in neuronal migration and neurite outgrowth during development raises the interesting prospect that inducible NDEL1 in the mature nervous system could contribute to the well-characterized structural and functional plasticity resulting from repetitive seizures | Status epilepticus stimulates NDEL1 expression via the CREB/CRE pathway in the adult mouse brain.
Choi YS, Lee B, Hansen KF, Aten S, Horning P, Wheaton KL, Impey S, Hoyt KR, Obrietan K., Free PMC Article | 07/15/2017 |
| NDEL1 facilitates the reversal of somatodendritic traansport in the proximal axon. | Dynein Regulator NDEL1 Controls Polarized Cargo Transport at the Axon Initial Segment.
Kuijpers M, van de Willige D, Freal A, Chazeau A, Franker MA, Hofenk J, Rodrigues RJ, Kapitein LC, Akhmanova A, Jaarsma D, Hoogenraad CC. | 07/2/2016 |
| study provided comprehensive documentation of the expression patterns of Nde1 and Ndel1 in cultured cells as well as in mouse and human brains, and also highlighting that dosage effects of these two proteins might contribute to some cases of mental disorder | The expression and roles of Nde1 and Ndel1 in the adult mammalian central nervous system.
Pei Z, Lang B, Fragoso YD, Shearer KD, Zhao L, Mccaffery PJ, Shen S, Ding YQ, McCaig CD, Collinson JM., Free PMC Article | 01/17/2015 |
| Results suggest that NDEL1 might interact with DISC1 to activate ERK signaling and function as a potential protective factor during the spontaneous seizure period after pilocarpine-induced status epilepticus | NDEL1 was decreased in the CA3 region but increased in the hippocampal blood vessel network during the spontaneous seizure period after pilocarpine-induced status epilepticus.
Wu Q, Li Y, Shu Y, Feng L, Zhou L, Yue ZW, Luo ZH, Wu ZG, Xiao B. | 12/20/2014 |
| Results show that LIS1 acts via the LIS1-NDEL1-dynein complex to regulate astral microtubule MT plus-ends dynamics and establish proper contacts of MTs with the cell cortex to ensure precise cell division. | LIS1 controls mitosis and mitotic spindle organization via the LIS1-NDEL1-dynein complex.
Moon HM, Youn YH, Pemble H, Yingling J, Wittmann T, Wynshaw-Boris A., Free PMC Article | 08/9/2014 |
| Nuclear distribution element-like 1 (Ndel1 or Nudel) was firstly described as a regulator of the cytoskeleton in microtubule and intermediate filament dynamics and microtubule-based transport. | Ndel1, Nudel (Noodle): flexible in the cell?
Chansard M, Hong JH, Park YU, Park SK, Nguyen MD. | 02/4/2012 |
| Expressing a mutant Ndel1 lacking key phosphorylation sites shuts down organelle transport completely in axons. | A Cdk5-dependent switch regulates Lis1/Ndel1/dynein-driven organelle transport in adult axons.
Pandey JP, Smith DS., Free PMC Article | 01/21/2012 |
| palmitoylated Ndel1 reduced cytoplasmic dynein activity as judged by Golgi distribution, VSVG and short microtubule trafficking, transport of endogenous Ndel1 and LIS1 from neurite tips to the cell body and neuronal migration | Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity.
Shmueli A, Segal M, Sapir T, Tsutsumi R, Noritake J, Bar A, Sapoznik S, Fukata Y, Orr I, Fukata M, Reiner O., Free PMC Article | 02/8/2010 |
| Lis1 and Ndel1 are essential for normal cortical neuronal migration, neurite outgrowth, and function of the microtubule organizing center in a dose-dependent manner. | Distinct dose-dependent cortical neuronal migration and neurite extension defects in Lis1 and Ndel1 mutant mice.
Youn YH, Pramparo T, Hirotsune S, Wynshaw-Boris A., Free PMC Article | 01/25/2010 |
| These findings demonstrate a surprising role of aPKC-Aurora A-NDEL1 pathway in microtubule remodelling during neurite extension. | An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics.
Mori D, Yamada M, Mimori-Kiyosue Y, Shirai Y, Suzuki A, Ohno S, Saya H, Wynshaw-Boris A, Hirotsune S. | 01/21/2010 |
| Results report that reduction of Lis1 and Ndel1 in a mitotic cell line impairs prophase nuclear envelope invagination. | Lis1 and Ndel1 influence the timing of nuclear envelope breakdown in neural stem cells.
Hebbar S, Mesngon MT, Guillotte AM, Desai B, Ayala R, Smith DS., Free PMC Article | 01/21/2010 |
| Ndel1 promotes axonal regeneration; activating this endogenous repair mechanism may enhance neuroregeneration during acute and chronic axonal degeneration. | Ndel1 promotes axon regeneration via intermediate filaments.
Toth C, Shim SY, Wang J, Jiang Y, Neumayer G, Belzil C, Liu WQ, Martinez J, Zochodne D, Nguyen MD., Free PMC Article | 01/21/2010 |
| Nudel facilitates cell migration by sequestering Cdc42GAP at the leading edge to stabilize active Cdc42 in response to extracellular stimuli. | Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells.
Shen Y, Li N, Wu S, Zhou Y, Shan Y, Zhang Q, Ding C, Yuan Q, Zhao F, Zeng R, Zhu X. | 01/21/2010 |
| The predicted peptide product resulting from the Scottish translocation removes the interaction domain for Nudel. Nudel is able to act as a bridge between DISC1 and Lis1 to allow formation of a trimolecular complex. | Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders.
Brandon NJ, Handford EJ, Schurov I, Rain JC, Pelling M, Duran-Jimeniz B, Camargo LM, Oliver KR, Beher D, Shearman MS, Whiting PJ. | 01/21/2010 |
| Ndel1 deficiency results in neuronal migration defects and early embryonic lethality | Complete loss of Ndel1 results in neuronal migration defects and early embryonic lethality.
Sasaki S, Mori D, Toyo-oka K, Chen A, Garrett-Beal L, Muramatsu M, Miyagawa S, Hiraiwa N, Yoshiki A, Wynshaw-Boris A, Hirotsune S., Free PMC Article | 01/21/2010 |
| NUDEL is important for NF assembly, transport and neuronal integrity. NUDEL facilitates the polymerization of NFs through a direct interaction with the NF light subunit (NF-L). | A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons.
Nguyen MD, Shu T, Sanada K, Larivière RC, Tseng HC, Park SK, Julien JP, Tsai LH. | 01/21/2010 |
| Aurora-A-mediated phosphorylation of NDEL1 is essential for centrosomal separation and centrosomal maturation and for mitotic entry | NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment.
Mori D, Yano Y, Toyo-oka K, Yoshida N, Yamada M, Muramatsu M, Zhang D, Saya H, Toyoshima YY, Kinoshita K, Wynshaw-Boris A, Hirotsune S., Free PMC Article | 01/21/2010 |