| SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis. | SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis.
Yu PC, Hou D, Chang B, Liu N, Xu CH, Chen X, Hu CL, Liu T, Wang X, Zhang Q, Liu P, Jiang Y, Fei MY, Zong LJ, Zhang JY, Liu H, Chen BY, Chen SB, Wang Y, Li ZJ, Li X, Deng CH, Ren YY, Zhao M, Jiang S, Wang R, Jin J, Yang S, Xue K, Shi J, Chang CK, Shen S, Wang Z, He PC, Chen Z, Chen SJ, Sun XJ, Wang L. | 09/13/2024 |
| Circular RNA SMARCA5 Promotes a Poor Prognosis and Radiotherapy Resistance for Patients with Hepatocellular Carcinoma. | Circular RNA SMARCA5 Promotes a Poor Prognosis and Radiotherapy Resistance for Patients with Hepatocellular Carcinoma.
Chang Z, Song Y, Luo F, Yang X, Cai Y, Guo H. | 08/30/2023 |
| Hyperglycemia-Suppressed SMARCA5 Disrupts Transcriptional Homeostasis to Facilitate Endothelial Dysfunction in Diabetes. | Hyperglycemia-Suppressed SMARCA5 Disrupts Transcriptional Homeostasis to Facilitate Endothelial Dysfunction in Diabetes.
Wang J, Zhou H, Shao J, Zhang S, Jin J., Free PMC Article | 06/13/2023 |
| The RPA-RNF20-SNF2H cascade promotes proper chromosome segregation and homologous recombination repair. | The RPA-RNF20-SNF2H cascade promotes proper chromosome segregation and homologous recombination repair.
Li J, Zhao J, Gan X, Wang Y, Jiang D, Chen L, Wang F, Xu J, Pei H, Huang J, Chen X., Free PMC Article | 05/12/2023 |
| Human SMARCA5 is continuously required to maintain nucleosome spacing. | Human SMARCA5 is continuously required to maintain nucleosome spacing.
Bomber ML, Wang J, Liu Q, Barnett KR, Layden HM, Hodges E, Stengel KR, Hiebert SW., Free PMC Article | 03/9/2023 |
| The miR-100-5p Targets SMARCA5 to Regulate the Apoptosis and Intracellular Survival of BCG in Infected THP-1 Cells. | The miR-100-5p Targets SMARCA5 to Regulate the Apoptosis and Intracellular Survival of BCG in Infected THP-1 Cells.
Su L, Zhu T, Liu H, Zhu Y, Peng Y, Tang T, Zhou S, Hu C, Chen H, Guo A, Chen Y., Free PMC Article | 02/16/2023 |
| Long noncoding RNA lncMREF promotes myogenic differentiation and muscle regeneration by interacting with the Smarca5/p300 complex. | Long noncoding RNA lncMREF promotes myogenic differentiation and muscle regeneration by interacting with the Smarca5/p300 complex.
Lv W, Jiang W, Luo H, Tong Q, Niu X, Liu X, Miao Y, Wang J, Guo Y, Li J, Zhan X, Hou Y, Peng Y, Wang J, Zhao S, Xu Z, Zuo B., Free PMC Article | 10/22/2022 |
| Circular RNA SMARCA5 functions as an anti-tumor candidate in colon cancer by sponging microRNA-552. | Circular RNA SMARCA5 functions as an anti-tumor candidate in colon cancer by sponging microRNA-552.
Yang S, Gao S, Liu T, Liu J, Zheng X, Li Z., Free PMC Article | 01/29/2022 |
| Negative Correlation Between Circular RNA SMARC5 and MicroRNA 432, and Their Clinical Implications in Bladder Cancer Patients. | Negative Correlation Between Circular RNA SMARC5 and MicroRNA 432, and Their Clinical Implications in Bladder Cancer Patients.
Zhang Z, Sang Y, Liu Z, Shao J., Free PMC Article | 01/29/2022 |
| A circular RNA, circSMARCA5, inhibits prostate cancer proliferative, migrative, and invasive capabilities via the miR-181b-5p/miR-17-3p-TIMP3 axis. | A circular RNA, circSMARCA5, inhibits prostate cancer proliferative, migrative, and invasive capabilities via the miR-181b-5p/miR-17-3p-TIMP3 axis.
Xie X, Sun FK, Huang X, Wang CH, Dai J, Zhao JP, Fang C, He W., Free PMC Article | 01/15/2022 |
| MicroRNA miR-100 Decreases Glioblastoma Growth by Targeting SMARCA5 and ErbB3 in Tumor-Initiating Cells. | MicroRNA miR-100 Decreases Glioblastoma Growth by Targeting SMARCA5 and ErbB3 in Tumor-Initiating Cells.
Alrfaei BM, Clark P, Vemuganti R, Kuo JS., Free PMC Article | 11/6/2021 |
| Circ-SMARCA5 suppresses colorectal cancer progression via downregulating miR-39-3p and upregulating ARID4B. | Circ-SMARCA5 suppresses colorectal cancer progression via downregulating miR-39-3p and upregulating ARID4B.
Miao X, Xi Z, Zhang Y, Li Z, Huang L, Xin T, Shen R, Wang T. | 09/4/2021 |
| Sequence and functional differences in the ATPase domains of CHD3 and SNF2H promise potential for selective regulability and drugability. | Sequence and functional differences in the ATPase domains of CHD3 and SNF2H promise potential for selective regulability and drugability.
Hoffmeister H, Fuchs A, Komives E, Groebner-Ferreira R, Strobl L, Nazet J, Heizinger L, Merkl R, Dove S, Längst G. | 08/7/2021 |
| Circular RNA SMARCA5 suppressed non-small cell lung cancer progression by regulating miR-670-5p/RBM24 axis. | Circular RNA SMARCA5 suppressed non-small cell lung cancer progression by regulating miR-670-5p/RBM24 axis.
Zhang D, Ma Y, Ma Z, Liu S, Sun L, Li J, Zhao F, Li Y, Zhang J, Li S, Jiang J. | 05/1/2021 |
| MiR-146b-5p suppresses the malignancy of GSC/MSC fusion cells by targeting SMARCA5. | MiR-146b-5p suppresses the malignancy of GSC/MSC fusion cells by targeting SMARCA5.
Wang H, Tan L, Dong X, Liu L, Jiang Q, Li H, Shi J, Yang X, Dai X, Qian Z, Dong J., Free PMC Article | 03/13/2021 |
| Loss of ISWI ATPase SMARCA5 (SNF2H) in Acute Myeloid Leukemia Cells Inhibits Proliferation and Chromatid Cohesion. | Loss of ISWI ATPase SMARCA5 (SNF2H) in Acute Myeloid Leukemia Cells Inhibits Proliferation and Chromatid Cohesion.
Zikmund T, Paszekova H, Kokavec J, Kerbs P, Thakur S, Turkova T, Tauchmanova P, Greif PA, Stopka T., Free PMC Article | 12/5/2020 |
| A conserved basic motif within SNF2h that is essential for chromatinremodeling activity. | A basic motif anchoring ISWI to nucleosome acidic patch regulates nucleosome spacing.
Dao HT, Dul BE, Dann GP, Liszczak GP, Muir TW., Free PMC Article | 05/2/2020 |
| Circ-SMARCA5 is downregulated and correlated with lower beta2-MG level and International Staging System stage as well as better prognosis in multiple myeloma patients, and it inhibits proliferation but promotes apoptosis of multiple myeloma cells via directly sponging miR-767-5p. | Circ-SMARCA5 suppresses progression of multiple myeloma by targeting miR-767-5p.
Liu H, Wu Y, Wang S, Jiang J, Zhang C, Jiang Y, Wang X, Hong L, Huang H., Free PMC Article | 02/29/2020 |
| Here, the authors show that the Chd1 remodeler from Saccharomyces cerevisiae and ISWI remodelers from human and Drosophila have distinct spatial requirements for the acidic patch. Unlike Chd1, which is equally affected by entry- and exit-side mutations, ISWI remodelers strongly depend on the entry-side acidic patch. | Asymmetry between the two acidic patches dictates the direction of nucleosome sliding by the ISWI chromatin remodeler.
Levendosky RF, Bowman GD., Free PMC Article | 02/22/2020 |
| The authors propose a model for allosteric control through the nucleosome, where one SNF2h protomer promotes asymmetric octamer deformation to inhibit the second protomer, while stimulating directional DNA translocation. | Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome.
Armache JP, Gamarra N, Johnson SL, Leonard JD, Wu S, Narlikar GJ, Cheng Y., Free PMC Article | 02/22/2020 |
| circSMARCA5/miR-620 regulatory axis is involved in the development of CC and may serve as a potential therapy target. | Involvement of circular RNA SMARCA5/microRNA-620 axis in the regulation of cervical cancer cell proliferation, invasion and migration.
Tian JDC, Liang L. | 12/14/2019 |
| cSMARCA5 (a circRNA derived from exons 15 and 16 of the SMARCA5 gene, hsa_circ_0001445) inhibits the growth and migration of hepatocellular carcinoma cells, making it a potential therapeutic target. | Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma.
Yu J, Xu QG, Wang ZG, Yang Y, Zhang L, Ma JZ, Sun SH, Yang F, Zhou WP. | 09/21/2019 |
| propose a model in which the acidic patch, formed by histones H2A and H2B, activates SNF2h by providing a landing pad for the NegC and AutoN auto-inhibitory domains. | The nucleosomal acidic patch relieves auto-inhibition by the ISWI remodeler SNF2h.
Gamarra N, Johnson SL, Trnka MJ, Burlingame AL, Narlikar GJ., Free PMC Article | 06/1/2019 |
| circular RNA SMARCA5 as a potential novel biomarker for hepatocellular carcinoma | Using circular RNA SMARCA5 as a potential novel biomarker for hepatocellular carcinoma.
Li Z, Zhou Y, Yang G, He S, Qiu X, Zhang L, Deng Q, Zheng F. | 03/23/2019 |
| our data show circSMARCA5 as a promising druggable tumor suppressor in GBM and suggest that it may exert its function by tethering the RBP SRSF1. | CircSMARCA5 Inhibits Migration of Glioblastoma Multiforme Cells by Regulating a Molecular Axis Involving Splicing Factors SRSF1/SRSF3/PTB.
Barbagallo D, Caponnetto A, Cirnigliaro M, Brex D, Barbagallo C, D'Angeli F, Morrone A, Caltabiano R, Barbagallo GM, Ragusa M, Di Pietro C, Hansen TB, Purrello M., Free PMC Article | 08/11/2018 |