| Force re-development after shortening reveals a role for titin in stretch-shortening performance enhancement in skinned muscle fibres. | Force re-development after shortening reveals a role for titin in stretch-shortening performance enhancement in skinned muscle fibres.
Tomalka A, Weidner S, Hahn D, Seiberl W, Siebert T. | 10/25/2024 |
| Modulation of Titin and Contraction-Regulating Proteins in a Rat Model of Heart Failure with Preserved Ejection Fraction: Limb vs. Diaphragmatic Muscle. | Modulation of Titin and Contraction-Regulating Proteins in a Rat Model of Heart Failure with Preserved Ejection Fraction: Limb vs. Diaphragmatic Muscle.
Vahle B, Heilmann L, Schauer A, Augstein A, Jarabo MP, Barthel P, Mangner N, Labeit S, Bowen TS, Linke A, Adams V., Free PMC Article | 07/3/2024 |
| Rbm20 ablation is associated with changes in the expression of titin-interacting and metabolic proteins. | Rbm20 ablation is associated with changes in the expression of titin-interacting and metabolic proteins.
Larson EJ, Gregorich ZR, Zhang Y, Li BH, Aballo TJ, Melby JA, Ge Y, Guo W., Free PMC Article | 08/20/2022 |
| Increased Expression of N2BA Titin Corresponds to More Compliant Myofibrils in Athlete's Heart. | Increased Expression of N2BA Titin Corresponds to More Compliant Myofibrils in Athlete's Heart.
Kellermayer D, Kiss B, Tordai H, Oláh A, Granzier HL, Merkely B, Kellermayer M, Radovits T., Free PMC Article | 01/22/2022 |
| Effects of vigorous isometric muscle contraction on titin stiffness-related contractile properties in rat fast-twitch muscles. | Effects of vigorous isometric muscle contraction on titin stiffness-related contractile properties in rat fast-twitch muscles.
Shi J, Watanabe D, Wada M. | 12/11/2021 |
| Inhibition of Histone Deacetylase 1 Prevents the Decrease in Titin (Connectin) Content and Development of Atrophy in Rat m. soleus after 3-Day Hindlimb Unloading. | Inhibition of Histone Deacetylase 1 Prevents the Decrease in Titin (Connectin) Content and Development of Atrophy in Rat m. soleus after 3-Day Hindlimb Unloading.
Ulanova AD, Gritsyna YV, Bobylev AG, Yakupova EI, Zhalimov VK, Belova SP, Mochalova EP, Nemirovskaya TL, Shenkman BS, Vikhlyantsev IM. | 07/10/2021 |
| Inhibition of Histone Deacetylases 4 and 5 Reduces Titin Proteolysis and Prevents Reduction of TTN Gene Expression in Atrophied Rat Soleus Muscle after Seven-Day Hindlimb Unloading. | Inhibition of Histone Deacetylases 4 and 5 Reduces Titin Proteolysis and Prevents Reduction of TTN Gene Expression in Atrophied Rat Soleus Muscle after Seven-Day Hindlimb Unloading.
Gritsyna YV, Ulanova AD, Popova SS, Bobylev AG, Zhalimov VK, Nemirovskaya TL, Shenkman BS, Vikhlyantsev IM. | 07/3/2021 |
| RBM20-Mediated Pre-mRNA Splicing Has Muscle-Specificity and Differential Hormonal Responses between Muscles and in Muscle Cell Cultures. | RBM20-Mediated Pre-mRNA Splicing Has Muscle-Specificity and Differential Hormonal Responses between Muscles and in Muscle Cell Cultures.
Maimaiti R, Zhu C, Zhang Y, Ding Q, Guo W., Free PMC Article | 04/24/2021 |
| Titin-truncating variants lead to impaired autophagy and mitochondrial function in the heart. These changes not only provide molecular mechanisms that underlie Titin-truncating variants-associated ventricular remodeling but also offer potential targets for its intervention. | Titin truncations lead to impaired cardiomyocyte autophagy and mitochondrial function in vivo.
Zhou J, Ng B, Ko NSJ, Fiedler LR, Khin E, Lim A, Sahib NE, Wu Y, Chothani SP, Schafer S, Bay BH, Sinha RA, Cook SA, Yen PM. | 02/8/2020 |
| In the context of pressure overload, Z-disc TTNtv is associated with cardiac fibrosis, diastolic dysfunction, and capillary rarefaction in the absence of overt systolic dysfunction. | Truncations of the titin Z-disc predispose to a heart failure with preserved ejection phenotype in the context of pressure overload.
Ye L, Su L, Wang C, Loo S, Tee G, Tan S, Khin SW, Ko S, Su B, Cook SA., Free PMC Article | 02/9/2019 |
| These findings reveal a major signal transduction pathway for insulin-induced titin alternative splicing, and place RBM20 in a central position in the pathway, which is consistent with the reputed role of RBM20 in titin alternative splicing. | Insulin regulates titin pre-mRNA splicing through the PI3K-Akt-mTOR kinase axis in a RBM20-dependent manner.
Zhu C, Yin Z, Tan B, Guo W., Free PMC Article | 12/1/2018 |
| Titin-truncating variant is associated with dilated cardiomyopathy. | Titin-truncating variants affect heart function in disease cohorts and the general population.
Schafer S, de Marvao A, Adami E, Fiedler LR, Ng B, Khin E, Rackham OJ, van Heesch S, Pua CJ, Kui M, Walsh R, Tayal U, Prasad SK, Dawes TJ, Ko NS, Sim D, Chan LL, Chin CW, Mazzarotto F, Barton PJ, Kreuchwig F, de Kleijn DP, Totman T, Biffi C, Tee N, Rueckert D, Schneider V, Faber A, Regitz-Zagrosek V, Seidman JG, Seidman CE, Linke WA, Kovalik JP, O'Regan D, Ware JS, Hubner N, Cook SA., Free PMC Article | 09/9/2017 |
| sarcomere stretch-induced simultaneous structural rearrangements within both thin and thick filaments that correlate with titin strain and myofilament length-dependent activation | Titin strain contributes to the Frank-Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins.
Ait-Mou Y, Hsu K, Farman GP, Kumar M, Greaser ML, Irving TC, de Tombe PP., Free PMC Article | 07/30/2016 |
| An increase in the degree of titin phosphorylation results in increased proteolytic degradation of this protein, that contributes to the development of skeletal muscle atrophy. | [On the Role of Titin Phosphorylation in Development of Muscular Atrophy].
Salmov NN, Gritsyna YV, Ulanova AD, Vikhlyantsev IM, Podlubnaya ZA. | 10/10/2015 |
| MMP-2 degraded Titin fragment in serum is related to induction of skeletal muscle atrophy. | Measurement of a MMP-2 degraded Titin fragment in serum reflects changes in muscle turnover induced by atrophy.
Sun S, Henriksen K, Karsdal MA, Armbrecht G, Belavý DL, Felsenberg D, Rittweger J, Wang Y, Zheng Q, Nedergaard AF. | 08/8/2015 |
| The uAUG motifs in titin 5'-UTR serve as translational repressors in the control of titin gene expression, and mutations/SNPs of the uAUGs or doxorubicin stress could alter titin translational efficiency. | Upstream open reading frame in 5'-untranslated region reduces titin mRNA translational efficiency.
Cadar AG, Zhong L, Lin A, Valenzuela MO, Lim CC., Free PMC Article | 02/14/2015 |
| The decrease of titin content in examined muscles and the decrease in titin gene expression in myocardium of chronically ethanol-fed rats have been shown | [Changes in gene expression and content of titin (connectin) in striated muscles of chronically etihanol-fed rats].
Gritsyna IuV, Salmov NN, Vikhliantsev IM, Ulanova AD, Sharapov MG, Teplova VV, Podlubnaia ZA. | 02/14/2015 |
| The study tested titin's role on myocyte force development, loaded shortening, and power output. Titin modulates both cross-bridge flexibility and thin filament activation. | Titin-mediated control of cardiac myofibrillar function.
Hanft LM, Greaser ML, McDonald KS., Free PMC Article | 08/23/2014 |
| Differential changes in titin domain phosphorylation increase myofilament stiffness in failing human hearts. | Differential changes in titin domain phosphorylation increase myofilament stiffness in failing human hearts.
Kötter S, Gout L, Von Frieling-Salewsky M, Müller AE, Helling S, Marcus K, Dos Remedios C, Linke WA, Krüger M. | 05/3/2014 |
| retention of intron 49 reveals a possible mechanism for the absence of the N2B unique region in the expressed titin protein of skeletal muscle | Comprehensive analysis of titin protein isoform and alternative splicing in normal and mutant rats.
Li S, Guo W, Schmitt BM, Greaser ML., Free PMC Article | 10/13/2012 |
| In addition to titin (TTN), we identified a set of 30 genes with conserved splicing regulation between humans and rats | RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing.
Guo W, Schafer S, Greaser ML, Radke MH, Liss M, Govindarajan T, Maatz H, Schulz H, Li S, Parrish AM, Dauksaite V, Vakeel P, Klaassen S, Gerull B, Thierfelder L, Regitz-Zagrosek V, Hacker TA, Saupe KW, Dec GW, Ellinor PT, MacRae CA, Spallek B, Fischer R, Perrot A, Özcelik C, Saar K, Hubner N, Gotthardt M., Free PMC Article | 07/28/2012 |
| role of passive tension regulators - titin and collagen - in the pathogenesis of diastolic dysfunction in cirrhosis | Role of cardiac myofilament proteins titin and collagen in the pathogenesis of diastolic dysfunction in cirrhotic rats.
Glenn TK, Honar H, Liu H, ter Keurs HE, Lee SS. | 04/7/2012 |
| In rat ventricle, the magnitude of sarcomere length-dependent changes in passive force, maximum Ca(2+)-activated force, pCa(50), n(H), and k(tr) is defined by the titin isoform. | Magnitude of length-dependent changes in contractile properties varies with titin isoform in rat ventricles.
Patel JR, Pleitner JM, Moss RL, Greaser ML., Free PMC Article | 03/24/2012 |
| MMP-2 localizes to titin at the Z-disk region of the cardiac sarcomere and contributes to titin degradation in myocardial ischemia/reperfusion injury. | Titin is a target of matrix metalloproteinase-2: implications in myocardial ischemia/reperfusion injury.
Ali MA, Cho WJ, Hudson B, Kassiri Z, Granzier H, Schulz R., Free PMC Article | 01/14/2012 |
| These data attest to the leading role of support stimulation in maintaining the structural and functional properties of the musculoskeletal system, specifically the titin N2A-isoform content in m. soleus of rat deprived of gravitational loading. | [Effect of vibrostimulation on support zones of rat's feet, and support loading on titin N2A-isoform and T2-fragment in m. soleus under the conditions of simulated microgravity].
Vikhliantsev IM, Terent'eva AV, Baltina TV, Podlubnaia ZA. | 01/22/2011 |