| Unravelling transcriptomic complexity in breast cancer through modulation of DARPP-32 expression and signalling pathways. | Unravelling transcriptomic complexity in breast cancer through modulation of DARPP-32 expression and signalling pathways.
Saidy B, Vasan R, Durant R, Greener MR, Immanuel A, Green AR, Rakha E, Ellis I, Ball G, Martin SG, Storr SJ., Free PMC Article | 12/6/2023 |
| DARPP32, a target of hyperactive mTORC1 in the retinal pigment epithelium. | DARPP32, a target of hyperactive mTORC1 in the retinal pigment epithelium.
Cai J, Litwin C, Cheng R, Ma JX, Chen Y., Free PMC Article | 08/27/2022 |
| A Homozygous Missense Variant in PPP1R1B/DARPP-32 Is Associated With Generalized Complex Dystonia. | A Homozygous Missense Variant in PPP1R1B/DARPP-32 Is Associated With Generalized Complex Dystonia.
Khan A, Molitor A, Mayeur S, Zhang G, Rinaldi B, Lannes B, Lhermitte B, Umair M, Arold ST, Friant S, Rastegar S, Anheim M, Bahram S, Carapito R. | 03/19/2022 |
| PP1, PKA and DARPP-32 in breast cancer: A retrospective assessment of protein and mRNA expression. | PP1, PKA and DARPP-32 in breast cancer: A retrospective assessment of protein and mRNA expression.
Saidy B, Kotecha S, Butler A, Rakha EA, Ellis IO, Green AR, Martin SG, Storr SJ., Free PMC Article | 10/2/2021 |
| Dopamine and cAMP-regulated phosphoprotein 32kDa (DARPP-32), protein phosphatase-1 and cyclin-dependent kinase 5 expression in ovarian cancer. | Dopamine and cAMP-regulated phosphoprotein 32kDa (DARPP-32), protein phosphatase-1 and cyclin-dependent kinase 5 expression in ovarian cancer.
Martin SG, Zhang S, Yang S, Saidy B, Deen S, Storr SJ., Free PMC Article | 09/18/2021 |
| ASCL1-regulated DARPP-32 and t-DARPP stimulate small cell lung cancer growth and neuroendocrine tumour cell proliferation. | ASCL1-regulated DARPP-32 and t-DARPP stimulate small cell lung cancer growth and neuroendocrine tumour cell proliferation.
Alam SK, Wang L, Ren Y, Hernandez CE, Kosari F, Roden AC, Yang R, Hoeppner LH., Free PMC Article | 04/3/2021 |
| Silencing of miR490-3p by H. pylori activates DARPP-32 and induces resistance to gefitinib. | Silencing of miR490-3p by H. pylori activates DARPP-32 and induces resistance to gefitinib.
Zhu S, Khalafi S, Chen Z, Poveda J, Peng D, Lu H, Soutto M, Que J, Garcia-Buitrago M, Zaika A, El-Rifai W., Free PMC Article | 02/27/2021 |
| Dopamine and cAMP-regulated phosphoprotein 32 kDa (DARPP-32) and survival in breast cancer: a retrospective analysis of protein and mRNA expression. | Dopamine and cAMP-regulated phosphoprotein 32 kDa (DARPP-32) and survival in breast cancer: a retrospective analysis of protein and mRNA expression.
Kotecha S, Lebot MN, Sukkarn B, Ball G, Moseley PM, Chan SY, Green AR, Rakha E, Ellis IO, Martin SG, Storr SJ., Free PMC Article | 11/21/2020 |
| Differential protein expression of DARPP-32 versus Calcineurin in the prefrontal cortex and nucleus accumbens in schizophrenia and bipolar disorder. | Differential protein expression of DARPP-32 versus Calcineurin in the prefrontal cortex and nucleus accumbens in schizophrenia and bipolar disorder.
Kunii Y, Hino M, Matsumoto J, Nagaoka A, Nawa H, Kakita A, Akatsu H, Hashizume Y, Yabe H., Free PMC Article | 11/21/2020 |
| the DARPP-32-IGF1R signaling axis plays a key role in regulating the STAT3 signaling, a critical step in gastric tumorigenesis | Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells.
Zhu S, Soutto M, Chen Z, Blanca Piazuelo M, Kay Washington M, Belkhiri A, Zaika A, Peng D, El-Rifai W., Free PMC Article | 02/29/2020 |
| Study shows that PPP1R1B expression in breast tumors is inversely correlated with IGF-1R expression and that the magnitude of PPP1R1B overexpression is associated with reduced overall survival of patients and describes a molecular mechanism in which t-Darpp interacts directly with IGF-1R to promote heterodimerization with EGFR and HER2, resulting in activation of the downstream signaling pathway and increased glycolysis. | t-Darpp Activates IGF-1R Signaling to Regulate Glucose Metabolism in Trastuzumab-Resistant Breast Cancer Cells.
Lenz G, Hamilton A, Geng S, Hong T, Kalkum M, Momand J, Kane SE, Huss JM., Free PMC Article | 09/14/2019 |
| The role of PPP1R1B and its Darpp-32 and t-Darpp protein products in neuronal cells and cancer.[ Review] | Darpp-32 and t-Darpp protein products of PPP1R1B: Old dogs with new tricks.
Avanes A, Lenz G, Momand J., Free PMC Article | 09/7/2019 |
| Single nucleotide polymorphisms related to dopamine are associated with individual differences in exploration strategies. Variation in a gene linked to prefrontal dopamine (COMT) predicted the degree of directed exploration, as well as the overall randomness of responding. Variation in a gene linked to striatal dopamine (DARPP-32) predicted the degree of both directed and random exploration. | Dopaminergic genes are associated with both directed and random exploration.
Gershman SJ, Tzovaras BG. | 02/16/2019 |
| t-Darpp phosphorylation at T39 seems to be crucial for t-Darpp-mediated PKA activation and this activation appears to occur through an association with RI and sequestering of RI away from PKAc. The t-Darpp-RI interaction could be a druggable target to reduce PKA activity in drug-resistant cancer. | t-Darpp stimulates protein kinase A activity by forming a complex with its RI regulatory subunit.
Theile D, Geng S, Denny EC, Momand J, Kane SE., Free PMC Article | 06/16/2018 |
| our results lend support for a potential role of DARPP-32 genetic variants in neural response to potential reward triggering cues | Influence of DARPP-32 genetic variation on BOLD activation to happy faces.
Persson N, Lavebratt C, Ebner NC, Fischer H., Free PMC Article | 05/26/2018 |
| To facilitate live-cell identification, a human embryonic stem cell line was generated using CRISPR-mediated gene editing at the DARPP32 locus. | Characterising the developmental profile of human embryonic stem cell-derived medium spiny neuron progenitors and assessing mature neuron function using a CRISPR-generated human DARPP-32(WT/eGFP-AMP) reporter line.
Hunt CPJ, Pouton CW, Haynes JM. | 03/24/2018 |
| Study associates polymorphisms in DRD2, DARPP-32, and COMT genes with novel category learning performance. Modeling results suggest that striatal dopaminergic genes influence selective attention processes whereas cortical genes mediate the ability to update complex rule representations. | Dopaminergic Genetic Polymorphisms Predict Rule-based Category Learning.
Byrne KA, Davis T, Worthy DA., Free PMC Article | 11/18/2017 |
| Results show that expression of human DARPP-32 protein isoforms depends on the striatal neurodevelopmental stage with t-DARPP being specific for the human adult striatum. | Human t-DARPP is induced during striatal development.
Straccia M, Carrere J, Rosser AE, Canals JM. | 09/9/2017 |
| In vivo xenograft models demonstrated that overexpression of DARPP-32 promotes angiogenesis and tumour growth. | Gastric tumour-derived ANGPT2 regulation by DARPP-32 promotes angiogenesis.
Chen Z, Zhu S, Hong J, Soutto M, Peng D, Belkhiri A, Xu Z, El-Rifai W., Free PMC Article | 08/12/2017 |
| This study strongly suggests that inflammation-regulated DARPP-32 constitutes a key component of H. pylori-mediated gastric tumourigenesis. | Helicobacter pylori-induced cell death is counteracted by NF-κB-mediated transcription of DARPP-32.
Zhu S, Soutto M, Chen Z, Peng D, Romero-Gallo J, Krishna US, Belkhiri A, Washington MK, Peek R, El-Rifai W., Free PMC Article | 07/15/2017 |
| This study did not find any statistical difference in the state-anxiety dimension for the rs12601930C/T, rs879606A/G, and rs3764352A/G genotypes, but statistical differences in the trait-anxiety dimension for the rs879606A/G (F = 5.207, P = 0.006) and rs3764352A/G (F = 3.960, P = 0.020) genotype. | Associations Between PPP1R1B Gene Polymorphisms and Anxiety Levels in the Chinese Population.
Ma H, Li X, Lin A, Yuan Z, Zhou J, Yang X, Cong Z, Huang Y, Zhu G., Free PMC Article | 03/4/2017 |
| DARPP-32 is mainly cleaved at Thr(153) by calpain and this cleavage of DARPP-32 reduces CREB phosphorylation via loss of its inhibitory function on PP1; results suggest a novel mechanism of DARPP-32-CREB signalling dysregulation in Alzheimer's disease | Calpain-mediated cleavage of DARPP-32 in Alzheimer's disease.
Cho K, Cho MH, Seo JH, Peak J, Kong KH, Yoon SY, Kim DH., Free PMC Article | 09/24/2016 |
| No significant differences in mRNA expression levels of DRD2 and DARPP-32 were found among controls, patients with psychotic disorder not otherwise specified, and schizophrenia/schizophreniform disorder. | The mRNA Expression Status of Dopamine Receptor D2, Dopamine Receptor D3 and DARPP-32 in T Lymphocytes of Patients with Early Psychosis.
Cui Y, Prabhu V, Nguyen TB, Yadav BK, Chung YC., Free PMC Article | 09/3/2016 |
| Striatal function was indexed by a gene coding for DARPP-32, which is densely expressed in the striatum where it is necessary for synaptic plasticity | Variability in Dopamine Genes Dissociates Model-Based and Model-Free Reinforcement Learning.
Doll BB, Bath KG, Daw ND, Frank MJ., Free PMC Article | 06/4/2016 |
| Findings show that PPP1R1B-STARD3 fusion transcript has a key role in subsets of gastric cancers through the activation of PI3K/AKT signaling. | PPP1R1B-STARD3 chimeric fusion transcript in human gastric cancer promotes tumorigenesis through activation of PI3K/AKT signaling.
Yun SM, Yoon K, Lee S, Kim E, Kong SH, Choe J, Kang JM, Han TS, Kim P, Choi Y, Jho S, Yoo H, Bhak J, Yang HK, Kim SJ. | 01/31/2015 |