| Heterodimerization of Chemoreceptors TAS1R3 and mGlu2 in Human Blood Leukocytes. | Heterodimerization of Chemoreceptors TAS1R3 and mGlu(2) in Human Blood Leukocytes.
Ball L, Bauer J, Krautwurst D., Free PMC Article | 08/31/2023 |
| Prediction of dynamic allostery for the transmembrane domain of the sweet taste receptor subunit, TAS1R3. | Prediction of dynamic allostery for the transmembrane domain of the sweet taste receptor subunit, TAS1R3.
Sanematsu K, Yamamoto M, Nagasato Y, Kawabata Y, Watanabe Y, Iwata S, Takai S, Toko K, Matsui T, Wada N, Shigemura N., Free PMC Article | 04/10/2023 |
| TAS1R3 and TAS2R38 Polymorphisms Affect Sweet Taste Perception: An Observational Study on Healthy and Obese Subjects. | TAS1R3 and TAS2R38 Polymorphisms Affect Sweet Taste Perception: An Observational Study on Healthy and Obese Subjects.
Cecati M, Vignini A, Borroni F, Pugnaloni S, Alia S, Sabbatinelli J, Nicolai G, Taus M, Santarelli A, Fabri M, Mazzanti L, Emanuelli M., Free PMC Article | 05/28/2022 |
| Polymorphic variants in Sweet and Umami taste receptor genes and birthweight. | Polymorphic variants in Sweet and Umami taste receptor genes and birthweight.
Farinella R, Erbi I, Bedini A, Donato S, Gentiluomo M, Angelucci C, Lupetti A, Cuttano A, Moscuzza F, Tuoni C, Rizzato C, Ciantelli M, Campa D., Free PMC Article | 12/11/2021 |
| Current Progress in Understanding the Structure and Function of Sweet Taste Receptor. | Current Progress in Understanding the Structure and Function of Sweet Taste Receptor.
Yang L, Cui M, Liu B. | 10/9/2021 |
| Artificial Sweeteners Disrupt Tight Junctions and Barrier Function in the Intestinal Epithelium through Activation of the Sweet Taste Receptor, T1R3. | Artificial Sweeteners Disrupt Tight Junctions and Barrier Function in the Intestinal Epithelium through Activation of the Sweet Taste Receptor, T1R3.
Shil A, Olusanya O, Ghufoor Z, Forson B, Marks J, Chichger H., Free PMC Article | 02/20/2021 |
| Binding Hotspot and Activation Mechanism of Maltitol and Lactitol toward the Human Sweet Taste Receptor. | Binding Hotspot and Activation Mechanism of Maltitol and Lactitol toward the Human Sweet Taste Receptor.
Mahalapbutr P, Lee VS, Rungrotmongkol T. | 01/23/2021 |
| Conserved Residues Control the T1R3-Specific Allosteric Signaling Pathway of the Mammalian Sweet-Taste Receptor. | Conserved Residues Control the T1R3-Specific Allosteric Signaling Pathway of the Mammalian Sweet-Taste Receptor.
Chéron JB, Soohoo A, Wang Y, Golebiowski J, Antonczak S, Jiang P, Fiorucci S., Free PMC Article | 10/3/2020 |
| Modeling and Structural Characterization of the Sweet Taste Receptor Heterodimer. | Modeling and Structural Characterization of the Sweet Taste Receptor Heterodimer.
Perez-Aguilar JM, Kang SG, Zhang L, Zhou R. | 08/13/2020 |
| Using homology modeling, molecular docking and molecular dynamics (MD) simulations, this study investigates the effects of five natural umami ligands on the structural dynamics of T1R1-T1R3. | Understanding the molecular mechanism of umami recognition by T1R1-T1R3 using molecular dynamics simulations.
Liu H, Da LT, Liu Y. | 06/20/2020 |
| Structural insights into the differences among lactisole derivatives in inhibitory mechanisms against the human sweet taste receptor. | Structural insights into the differences among lactisole derivatives in inhibitory mechanisms against the human sweet taste receptor.
Nakagita T, Ishida A, Matsuya T, Kobayashi T, Narukawa M, Hirokawa T, Hashimoto M, Misaka T., Free PMC Article | 12/7/2019 |
| The data further reveal that the C terminus of the extracellular cysteine-rich domain needs to be properly folded for T1R3 dimerization and co-trafficking, but not for surface expression of T1R2 alone. These results guided the modeling of the T1R2-T1R3 dimer in living cells. | Structural architecture of a dimeric class C GPCR based on co-trafficking of sweet taste receptor subunits.
Park J, Selvam B, Sanematsu K, Shigemura N, Shukla D, Procko E., Free PMC Article | 10/19/2019 |
| Studied association of taste 1 receptor member 1 (TAS1R1) and taste 1 receptor member 3 (TAS1R3) single nucleotide polymorphisms (SNPs) with food choices at a buffet meal. and found certain TAS1R1 and TAS1R3 SNPs to be associated with fat and savoury-tasting and protein-rich food choices following a laboratory buffet in humans. | TAS1R1 and TAS1R3 Polymorphisms Relate to Energy and Protein-Rich Food Choices from a Buffet Meal Respectively.
Han P, Keast R, Roura E., Free PMC Article | 02/23/2019 |
| These studies are the first to demonstrate a protective effect of an artificial sweetener, through the sweet taste receptor T1R3, on VEGF-induced vasculogenesis in a retinal microvascular endothelial cell line. | Activation of the sweet taste receptor T1R3 by sucralose attenuates VEGF-induced vasculogenesis in a cell model of the retinal microvascular endothelium.
Lizunkova P, Enuwosa E, Chichger H., Free PMC Article | 02/2/2019 |
| We observe that binding of agonists to VFD2 of TAS1R2 leads to major conformational changes to form a TM6/TM6 interface between TMDs of TAS1R2 and TAS1R3, which is consistent with the activation process observed biophysically on the metabotropic glutamate receptor 2 homodimer. | Activation mechanism of the G protein-coupled sweet receptor heterodimer with sweeteners and allosteric agonists.
Kim SK, Chen Y, Abrol R, Goddard WA 3rd, Guthrie B., Free PMC Article | 04/21/2018 |
| Regarding "consumption of carbohydrates (% energy) and higher amount of sweet foods, respectively...no associations were found for the TAS1R3 alleles." | Salivary leptin and TAS1R2/TAS1R3 polymorphisms are related to sweet taste sensitivity and carbohydrate intake from a buffet meal in healthy young adults.
Han P, Keast RSJ, Roura E. | 12/16/2017 |
| The molecular anatomy of sweet taste receptor dimers T1R2-T1R3 has been presented. | The anatomy of mammalian sweet taste receptors.
Chéron JB, Golebiowski J, Antonczak S, Fiorucci S. | 06/24/2017 |
| TAS1R3 gene rs307355 polymorphism found independent risk factor for dental caries experience by logistic regression & increased risk of caries. Moderate caries (4-7 caries) found to be associated w/TAS1R3 rs307355 heterozygous genotype | Association of sweet taste receptor gene polymorphisms with dental caries experience in school children.
Haznedaroğlu E, Koldemir-Gündüz M, Bakır-Coşkun N, Bozkuş HM, Çağatay P, Süsleyici-Duman B, Menteş A. | 07/30/2016 |
| T1R3 gene expression in the tongue is suppressed by chemotherapy. | Effects of chemotherapy on gene expression of lingual taste receptors in patients with head and neck cancer.
Tsutsumi R, Goda M, Fujimoto C, Kanno K, Nobe M, Kitamura Y, Abe K, Kawai M, Matsumoto H, Sakai T, Takeda N. | 06/28/2016 |
| The transcripts of TAS1R3 and UCN2 in peripheral blood cells may be considered potential biomarkers of consumption of sugary and fatty food, respectively, to complement data of food-intake questionnaires. | TAS1R3 and UCN2 Transcript Levels in Blood Cells Are Associated With Sugary and Fatty Food Consumption in Children.
Priego T, Sánchez J, Picó C, Ahrens W, De Henauw S, Kourides Y, Lissner L, Molnár D, Moreno LA, Russo P, Siani A, Veidebaum T, Palou A, IDEFICS and the I.Family consortia. | 11/28/2015 |
| human and mouse membrane trafficking systems for sweet taste receptors T1r2 and T1r3 | Distinct human and mouse membrane trafficking systems for sweet taste receptors T1r2 and T1r3.
Shimizu M, Goto M, Kawai T, Yamashita A, Kusakabe Y., Free PMC Article | 03/21/2015 |
| A complex molecular mechanism involving changes in the properties of both the orthosteric and non-orthosteric sites of T1R1 underlies the determination of ligand specificity in mammalian T1R1/T1R3. | Two distinct determinants of ligand specificity in T1R1/T1R3 (the umami taste receptor).
Toda Y, Nakagita T, Hayakawa T, Okada S, Narukawa M, Imai H, Ishimaru Y, Misaka T., Free PMC Article | 02/22/2014 |
| effects of artificial sweeteners on adipose tissue may be largely independent of the classical sweet taste receptors, T1R2 and T1R3 | Artificial sweeteners stimulate adipogenesis and suppress lipolysis independently of sweet taste receptors.
Simon BR, Parlee SD, Learman BS, Mori H, Scheller EL, Cawthorn WP, Ning X, Gallagher K, Tyrberg B, Assadi-Porter FM, Evans CR, MacDougald OA., Free PMC Article | 01/25/2014 |
| Five amino acid residues in cysteine-rich domain of human T1R3 were involved in the response for sweet-tasting protein, thaumatin | Five amino acid residues in cysteine-rich domain of human T1R3 were involved in the response for sweet-tasting protein, thaumatin.
Masuda T, Taguchi W, Sano A, Ohta K, Kitabatake N, Tani F. | 01/11/2014 |
| T1R3 is a receptor responsible for the detection of calcium by taste. | T1R3: a human calcium taste receptor.
Tordoff MG, Alarcón LK, Valmeki S, Jiang P., Free PMC Article | 03/23/2013 |