| HSH2D contributes to methotrexate resistance in human Tcell acute lymphoblastic leukaemia. | HSH2D contributes to methotrexate resistance in human T‑cell acute lymphoblastic leukaemia.
Wang J, Xiong Y., Free PMC Article | 07/10/2021 |
| Both ALX and ChemR23 were present in human synovium and medial tibial plateau bone obtained following total knee replacement surgery for osteoarthritis. | Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain.
Huang J, Burston JJ, Li L, Ashraf S, Mapp PI, Bennett AJ, Ravipati S, Pousinis P, Barrett DA, Scammell BE, Chapman V., Free PMC Article | 08/19/2017 |
| pro-inflammatory stimuli lead to FPR2/ALX expression while LXA4 induces an anti-inflammatory response | Differential regulation of monocytic expression of leukotriene and lipoxin receptors.
Petri MH, Thul S, Ovchinnikova O, Bäck M. | 09/24/2016 |
| LXA decreased IgM and IgG production on activated human B cells through ALX/FPR2-dependent signaling. | Lipoxin A₄ modulates adaptive immunity by decreasing memory B-cell responses via an ALX/FPR2-dependent mechanism.
Ramon S, Bancos S, Serhan CN, Phipps RP., Free PMC Article | 04/26/2014 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| although ALX is inducibly phosphorylated upon TCR/CD28 stimulation, this phosphorylation is not required for ALX to inhibit T cell activation. | Phosphorylation at serine 318 is not required for inhibition of T cell activation by ALX.
Shapiro MJ, Spruce L, Sundsbak R, Thapa P, Shapiro VS., Free PMC Article | 07/19/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesNew genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. | 04/7/2010 |
| results indicate that RvD1 specifically interacts with both ALX and GPR32 on phagocytes. | Resolvin D1 binds human phagocytes with evidence for proresolving receptors.
Krishnamoorthy S, Recchiuti A, Chiang N, Yacoubian S, Lee CH, Yang R, Petasis NA, Serhan CN., Free PMC Article | 03/15/2010 |
| ALX is an adaptor involved in T cell activation and interleukin-2 (IL-2) promoter activation | Cloning and characterization of ALX, an adaptor downstream of CD28.
Greene TA, Powell P, Nzerem C, Shapiro MJ, Shapiro VS. | 01/21/2010 |
| involved in tyrosine kinase signaling in hematopoietic cells | HSH2: a novel SH2 domain-containing adapter protein involved in tyrosine kinase signaling in hematopoietic cells.
Oda T, Muramatsu MA, Isogai T, Masuho Y, Asano S, Yamashita T. | 01/21/2010 |
| the ALX SH2 domain plays a critical role in ALX function downstream of CD28 | The ALX Src homology 2 domain is both necessary and sufficient to inhibit T cell receptor/CD28-mediated up-regulation of RE/AP.
Shapiro MJ, Powell P, Ndubuizu A, Nzerem C, Shapiro VS. | 01/21/2010 |
| ALX exerts its effect on IL-2 up-regulation in the cytoplasm and responds to TCR and CD28 signaling | The carboxyl-terminal segment of the adaptor protein ALX directs its nuclear export during T cell activation.
Shapiro MJ, Chen YY, Shapiro VS. | 01/21/2010 |