| TRAF2 associates with cullin neddylation complex assembly. | TRAF2 associates with cullin neddylation complex assembly.
Wang T, Zhang Q, Xu Y, Yan R, Pan Y, Xuan Y, Shen M, Chen X, Zhu H, Ke X, Qu Y, Zhang X. | 10/25/2024 |
| Comprehensive prognostic and immunological analysis of Cullin2 in pan-cancer and its identification in hepatocellular carcinoma. | Comprehensive prognostic and immunological analysis of Cullin2 in pan-cancer and its identification in hepatocellular carcinoma.
Jia L, Zhang X, Zhou T, Xie J, Jin J, Zhang D, Zhu C, Wan R., Free PMC Article | 10/11/2024 |
| MicroRNA-154-5p suppresses cervical carcinoma growth and metastasis by silencing Cullin2 in vitro and in vivo. | MicroRNA-154-5p suppresses cervical carcinoma growth and metastasis by silencing Cullin2 in vitro and in vivo.
Li Y, Wei Y, Zhang H, Bai Y, Wang X, Li Q, Liu Y, Wang S, Wang J, Wen S, Li J, Zhao W., Free PMC Article | 07/10/2023 |
| MicroRNA-574-3p Regulates HIF-alpha Isoforms Promoting Gastric Cancer Epithelial-Mesenchymal Transition via Targeting CUL2. | MicroRNA-574-3p Regulates HIF-α Isoforms Promoting Gastric Cancer Epithelial-Mesenchymal Transition via Targeting CUL2.
Ji Z, Wang X, Liu Y, Zhong M, Sun J, Shang J. | 07/23/2022 |
| A close shave: How SARS-CoV-2 induces the loss of cilia. | A close shave: How SARS-CoV-2 induces the loss of cilia.
Fonseca BF, Chakrabarti LA., Free PMC Article | 06/18/2022 |
| CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2. | CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2.
Meng L, Zhang Y, Wu P, Li D, Lu Y, Shen P, Yang T, Shi G, Chen Q, Yuan H, Ge W, Miao Y, Tu M, Jiang K., Free PMC Article | 06/11/2022 |
| Immunoexpression of HSPA9 and CUL2 in prostatic tissue and adenocarcinoma. | Immunoexpression of HSPA9 and CUL2 in prostatic tissue and adenocarcinoma.
Hirth CG, Vasconcelos GR, da Cunha MDPSS, Leite CHB, Dornelas CA. | 03/26/2022 |
| Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes. | Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes.
Le TT, Ainsworth J, Polo Rivera C, Macartney T, Labib KPM., Free PMC Article | 12/4/2021 |
| Integrating cullin2-RING E3 ligase as a potential biomarker for glioblastoma multiforme prognosis and radiosensitivity profiling. | Integrating cullin2-RING E3 ligase as a potential biomarker for glioblastoma multiforme prognosis and radiosensitivity profiling.
Zheng S, Wu Y, Li Z. | 05/1/2021 |
| ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection. | ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection.
Mena EL, Donahue CJ, Vaites LP, Li J, Rona G, O'Leary C, Lignitto L, Miwatani-Minter B, Paulo JA, Dhabaria A, Ueberheide B, Gygi SP, Pagano M, Harper JW, Davey RA, Elledge SJ., Free PMC Article | 04/24/2021 |
| Roles of Cullin-2 E3 Ubiquitin Ligase Complex in Cancer | The Roles of Cullin-2 E3 Ubiquitin Ligase Complex in Cancer.
Liu X, Zurlo G, Zhang Q. | 02/29/2020 |
| Twist1 bound the Cul2 promoter. | Twist1 Regulates Vimentin through Cul2 Circular RNA to Promote EMT in Hepatocellular Carcinoma.
Meng J, Chen S, Han JX, Qian B, Wang XR, Zhong WL, Qin Y, Zhang H, Gao WF, Lei YY, Yang W, Yang L, Zhang C, Liu HJ, Liu YR, Zhou HG, Sun T, Yang C. | 08/31/2019 |
| direct evidence that both A3A and HPV16 E7 interact with CUL2, suggesting that the E7-CUL2 complex formed during HPV infection may regulate A3A protein levels in the cell. | Human Papillomavirus 16 E7 Stabilizes APOBEC3A Protein by Inhibiting Cullin 2-Dependent Protein Degradation.
Westrich JA, Warren CJ, Klausner MJ, Guo K, Liu CW, Santiago ML, Pyeon D., Free PMC Article | 04/21/2018 |
| The crystal structure of a pentameric CRL2(VHL) complex, composed of Cul2, Rbx1, Elongin B, Elongin C, and pVHL reveals hydrophobic contact residues critical for the Cul2 interactions. | Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex.
Cardote TAF, Gadd MS, Ciulli A., Free PMC Article | 03/24/2018 |
| Results suggest that E7 recruited CUL2, driven by CUL2/E2F1/miR-424 regulatory loop, is overexpressed and accelerates HPV16-induced cervical carcinogenesis. | CUL2 overexpression driven by CUL2/E2F1/miR-424 regulatory loop promotes HPV16 E7 induced cervical carcinogenesis.
Xu J, Fang Y, Wang X, Wang F, Tian Q, Li Y, Xie X, Cheng X, Lu W., Free PMC Article | 12/30/2017 |
| misfolded TDP-43 is cleared by VHL/CUL2 in a step-wise manner via fragmentation. | CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS.
Uchida T, Tamaki Y, Ayaki T, Shodai A, Kaji S, Morimura T, Banno Y, Nishitsuji K, Sakashita N, Maki T, Yamashita H, Ito H, Takahashi R, Urushitani M., Free PMC Article | 12/17/2016 |
| Cullins are a family of NEDD8 targets important in the stabilization and degradation of proteins, such as hypoxia-inducible factor (HIF1A), via Cullin-2. | Stabilization of HIF through inhibition of Cullin-2 neddylation is protective in mucosal inflammatory responses.
Curtis VF, Ehrentraut SF, Campbell EL, Glover LE, Bayless A, Kelly CJ, Kominsky DJ, Colgan SP., Free PMC Article | 05/2/2015 |
| Nevertheless, the identification of the Cul2 box may allow prediction of Cullin specificity for all E4orf6-containing Adenoviridae. | Analysis of the Cullin binding sites of the E4orf6 proteins of human adenovirus E3 ubiquitin ligases.
Gilson T, Cheng CY, Hur WS, Blanchette P, Branton PE., Free PMC Article | 05/10/2014 |
| a novel link between the oncoprotein PRAME and the conserved EKC complex | The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME.
Costessi A, Mahrour N, Sharma V, Stunnenberg R, Stoel MA, Tijchon E, Conaway JW, Conaway RC, Stunnenberg HG., Free PMC Article | 04/27/2013 |
| Study finds that UBXN7 over-expression converts CUL2 to its neddylated form and causes the accumulation of non-ubiquitylated HIF1alpha. | UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation.
Bandau S, Knebel A, Gage ZO, Wood NT, Alexandru G., Free PMC Article | 10/6/2012 |
| The authors applied protein-complex purification strategies and identified PRAME as a substrate recognition subunit of a Cullin2-based E3 ubiquitin ligase. | The tumour antigen PRAME is a subunit of a Cul2 ubiquitin ligase and associates with active NFY promoters.
Costessi A, Mahrour N, Tijchon E, Stunnenberg R, Stoel MA, Jansen PW, Sela D, Martin-Brown S, Washburn MP, Florens L, Conaway JW, Conaway RC, Stunnenberg HG., Free PMC Article | 11/5/2011 |
| The data suggest that neither HIF1alpha nor CUL2 mutation may play a central role in HIF1alpha activation in gastric, colorectal, breast, lung and hepatocellular carcinomas, and acute leukemias. | Mutational analysis of hypoxia-related genes HIF1alpha and CUL2 in common human cancers.
Park SW, Chung NG, Hur SY, Kim HS, Yoo NJ, Lee SH, Park SW, Chung NG, Hur SY, Kim HS, Yoo NJ, Lee SH. | 02/8/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (4) articlesMutational analysis of hypoxia-related genes HIF1alpha and CUL2 in common human cancers.
Park SW, Chung NG, Hur SY, Kim HS, Yoo NJ, Lee SH, Park SW, Chung NG, Hur SY, Kim HS, Yoo NJ, Lee SH. Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients.
Törkvist L, Halfvarson J, Ong RT, Lördal M, Sjöqvist U, Bresso F, Björk J, Befrits R, Löfberg R, Blom J, Carlson M, Padyukov L, D'Amato M, Seielstad M, Pettersson S. KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise.
Argyropoulos G, Stütz AM, Ilnytska O, Rice T, Teran-Garcia M, Rao DC, Bouchard C, Rankinen T. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A. | 01/11/2009 |
| CUL2 is required for normal vasculogenesis, at least in part mediated by its regulation of HIF-mediated transcription. | CUL2 is required for the activity of hypoxia-inducible factor and vasculogenesis.
Maeda Y, Suzuki T, Pan X, Chen G, Pan S, Bartman T, Whitsett JA., Free PMC Article | 01/21/2010 |
| the HPV16 E7-associated cullin 2 ubiquitin ligase complex contributes to aberrant degradation of the pRB tumor suppressor in HPV16 E7-expressing cells. | Human papillomavirus type 16 E7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor.
Huh K, Zhou X, Hayakawa H, Cho JY, Libermann TA, Jin J, Harper JW, Munger K., Free PMC Article | 01/21/2010 |