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    RAD18 E3 ubiquitin-protein ligase RAD18 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850430, updated on 9-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The Zn-finger of Saccharomyces cerevisiae Rad18 and its adjacent region mediate interaction with Rad5.

    The Zn-finger of Saccharomyces cerevisiae Rad18 and its adjacent region mediate interaction with Rad5.
    Frittmann O, Gali VK, Halmai M, Toth R, Gyorfy Z, Balint E, Unk I., Free PMC Article

    08/7/2021
    The Pol30-K196 residue plays a critical role in budding yeast DNA post-replication repair through interaction with Rad18.

    The Pol30-K196 residue plays a critical role in budding yeast DNA postreplication repair through interaction with Rad18.
    Fan L, Xiao W.

    05/20/2017
    following UV-induced damage, reactivation of Rad18, even after prolonged G2 arrest, restores viability and genome integrity.

    The preference for error-free or error-prone postreplication repair in Saccharomyces cerevisiae exposed to low-dose methyl methanesulfonate is cell cycle dependent.
    Huang D, Piening BD, Paulovich AG., Free PMC Article

    06/15/2013
    The results imply that sumoylated PCNA is the physiological ubiquitylation target of budding yeast Rad18.

    A SUMO-interacting motif activates budding yeast ubiquitin ligase Rad18 towards SUMO-modified PCNA.
    Parker JL, Ulrich HD., Free PMC Article

    02/23/2013
    In this study we showed that DNA damage induced by hydrogen peroxide at the same mutagen doses causes significantly more mutations and lethal events in the rad18 mutant cells compared to control wild-type cells

    [RAD18 gene product of yeast Saccharomyces cerevisiae controls mutagenesis induced by hydrogen peroxide].
    Kozhina TN, Korolev VG.

    08/4/2012
    Rad17, a subunit of the PCNA-like 9-1-1 checkpoint clamp is ubiquitylated; however, in contrast to previous results, modification of Rad17 is found to be independent of DNA damage, the Rad6-Rad18 complex.

    Ubiquitylation of the 9-1-1 checkpoint clamp is independent of rad6-rad18 and DNA damage.
    Davies AA, Neiss A, Ulrich HD.

    06/28/2010
    Rad6-Rad18 and Ubc13-Mms2-Rad5 act sequentially and mediate proliferating cell nuclear antigen poly-ubiquitylation by stepwise addition of ubiquitin monomers.

    Mechanistic analysis of PCNA poly-ubiquitylation by the ubiquitin protein ligases Rad18 and Rad5.
    Parker JL, Ulrich HD., Free PMC Article

    01/21/2010
    key role for the RAD6-RAD18-RAD5 error-free postreplication repair (RAD6 error-free PRR) pathway in promoting cell growth and survival, in response to chronic low-dose ultraviolet light

    RAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light.
    Hishida T, Kubota Y, Carr AM, Iwasaki H.

    01/21/2010
    The interactions between Rad18, RPA and DNA and discuss their contribution to the activation of DNA damage bypass, was examined.

    Cooperation of replication protein A with the ubiquitin ligase Rad18 in DNA damage bypass.
    Huttner D, Ulrich HD.

    01/21/2010
    Rad18 is required for the formation of X-shaped sister chromatid junctions (SCJs) at damaged replication forks through a process involving PCNA polyubiquitylation and the ubiquitin-conjugating enzymes Mms2 and Ubc13

    SUMOylation regulates Rad18-mediated template switch.
    Branzei D, Vanoli F, Foiani M.

    01/21/2010
    Rad6-Rad18 promotes DNA-damage-dependent transcriptional induction as well as checkpoint functions by catalyzing monoubiquitination at the K197 residue of the Rad17 subunit of the 9-1-1 complex.

    Rad6-Rad18 mediates a eukaryotic SOS response by ubiquitinating the 9-1-1 checkpoint clamp.
    Fu Y, Zhu Y, Zhang K, Yeung M, Durocher D, Xiao W.

    01/21/2010
    error-free component of the RAD6/RAD18 pathway completes replication by a mechanism employing recombination between partially replicated sister strands, possibly by means of transient template strand switching or copy choice.

    The error-free component of the RAD6/RAD18 DNA damage tolerance pathway of budding yeast employs sister-strand recombination.
    Zhang H, Lawrence CW., Free PMC Article

    01/21/2010
    role in polyubiquitination of PCNA

    Rad18/Rad5/Mms2-mediated polyubiquitination of PCNA is implicated in replication completion during replication stress.
    Branzei D, Seki M, Enomoto T.

    01/21/2010
    Study suggests that Rad18/Rad5/Mms2 and Mgs1 are required to promote replication when forks are destabilized or stalled due to defects in Pol delta.

    Mgs1 and Rad18/Rad5/Mms2 are required for survival of Saccharomyces cerevisiae mutants with novel temperature/cold sensitive alleles of the DNA polymerase delta subunit, Pol31.
    Vijeh Motlagh ND, Seki M, Branzei D, Enomoto T.

    01/21/2010
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