| Gstp1 negatively regulates blood pressure in hypertensive rat via promoting APLNR ubiquitination degradation mediated by Nedd4. | Gstp1 negatively regulates blood pressure in hypertensive rat via promoting APLNR ubiquitination degradation mediated by Nedd4.
Lei J, Zheng F, Chen L, Zhang R, Yang Y, Yin Z, Luo L. | 07/18/2024 |
| The apelin-apela receptor APJ is necessary for formation and healing of ischemia reperfusion-induced gastric ulcer in rats. | The apelin-apela receptor APJ is necessary for formation and healing of ischemia reperfusion-induced gastric ulcer in rats.
Gemici B, Birsen İ, İzgüt-Uysal VN. | 07/12/2023 |
| ELABELA-APJ-Akt/YAP Signaling Axis: A Novel Mechanism of Aerobic Exercise in Cardioprotection of Myocardial Infarction Rats. | ELABELA-APJ-Akt/YAP Signaling Axis: A Novel Mechanism of Aerobic Exercise in Cardioprotection of Myocardial Infarction Rats.
Xi Y, Li Y, Ren W, Bo W, Ma Y, Pan S, Gong DW, Tian Z. | 06/16/2023 |
| The effect of experimental varicocele on the apelin and APJ expressions in rat testis tissue. | The effect of experimental varicocele on the apelin and APJ expressions in rat testis tissue.
Akkan SS, İzgüt-Uysal VN, Çakır T, Özbey Ö, Üstünel İ. | 11/21/2020 |
| The enhanced activity of endogenous apelin and APJ receptor in paraventricular nucleus contributes to sympathetic activation in hypertension. | Superoxide anions modulate the performance of apelin in the paraventricular nucleus on sympathetic activity and blood pressure in spontaneously hypertensive rats.
Zhao Y, Li Y, Li Z, Xu B, Chen P, Yang X. | 07/4/2020 |
| The present study describes the role of spinal apelin in the processing of neuropathic pain induced by chronic constriction of the sciatic nerve, and elucidates receptor and intracellular mechanisms underlying apelin-mediated pain modulation. | Effect of the spinal apelin‑APJ system on the pathogenesis of chronic constriction injury‑induced neuropathic pain in rats.
Xiong Q, He W, Wang H, Zhou J, Zhang Y, He J, Yang C, Zhang B., Free PMC Article | 04/7/2018 |
| Apelin- induced recovery of ERK1/2 phosphorylation and Kappa Opioid receptors -APJ dimerization may nominate apelin as a therapeutic goal in treatment of renovascular hypertension. | Heterodimerization of apelin and opioid receptors and cardiac inotropic and lusitropic effects of apelin in 2K1C hypertension: Role of pERK1/2 and PKC.
Rostamzadeh F, Najafipour H, Yeganeh-Hajahmadi M, Esmaeili-Mahani S, Joukar S, Iranpour M. | 12/2/2017 |
| Apelin receptor and apelin mRNA were significantly increased in the left ventricle following a high fat diet. | The role of apelin in central cardiovascular regulation in rats with post-infarct heart failure maintained on a normal fat or high fat diet.
Czarzasta K, Cudnoch-Jedrzejewska A, Szczepanska-Sadowska E, Fus L, Puchalska L, Gondek A, Dobruch J, Gomolka R, Wrzesien R, Zera T, Gornicka B, Kuch M. | 09/16/2017 |
| Electroacupuncture stimulation could alleviate inflammatory pain, at least in part, by restoring apelin and APJ mRNA and protein expression levels, which are downregulated in the complete Freund's adjuvant pain model. | The Effects of Electroacupuncture on the Apelin/APJ System in the Spinal Cord of Rats With Inflammatory Pain.
Wang K, Ju Z, Yong Y, Chen T, Song J, Zhou J. | 07/15/2017 |
| Apelin-36-[L28C(30kDa-PEG)] provides a starting point for the development of diabetes therapeutics that are devoid of the blood pressure effects associated with canonical APJ activation | Apelin-36 Modulates Blood Glucose and Body Weight Independently of Canonical APJ Receptor Signaling.
Galon-Tilleman H, Yang H, Bednarek MA, Spurlock SM, Paavola KJ, Ko B, To C, Luo J, Tian H, Jermutus L, Grimsby J, Rondinone CM, Konkar A, Kaplan DD., Free PMC Article | 06/3/2017 |
| APJ mRNA levels were similar in placenta and mesometrial triangle at embryonic day 13. In the placenta, APJ expression was increased at E17 versus the E13 level and reduced at E21, whereas in the Meso-tr an opposite modulation was observed. | Apelin Controls Fetal and Neonatal Glucose Homeostasis and Is Altered by Maternal Undernutrition.
Mayeur S, Wattez JS, Lukaszewski MA, Lecoutre S, Butruille L, Drougard A, Eberlé D, Bastide B, Laborie C, Storme L, Knauf C, Vieau D, Breton C, Lesage J. | 07/16/2016 |
| Apelin receptor mRNA and protein expression in the myocardium and aorta of rats with Goldblatt hypertension. | Investigation of changes in apelin receptor mRNA and protein expression in the myocardium and aorta of rats with two-kidney, one-clip (2K1C) Goldblatt hypertension.
Najafipour H, Vakili A, Shahouzehi B, Soltani Hekmat A, Masoomi Y, Yeganeh Hajahmadi M, Esmaeli-Mahani S. | 02/20/2016 |
| Apela binds directly to APJ and acts through the Gi pathway. Apela is expressed exclusively in adult kidney and regulates fluid homeostasis | Apela Regulates Fluid Homeostasis by Binding to the APJ Receptor to Activate Gi Signaling.
Deng C, Chen H, Yang N, Feng Y, Hsueh AJ., Free PMC Article | 10/24/2015 |
| results suggested that static pressure up-regulates APJ expression to promote cardiomyocyte hypertrophy by a PI3K-autophagy pathway | A static pressure sensitive receptor APJ promote H9c2 cardiomyocyte hypertrophy via PI3K-autophagy pathway.
Xie F, Liu W, Feng F, Li X, Yang L, Lv D, Qin X, Li L, Chen L. | 06/6/2015 |
| It has been implicated in obesity-related hypertension. | Regulation of apelin and its receptor expression in adipose tissues of obesity rats with hypertension and cultured 3T3-L1 adipocytes.
Wu H, Cheng XW, Hao C, Zhang Z, Yao H, Murohara T, Dai Q., Free PMC Article | 10/25/2014 |
| Data show that the expression of apelin mRNA and protein in ischemic and non-ischemic kidneys was increased significantly; the expression of APJ mRNA and protein in ischemic kidneys had no significance, while that in non-ischemic kidneys was decreased. | [Effect of puerarin combined with felodipine on mRNA and protein expression of apelin and APJ in renovascular hypertensive rat].
Huang ZG, Bai S, Chen L, Wang JT, Ding BP. | 07/27/2013 |
| Data suggest that apelin receptor has role in regulation of hypothalamic-pituitary-adrenal (HPA) axis response in several models of acute stress and has gender-specific function in peripheral immune activation of HPA axis. | Stress-dependent and gender-specific neuroregulatory roles of the apelin receptor in the hypothalamic-pituitary-adrenal axis response to acute stress.
Newson MJ, Pope GR, Roberts EM, Lolait SJ, O'Carroll AM., Free PMC Article | 03/2/2013 |
| Physical exercise decreased apelin expression and elevated APJ expression in pulmonary tissues of rats with hypoxic pulmonary hypertension. | [Effect of swimming exercise on the expression of apelin and its receptor in pulmonary tissues of rats with hypoxic pulmonary hypertension].
Chen S, Xue F, Jin HL, Chen L, Chen Y, Wang GF, Fan XF, Gong YS. | 02/16/2013 |
| Reduction in APJ gene expression during renovascular hypertension in a rat model. | Apelin receptor expression in ischemic and non- ischemic kidneys and cardiovascular responses to apelin in chronic two-kidney-one-clip hypertension in rats.
Najafipour H, Soltani Hekmat A, Nekooian AA, Esmaeili-Mahani S. | 01/26/2013 |
| At term, plasma levels of apelin were not modulated by maternal hypertension but APJ expression was increased in placenta and lung but reduced in heart. | Maternal hypertension induces tissue-specific modulations of the apelinergic system in the fetoplacental unit in rat.
Ivars J, Butruille L, Knauf C, Bouckenooghe T, Mayeur S, Vieau D, Valet P, Deruelle P, Lesage J. | 08/11/2012 |
| APJ exhibits nuclear localization in pulmonary epithelium. | The apelinergic system in the developing lung: expression and signaling.
Piairo P, Moura RS, Nogueira-Silva C, Correia-Pinto J. | 03/31/2012 |
| These findings bring new insights into apelin receptor activation and show that Phe(255) and Trp(259), by interacting with the C-terminal Phe of the pyroglutamyl form of apelin 13 (pE13F) or K17F, are crucial for apelin receptor internalization. | By interacting with the C-terminal Phe of apelin, Phe255 and Trp259 in helix VI of the apelin receptor are critical for internalization.
Iturrioz X, Gerbier R, Leroux V, Alvear-Perez R, Maigret B, Llorens-Cortes C., Free PMC Article | 12/11/2010 |
| While apelin/APJ myocardial expression decreases, apelin plasma levels increase in left ventricular hypertrophy | Correlation between plasma levels of apelin and myocardial hypertrophy in rats and humans: possible target for treatment?
Falcão-Pires I, Gonçalves N, Gavina C, Pinho S, Teixeira T, Moura C, Amorim MJ, Pinho P, Areias JC, Leite-Moreira A. | 05/3/2010 |
| data support a role for the apelin-APJ system in the regulation of smooth muscle, epithelial and goblet cell function in the GI tract | Ontogeny of apelin and its receptor in the rodent gastrointestinal tract.
Wang G, Kundu R, Han S, Qi X, Englander EW, Quertermous T, Greeley GH Jr., Free PMC Article | 02/1/2010 |
| Rats with cirrhosis treated with the apelin receptor antagonist showed diminished hepatic fibrosis and vessel density, improved cardiovascular performance, and renal function and lost ascites | The hepatic apelin system: a new therapeutic target for liver disease.
Principe A, Melgar-Lesmes P, Fernández-Varo G, del Arbol LR, Ros J, Morales-Ruiz M, Bernardi M, Arroyo V, Jiménez W. | 01/21/2010 |