| FLI1 induces erythroleukemia through opposing effects on UBASH3A and UBASH3B expression. | FLI1 induces erythroleukemia through opposing effects on UBASH3A and UBASH3B expression.
Wang J, Wang C, Hu A, Yu K, Kuang Y, Gajendran B, Zacksenhaus E, Sample KM, Xiao X, Liu W, Ben-David Y., Free PMC Article | 03/28/2024 |
| Ubash3b promotes TPA-mediated suppression of leukemogenesis through accelerated downregulation of PKCdelta protein. | Ubash3b promotes TPA-mediated suppression of leukemogenesis through accelerated downregulation of PKCδ protein.
Yao Y, Liu W, Gajendran B, Wang C, Zacksenhaus E, Sample KM, Varier KM, Hao X, Ben-David Y. | 07/17/2021 |
| An unexpected 2-histidine phosphoesterase activity of suppressor of T-cell receptor signaling protein 1 contributes to the suppression of cell signaling. | An unexpected 2-histidine phosphoesterase activity of suppressor of T-cell receptor signaling protein 1 contributes to the suppression of cell signaling.
Yin Y, Frank D, Zhou W, Kaur N, French JB, Carpino N., Free PMC Article | 01/9/2021 |
| These studies help define a critical role of Ubash3b in leukemia | Integrative phosphoproteome and interactome analysis of the role of Ubash3b in BCR-ABL signaling.
Cutler JA, Udainiya S, Madugundu AK, Renuse S, Xu Y, Jung J, Kim KP, Wu X, Pandey A., Free PMC Article | 07/4/2020 |
| the UBASH3B gene rs4936742 (T > C) polymorphism is associated with an increased risk of Behcet's disease, especially non-ocular BD, in Iranian population. We could not find any susceptibility role of this genetic locus for posterior uveitis in Behcet's disease. | Ubiquitin Associated and SH3 Domain Containing B (UBASH3B) Gene Association with Behcet's Disease in Iranian Population.
Shahriyari E, Bonyadi M, Jabbarpoor Bonyadi MH, Soheilian M, Yaseri M, Ebrahimiadib N. | 04/18/2020 |
| Sts-1 is a negative regulator. | The phosphatase UBASH3B/Sts-1 is a negative regulator of Bcr-Abl kinase activity and leukemogenesis.
Mian AA, Baumann I, Liebermann M, Grebien F, Superti-Furga G, Ruthardt M, Ottmann OG, Hantschel O., Free PMC Article | 02/8/2020 |
| UBASH3A/STS-2/TULA exhibits substantial homology to UBASH3B/STS-1/TULA-2, but possesses only a small fraction of phosphatase activity of UBASH3B/STS-1/TULA-2, and thus, its regulatory effect may be based also on the phosphatase-independent mechanisms. Critical physiologic effects of these proteins have been demonstrated in T lymphocytes, platelets, stem cells, and other important cell types. | TULA-family proteins: Jacks of many trades and then some.
Tsygankov AY. | 10/5/2019 |
| Data suggest that Sts1 (suppressor of T-cell receptor signaling-1) negatively regulates TCR (T-cell receptor) signaling in activated T-lymphocytes via dephosphorylation of ZAP70. | Insights into the suppressor of T-cell receptor (TCR) signaling-1 (Sts-1)-mediated regulation of TCR signaling through the use of novel substrate-trapping Sts-1 phosphatase variants.
Luis BS, Carpino N., Free PMC Article | 10/26/2017 |
| The results show that the interaction between STS-1 and ShcA is regulated in response to EGF receptor activation. | Identification of STS-1 as a novel ShcA-binding protein.
van der Meulen T, Swarts S, Fischer W, van der Geer P. | 08/12/2017 |
| The study reveals a role of CBL in restricting myeloid proliferation of human AML1-ETOinduced leukemia, and identifies UBASH3B as a potential target for pharmaceutical intervention. | UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO.
Goyama S, Schibler J, Gasilina A, Shrestha M, Lin S, Link KA, Chen J, Whitman SP, Bloomfield CD, Nicolet D, Assi SA, Ptasinska A, Heidenreich O, Bonifer C, Kitamura T, Nassar NN, Mulloy JC., Free PMC Article | 07/30/2016 |
| targeting Aurora B to microtubules by UBASH3B is necessary for the timing and fidelity of chromosome segregation in human cells | Ubiquitin Receptor Protein UBASH3B Drives Aurora B Recruitment to Mitotic Microtubules.
Krupina K, Kleiss C, Metzger T, Fournane S, Schmucker S, Hofmann K, Fischer B, Paul N, Porter IM, Raffelsberger W, Poch O, Swedlow JR, Brino L, Sumara I., Free PMC Article | 05/28/2016 |
| These results show that TULA-2 is a target of miR-148a-3p | Anti-miR-148a regulates platelet FcγRIIA signaling and decreases thrombosis in vivo in mice.
Zhou Y, Abraham S, Andre P, Edelstein LC, Shaw CA, Dangelmaier CA, Tsygankov AY, Kunapuli SP, Bray PF, McKenzie SE., Free PMC Article | 05/7/2016 |
| This recovery involves the phosphorylation of p70 independent of mTOR. | Placenta growth factor induces invasion and activates p70 during rapamycin treatment in trophoblast cells.
Knuth A, Liu L, Nielsen H, Merril D, Torry DS, Arroyo JA. | 11/28/2015 |
| results demonstrate the importance of STS-1 in regulating IFN-alpha-induced autophagy in B cells | STS-1 promotes IFN-α induced autophagy by activating the JAK1-STAT1 signaling pathway in B cells.
Dong G, You M, Fan H, Ding L, Sun L, Hou Y. | 10/31/2015 |
| UBASH3B is a functional target of anti-invasive microRNA200a that is down-regulated in triple negative breast cancer. Importantly, the oncogenic potential of UBASH3B is dependent on its tyrosine phosphatase activity. | Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis.
Lee ST, Feng M, Wei Y, Li Z, Qiao Y, Guan P, Jiang X, Wong CH, Huynh K, Wang J, Li J, Karuturi KM, Tan EY, Hoon DS, Kang Y, Yu Q., Free PMC Article | 09/28/2013 |
| Ablation of TULA-2 resulted in hyperphosphorylation of Syk and its downstream effector phospholipase C-gamma2 as well as enhanced GPVI-mediated platelet functional responses. | A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets.
Thomas DH, Getz TM, Newman TN, Dangelmaier CA, Carpino N, Kunapuli SP, Tsygankov AY, Daniel JL., Free PMC Article | 11/27/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| TULA proteins TULA and TULA-2 regulate activity of the protein tyrosine kinase Syk | TULA proteins regulate activity of the protein tyrosine kinase Syk.
Agrawal R, Carpino N, Tsygankov A. | 01/21/2010 |
| hsp70 inhibits apoptosis upstream and downstream of the mitochondria and is a promising therapeutic target for reversing drug-resistance in chronic myeloid leukemia-blast crisis and acute myeloid leukemia cells. | Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells.
Guo F, Sigua C, Bali P, George P, Fiskus W, Scuto A, Annavarapu S, Mouttaki A, Sondarva G, Wei S, Wu J, Djeu J, Bhalla K. | 01/21/2010 |
| Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases | Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases.
Kowanetz K, Crosetto N, Haglund K, Schmidt MHH, Heldin CH, Dikic I. | 01/21/2010 |