| LIM domain-containing protein Ajuba inhibits chemotherapy-induced apoptosis by negatively regulating p53 stability in colorectal cancer cells. | LIM domain-containing protein Ajuba inhibits chemotherapy-induced apoptosis by negatively regulating p53 stability in colorectal cancer cells.
Xu B, Li Q, Zhang J, Chen F., Free PMC Article | 08/4/2023 |
| Ajuba Overexpression Promotes Breast Cancer Chemoresistance and Glucose Uptake through TAZ-GLUT3/Survivin Pathway. | Ajuba Overexpression Promotes Breast Cancer Chemoresistance and Glucose Uptake through TAZ-GLUT3/Survivin Pathway.
Li X, Zhao G, Mi X, Xu T, Li X, Liu B., Free PMC Article | 04/16/2022 |
| miR-433-3p Targets AJUBA to Inhibit Malignant Progression of Glioma. | miR-433-3p Targets AJUBA to Inhibit Malignant Progression of Glioma.
Zhang J, Guo Y, Ma Y, Wang L, Li W, Zhang M, Zhao J, Hu Y, Yu H, Hu G. | 03/12/2022 |
| Ajuba transactivates N-cadherin expression in colorectal cancer cells through interaction with Twist. | Ajuba transactivates N-cadherin expression in colorectal cancer cells through interaction with Twist.
Wu Z, Zou X, Xu Y, Zhou F, Kuai R, Li J, Yang D, Chu Y, Peng H., Free PMC Article | 02/19/2022 |
| Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues. | Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues.
Ponia SS, Robertson SJ, McNally KL, Subramanian G, Sturdevant GL, Lewis M, Jessop F, Kendall C, Gallegos D, Hay A, Schwartz C, Rosenke R, Saturday G, Bosio CM, Martens C, Best SM. | 02/12/2022 |
| Hsa_circ_0128846 promotes tumorigenesis of colorectal cancer by sponging hsa-miR-1184 and releasing AJUBA and inactivating Hippo/YAP signalling. | Hsa_circ_0128846 promotes tumorigenesis of colorectal cancer by sponging hsa-miR-1184 and releasing AJUBA and inactivating Hippo/YAP signalling.
Wang X, Chen Y, Liu W, Liu T, Sun D., Free PMC Article | 09/18/2021 |
| Super-enhancer-driven AJUBA is activated by TCF4 and involved in epithelial-mesenchymal transition in the progression of Hepatocellular Carcinoma. | Super-enhancer-driven AJUBA is activated by TCF4 and involved in epithelial-mesenchymal transition in the progression of Hepatocellular Carcinoma.
Zhang C, Wei S, Sun WP, Teng K, Dai MM, Wang FW, Chen JW, Ling H, Ma XD, Feng ZH, Duan JL, Cai MY, Xie D., Free PMC Article | 06/5/2021 |
| Knockout of Ajuba Attenuates the Growth and Migration of Hepatocellular Carcinoma Cells. | Knockout of Ajuba Attenuates the Growth and Migration of Hepatocellular Carcinoma Cells.
Le Y, He Y, Bai M, Wang Y, Wu J, Yu L. | 04/17/2021 |
| Ajuba: An emerging signal transducer in oncogenesis. | Ajuba: An emerging signal transducer in oncogenesis.
Jia H, Peng H, Hou Z. | 01/9/2021 |
| Ajuba functions as a co-activator of SP1 to induce its target gene, and that Ajuba itself is a target genes of SP1. Ajuba/SP1 complex could form a feed forward loop to drive SP1 target gene transcription and promote cell proliferation of pancreatic cancer cells. | The LIM protein Ajuba/SP1 complex forms a feed forward loop to induce SP1 target genes and promote pancreatic cancer cell proliferation.
Zhang B, Song L, Cai J, Li L, Xu H, Li M, Wang J, Shi M, Chen H, Jia H, Hou Z., Free PMC Article | 12/21/2019 |
| It is an oncogene in CRC oncogenesis and development. | Identification of genes with universally upregulated or downregulated expressions in colorectal cancer.
Song K, Su W, Liu Y, Zhang J, Liang Q, Li N, Guan Q, He J, Bai X, Zhao W, Guo Z. | 11/30/2019 |
| LIM Protein Ajuba associates with the RPA complex through direct cell cycle-dependent interaction with the RPA70 subunit | LIM Protein Ajuba associates with the RPA complex through direct cell cycle-dependent interaction with the RPA70 subunit.
Fowler S, Maguin P, Kalan S, Loayza D., Free PMC Article | 10/19/2019 |
| data demonstrate that Ajuba functions as a novel co-activator of ERalpha and that Ajuba/DBC1/CBP/p300 ternary complex may be a new target for developing therapeutics to treat breast cancer | The LIM protein Ajuba recruits DBC1 and CBP/p300 to acetylate ERα and enhances ERα target gene expression in breast cancer cells.
Xu B, Li Q, Chen N, Zhu C, Meng Q, Ayyanathan K, Qian W, Jia H, Wang J, Ni P, Hou Z., Free PMC Article | 10/12/2019 |
| We show that all three mammalian Ajuba family proteins - AJUBA, LIMD1 and WTIP - exhibit tension-dependent localization to adherens junctions, and that both LATS family proteins, LATS1 and LATS2, exhibit an overlapping tension-dependent junctional localization | Tension-dependent regulation of mammalian Hippo signaling through LIMD1.
Ibar C, Kirichenko E, Keepers B, Enners E, Fleisch K, Irvine KD., Free PMC Article | 09/14/2019 |
| we unveil a unique participation of Ajuba in maintaining CdGAP in an inactivated status to modulate Rac1 activity and stabilize junctions. | The scaffold protein Ajuba suppresses CdGAP activity in epithelia to maintain stable cell-cell contacts.
McCormack JJ, Bruche S, Ouadda ABD, Ishii H, Lu H, Garcia-Cattaneo A, Chávez-Olórtegui C, Lamarche-Vane N, Braga VMM., Free PMC Article | 04/13/2019 |
| High AJUBA level enhances cervical cancer cells. | AJUBA increases the cisplatin resistance through hippo pathway in cervical cancer.
Bi L, Ma F, Tian R, Zhou Y, Lan W, Song Q, Cheng X. | 01/20/2018 |
| Data show that AJUBA upregulated MMP10 and MMP13 expression in esophageal squamous cell carcinoma (ESCC). | AJUBA promotes the migration and invasion of esophageal squamous cell carcinoma cells through upregulation of MMP10 and MMP13 expression.
Shi X, Chen Z, Hu X, Luo M, Sun Z, Li J, Shi S, Feng X, Zhou C, Li Z, Yang W, Li Y, Wang P, Zhou F, Gao Y, He J., Free PMC Article | 12/30/2017 |
| Mechanistic investigations reveal that AJUBA specifically binds the FERM domain of JAK1 to dissociate JAK1 from the IFNgamma recepter, resulting in an inhibition of STAT1 phosporylation and concomitantly its nuclear translocation. Clinically, the level of AJUBA in CRC specimens is negatively correlated with the levels of IFIT2 and pSTAT1 | The LIM protein AJUBA promotes colorectal cancer cell survival through suppression of JAK1/STAT1/IFIT2 network.
Jia H, Song L, Cong Q, Wang J, Xu H, Chu Y, Li Q, Zhang Y, Zou X, Zhang C, Chin YE, Zhang X, Li Z, Zhu K, Wang B, Peng H, Hou Z. | 09/9/2017 |
| AJUBA is a LIM domain protein and contributes to the formation and stability of cadherin-mediated cell-cell adhesion. Loss of AJUBA enhances Prostate cancer cell migration and downregulation of AJUBA expression is observed in metastatic Prostate cancer. | Androgen receptor-regulated miRNA-193a-3p targets AJUBA to promote prostate cancer cell migration.
Jia L, Gui B, Zheng D, Decker KF, Tinay I, Tan M, Wang X, Kibel AS. | 08/26/2017 |
| Mutations of the LIM protein AJUBA mediate sensitivity of head and neck squamous cell carcinomas to treatment with PLK1 inhibitors. | Mutations of the LIM protein AJUBA mediate sensitivity of head and neck squamous cell carcinoma to treatment with cell-cycle inhibitors.
Zhang M, Singh R, Peng S, Mazumdar T, Sambandam V, Shen L, Tong P, Li L, Kalu NN, Pickering CR, Frederick M, Myers JN, Wang J, Johnson FM., Free PMC Article | 08/12/2017 |
| mitotic phosphorylation of Ajuba is sufficient to promote cell proliferation and anchorage-independent growth in vitro and tumorigenesis in vivo | Ajuba Phosphorylation by CDK1 Promotes Cell Proliferation and Tumorigenesis.
Chen X, Stauffer S, Chen Y, Dong J., Free PMC Article | 01/14/2017 |
| The results in this study uncovered that JUB was a regulator involved in proliferation of glioma cells, and it could be used as a potential therapeutic target for glioma. | siRNA-mediated knockdown of JUB expression suppresses the proliferation of glioblastoma cells.
Ouyang H, Guo Z, Cheng Z, Guo Y. | 07/2/2016 |
| AJUBA negatively regulates YAP activity through the LATS family, and inactivation of AJUBA is a novel key mechanism in malignant mesothelioma cell proliferation | LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade.
Tanaka I, Osada H, Fujii M, Fukatsu A, Hida T, Horio Y, Kondo Y, Sato A, Hasegawa Y, Tsujimura T, Sekido Y. | 03/21/2015 |
| the LIM protein JUB serves as a tumor-promoting gene in colorectal cancer by promoting epithelial-mesenchymal transition, a critical process of metastasis. | LIM protein JUB promotes epithelial-mesenchymal transition in colorectal cancer.
Liang XH, Zhang GX, Zeng YB, Yang HF, Li WH, Liu QL, Tang YL, He WG, Huang YN, Zhang L, Yu LN, Zeng XC., Free PMC Article | 08/9/2014 |
| The LIM domain of Ajuba can competitively bind to the N-terminal of Aurora-A, and inhibited the interaction between N-terminal and C-terminal of Aurora A. | A novel mechanism for activation of Aurora-A kinase by Ajuba.
Bai M, Ni J, Wu J, Wang B, Shen S, Yu L. | 07/5/2014 |