| Based on these results, the genetic engineering on Gat1p has a great potential in enhancing non-preferred nitrogen metabolism in S. cerevisiae. | The modification of Gat1p in nitrogen catabolite repression to enhance non-preferred nitrogen utilization in Saccharomyces cerevisiae.
Zhao X, Zou H, Chen J, Du G, Zhou J., Free PMC Article | 12/31/2016 |
| Data show that the GAT1 gene, encoding a transcriptional activator of nitrogen-responsive catabolic genes, produces a variety of mRNAs differing in their 5' and 3' termini. | Premature termination of GAT1 transcription explains paradoxical negative correlation between nitrogen-responsive mRNA, but constitutive low-level protein production.
Georis I, Tate JJ, Vierendeels F, Cooper TG, Dubois E., Free PMC Article | 06/4/2016 |
| We demonstrate that wild type Gat1 isoforms (IsoA and IsoB) are initiated at Gat1 methionines 40, 95, and/or 102, but not at methionine 1 regardless of nitrogen conditions. | Constitutive and nitrogen catabolite repression-sensitive production of Gat1 isoforms.
Rai R, Tate JJ, Georis I, Dubois E, Cooper TG., Free PMC Article | 04/12/2014 |
| Rapamycin-dependent Gat1 and Gln3 binding to the Aro80 target promoters is not affected by tryptophan availability, suggesting that transactivation activity of Aro80 is not necessary for the recruitment of GATA factors. | Interplay of Aro80 and GATA activators in regulation of genes for catabolism of aromatic amino acids in Saccharomyces cerevisiae.
Lee K, Hahn JS. | 01/4/2014 |
| Gln3, Gat1, and Ure2 respond to TorC1 and nitrogen availability via distinct regulatory pathways. | Alterations in the Ure2 αCap domain elicit different GATA factor responses to rapamycin treatment and nitrogen limitation.
Feller A, Georis I, Tate JJ, Cooper TG, Dubois E., Free PMC Article | 03/30/2013 |
| Controlling lipid fluxes at glycerol-3-phosphate acyltransferase step in yeast: unique contribution of Gat1p to oleic acid-induced lipid particle formation. | Controlling lipid fluxes at glycerol-3-phosphate acyltransferase step in yeast: unique contribution of Gat1p to oleic acid-induced lipid particle formation.
Marr N, Foglia J, Terebiznik M, Athenstaedt K, Zaremberg V., Free PMC Article | 05/19/2012 |
| Nitrogen-responsive regulation of GATA protein family activators Gln3 and Gat1 occurs by two distinct pathways, one inhibited by rapamycin and the other by methionine sulfoximine. | Nitrogen-responsive regulation of GATA protein family activators Gln3 and Gat1 occurs by two distinct pathways, one inhibited by rapamycin and the other by methionine sulfoximine.
Georis I, Tate JJ, Cooper TG, Dubois E., Free PMC Article | 03/3/2012 |
| Gln3 and Gat1 localizations are controlled by two different regulatory pathways | Distinct phosphatase requirements and GATA factor responses to nitrogen catabolite repression and rapamycin treatment in Saccharomyces cerevisiae.
Tate JJ, Georis I, Dubois E, Cooper TG., Free PMC Article | 06/28/2010 |
| The phosphorylation of Put3p appears to influence the association of Gat1p, but not Gln3p, to the PUT1 promoter. | Mutation of a phosphorylatable residue in Put3p affects the magnitude of rapamycin-induced PUT1 activation in a Gat1p-dependent manner.
Leverentz MK, Campbell RN, Connolly Y, Whetton AD, Reece RJ., Free PMC Article | 01/21/2010 |
| Results show that Gat1 is a key factor for the integrated control of nitrogen catabolite repression in Saccharomyces cerevisiae. | The yeast GATA factor Gat1 occupies a central position in nitrogen catabolite repression-sensitive gene activation.
Georis I, Feller A, Vierendeels F, Dubois E., Free PMC Article | 01/21/2010 |
| Tor pathway control of the nitrogen-responsive DAL5 gene bifurcates at the level of Gln3 and Gat1 regulation in Saccharomyces cerevisiae | Tor pathway control of the nitrogen-responsive DAL5 gene bifurcates at the level of Gln3 and Gat1 regulation in Saccharomyces cerevisiae.
Georis I, Tate JJ, Cooper TG, Dubois E., Free PMC Article | 01/21/2010 |
| in the absence of urmylation, nuclear/cytosolic shuffling of both Nil1 and Gln3 transcriptional factors is altered, ultimately leading to inability to repress GAP1 gene | Urmylation controls Nil1p and Gln3p-dependent expression of nitrogen-catabolite repressed genes in Saccharomyces cerevisiae.
Rubio-Texeira M. | 01/21/2010 |
| Rtg1/3p, Gln3p, and Gat1p can be differentially regulated through different nutrient-sensing pathways, such as TOR and retrograde signaling, and by multiple factors, such as Lst8p, which is suggested to have a role in connecting the RTG and TOR pathways | Retrograde response to mitochondrial dysfunction is separable from TOR1/2 regulation of retrograde gene expression.
Giannattasio S, Liu Z, Thornton J, Butow RA. | 01/21/2010 |
| role in regulation of invertase activity and SUC2 expression | Gln3p and Nil1p regulation of invertase activity and SUC2 expression in Saccharomyces cerevisiae.
Oliveira EM, Mansure JJ, Bon EP. | 01/21/2010 |