| Systematic analysis of tup1 and cyc8 mutants reveals distinct roles for TUP1 and CYC8 and offers new insight into the regulation of gene transcription by the yeast Tup1-Cyc8 complex. | Systematic analysis of tup1 and cyc8 mutants reveals distinct roles for TUP1 and CYC8 and offers new insight into the regulation of gene transcription by the yeast Tup1-Cyc8 complex.
Lee B, Church M, Hokamp K, Alhussain MM, Bamagoos AA, Fleming AB., Free PMC Article | 08/30/2023 |
| Functional characterization and comparative analysis of gene repression-mediating domains interacting with yeast pleiotropic corepressors Sin3, Cyc8 and Tup1. | Functional characterization and comparative analysis of gene repression-mediating domains interacting with yeast pleiotropic corepressors Sin3, Cyc8 and Tup1.
Lettow J, Kliewe F, Aref R, Schüller HJ., Free PMC Article | 05/22/2023 |
| Tup1 is critical for transcriptional repression in Quiescence in S. cerevisiae. | Tup1 is critical for transcriptional repression in Quiescence in S. cerevisiae.
Bailey TB, Whitty PA, Selker EU, McKnight JN, McKnight LE., Free PMC Article | 01/14/2023 |
| Genetic analysis argues for a coactivator function for the Saccharomyces cerevisiae Tup1 corepressor. | Genetic analysis argues for a coactivator function for the Saccharomyces cerevisiae Tup1 corepressor.
Parnell EJ, Parnell TJ, Stillman DJ., Free PMC Article | 03/26/2022 |
| Transcriptional repressor Gal80 recruits corepressor complex Cyc8-Tup1 to structural genes of the Saccharomyces cerevisiae GAL regulon. | Transcriptional repressor Gal80 recruits corepressor complex Cyc8-Tup1 to structural genes of the Saccharomyces cerevisiae GAL regulon.
Lettow J, Aref R, Schüller HJ., Free PMC Article | 03/19/2022 |
| Functional analysis of Cti6 core domain responsible for recruitment of epigenetic regulators Sin3, Cyc8 and Tup1. | Functional analysis of Cti6 core domain responsible for recruitment of epigenetic regulators Sin3, Cyc8 and Tup1.
Aref R, Schüller HJ., Free PMC Article | 06/5/2021 |
| Glucose, Cyc8p and Tup1p regulate biofilm formation and dispersal in wild Saccharomyces cerevisiae. | Glucose, Cyc8p and Tup1p regulate biofilm formation and dispersal in wild Saccharomyces cerevisiae.
Van Nguyen P, Plocek V, Váchová L, Palková Z., Free PMC Article | 03/27/2021 |
| Ash1 and Tup1 dependent repression of the Saccharomyces cerevisiae HO promoter requires activator-dependent nucleosome eviction. | Ash1 and Tup1 dependent repression of the Saccharomyces cerevisiae HO promoter requires activator-dependent nucleosome eviction.
Parnell EJ, Parnell TJ, Yan C, Bai L, Stillman DJ., Free PMC Article | 01/23/2021 |
| Study provides clear evidence of the functions of the Tup1p and Cyc8p regulators in biofilm colony formation. Cyc8p itself is a repressor of FLO11 gene expression and of the formation of the structured architecture of colony biofilms, whereas Tup1p counteracts Cyc8p, being a positive regulator of FLO11 expression and colony complexity. | Cyc8p and Tup1p transcription regulators antagonistically regulate Flo11p expression and complexity of yeast colony biofilms.
Nguyen PV, Hlaváček O, Maršíková J, Váchová L, Palková Z., Free PMC Article | 01/19/2019 |
| Tup1 regulates GAL1 epigenetic transcriptional memory. Tup1 is necessary for incorporation of both H2A.Z and H3K4me2 at the GAL1 promoter. | Epigenetic Transcriptional Memory of GAL Genes Depends on Growth in Glucose and the Tup1 Transcription Factor in Saccharomyces cerevisiae.
Sood V, Cajigas I, D'Urso A, Light WH, Brickner JH., Free PMC Article | 12/16/2017 |
| we identified a transposable element insertion in the promoter region of known flocculation gene FLO1, and, in an additional five clones, we recovered loss-of-function mutations in transcriptional repressor TUP1, which regulates FLO1 and other related genes | Experimental Evolution Reveals Favored Adaptive Routes to Cell Aggregation in Yeast.
Hope EA, Amorosi CJ, Miller AW, Dang K, Heil CS, Dunham MJ., Free PMC Article | 07/15/2017 |
| CYC8 and TUP1 were required for transcription of the amino acid transporter genes. | Yeast Cyc8p and Tup1p proteins function as coactivators for transcription of Stp1/2p-dependent amino acid transporter genes.
Tanaka N, Mukai Y. | 03/26/2016 |
| coordinated sumoylation of Gcn4, Tup1 and likely other factors dampens activated transcription by stabilizing Tup1 binding and stimulating Gcn4 and RNAP II removal | Sumoylation controls the timing of Tup1-mediated transcriptional deactivation.
Ng CH, Akhter A, Yurko N, Burgener JM, Rosonina E, Manley JL., Free PMC Article | 08/15/2015 |
| These data suggest that distinctly bound Cyc8-Tup1 cooperates with Hda1p and Rpd3p to establish or maintain an extensive array of strongly positioned, deacetylated nucleosomes over the FLO1 promoter and upstream region which inhibit histone acetylation, block Swi-Snf binding and prevent transcription. | The yeast Cyc8-Tup1 complex cooperates with Hda1p and Rpd3p histone deacetylases to robustly repress transcription of the subtelomeric FLO1 gene.
Fleming AB, Beggs S, Church M, Tsukihashi Y, Pennings S., Free PMC Article | 01/17/2015 |
| Data indicate that Tup1 and the metabolic enzymes that control PI(3,5)P2 are highly conserved among eukaryotes. | The phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2)-dependent Tup1 conversion (PIPTC) regulates metabolic reprogramming from glycolysis to gluconeogenesis.
Han BK, Emr SD., Free PMC Article | 09/28/2013 |
| data presented herein highlight the importance of the architecture of the Tup1p N-terminal domain for self-association | Crystal structure of the N-terminal domain of the yeast general corepressor Tup1p and its functional implications.
Matsumura H, Kusaka N, Nakamura T, Tanaka N, Sagegami K, Uegaki K, Inoue T, Mukai Y., Free PMC Article | 11/17/2012 |
| Cyc8-Tup1 regulates transcription primarily by masking and inhibiting the transcriptional activation domains of the recruiting proteins, not by acting as a corepressor | The Cyc8-Tup1 complex inhibits transcription primarily by masking the activation domain of the recruiting protein.
Wong KH, Struhl K., Free PMC Article | 02/11/2012 |
| Analysis of wild-type and tup1 Delta chromatin data sets revealed unique organizational themes relating to the function of Tup1. | Tup1 stabilizes promoter nucleosome positioning and occupancy at transcriptionally plastic genes.
Rizzo JM, Mieczkowski PA, Buck MJ., Free PMC Article | 01/21/2012 |
| Tup1--which associates with multiple transcriptional regulators, including the HDAC (histone deacetylase) and SAGA complexes--plays a crucial role in determining an activated or repressed chromatin state of numerous genes, including GAL1. | Phosphoinositide [PI(3,5)P2] lipid-dependent regulation of the general transcriptional regulator Tup1.
Han BK, Emr SD., Free PMC Article | 06/25/2011 |
| analysis of functional links between the amino acids-sensing SPS system, the CUP9-TUP1-SSN6 repressor complex, the PTR2 peptide transporter, and the UBR1-dependent N-end rule pathway | Amino acids induce peptide uptake via accelerated degradation of CUP9, the transcriptional repressor of the PTR2 peptide transporter.
Xia Z, Turner GC, Hwang CS, Byrd C, Varshavsky A., Free PMC Article | 01/21/2010 |
| Chromatin immunoprecipitation analyses of the GRE2 promoter in the mutants demonstrated that the Sko1-Tup1-Cyc8 complex was localized to the promoter | Identification of Tup1 and Cyc8 mutations defective in the responses to osmotic stress.
Kobayashi Y, Inai T, Mizunuma M, Okada I, Shitamukai A, Hirata D, Miyakawa T. | 01/21/2010 |
| in the absence of Tup1, TPR1 is partially unfolded with its helix B being highly dynamic exposing an apolar surface to the solvent | Investigating the structural stability of the Tup1-interaction domain of Ssn6: evidence for a conformational change on the complex.
Palaiomylitou M, Tartas A, Vlachakis D, Tzamarias D, Vlassi M. | 01/21/2010 |
| in Srb10p derivatives, the absence of CM-1 & CM-II motifs decreases the interaction of Srb10p with its cyclin partner Srb11p and with the component Tup1p of the general co-repressor complex Tup1p-Ssn6p. | Functional motifs outside the kinase domain of yeast Srb10p. Their role in transcriptional regulation and protein-interactions with Tup1p and Srb11p.
Núñez L, González-Siso MI, Becerra M, Cerdán ME. | 01/21/2010 |
| Ssn6-Tup1 requires ISW2 complex to position nucleosomes. | Ssn6-Tup1 requires the ISW2 complex to position nucleosomes in Saccharomyces cerevisiae.
Zhang Z, Reese JC., Free PMC Article | 01/21/2010 |
| A genome-wide analysis was made of the functions of a conserved surface on the corepressor TUP1. | Genome-wide analysis of the functions of a conserved surface on the corepressor Tup1.
Green SR, Johnson AD., Free PMC Article | 01/21/2010 |