| HDAC3 Impairs Cardiac Function in Chronic Heart Failure Rats via Mediating MicroRNA-26b-3p to Target High Mobility Group AT-Hook 2. | HDAC3 Impairs Cardiac Function in Chronic Heart Failure Rats via Mediating MicroRNA-26b-3p to Target High Mobility Group AT-Hook 2.
Han X, Wang S, Yong Z, Zhang X, Wang X, Sun C. | 05/19/2023 |
| Depleted HDAC3 attenuates hyperuricemia-induced renal interstitial fibrosis via miR-19b-3p/SF3B3 axis. | Depleted HDAC3 attenuates hyperuricemia-induced renal interstitial fibrosis via miR-19b-3p/SF3B3 axis.
Hu L, Yang K, Mai X, Wei J, Ma C., Free PMC Article | 07/23/2022 |
| Depleted histone deacetylase 3 or restored microRNA-19b-1-5p facilitates recovery of spinal cord injury via inactivating JAK2/STAT3 signaling pathway. | Depleted histone deacetylase 3 or restored microRNA-19b-1-5p facilitates recovery of spinal cord injury via inactivating JAK2/STAT3 signaling pathway.
Niu H, Song W, Pei D, Ma C, Liu F, Li Y, Han S. | 04/30/2022 |
| Histone deacetylase 3 suppresses the expression of SHP-1 via deacetylation of DNMT1 to promote heart failure. | Histone deacetylase 3 suppresses the expression of SHP-1 via deacetylation of DNMT1 to promote heart failure.
Wang YY, Gao B, Yang Y, Jia SB, Ma XP, Zhang MH, Wang LJ, Ma AQ, Zhang QN. | 02/12/2022 |
| Inhibited histone deacetylase 3 ameliorates myocardial ischemia-reperfusion injury in a rat model by elevating microRNA-19a-3p and reducing cyclin-dependent kinase 2. | Inhibited histone deacetylase 3 ameliorates myocardial ischemia-reperfusion injury in a rat model by elevating microRNA-19a-3p and reducing cyclin-dependent kinase 2.
Song K, Li L, Quan Q, Wei Y, Hu S. | 11/27/2021 |
| miR-27a promotion resulting from silencing of HDAC3 facilitates the recovery of spinal cord injury by inhibiting PAK6 expression in rats. | miR-27a promotion resulting from silencing of HDAC3 facilitates the recovery of spinal cord injury by inhibiting PAK6 expression in rats.
Zhou Q, Feng X, Ye F, Lei F, Jia X, Feng D. | 11/21/2020 |
| we show that Nr4a2 is regulated by histone deacetylase HDAC3 in the aged mouse hippocampus. | HDAC3-Mediated Repression of the Nr4a Family Contributes to Age-Related Impairments in Long-Term Memory.
Kwapis JL, Alaghband Y, López AJ, Long JM, Li X, Shu G, Bodinayake KK, Matheos DP, Rapp PR, Wood MA., Free PMC Article | 06/20/2020 |
| In healthy cerebellar granule neurons HDAC3 associates weakly with the Npas4 promoter, however, this association is robustly increased in neurons primed to die. Study found that HDAC3 also associates differentially with the Bdnfr gene promoter, with higher association in dying neurons. Overexpression of HDAC3 leads to a suppression of Npas4 and Bdnf expression in cortical neurons. | The Bdnf and Npas4 genes are targets of HDAC3-mediated transcriptional repression.
Louis Sam Titus ASC, Sharma D, Kim MS, D'Mello SR., Free PMC Article | 05/30/2020 |
| findings suggest that HDAC3, and its cross talk function with GSK-3beta, may be a promising target for myocardium I/R injury. | HDAC3 Mediates Cardioprotection of Remifentanil Postconditioning by Targeting GSK-3β in H9c2 Cardiomyocytes in Hypoxia/Reoxygenation Injury.
Chen M, Liu Q, Chen L, Zhang L, Cheng X, Gu E. | 10/5/2019 |
| Study shows that habits are negatively regulated by histone deacetylase 3 in the dorsal striatum. | Habits Are Negatively Regulated by Histone Deacetylase 3 in the Dorsal Striatum.
Malvaez M, Greenfield VY, Matheos DP, Angelillis NA, Murphy MD, Kennedy PJ, Wood MA, Wassum KM., Free PMC Article | 09/28/2019 |
| Co-regulation of H3K9ac by HDAC1 and HDAC3 is important development of the pathophysiology of a schizophrenia-like phenotype. | HDAC1 and HDAC3 underlie dynamic H3K9 acetylation during embryonic neurogenesis and in schizophrenia-like animals.
Večeřa J, Bártová E, Krejčí J, Legartová S, Komůrková D, Rudá-Kučerová J, Štark T, Dražanová E, Kašpárek T, Šulcová A, Dekker FJ, Szymanski W, Seiser C, Weitzer G, Mechoulam R, Micale V, Kozubek S., Free PMC Article | 10/28/2017 |
| Findings provide evidence that amyloid-beta oligomer-induced synaptic plasticity impairment can be prevented by inhibition of HDAC3 enzyme both at the single neuron as well as in a population of neurons, thus identifying HDAC3 as a potential target for ameliorating Alzheimer's disease related plasticity impairments | Inhibition of Histone Deacetylase 3 Restores Amyloid-β Oligomer-Induced Plasticity Deficit in Hippocampal CA1 Pyramidal Neurons.
Krishna K, Behnisch T, Sajikumar S. | 12/24/2016 |
| c-Fos can protect against HDAC3 neurotoxicity. | c-Fos Protects Neurons Through a Noncanonical Mechanism Involving HDAC3 Interaction: Identification of a 21-Amino Acid Fragment with Neuroprotective Activity.
Rawat V, Goux W, Piechaczyk M, D Mello SR., Free PMC Article | 12/17/2016 |
| There was no difference in striatal HDAC3 expression between maternally deprived rats and controls. | Vulnerability to opiate intake in maternally deprived rats: implication of MeCP2 and of histone acetylation.
Tesone-Coelho C, Morel LJ, Bhatt J, Estevez L, Naudon L, Giros B, Zwiller J, Daugé V. | 08/29/2015 |
| Using genome-wide analysis study shows that histone deacetylase (HDAC)2 and HDAC3 show overlapping and distinct promoter occupancy at neuronal and oligodendrocyte-related genes in neural stem cells. | Neural stem cell differentiation is dictated by distinct actions of nuclear receptor corepressors and histone deacetylases.
Castelo-Branco G, Lilja T, Wallenborg K, Falcão AM, Marques SC, Gracias A, Solum D, Paap R, Walfridsson J, Teixeira AI, Rosenfeld MG, Jepsen K, Hermanson O., Free PMC Article | 06/6/2015 |
| HDAC3 interacts with sumoylated CEBPalpha to negatively regulate the LXRalpha expression. | HDAC3 interacts with sumoylated C/EBPα to negatively regulate the LXRα expression in rat hepatocytes.
Ren J, Li D, Li Y, Lan X, Zheng J, Wang X, Ma J, Lu S. | 01/4/2014 |
| PCOS rat models also showed alterations of PPARG1, NCOR1, and HDAC3 mRNA expression and methylation changes of PPARG1 and NCOR1, consistent with the results from humans. | A molecular mechanism underlying ovarian dysfunction of polycystic ovary syndrome: hyperandrogenism induces epigenetic alterations in the granulosa cells.
Qu F, Wang FF, Yin R, Ding GL, El-Prince M, Gao Q, Shi BW, Pan HH, Huang YT, Jin M, Leung PC, Sheng JZ, Huang HF. | 11/17/2012 |
| Maternal high fat exposure represses p16 (INK4a) gene expression in the mammary gland of offspring through changes of histone modifications and HDAC3 binding activity within the regulatory regions of the p16 (INK4a) gene. | Histone deacetylase 3 (HDAC3) participates in the transcriptional repression of the p16 (INK4a) gene in mammary gland of the female rat offspring exposed to an early-life high-fat diet.
Zheng S, Li Q, Zhang Y, Balluff Z, Pan YX., Free PMC Article | 09/29/2012 |
| High expression of liver histone deacetylase 3 contributes to high-fat-diet-induced metabolic syndrome by suppressing the peroxisome proliferator-activated receptor gamma and liver X receptor-alpha-pathways | High expression of liver histone deacetylase 3 contributes to high-fat-diet-induced metabolic syndrome by suppressing the PPAR-γ and LXR-α-pathways in E3 rats.
Li D, Wang X, Ren W, Ren J, Lan X, Wang F, Li H, Zhang F, Han Y, Song T, Holmdahl R, Lu S. | 12/24/2011 |
| SMRT's RD4 region can recruit factors capable of mediating nuclear export of SMRT, but whose function and/or recruitment is suppressed by HDAC3 activity | In cortical neurons HDAC3 activity suppresses RD4-dependent SMRT export.
Soriano FX, Hardingham GE., Free PMC Article | 10/22/2011 |
| Data shows that HDAC3 is a substrate of GSK3beta and that HDAC3 represents a downstream effector of GSK3beta neurotoxicity. | Selective toxicity by HDAC3 in neurons: regulation by Akt and GSK3beta.
Bardai FH, D'Mello SR., Free PMC Article | 04/2/2011 |
| Report that clinically relevant concentrations of valproic acid modulate melatonin MT(1) receptor, HDAC and MeCP2 mRNA expression in C6 glioma cells. | Clinically relevant concentrations of valproic acid modulate melatonin MT(1) receptor, HDAC and MeCP2 mRNA expression in C6 glioma cells.
Kim B, Rincón Castro LM, Jawed S, Niles LP. | 01/21/2010 |
| recruitment of HDAC3 is a process by which Myc represses gene activity | Myc-mediated transcriptional repression by recruitment of histone deacetylase.
Kurland JF, Tansey WP. | 01/21/2010 |