| PGK1 represses autophagy-mediated cell death to promote the proliferation of liver cancer cells by phosphorylating PRAS40. | PGK1 represses autophagy-mediated cell death to promote the proliferation of liver cancer cells by phosphorylating PRAS40.
Zhang T, Wang Y, Yu H, Zhang T, Guo L, Xu J, Wei X, Wang N, Wu Y, Wang X, Huang L., Free PMC Article | 04/16/2022 |
| PRAS40 Phosphorylation Correlates with Insulin-Like Growth Factor-1 Receptor-Induced Resistance to Epidermal Growth Factor Receptor Inhibition in Head and Neck Cancer Cells. | PRAS40 Phosphorylation Correlates with Insulin-Like Growth Factor-1 Receptor-Induced Resistance to Epidermal Growth Factor Receptor Inhibition in Head and Neck Cancer Cells.
Dougherty MI, Lehman CE, Spencer A, Mendez RE, David AP, Taniguchi LE, Wulfkuhle J, Petricoin EF, Gioeli D, Jameson MJ., Free PMC Article | 08/14/2021 |
| M2-polarized tumor-associated macrophages promote epithelial-mesenchymal transition via activation of the AKT3/PRAS40 signaling pathway in intrahepatic cholangiocarcinoma. | M2-polarized tumor-associated macrophages promote epithelial-mesenchymal transition via activation of the AKT3/PRAS40 signaling pathway in intrahepatic cholangiocarcinoma.
Sun D, Luo T, Dong P, Zhang N, Chen J, Zhang S, Dong L, Janssen HLA, Zhang S. | 07/10/2021 |
| Dual Specificity Kinase DYRK3 Promotes Aggressiveness of Glioblastoma by Altering Mitochondrial Morphology and Function. | Dual Specificity Kinase DYRK3 Promotes Aggressiveness of Glioblastoma by Altering Mitochondrial Morphology and Function.
Kim K, Lee S, Kang H, Shin E, Kim HY, Youn H, Youn B., Free PMC Article | 04/24/2021 |
| PRAS40 suppresses atherogenesis through inhibition of mTORC1-dependent pro-inflammatory signaling in endothelial cells. | PRAS40 suppresses atherogenesis through inhibition of mTORC1-dependent pro-inflammatory signaling in endothelial cells.
Zhang KS, Schecker J, Krull A, Riechert E, Jürgensen L, Kamuf-Schenk V, Burghaus J, Kiper L, Cao Ho T, Wöltje K, Stangl V, Katus HA, Stangl K, Völkers M, Althoff TF., Free PMC Article | 11/21/2020 |
| PRAS40 hyperexpression promotes hepatocarcinogenesis. | PRAS40 hyperexpression promotes hepatocarcinogenesis.
Qi Z, Zhang T, Song L, Fu H, Luo H, Wu J, Zhao S, Zhang T, Guo L, Jin L, Zhang H, Huang G, Ma T, Wu Y, Huang L., Free PMC Article | 10/3/2020 |
| MELK is Upregulated in Advanced Clear Cell Renal Cell Carcinoma and Promotes Disease Progression by Phosphorylating PRAS40. | MELK is Upregulated in Advanced Clear Cell Renal Cell Carcinoma and Promotes Disease Progression by Phosphorylating PRAS40.
Zhang H, Wei P, Lv W, Han X, Yang J, Qin S, Zhang Y., Free PMC Article | 09/19/2020 |
| This study, for the first time, links PF4's anti-RNV function to an intracellular signaling molecule PRAS40 and its phosphorylation. | PF4 antagonizes retinal neovascularization via inhibiting PRAS40 phosphorylation in a mouse model of oxygen-induced retinopathy.
Cai S, Yang Q, Cao Y, Li Y, Liu J, Wang J, Zhang X, Liu L, Li X, Zhang Y. | 08/13/2020 |
| ROS act in concert with BLM to facilitate Prostate cancer (PC) oncogenesis, potentially via further enhancing AKT signaling and downregulating PTEN expression. Importantly, inhibiting the BLM-AKT-PRAS40 axis induced PC cell apoptosis. | Bloom Syndrome Protein Activates AKT and PRAS40 in Prostate Cancer Cells.
Chen K, Xu H, Zhao J., Free PMC Article | 12/14/2019 |
| The Akt-PRAS40 pathway is activated by uric acid, which inhibits autophagy and recapitulates the uric acid-induced proinflammatory cytokine phenotype. | Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway.
Crişan TO, Cleophas MCP, Novakovic B, Erler K, van de Veerdonk FL, Stunnenberg HG, Netea MG, Dinarello CA, Joosten LAB., Free PMC Article | 05/19/2018 |
| crystal structures of RAPTOR-TOS motif complexes that define the determinants of TOS recognition, of an mTOR FKBP12-rapamycin-binding (FRB) domain-substrate complex that establishes a second substrate-recruitment mechanism, and of a truncated mTOR-PRAS40 complex that reveals PRAS40 inhibits both substrate-recruitment sites | Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Yang H, Jiang X, Li B, Yang HJ, Miller M, Yang A, Dhar A, Pavletich NP., Free PMC Article | 05/19/2018 |
| Study found that activated PRAS40 acts not only as a regulator of TGFA-triggered exosome secretion but also as a common regulator of distinct microenvironmental and oncogenic signal-triggered exosome secretion in both normal and tumor cell types. PRAS40 is the first regulator identified for stress-induced exosome secretion. | PRAS40 Connects Microenvironmental Stress Signaling to Exosome-Mediated Secretion.
Guo J, Jayaprakash P, Dan J, Wise P, Jang GB, Liang C, Chen M, Woodley DT, Fabbri M, Li W., Free PMC Article | 10/7/2017 |
| PRAS40 was downregulated in the DU145 cells following MYO6 knockdown. | MYO6 knockdown inhibits the growth and induces the apoptosis of prostate cancer cells by decreasing the phosphorylation of ERK1/2 and PRAS40.
Wang D, Zhu L, Liao M, Zeng T, Zhuo W, Yang S, Wu W. | 03/11/2017 |
| Phosphorylation of S202/203 of AKT1S1 by PKM2 released AKT1S1 from raptor and facilitated its binding to 14-3-3, resulted in hormonal- and nutrient-signals independent activation of mTORC1 signaling and led accelerated oncogenic growth and autophagy inhibition in cancer cells. | Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1.
He CL, Bian YY, Xue Y, Liu ZX, Zhou KQ, Yao CF, Lin Y, Zou HF, Luo FX, Qu YY, Zhao JY, Ye ML, Zhao SM, Xu W., Free PMC Article | 12/17/2016 |
| The frameshift mutation detected in the current study would result in a premature stop of amino-acid synthesis in AKT1S1 protein and hence resembles a typical loss-of-function mutation. | Inactivating frameshift mutation of AKT1S1, an mTOR inhibitory gene, in colorectal cancers.
Choi MR, Gwak M, Yoo NJ, Lee SH. | 12/5/2015 |
| Supporting this idea, we identified a downstream target of the TGFb-miR-96 signaling pathway to be AKT1S1 mRNA, whose translated protein is a negative regulator of mTOR kinase. | Transforming growth factor-β promotes prostate bone metastasis through induction of microRNA-96 and activation of the mTOR pathway.
Siu MK, Tsai YC, Chang YS, Yin JJ, Suau F, Chen WY, Liu YN. | 11/28/2015 |
| This review discusses the role of PRAS40 and possible feedback mechanisms, and alterations in AKT/PRAS40/mTOR signaling that have been implicated in the pathogenesis of tumor progression. [review] | Proline-rich AKT substrate of 40-kDa (PRAS40) in the pathophysiology of cancer.
Malla R, Ashby CR Jr, Narayanan NK, Narayanan B, Faridi JS, Tiwari AK. | 09/12/2015 |
| Findings indicate that dual phosphorylation of PRAS40 by Akt and mTORC1 promotes formation of a nuclear-specific PRAS40- and RPL11-containing complex distinct from mTORC1 that inhibits the RPL11-HDM2-p53 pathway. | Nuclear PRAS40 couples the Akt/mTORC1 signaling axis to the RPL11-HDM2-p53 nucleolar stress response pathway.
Havel JJ, Li Z, Cheng D, Peng J, Fu H., Free PMC Article | 06/20/2015 |
| PRAS40 as a regulator of insulin sensitivity in hSkMC | Over-expression of PRAS40 enhances insulin sensitivity in skeletal muscle.
Wiza C, Chadt A, Blumensatt M, Kanzleiter T, Herzfeld De Wiza D, Horrighs A, Mueller H, Nascimento EB, Schürmann A, Al-Hasani H, Ouwens DM. | 11/22/2014 |
| PRAS40 contains a functional nuclear export signal. Furthermore, enforced nuclear accumulation of PRAS40 impairs insulin action, thereby substantiating the function of this protein in the regulation of insulin sensitivity. | Proline-rich Akt substrate of 40-kDa contains a nuclear export signal.
Wiza C, Nascimento EB, Linssen MM, Carlotti F, Herzfeld de Wiza D, van der Zon GC, Maassen JA, Diamant M, Guigas B, Ouwens DM. | 02/1/2014 |
| Data suggest that PRAS40 modulates insulin action in skeletal muscle; knockdown of PRAS40 inhibits insulin action in cultured myotubes and is associated with up-regulation of IRS1 (insulin receptor substrate 1) degradation via proteasome proteolysis. | Knockdown of PRAS40 inhibits insulin action via proteasome-mediated degradation of IRS1 in primary human skeletal muscle cells.
Wiza C, Herzfeld de Wiza D, Nascimento EB, Lehr S, Al-Hasani H, Ouwens DM. | 11/2/2013 |
| WISP1 governs PRAS40 by sequestering PRAS40 intracellularly through post-translational phosphorylation. | Wnt1 inducible signaling pathway protein 1 (WISP1) targets PRAS40 to govern β-amyloid apoptotic injury of microglia.
Shang YC, Chong ZZ, Wang S, Maiese K., Free PMC Article | 10/19/2013 |
| study found tuberin and PRAS40 to be potent anti-apoptotic gatekeepers in early stem-cell differentiation; data allow new insights into the regulation of early stem-cell maintenance and differentiation and identify a new role of the tumor suppressor tuberin and the oncogenic protein PRAS40 | Tuberin and PRAS40 are anti-apoptotic gatekeepers during early human amniotic fluid stem-cell differentiation.
Fuchs C, Rosner M, Dolznig H, Mikula M, Kramer N, Hengstschläger M. | 11/24/2012 |
| This review summarizes the regulation and potential function(s) of PRAS40 in the complex Akt- and mTOR-signaling network in health and disease--{REVIEW} | Role of PRAS40 in Akt and mTOR signaling in health and disease.
Wiza C, Nascimento EB, Ouwens DM. | 09/1/2012 |
| our findings suggest that PRAS40 promotes the development of ESFT | PRAS40 is a functionally critical target for EWS repression in Ewing sarcoma.
Huang L, Nakai Y, Kuwahara I, Matsumoto K. | 04/28/2012 |