| Lnc-RGS5 sponges miR-542-5p to promote FoxM1/VEGFA signaling and breast cancer cell proliferation. | Lnc‑RGS5 sponges miR‑542‑5p to promote FoxM1/VEGFA signaling and breast cancer cell proliferation.
Song J, Tang Y, Song F., Free PMC Article | 08/22/2023 |
| RGS5: a novel role as a hypoxia-responsive protein that suppresses chemokinetic and chemotactic migration in brain pericytes. | RGS5: a novel role as a hypoxia-responsive protein that suppresses chemokinetic and chemotactic migration in brain pericytes.
Enström A, Carlsson R, Özen I, Paul G., Free PMC Article | 10/22/2022 |
| Implications of regulator of G-protein signaling 5 expression in the pathogenesis of primary and secondary hyperparathyroidism. | Implications of regulator of G-protein signaling 5 expression in the pathogenesis of primary and secondary hyperparathyroidism.
Li X, Lu Y, Zhang L, Song A, Zhang H, Pang B, Liu J, Sun X, Ji H, Huang L, Yang M., Free PMC Article | 06/18/2022 |
| Integration of NRP1, RGS5, and FOXM1 expression, and tumour necrosis, as a postoperative prognostic classifier based on molecular subtypes of clear cell renal cell carcinoma. | Integration of NRP1, RGS5, and FOXM1 expression, and tumour necrosis, as a postoperative prognostic classifier based on molecular subtypes of clear cell renal cell carcinoma.
Yoshida T, Ohe C, Ikeda J, Atsumi N, Saito R, Taniguchi H, Ohsugi H, Sugi M, Tsuta K, Matsuda T, Kinoshita H., Free PMC Article | 02/12/2022 |
| RGS5 Attenuates Baseline Activity of ERK1/2 and Promotes Growth Arrest of Vascular Smooth Muscle Cells. | RGS5 Attenuates Baseline Activity of ERK1/2 and Promotes Growth Arrest of Vascular Smooth Muscle Cells.
Demirel E, Arnold C, Garg J, Jäger MA, Sticht C, Li R, Kuk H, Wettschureck N, Hecker M, Korff T., Free PMC Article | 10/30/2021 |
| RGS5 rs4657251 polymorphism is associated with small vessel occlusion stroke in Taiwan Han Chinese. | RGS5 rs4657251 polymorphism is associated with small vessel occlusion stroke in Taiwan Han Chinese.
Hsu LC, Hsu LS, Lee TH. | 10/23/2021 |
| Down-regulated RGS5 by genetic variants impairs endothelial cell function and contributes to coronary artery disease. | Down-regulated RGS5 by genetic variants impairs endothelial cell function and contributes to coronary artery disease.
Li Y, Yan H, Guo J, Han Y, Zhang C, Liu X, Du J, Tian XL. | 10/9/2021 |
| Hepatic Regulator of G Protein Signaling 5 Ameliorates Nonalcoholic Fatty Liver Disease by Suppressing Transforming Growth Factor Beta-Activated Kinase 1-c-Jun-N-Terminal Kinase/p38 Signaling. | Hepatic Regulator of G Protein Signaling 5 Ameliorates Nonalcoholic Fatty Liver Disease by Suppressing Transforming Growth Factor Beta-Activated Kinase 1-c-Jun-N-Terminal Kinase/p38 Signaling.
Wang J, Ma J, Nie H, Zhang XJ, Zhang P, She ZG, Li H, Ji YX, Cai J. | 06/19/2021 |
| Human cytomegalovirus promoting endothelial cell proliferation by targeting regulator of G-protein signaling 5 hypermethylation and downregulation. | Human cytomegalovirus promoting endothelial cell proliferation by targeting regulator of G-protein signaling 5 hypermethylation and downregulation.
Zhang X, Tang N, Xi D, Feng Q, Liu Y, Wang L, Tang Y, Zhong H, He F., Free PMC Article | 11/21/2020 |
| Expression and role of regulator of G-protein signaling 5 in squamous cell carcinoma of the tongue. | Expression and role of regulator of G-protein signaling 5 in squamous cell carcinoma of the tongue.
Abe Y, Ogasawara S, Akiba J, Naito Y, Kondo R, Nakamura K, Kusukawa J, Yano H., Free PMC Article | 10/3/2020 |
| In biopsy specimens of hepatocellular carcinoma, RGS5 and GPC3 expression were useful molecular makers for predicting portal vein invasion. | Usefulness of Tumor Tissue Biopsy for Predicting the Biological Behavior of Hepatocellular Carcinoma.
Shioga T, Kondo R, Ogasawara S, Akiba J, Mizuochi S, Kusano H, Mihara Y, Tanigawa M, Kinjyo Y, Naito Y, Kuromatsu R, Nakashima O, Yano H. | 07/18/2020 |
| Results show that RGS5 was highly expressed in the cytoplasm of epithelial ovarian cancer (EOC) cells and in microvascular structures. The expression of RGS5 in EOC was negatively associated with peritoneal metastasis. Hypoxia increased RGS5 expression in ovarian carcinomaderived endothelial cells (ODMECs). Further data indicated that RGS5 is crucial for the occurrence and development of ovarian cancer. | RGS5 decreases the proliferation of human ovarian carcinoma‑derived primary endothelial cells through the MAPK/ERK signaling pathway in hypoxia.
Wang D, Xu Y, Feng L, Yin P, Song SS, Wu F, Yan P, Liang Z., Free PMC Article | 01/26/2019 |
| The chimeric RGS8 domains containing the first or the second exon part of RGS5 showed strong inhibitory effects similar to that of wild type RGS8, but the chimeric domain with the third exon part of RGS5 lost its activity | Potent inhibition of angiotensin AT1 receptor signaling by RGS8: importance of the C-terminal third exon part of its RGS domain.
Song D, Nishiyama M, Kimura S. | 04/8/2017 |
| Rgs5 prevents vagal-related bradycardia and atrial tachycardia by negatively regulating the IKA Ach current. | Potential Role of Regulator of G-Protein Signaling 5 in the Protection of Vagal-Related Bradycardia and Atrial Tachyarrhythmia.
Qin M, Liu X, Liu T, Wang T, Huang C., Free PMC Article | 12/17/2016 |
| The rs16849802 of RGS5 and haplotype GAA independently increased the risk of essential hypertension in Mongolian patients, and may be used as a risk factor for the prediction of high blood pressure. | Association of regulator of G protein signaling (RGS5) gene variants and essential hypertension in Mongolian and Han populations.
Chang PY, Qin L, Zhao P, Liu ZY. | 10/22/2016 |
| Downregulation of RGS5 is an important prerequisite for smooth muscle cell proliferation in vascular injury model. | Regulator of G-Protein Signaling 5 Prevents Smooth Muscle Cell Proliferation and Attenuates Neointima Formation.
Daniel JM, Prock A, Dutzmann J, Sonnenschein K, Thum T, Bauersachs J, Sedding DG. | 06/4/2016 |
| The pericyte marker RGS5 may be of future clinical utility for the evaluation of pericytic differentiation in soft tissue tumors. | The pericyte antigen RGS5 in perivascular soft tissue tumors.
Shen J, Shrestha S, Yen YH, Scott MA, Soo C, Ting K, Peault B, Dry SM, James AW., Free PMC Article | 04/23/2016 |
| RGS5 enhanced the cytotoxic effect of radiation in the human lung cancer cells. Our results indicated that RGS5 may be a potential target for cancer therapy. | Overexpression of the regulator of G-protein signaling 5 reduces the survival rate and enhances the radiation response of human lung cancer cells.
Xu Z, Zuo Y, Wang J, Yu Z, Peng F, Chen Y, Dong Y, Hu X, Zhou Q, Ma H, Bao Y, Chen M. | 02/13/2016 |
| Our work identifies a new genetic variant in RGS5 demonstrating additive effect with PDE4D, both implicated in modulation of asthma treatment. | RGS5 gene and therapeutic response to short acting bronchodilators in paediatric asthma patients.
Labuda M, Laberge S, Brière J, Bérubé D, Krajinovic M. | 04/26/2014 |
| ectopic expression of R4 subfamily members RGS2, RGS3, RGS4, and RGS5 reduced activated PAR1 wild-type signaling, whereas signaling by the PAR1 AKKAA mutant was minimally affected. | Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins.
Chen B, Siderovski DP, Neubig RR, Lawson MA, Trejo J., Free PMC Article | 03/22/2014 |
| RGS1 is largely upregulated, whereas RGS2 is downregulated in the majority of solid tumors, whereas RGS5 transcripts are greatly increased in eight subtypes of lymphoma with no reports of downregulation in hematological malignancies | RGS expression in cancer: oncomining the cancer microarray data.
Sethakorn N, Dulin NO. | 01/4/2014 |
| Over-expression of regulator of G protein signaling 5 promotes tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma cells. | Over-expression of regulator of G protein signaling 5 promotes tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma cells.
Hu M, Chen X, Zhang J, Wang D, Fang X, Wang X, Wang G, Chen G, Jiang X, Xia H, Wang Y. | 10/19/2013 |
| demonstrate RGS5 in the blood vessels of other cancer models endowed with a proangiogenic environment, such as human melanoma and renal carcinoma xenografts | Regulator of G-protein signaling 5 (RGS5) protein: a novel marker of cancer vasculature elicited and sustained by the tumor's proangiogenic microenvironment.
Silini A, Ghilardi C, Figini S, Sangalli F, Fruscio R, Dahse R, Pedley RB, Giavazzi R, Bani M., Free PMC Article | 05/5/2012 |
| Low expression of RGS5 was strongly associated with cancer vasculature invasion and lymph node metastasis in non-small cell lung cancer. | The relationship between RGS5 expression and cancer differentiation and metastasis in non-small cell lung cancer.
Huang G, Song H, Wang R, Han X, Chen L. | 03/24/2012 |
| examined polymorphisms in three genes (ATP1B1, RGS5 and SELE) in relation to hypertension and blood pressure in a cohort of African-Americans | Association of ATP1B1, RGS5 and SELE polymorphisms with hypertension and blood pressure in African-Americans.
Faruque MU, Chen G, Doumatey A, Huang H, Zhou J, Dunston GM, Rotimi CN, Adeyemo AA., Free PMC Article | 01/21/2012 |