| TLR2 and CASP7 as the biomarkers associated with non-alcoholic fatty liver disease and chronic kidney disease. | TLR2 and CASP7 as the biomarkers associated with non-alcoholic fatty liver disease and chronic kidney disease.
Wang Z, Huang Y, Zhu M, Cao J, Xiong Z. | 06/15/2023 |
| Role of CASP7 polymorphisms in noise-induced hearing loss risk in Han Chinese population. | Role of CASP7 polymorphisms in noise-induced hearing loss risk in Han Chinese population.
Ruan Y, Zhang J, Mai S, Zeng W, Huang L, Gu C, Liu K, Ma Y, Wang Z., Free PMC Article | 12/25/2021 |
| Characterization of caspase-7 interaction with RNA. | Characterization of caspase-7 interaction with RNA.
Desroches A, Denault JB. | 12/4/2021 |
| Combination treatment of Src inhibitor Saracatinib with GMI, a Ganoderma microsporum immunomodulatory protein, induce synthetic lethality via autophagy and apoptosis in lung cancer cells. | Combination treatment of Src inhibitor Saracatinib with GMI, a Ganoderma microsporum immunomodulatory protein, induce synthetic lethality via autophagy and apoptosis in lung cancer cells.
Chiu LY, Hsin IL, Tsai JN, Chen CJ, Ou CC, Wu WJ, Sheu GT, Ko JL. | 09/11/2021 |
| Engineering caspase 7 as an affinity reagent to capture proteolytic products. | Engineering caspase 7 as an affinity reagent to capture proteolytic products.
Razai AS, Snipas SJ, Poreba M, Fasci D, Salvesen GS., Free PMC Article | 07/31/2021 |
| Autoimmune inner ear disease patient-associated 28-kDa proinflammatory IL-1beta fragment results from caspase-7-mediated cleavage in vitro. | Autoimmune inner ear disease patient-associated 28-kDa proinflammatory IL-1β fragment results from caspase-7-mediated cleavage in vitro.
Pathak S, Vambutas A., Free PMC Article | 06/26/2021 |
| The Relevance of SNPs at 3'UTR Region of CASP7 and miR-371b-5p Associated Diseases: A Computational Analysis. | The Relevance of SNPs at 3'UTR Region of CASP7 and miR-371b-5p Associated Diseases: A Computational Analysis.
Safdar M, Zaheer S, Khailany RA, Parvez S, Naveed M, Bhuiyan P, Ozaslan M, Moatasam R, Al-Attar MS, Khan MA, Junejo Y. | 05/22/2021 |
| Association of genetic polymorphisms in CASP7 with risk of ischaemic stroke. | Association of genetic polymorphisms in CASP7 with risk of ischaemic stroke.
Zheng Z, Liu S, Wang C, Wang C, Tang D, Shi Y, Han X., Free PMC Article | 12/19/2020 |
| Endocrine resistant breast cancer cells with loss of ERalpha expression retain proliferative ability by reducing caspase7-mediated HDAC3 cleavage. | Endocrine resistant breast cancer cells with loss of ERα expression retain proliferative ability by reducing caspase7-mediated HDAC3 cleavage.
Yu S, Gong X, Ma Z, Zhang M, Huang L, Zhang J, Zhao S, Zhu T, Yu Z, Chen L. | 10/10/2020 |
| Study identified associations in people of European ancestry with variants in 12 novel loci. The most robust finding is a rare CASP7 missense variant which improved when combined with results from stage 2 data sets. This study demonstrated that an enriched case design can strengthen genetic signals, thus allowing detection of associations that would otherwise be missed in a traditional case-control study. | A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease.
Zhang X, Zhu C, Beecham G, Vardarajan BN, Ma Y, Lancour D, Farrell JJ, Chung J, Alzheimer's Disease Sequencing Project, Mayeux R, Haines JL, Schellenberg GD, Pericak-Vance MA, Lunetta KL, Farrer LA., Free PMC Article | 05/9/2020 |
| Thus, activation of effector caspase-3 or -7 sets off explosive feedback amplification of upstream apoptotic events, which is a key feature of apoptotic signaling essential for efficient apoptotic cell death. | Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7.
McComb S, Chan PK, Guinot A, Hartmannsdottir H, Jenni S, Dobay MP, Bourquin JP, Bornhauser BC., Free PMC Article | 05/2/2020 |
| 4 lysine residues (K38KKK) located in the N-terminal domain of caspase-7 form such an exosite and promote the rapid proteolysis of the poly(ADP-ribose) polymerase 1. | Caspase-7 uses RNA to enhance proteolysis of poly(ADP-ribose) polymerase 1 and other RNA-binding proteins.
Desroches A, Denault JB., Free PMC Article | 04/4/2020 |
| SREBP1 overexpression downregulated caspase-7 and decreased CRC cell sensitivity to gemcitabine. | Targeting SREBP1 chemosensitizes colorectal cancer cells to gemcitabine by caspase-7 upregulation.
Shen W, Xu T, Chen D, Tan X., Free PMC Article | 03/28/2020 |
| this is the first study to show that GADD45gamma is required for the caspase-dependent apoptosis of renal tubular cells induced by nephrotoxic drugs. | Growth arrest and DNA damage 45γ is required for caspase-dependent renal tubular cell apoptosis.
Shin GT, Lee HJ, Park JE., Free PMC Article | 11/23/2019 |
| A combination of low BCL2 and low cleaved caspase-7 protein levels was highly prognostic of unfavourable outcome across all breast cancers. | Low cleaved caspase-7 levels indicate unfavourable outcome across all breast cancers.
Lindner AU, Lucantoni F, Varešlija D, Resler A, Murphy BM, Gallagher WM, Hill ADK, Young LS, Prehn JHM. | 11/9/2019 |
| Down-regulation of SAF with siRNA treatment increases caspase-3/7 activity levels in virus-infected MDMs. This induction of apoptotic caspases occurs exclusively in HIV-1-infected macrophages and not in bystander cells, leading to a significant reduction in HIV-1 replication and overall viral burden in the macrophage culture. | Inhibition of the lncRNA SAF drives activation of apoptotic effector caspases in HIV-1-infected human macrophages.
Boliar S, Gludish DW, Jambo KC, Kamng'ona R, Mvaya L, Mwandumba HC, Russell DG., Free PMC Article | 05/25/2019 |
| Gallium complexes significantly depleted cellular iron, resulting in upregulation of transferrin receptor-1 and downregulation of ferritin. They also effectively activate the caspase family proteins (caspase-3/7/9), promote the release of cytochromes from the mitochondria, and ultimately lead to apoptosis. | Gallium(III) complexes of α-N-heterocyclic piperidylthiosemicarbazones: Synthesis, structure-activity relationship, cellular uptake and activation of caspases-3/7/9.
Qi J, Yao Q, Qian K, Tian L, Cheng Z, Wang Y. | 05/18/2019 |
| Yellow fever virus induces activation of caspase 3/7 in the human HepG2 cells. | Yellow fever virus modulates cytokine mRNA expression and induces activation of caspase 3/7 in the human hepatocarcinoma cell line HepG2.
Holanda GM, Casseb SMM, Quaresma JAS, Vasconcelos PFC, Cruz ACR. | 03/23/2019 |
| Pyrin signaling is dispensable for Clostridium difficile infection (CDI) associated intestinal epithelial cells death and for in vivo pathogenesis; C. difficile enterotoxins induce activation of executioner caspases 3/7 via the intrinsic apoptosis pathway indicating that caspase-3/7-mediated intestinal epithelial cells apoptosis is critical for in vivo host defense during early stages of CDI. | Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis.
Saavedra PHV, Huang L, Ghazavi F, Kourula S, Vanden Berghe T, Takahashi N, Vandenabeele P, Lamkanfi M., Free PMC Article | 12/22/2018 |
| overexpressed miR-337-3p and miR-17-5p/miR-132-3p/-212-3p can regulate executioner caspases-3 and -7, respectively. | MicroRNAs Targeting Caspase-3 and -7 in PANC-1 Cells.
Park JK, Doseff AI, Schmittgen TD., Free PMC Article | 09/22/2018 |
| Everolimus also induced higher levels of caspase-3/-7 activation in GR over GS cells, and everolimus-mediated mTOR inhibition lead to G2 arrest in GR cells but G1 arrest in GS cells. | Everolimus Inhibits Growth of Gemcitabine-Resistant Pancreatic Cancer Cells via Induction of Caspase-Dependent Apoptosis and G(2) /M Arrest.
Peng T, Dou QP. | 12/23/2017 |
| CASP8: rs1045494 (C > T), PIK3R1: rs3756668 (A > G) and CASP7: rs4353229 (T > C), were associated with longer overall survival in limited disease-small cell lung cancer patients after chemoradiotherapy | MicroRNA-related polymorphisms in apoptosis pathway genes are predictive of clinical outcome in patients with limited disease small cell lung cancer.
Jiang W, Bi N, Zhang WJ, Wu LH, Liu LP, Men Y, Wang JB, Liang J, Hui ZG, Zhou ZM, Wang LH., Free PMC Article | 12/9/2017 |
| Results show that caspase-7 is phosphorylated by PAK2 at S239 which inhibits its activity by two divergent mechanisms prior to and following caspase activation: initial phosphorylation allosterically slows activation by upstream initiator caspases by impeding cleavage at the intersubunit linker and a second phosphorylation site directly blocks substrate binding. | Dual Site Phosphorylation of Caspase-7 by PAK2 Blocks Apoptotic Activity by Two Distinct Mechanisms.
Eron SJ, Raghupathi K, Hardy JA., Free PMC Article | 10/21/2017 |
| Caspase-7 regions involved in the interaction with Hsp90 co-chaperone p23 and substrate recognition. | Characterization of Hsp90 Co-Chaperone p23 Cleavage by Caspase-7 Uncovers a Peptidase-Substrate Interaction Involving Intrinsically Disordered Regions.
Martini C, Bédard M, Lavigne P, Denault JB. | 10/14/2017 |
| Study provides evidence that a loss-of-function variant rs10553596 in CASP7 associates with significantly reduced Alzheimer's disease incidence in elder populations. | A loss of function variant in CASP7 protects against Alzheimer's disease in homozygous APOE ε4 allele carriers.
Ayers KL, Mirshahi UL, Wardeh AH, Murray MF, Hao K, Glicksberg BS, Li S, Carey DJ, Chen R., Free PMC Article | 09/9/2017 |